Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 51 - 60 of 291

Investigator:Randy Buckner


Title:Exploration of multimodal MRI Biomarkers in preclinical stage of Alzheimer's Disease

Date of Request:03/16/2022

ID:DIAN-D2206




Aim 1:The goal of this study is to combine multimodal structural imaging biomarkers to optimistically distinguish Alzheimer’s disease and normal aging in the early and mild stages of Alzheimer’s disease.










Investigator:Professor John Gallacher


Title:The biopsychosocial determinants of cognitive change and Alzheimer's disease

Date of Request:02/14/2022

ID:DIAN-D2205




Aim 1:The overall aim of the project will be to assess the biopsychosocial determinants of Alzheimer’s disease across modifiable and non-modifiable factors




Aim 2:To profile cognitive change by biopsychosocial construct determinants




Aim 3:To profile cognitive change and AD by biopsychosocial construct determinants and genetic stratification




Aim 4To create a biopsychosocial risk profiling tool for brain health

Investigator:John Ringman


Title:Biomarker Characterization of the A431E mutation in PSEN1

Date of Request:02/11/2022

Status:approved

ID:DIAN-D2204




Aim 1:To assess plasma and CSF biomarkers associated with the A431E mutation in PSEN1.




Aim 2:To assess volumetric changes, white matter hyperintensities, and microhemorrhages on MRI seen in association with the A4341E mutation in PSEN1.




Aim 3:To assess cerebral amyloid deposition measured using PiB PET associated with the A4341E mutation in PSEN1.




Aim 4To assess cerebral tau deposition measured using flortaucipir PET associated with the A4341E mutation in PSEN1.

Investigator:Jasmeer Chhatwal


Title:Evaluating ADAD Mutation-specific Biomarker and Cognitive Trajectories (Renewal of 1606A)

Date of Request:02/09/2022

ID:DIAN-D2203




Aim 1:Determine if simple categorizations of ADAD mutations can explain variability in biomarker and cognitive trajectories




Aim 2:Determine if biochemical characterizations of individual PSEN1 mutations can elucidate cognitive and biomarker trajectories in DIAN




Aim 3:Determine if there are mutation-specific effects that predict the development of CAA in mutation carriers




Investigator:Jan Torleif Pedersen, PhD MSc


Title:Investigation of pS396-tau in samples from DIAN-TU biobank

Date of Request:02/01/2022

ID:DIAN-D2202




Aim 1:Investigation of pS396-tau in samples from DIAN-TU biobank




Aim 2:To investigate pT217-tau levels in CSF samples from DIAN-TU




Aim 3:To establish potential correlation between pS396-tau, pT217-Tau and clinical progression parameters




Aim 4To investigate tau species in post-mortem brain material targeted by Lu AF87908

Investigator:Christopher Weise


Title:Hypothalamic volume in familial Alzheimer’s disease (FAD) and its associations with body weight and other FAD biomarkers

Date of Request:01/06/2022

ID:DIAN-D2201




Aim 1:• To compare hypothalamic volume in symptomatic and asymptomatic FAD with healthy controls




Aim 2:• To investigate potential associations of hypothalamic volume with cross sectional body weight (BMI) and longitudinal body weight changes in participants with FAD




Aim 3:• To explore the relationship of hypothalamic volume with additional biomarkers (Aß-burden, glucose metabolism and CSF based biomarkers), clinical/cognitive parameters and EYO




Investigator:Jee Hoon Roh/Jae-Hong Lee


Title:Epigenetic analyses to assess the resilience among DIAN mutation carriers

Date of Request:12/15/2021




Aim 1:To investigate the potential epigenetic causes of resilience among DIAN mutation carriers who are discordant in disease courses measured by biomarkers.










Investigator:Ni Shu


Title:Human brain connectome study with AD biomarkers

Date of Request:12/06/2021




Aim 1:To develop an association analysis method for multi-modal human connectome




Aim 2:To systematically evaluate the damage patterns of the brain network due to AD biomarkers




Aim 3:To establish cross-scale correlation models for different stages of AD




Aim 4To establish an accurate AD prediction model based on features extracted from brain networks that are sensitive to biomarker changes

Investigator:Rawan Tarawneh


Title:Proteomic and Transcriptomic Measures of Vascular Injury Markers in AD

Date of Request:11/23/2021




Aim 1:Compare differences in CSF and brain RNA levels of the vascular injury markers (GDF-15, MCP-1, RAGE, MPO, IL-18, ST2/IL1R1, CDH5 [VE-cadherin], E-selectin, SDC3) between symptomatic ADAD mutation carriers, asymptomatic ADAD mutation carriers, and healthy controls.










Investigator:Rawan Tarawneh


Title:Proteomic analyses of inflammatory pathways in ADAD

Date of Request:11/09/2021




Aim 1:Investigate the association of CSF proteomic signatures with cognition in ADAD




Aim 2:Investigate the associations of CSF proteomic signatures with brain atrophy in ADAD




Aim 3:Investigate the associations of CSF proteomics with amyloid and tau imaging in ADAD