Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

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Investigator:Carlos Cruchaga


Title:Using quantitative traits to identify new genes, biomarkers and drug targets for ADAD and LOAD

Date of Request:09/08/2020




Aim 1:To identify genetic variants associated with biomarker levels and quantitative traits in ADAD




Aim 2:To identify novel variants and genes associated with onset and progression by using multi-omics QTL data




Aim 3:To identify novel molecular biomarkers and drug targets by combining multi-omic QTL and Mendelian randomization analysis




Investigator:Patrick Lao


Title:Imaging White matter hyperintensities and Tau in Autosomal Dominant Alzheimer’s Disease

Date of Request:09/04/2020




Aim 1:To determine the difference in the relationship among tau and WMH, independent or dependent on amyloid, between mutation carriers and controls.




Aim 2:To characterize the timing of the relationship among tau and WMH in mutation carriers compared to controls.




Aim 3:To characterize any added benefit to incorporating spatial information from tau PET in Aims 1 and 2.




Aim 4To determine the difference in the relationship among baseline WMH and tau accumulation between mutation carriers and controls.

Investigator:Anna Dieffenbacher


Title:Specific facets of Personality traits in Autosomal Dominant Alzheimer disease

Date of Request:08/30/2020




Aim 1:1) to determine the different baseline differences between mutation carriers and non-mutation carriers in respect to the facets within each Personality Factor (OCEAN: openness to experience, conscientiousness, extraversion, agreeableness, and neuroticism). 2) to analyze longitudinal changes of facets within mutation-carriers and non-carriers.










Investigator:Ronald Hawley


Title:TEST DATA REQUEST

Date of Request:08/07/2020




Aim 1:test the form




Aim 2:test the form 2




Aim 3:test the form 3




Aim 4test the form 4








































Investigator:Suman Jayadev


Title:Investigating microRNA and immune gene regulation in fAD gene carriers

Date of Request:07/30/2020




Aim 1:To determine if AD pathogenesis involves altered gene regulation of peripheral macrophage function, we will profile miRNA/mRNA expression in monocytes isolated from ADAD gene carriers or age-matched controls. We hypothesize that dysregulated peripheral immune cells in ADAD further contribute to disease. In collaboration with the Wash U DIAN site, we have collected CD14 cells from DIAN participants. We will use computational approaches to characterize the impact of ADAD mutations on peripheral cells. We include DIAN collected variables for analyses.










Investigator:Disha Shah


Title:Functional connectivity disruptions at early stages in Alzheimer’s Disease: a comparison of brain networks in mouse models and humans.

Date of Request:07/20/2020




Aim 1:We would like to access rsfMRI data from APP and PSEN1/2 carriers versus non carriers to compare functional connectivity disruptions in human AD with functional connectivity disruptions we observe in mouse models of Alzheimer's pathology. We would like to compare whether the same brain regions are involved, to study the extent to which our findings in mice can be translated to humans.










Investigator:n.a.


Title:Neurological examination findings in Alzheimer disease

Date of Request:06/22/2020




Aim 1:to determine a muster of neurological examination findings in AD and to investigate their prevalences over the disease course




Aim 2:evaluate the capability of neurological examinations findings in Alzheimer disease to distinguish mutation carriers from non mutation carriers among mildly cognitive symptomatic at risk individuals




Aim 3:to analyze cross-sectional and




Aim 4longitudinal associations between cognitive performance and neurological examination findings in Alzheimer disease

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