Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 1 - 10 of 156

Investigator:Maxime Descoteaux


Title:Tractometry informed dementia predictor

Date of Request:10/17/2018

Status:Pending

ID:DIAN-D1818




Aim 1:Look at longitudinal values of white matter tractometry to find which metrics or combination of metrics predicts best incoming dementia symptoms. Our tractometry algorithm will look at 12 metrics (DTI, HARDI, Freewater and microstructure) inside 33 white matter bundles each split in multiple subsections.










Investigator:Barbara Bendlin/Vikas Singh


Title:Characterizing disease propagation in autosomal dominant Alzheimer's disease

Date of Request:10/03/2018

Status:Pending

ID:DIAN-D1817




Aim 1:To utilize a non-Euclidean wavelet transform for connectivity signature (WaCS) to characterize structural connectivity alterations in autosomal AD.




Aim 2:To create subject specific propagation maps utilizing PET data in order to predict the spread of AD pathophysiologic markers over time.




Aim 3:To predict longitudinal cognitive decline or end-stage disease (EYO) using markers of AD pathology (CSF and PET based).




Investigator:Prof Dr Baris Topcular


Title:Amyloid Imagıng in Familial and Non-Familial AD

Date of Request:09/29/2018

Status:Pending

ID:DIAN-D1816




Aim 1:Detection of similarities in terms of Amyloid Imaging




Aim 2:Detection of differences in terms of Amyloid Imaging







Investigator:Sarah Eisenstein


Title:Neuroinflammation in Obesity

Date of Request:09/13/2018

Status:Pending

ID:DIAN-D1815




Aim 1:The first aim is to replicate in the DIAN controls cohort our finding that DTI-based indicators of neuroinflammation are greater in obese individuals compared to normal-weight individuals.










Investigator:Guoqiao Wang


Title:Build a predictive model to estimate EYO for sporadic Alzheimer disease

Date of Request:09/05/2018

Status:Pending

ID:DIAN-D1814




Aim 1:Validate the generalizability of the EYO estimation models using the ACS study




Aim 2:Evaluate the goodness-of-estimation of these statistical models by comparing the model estimate EYO with the mutation/parent EYO (calculated using mutation mean age of onset or parent age of onset) using the DIAN observational study




Aim 3:Improve the accuracy of the EYO for the ADAD population by modifying the statistical model to estimate a shift in the EYO using the biomarker, imaging, and cognition information.




Aim 4Build a predictive model for sporadic EYO by optimizing/modifying the statistical models to select the most appropriate model for each outcome (e.g. with/without monotonic assumption) and to select the most sensitive outcomes.

Investigator:Steve Petersen


Title:How the brain breaks: Non-linear network level changes in neurodegenerative diseases.

Date of Request:08/23/2018

Status:Pending

ID:DIAN-D1813




Aim 1:To see how resting state networks change as a function of estimated years to symptom onset




Aim 2:To explore the idea of "cascading network failure" in DIAN




Aim 3:To relate changes in resting state functional connectivity to other AD biomarkers




Investigator:N/A


Title:QMENTA Data Request

Date of Request:07/06/2018

Status:Pending

ID:DIAN-D1812




Aim 1:run data analysis




Aim 2:internal R&D purposes







Investigator:Raquel Sánchez-Valle


Title:Early cortical micro and macrostructural changes in autosomal dominant Alzheimer’s disease

Date of Request:05/30/2018

Status:Pending

ID:DIAN-D1811




Aim 1:Assess the micro and macrostructrure cortical changes in ADAD. We will investigate these changes in relation to the estimated years to symptom onset.




Aim 2:Study the relationship between CSF biomarker levels, plasma NfL levels and the aforementioned cortical micro and macrostructural changes. We will investigate the effect of CSF Aß1-42 and PIB values, t-tau, p-tau, NfL levels and plasma NfL levels on the trajectory of changes.







Investigator:Tammie Benzinger


Title:Aging Independent Detection of Atrophy: Validating A Structural MR-based Diagnostic Tool

Date of Request:05/17/2018

Status:Pending

ID:DIAN-D1810




Aim 1:Improve the Individual Longitudinal Participant Report (clinical tool used to analyze structural MR data currently in use at Barnes-Jewish Hospital) in order to maximize its diagnostic utility.




Aim 2:Determine how effectively the ILP can use structural MR data to distinguish different dementia types in a clinical setting.







Investigator:Marco Duering


Title:Disentangling brain damage due to Alzheimer’s and vascular disease using a novel diffusion bitensor model

Date of Request:04/19/2018

Status:Approved

ID:DIAN-D1809




Aim 1:To determine the diffusion signature in different patient samples, covering the entire spectrum of neurodegenerative and small vessel pathology




Aim 2:To assess the association between the bitensor DTI measures and biomarkers for AD and SVD