Investigator:Prof. Ralph Martins
Title:Plasma and cerebrospinal fluid phospholipid profiles in a DIAN cohort subset
Date of Request:11/22/2013
Status:A
ID:DIAN-D1317
Aim 1:To find phospholipid species which significantly differ in concentrations between mutation carriers and non carriers.
Aim 2:To correlate the phospholipid species obtained in aim 1, with the established gold standard biomarkers such as PiB-PET SUVR, cerebrospinal fluid concentrations of total-tau, phosphorylated-tau and Aβ42.
Aim 3:correlate the plasma phospholipid species obtained in aim 1, with FDG-PET SUVR, MRI data and plasma Abeta levels.