Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 251 - 260 of 294

Investigator:Suprateek Kundu


Title:Statistical approaches for early detection of Alzheimer's Disease

Date of Request:7/17/2015

ID:DIAN-D1507




Aim 1:Based on previous data on amyloids, predict if a future subject is likely to have Alzheimer's




Aim 2:Develop flexible statistical methodology for detecting the time of onset of Alzheimer's disease based on studying amyloid levels







Investigator:John Ringman


Title:White matter pathology in PSEN1-related spastic paraparesis

Date of Request:7/17/2015

ID:DIAN-D1508




Aim 1:To assess MRI measures of white matter pathology in PSEN1 mutation carriers with spastic paraparesis relative to those without










Investigator:Alex Whittington


Title:Spatiotemporal Modelling of misfolded proteins in AD

Date of Request:7/22/2015

ID:DIAN-D1509




Aim 1:Characterising the spatiotemporal pattern of Beta-amyloid in AD in vivo




Aim 2:Temporal ordering of subjects in AD




Aim 3:Using temporal ordering as a classifier




Investigator:Jason Hassenstab


Title:Using Run-in Data for Cognitive Endpoint Secondary Prevention Trials

Date of Request:8/12/2015

ID:DIAN-D1510




Aim 1:Determine if data collected prior to randomization can increase power of seconday prevention trials.










Investigator:Dr Vincent de la Sayette


Title:Amyloid imaging in young to middle-aged adults

Date of Request:8/17/2015

ID:DIAN-D1511




Aim 1:understand AB deposition and progression in young to middle-aged cognitively normal adults










Investigator:Ryoko Ihara


Title:Outcomes from awareness of mutation status in DIAN study

Date of Request:8/21/2015

ID:DIAN-D1512




Aim 1:To investigate how awareness of mutation status affects mental status and cognitive decline both in short term and long term




Aim 2:To investigate how awareness of mutation status before participation affects motivation for the study participation afterwards







Investigator:Serge Gauthier


Title:Neurobiological Markers of Suicide Vulnerability in Alzheimer?s Disease Patients

Date of Request:9/3/2015

ID:DIAN-D1513




Aim 1:to characterize neurobiological markers (socio-demographic, clinical, neuropsychological, and biological profile) of asymptomatic ADAD mutation carriers and symptomatic ADAD mutation carriers with suicidal ideations (suicidal patients).




Aim 2:to compare neurobiological markers (socio-demographic, clinical, neuropsychological, and biological) in a) asymptomatic ADAD mutation carriers suicidal patients, b) symptomatic ADAD mutation carriers suicidal patients, c) asymptomatic non-mutation carrier non-suicidal controls, and to d) symptomatic







Investigator:NA


Title:Examining the relationship between exercise, Aβ accumulation, brain atrophy and age at onset: A study of autosomal-dominant Alzheimer?s disease mutation carriers

Date of Request:11/3/2015

ID:DIAN-D1514




Aim 1:1. Examine the rates of brain Aβ accumulation between exercising and sedentary asymptomatic mutation carriers, versus aged matched non-mutation carriers.




Aim 2:2. Examine rates of hippocampal and prefrontal cortex atrophy between exercising and sedentary asymptomatic mutation carriers, versus aged matched non-mutation carriers.




Aim 3:3. Examine the relationship between baseline exercise levels and age at onset in symptomatic mutation carriers.




Investigator:John Ringman/JJ Wang


Title:Microhemorrhages and vascular compliance

Date of Request:11/9/2015

ID:DIAN-D1515




Aim 1:To relate number of micro hemorrhages to cerebrovascular compliance for UCLA DIAN subjects










Investigator:Prof. Dr. Adrian Danek


Title:Frequency of seizures in the DIAN cohort: A comparison between mutation carriers and non-carriers

Date of Request:11/23/2015

ID:DIAN-D1516




Aim 1:Our specific aim for our proposed work with the DIAN data set is to find out whether there is a difference in frequency of seizures in mutation carriers of familial Alzheimer?s disease in comparison to non-carriers.




Aim 2:Furthermore we are planning to follow an enhanced approach by querying the NACC data base for a comparison of frequency of seizures between patients with sporadic Alzheimer?s disease, mutation carriers for the familial Alzheimer?s disease and non-carriers.




Aim 3:A further possibility is to additionally include patients with frontotemporal lobar degeneration for comparison of frequency of seizures.




Displaying 251 - 260 of 294