Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

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Investigator:Dawn Matthews


Title:Multimodality Imaging Diagnostic for Preclinical and Prodromal AD

Date of Request:1/25/2016

ID:DIAN-D1603




Aim 1:Further refine and validate our use of early frame amyloid data as a marker of disease and predictor of functional change




Aim 2:Refine and validate PET and structural MRI classifiers in differentiating amyloid positive and negative populations and predicting rate of clinical decline.




Aim 3:Optimize processing and classification approaches to functional MRI data as available to characterize disease state and progression




Aim 4Compare imaging markers of disease progression in the DIAN population to Late Onset populations

Investigator:Eric McDade


Title:Task Based Functional MRI in Preclinical Autosomal Dominant Alzheimer Dementia

Date of Request:1/27/2016

ID:DIAN-D1604




Aim 1:To identify differences in neuronal network function during working memory and learning in preclinical ADAD




Aim 2:To explore the association of task-based functional MRI activity in preclinical mutation carriers with imaging and CSF based AD pathology.




Aim 3:To explore task-based function MRI activity with longitudinal PET amyloid deposition.




Investigator:John M. Ringman, M.D., M.S.


Title:Description of a novel pathogenic PSEN1 mutation (S230N)

Date of Request:1/31/2016

ID:DIAN-D1605




Aim 1:We want to write a manuscript presenting the comprehensive descriptions of 3 persons from a family featuring a novel PSEN1 mutation, including PiB scans, quantification of MRI and CSF variables.










Investigator:Jasmeer Chhatwal


Title:Evaluating Mutation Type and Genotype Specific Amyloid Trajectories in DIAN

Date of Request:2/9/2016

ID:DIAN-D1606




Aim 1:Determine if mutation genotype significantly interacts with EYO in predicting amyloid burden measured by PET and CSF.










Investigator:Carlos Cruchaga


Title:Genetic Studies Using CSF biomarker levels

Date of Request:2/19/2016

ID:DIAN-D1607




Aim 1:to identify novel genetic modifiers factors using use the CSF biomarker levels (tau, ptau, AB, YKL40, VILIP1, GRN and TREM2) as endophenotype for genetic studies




Aim 2:to determine whether we can incorporate genetic information to increase the sensitivity and specify of the CSF biomarkers







Investigator:PD Dr. Johannes Levin


Title:Frequency of movement disorders in ADAD mutation carriers

Date of Request:2/24/2016

ID:DIAN-D1608




Aim 1:The specific aim for the proposed work with the DIAN data set is to find out whether there is a difference in frequency of movement disorders in ADAD mutation carriers compared to non-carriers.




Aim 2:Additionally we aim for the examination of the kind of movement disorders respectively their particular frequency and the time of occurrence in the course of the disease.




Aim 3:Furthermore we are planning to follow an enhanced approach by querying the NACC data base for a comparison of frequency of movement disorders between patients with sporadic Alzheimer�s disease, ADAD mutation carriers and non-carriers.




Aim 4A further possibility is to additionally include patients with frontotemporal lobar degeneration for comparison of frequency of movement disorders.

Investigator:John C. Morris, MD


Title:Prevelence and growth of microbleeds in autosomal dominant Alzheimer's disease: link with amyloidosis and white matter disease

Date of Request:3/8/2016

ID:DIAN-D1609




Aim 1:Evaluate correspondance between microbleeds oberved in vivo and vascular abnormalities (as CAA) observed at autopsie




Aim 2:Evaluate impact of the mutation type on microbleeds and CAA observed on imaging and at autopsie







Investigator:Jonathan V�glein


Title:Effect of cigarette smoking on the age of onset in ADAD

Date of Request:3/29/2016

ID:DIAN-D1610




Aim 1:The specific aim for the proposed work with the DIAN data set is to find out whether there is an influence of cigarette smoking on the age of onset in individuals with ADAD.










Investigator:Beau Ances


Title:Structure Function of Amyloid Progression

Date of Request:4/15/2016

ID:DIAN-D1611




Aim 1:Can function alone predict Amyloid Progression across time.




Aim 2:Can structure alone predict Amyloid Progression across time.




Aim 3:Can structure and function predict Amyloid Progression across time.




Investigator:Beau Ances


Title:Structure Function of Amyloid Progression

Date of Request:5/17/2016

ID:-




Aim 1:Can function alone predict Amyloid Progression across time.




Aim 2:Can structure alone predict Amyloid Progression across time.




Aim 3:Can structure and function predict Amyloid Progression across time.