Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 11 - 20 of 157

Investigator:Marco Duering

Title:Disentangling brain damage due to Alzheimer’s and vascular disease using a novel diffusion bitensor model

Date of Request:04/19/2018



Aim 1:To determine the diffusion signature in different patient samples, covering the entire spectrum of neurodegenerative and small vessel pathology

Aim 2:To assess the association between the bitensor DTI measures and biomarkers for AD and SVD

Investigator:Corey Bolton

Title:Neuropsychological differentiation of autosomal dominant and sporadic early-onset Alzheimer's disease

Date of Request:03/29/2018



Aim 1:To describe the typical neurocognitive profile of autosomal-dominant Alzheimer's disease

Aim 2:To distinguish differences in neurocognitive presentation between patients with autosomal-dominant Alzheimer's disease from the DIAN database and those with sporadic, early-onset Alzheimer's disease from the NACC database.

Investigator:Michele Cavallari

Title:Assessing the association between perivascular dysfunction and beta-amyloid burden in subjects with or at risk for dementia

Date of Request:03/21/2018



Aim 1:To assess group differences in perivascular dysfunction, under the hypothesis that the number of MRI-evident ePVS is: symptomatic carriers > asymptomatic carriers > mutation non-carriers.

Aim 2:To estimate the association between MRI-evident ePVS and PET-derived measures of beta-amyloid load in cross-sectional and longitudinal analyses, under the hypothesis that perivascular dysfunction contributes to the accrual of beta-amyloid.

Investigator:Simone Wahl

Title:DIAN Elecsys CSF and Amyloid Imaging Concordance

Date of Request:02/21/2018



Aim 1:Determine the concordance between CSF measures obtained via the Elecsys platform

Aim 2:Assess Elecsys CSF measure relative to other clinical and cognitive variables

Aim 3:Assess how well Elecsys measures predict clinical and cognitive progression

Investigator:Viktoria Andreeva

Title:DIAN data analysis in a tranSMART platform

Date of Request:02/16/2018



Aim 1:Curate the DIAN data and prepare for tranSMART loading

Aim 2:Perform investigation of data in tranSMART platform

Investigator:Dr. Alan C. Evans

Title:Comparing Multifactorial Pathologic Trajectories in Asymptomatic Autosomal Dominant Alzheimer’s Disease Mutation Carriers and Late-Onset Alzheimer’s Disease patients

Date of Request:02/04/2018



Aim 1:Identify disease triggering events in each DIAN subject, using all the available multimodal neuroimaging data

Aim 2:Subdivide and stage the DIAN subjects based on the identified individual causal pathological mechanisms (from Aim 1)

Aim 3:Compare both the obtained potential triggering events and the subjects’ subdivision/staging (from Aims 1 and 2 respectively) with the equivalent results previously obtained for LOAD patients from ADNI database.

Investigator:Howard Rosen, Brad Boeve, Adam Boxer

Title:Quantification of Longitudinal Volume Change in Familial FTD (fFTD)

Date of Request:01/28/2018



Aim 1:To quantify rates of change in structural (T1w) imaging in symptomatic fFTD

Aim 2:To quantify rates of change in structural (T1w) imaging in presymptomatic fFTD

Aim 3:To derive subject-specific maps of volumetric change in fFTD

Investigator:Betty Tijms

Title:Linking brain connectivity changes to development of symptoms in autosomal dominant AD

Date of Request:01/27/2018



Aim 1:To study the association of grey matter connectivity in autosomal dominant AD with estimated year of onset and cognitive decline.

Aim 2:To study associations between grey matter connectivity alterations and AD and injury markers in CSF (aβ42, aβ40, p-tau, t-tau, neurogranin, VLIP-1, SNAP-25, NRGN, YKL-40) and PET (aβ, FDG, and tau) cross-sectionally and longitudinally.

Aim 3:Compare cross-sectional findings in grey matter connectivity with longitudinal changes.


Title:Updated analyses of Dominantly Inherited Alzheimer Disease (AD) neuroimaging data using new biomarker, clinical, genetic, and psychometric data

Date of Request:01/26/2018



Aim 1:Cross-sectional evaluation of the temporal ordering of imaging biomarkers in asymptomatic ADAD with current biomarker, clinical, genetic, and psychometric data.

Aim 2:Harmonization of refined ADAD imaging processed values with the ADNI sporadic AD studies (ADNI)

Investigator:Carlos Cruchaga/Celeste Karch

Title:Clinical and Molecular Characterization of PSEN1 and PSEN2 Variants of Unknown Pathogenicity

Date of Request:12/21/2017



Aim 1:To describe imaging and fluid biomarkers for PSEN1 and PSEN2 variants of unknown pathogenicity