Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

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Investigator:Perminder S Sachdev

Title:CSF and blood protein biomarkers and APOE genotype status of early-onset Alzheimer’s disease variants: A systematic review and meta-analysis

Date of Request:03/20/2019

Aim 1:We have performed a meta-analysis and systematic review to compare core biomarkers (CSF Aβ42 and tau) across early-onset AD (EOAD) subtypes i.e. autosomal dominant Alzheimer’s disease (ADAD) and early onset sporadic Alzheimer’s disease (EOsAD). Furthermore, we are exploring several other potential markers of neurodegeneration in EOAD, including NFL, IgG and IL-6 which are emerging in the literature. A recent published article from DIAN group “Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease” Nature Medicine volume 25, pages 277–283 (2019)”. This article includes data for measurement of NFL in serum and CSF, provided data in graphical format. We need data in mean and standard deviation format to perform meta-analysis on NFL serum and CSF.

Investigator:Prof. Vijayalakshmi Ravindranath

Title:Sex-specific differences in cognitive decline in AD

Date of Request:03/05/2019

Aim 1:Study differences in trajectory of cognitive decline in males and females from DIAN dataset

Aim 2:Study differences in age of onset in AD between males and females

Investigator:Steven L. Wagner

Title:Dedifferentiation and neuronal lineage repression orchestrated through remodeling of the chromatin landscape define PSEN1 mutation-induced Alzheimer’s Disease

Date of Request:02/27/2019

Aim 1:Compare gene signature profiles and changes in chromatin topology observed in iPSC-derived EOFAD neurons to those reported in EOFAD subject post-mortem brain tissue

Investigator:Ting Ma

Title:Association of morphology and network connectivity of degenerative disease

Date of Request:02/21/2019

Aim 1:Morphological change mechanism of Alzheimer’s continuum

Aim 2:Structural connectivity change mechanism of Alzheimer’s continuum

Aim 3:Brain function connectivity variation of Alzheimer’s continuum

Aim 4Association of morphology and network connectivity in AD development

Investigator:Suman Jayadev

Title:MicroRNA regulation of central nervous system and systemic inflammation in AD

Date of Request:05/25/2017


Aim 1:Determine if FAD and SAD brain develop distinct patterns of myeloid cell heterogeneity.

Investigator:Adam L. Boxer, MD, PhD

Title:Individualized prediction of symptom onset in familial AD using structural MRI

Date of Request:02/11/2019

Aim 1:create individualized atrophy maps in patients with fAD

Aim 2:investigate the utility of these maps for predicting the likelihood of developing symptoms of dementia on longitudinal follow-up

Investigator:Randall Bateman MD

Title:Dominantly Inherited Alzheimer's Disease Protective Factor Study

Date of Request:01/29/2019

Aim 1:The overall objective is to identify factors that protect mutation-carriers from AD symptoms.

Aim 2:1. Obtaining the clinical, cognitive, biomarker and genetic results from the DIAN research study .

Aim 3:2. Administering a number of questionnaires assessing health and lifestyle factors to include the following: Current Health Status, Medical Conditions, Physical Functioning, Exposure History Form, Occupational and Environmental Exposure History.


Title:Advanced analytics on DIAN imaging data

Date of Request:01/28/2019

Aim 1:Use advanced analytics to predict mutation carrier status of DIAN patients by vMRI data only

Aim 2:Use advanced analytics to predict mutation carrier status of DIAN patients by amyloid PET data only

Investigator:Randall Bateman. MD

Title:Relationship between literacy, socio-economic status, Alzheimer pathology and cognitive decline in autosomal dominant Alzheimer’s disease.

Date of Request:12/27/2018

Aim 1:Aim 1: To examine the extent to which environmental risk factors like level of education and SES influence age of onset in ADAD. Hypothesis 1a: Age at symptom onset will be earlier in those with a lower level of education or lower SES.

Aim 2:Aim 2: To determine the influence of educational level (EL) and SES on cognitive decline, disease progression and mortality rate. Hypothesis 2a: Educational Level and SES has a significant effect on cognitive decline and mortality rate after diagnosis, so cognitive decline rate and mortality rate will be faster in those with less than 9 years of education and lower SES.

Investigator:Randall Bateman. MD

Title:Relationship between clinical heterogeneity and neuroanatomical variability in Autosomal dominant familial Alzheimer disease.

Date of Request:12/12/2018



Aim 1:Examine the extent to which factors like atrophy pattern, regional brain metabolism and underlying pathology (regional AB and TAU) influence clinical heterogeneity in ADAD. Hypothesis 1a: Regional brain atrophy, hypometabolism, and underlying pathology will correlate with distinct clinical phenotypes in ADAD.

Aim 2:To determine the influence of underlying pathology (regional AB and TAU) on cognitive decline and neuropsychological profiles. Hypothesis 2a: the amount and distribution of 18F-AV1451 retention will correlate with cognitive decline rate and neuropsychological performance.