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In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

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Investigator:Josephine Barnes

Title:Baseline volumes and rates of WMH accrual in familial AD: relationships with brain atrophy and cognitive measures

Date of Request:1/26/2017


Aim 1:to quantify WMH accrual in FAD using our longitudinal WMH measurement tool

Aim 2:to assess whether WMH accrual is related to concurrent atrophy of the brain and hippocampus, estimated using the boundary shift integral, and also to change in cognition.

Aim 3:to investigate whether any potential relationships from aims 1) and 2) differ according to genetic status (APP vs. PSEN1 vs. PSEN2).

Aim 4to investigate whether any potential relationships from aims 1) and 2) are materially altered by adjustment for APOE e4 status