Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

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Investigator:n.a.


Title:Neurological examination findings in Alzheimer disease

Date of Request:06/22/2020




Aim 1:to determine a muster of neurological examination findings in AD and to investigate their prevalences over the disease course




Aim 2:evaluate the capability of neurological examinations findings in Alzheimer disease to distinguish mutation carriers from non mutation carriers among mildly cognitive symptomatic at risk individuals




Aim 3:to analyze cross-sectional and




Aim 4longitudinal associations between cognitive performance and neurological examination findings in Alzheimer disease

Investigator:Jeremy Strain


Title:Functional and Structural Correlates of Genetics in ADAD

Date of Request:06/15/2020




Aim 1:Does connectivity strength change based on APOE status or associate with the polygenetic risk score in an ADAD cohort.




Aim 2:Does structural connectivity change based on APOE status or associate with the polygenetic risk score in an ADAD cohort.




Aim 3:Does structural or functional connectivity temporally associate with proteomic data.




Investigator:NA


Title:Changes in personality in DIAN

Date of Request:05/08/2020




Aim 1:To evaluate the magnitude of within person personality change in DIAN.




Aim 2:To establish a causal link between personality change and AD biomarkers




Aim 3:Evaluate which specific “facets” of personality shown the most reliable change in preclinical ADAD.




Investigator:Patrick Luckett


Title:Effects of HIV and Aging on Resting-state Networks

Date of Request:05/06/2020




Aim 1:Combine data from numerous studies to investigate changes in resting state networks and volumetrics that occur over the lifespan in healthy controls and people living with HIV with machine learning.




Aim 2:Utilize data driven machine learning based feature selection methods to search for complex relationships among volumetrics, resting state, and genetic data.







Investigator:Ruth Peters


Title:Blood pressure and Alzheimer's pathology, the next step in understanding the relationship

Date of Request:05/04/2020




Aim 1:To examine the impact of blood pressure on cognitive function in the well characterised DIAN population




Aim 2:To evaluate the relationship between BP and Aß accumulation







Investigator:Xiaolei Shi


Title:The investigation of cerebral small vessel disease in The Dominantly Inherited Alzheimer Network

Date of Request:05/03/2020




Aim 1:To study the burden of cerebral small vessel disease in DIAN




Aim 2:To study the associations of cerebral small vessel disease neuroimaging markers with PSEN1, PSEN2, or APP gene mutations




Aim 3:To investigate the longitudinal changes of cerebral small vessel disease in DIAN




Investigator:Prof. dr. G.J. Biessels


Title:Critical white matter connections in AD: unraveling their sensitivity to AD pathology and functional relevance

Date of Request:04/06/2020




Aim 1:To examine if critical and non-critical white matter connections are differentially affected by AD in mutation carriers as compared to non-carriers, also considering burden of AD pathology and disease stage.




Aim 2:To explore if critical and non-critical white matter connections differentially affect cognition in AD mutation carriers, again also considering disease stage.







Investigator:Bret Bostwick


Title:Biomarker Modeling in Dominantly Inherited Alzheimer's Disease

Date of Request:03/17/2020




Aim 1:Compare longitudinal changes in CSF biomarkers, serum biomarkers and neuroimaging biomarkers.




Aim 2:Analyze longitudinal changes in CSF biomarkers, serum biomarkers and neuroimaging biomarkers.







Investigator:Nelly Joseph-Mathurin


Title:Genotype in dominantly inherited AD for clinical trial design

Date of Request:03/04/2020




Aim 1:Describe A/T/N trajectories per mutation type (APP, PS1, and PS2)




Aim 2:Define risk factors for ARIA per mutation type (APP, PS1, and PS2)




Aim 3:Develop and validate a prediction model for positive or adverse outcomes of anti-Aβ disease modifying treatment for DIAD individuals in clinical trials




Investigator:-


Title:Cortical diffusion analysis in Dominantly Inherited Alzheimer’s disease (DIAD)

Date of Request:02/27/2020




Aim 1:Test a novel MRI analysis tool to investigate the cortical architecture




Aim 2:Identify neural cortical architecture signature in DIAD




Aim 3:Test the discrimination power of the novel cortical diffusivity measures in Alzhiemer's disease groups




Aim 4Test the prediction power of the novel cortical measures in Alzheimer’s disease groups