Investigator:Suman Jayadev
Title:Investigating microRNA and immune gene regulation in fAD gene carriers
Date of Request:07/30/2020
Aim 1:To determine if AD pathogenesis involves altered gene regulation of peripheral macrophage function, we will profile miRNA/mRNA expression in monocytes isolated from ADAD gene carriers or age-matched controls. We hypothesize that dysregulated peripheral immune cells in ADAD further contribute to disease. In collaboration with the Wash U DIAN site, we have collected CD14 cells from DIAN participants. We will use computational approaches to characterize the impact of ADAD mutations on peripheral cells. We include DIAN collected variables for analyses.