Search DIAN Tissue Requests
In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-T1004), the full request has been submitted and is either approved, disapproved or in process.
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Role of PS1 and FAD mutants on neuronal receptor complexes.
Examine role of PS1 and FAD mutants on neuronal receptor complexes and dimerization
Examine effects of PS1 and FAD mutants on the neuroprotective activities of BDNF and ephrins
Comparison of intra-individual change in INNOTEST CSF biomarkers in Autosomal Dominant Alzheimer Disease and Late Onset Alzheimer Disease
Aim 1: Characterization of intra-individual CSF biomarker changes
Aim 2: Correlation of CSF and imaging biomarkers of neurodegeneration
Aim 3: CSF biomarkers predict cognitive performance
Assistant professor Henrietta M Nielsen, PhD
CSF alpha-synuclein in familial versus sporadic AD
To assess CSF alpha-synuclein levels in patients with familial AD versus sporadic AD and controls
To investigate potential associations between CSF alpha-synuclein levels, AD biomarkers (piB-PET and CSF AD biomarkers) and cognitive status in familiar AD patients
To investigate potential effects of APOE genotype on CSF alpha-synuclein levels in familial versus sporadic AD patients
Perminder S Sachdev
Identification and preliminary validation of plasma protein, lipid and metabolite biomarkers in autosomal dominant Alzheimer?s disease
Identification of plasma protein biomarker candidates using two discovery proteomics approaches (iTRAQ and SWATH-MS)
Targeted proteomics for validation of protein biomarker candidates and comparison of proteins changes in ADAD and LOAD
Identification of metabolite biomarkers using targeted and non-targeted metabolomics
Investigate and validate lipid and metabolite alterations using liquid chromatography coupled with mass spectrometry (LC-MS) in autosomal dominant Alzheimers disease
Neurofilament light chain in blood serum as marker of disease progression in neurodegenerative diseases
Determine whether and how many years before the estimated time point of symptom onset (EYO) mutation carriers (MC) of autosomal dominant Alzheimer?s disease (ADAD) show altered blood (serum) levels of neurofilament light chain (NfL) compared to non-mutation carriers (nMC).
Test whether serum levels of NfL are correlated with previous measured CSF levels and are associated with longitudinal changes in PIB-PET, FDG-PET, and structural MRI, resting state fMRI, with other CSF biomarkers, clinical symptoms and performance
DIAN-ADNI Comparison study
characterize the stages of preclinical AD with amyloid PET and cerebrospinal fluid (CSF) concentrations of Aβ and tau and phosphorylated tau (p-tau) and determine whether both groups demonstrate initial cerebral amyloidosis that is followed by the development of neurodegeneration prior to onset of A
In both ADAD and LOAD, determine whether initial symptoms of AD are characterized by subjective reports (self-reported and those of a study partner) of the gradual onset of memory impairment as well as by deficits in objective measures of episodic memory
In both LOAD and ADAD, determine whether there is a pattern of disease progression that is marked by intra-individual global cognitive and functional decline that culminates in death.
Characterize other similarities and any differences in AD phenotypes between LOAD and ADAD
Aβ-specific fibrin fragment resistant to fibrinolysis in the CSF and plasma of familial AD patients with HCHWA
Analyze the level of fibrin degradation products in the antemortem CSF of HCHWA patients and compare levels to sporadic AD cases and non-demented controls.
Analyze the level of an A?-specific fibrin fragment resistant to fibrinolysis in the plasma of AD patients with HCHWA and compare levels to sporadic AD cases and non-demented controls.
Human iPSC-derived organoids to study Alzheimer?s disease
to generate cortical organoids from iPSCs of AD patients and controls
to generate iPSCs from APP mutation fibroblasts
To study pathological events of AD in organoids
Dr. A Claudio Cuello
Investigating early NGF dysmetabolism as a source of novel biomarkers in ?silent? stages of Alzheimer?s disease
To investigate plasma markers of NGF dysmetabolism as a source of biomarkers in pre-clinical AD
To investigate CSF markers of NGF dysmetabolism as a source of biomarkers in pre-clinical AD
In-depth characterization of iPSC-derived neuronal models carrying familial dementia mutations
Generation and development of human neuronal models with dementia-related dysfunctions
To explore molecular mechanism of neuronal malfunctions by FAD-linked mutations