Search DIAN Data Resource Requests

Title:The Virtual Brain Cloud

Date of Request:10/29/2019

Aim 1:Provide an overview on all accessible AD/dementia clinical cohort datasets. Systematically compare them by looking at the actual data and not only meta-data. Assess the state of data sharing in the dementia field.

Aim 2:Multi-study comparative modeling of longitudinal patient trajectories.

Aim 3:Include longitudinal models into The Virtual Brain platform to allow for individual patient brain simulations.

Title:Integrative modeling and dynamic prediction of Alzheimer’s disease

Date of Request:10/24/2019

Aim 1:To develop a novel integrative modeling framework for clinical studies of AD that collect longitudinal clinical data.

Aim 2:To generalize the integrative modeling framework for the joint analysis of longitudinal clinical data and high-dimensional MRI data.

Aim 3:To advance the integrative modeling framework to incorporate relevant genetic markers from genome-wide association studies

Title:Functional evaluation of a novel Alzheimer disease candidate gene, AGFG2.

Date of Request:10/06/2019

Aim 1:Evaluation of AGFG2 as a potential disease driver in Alzheimer Disease

Title:Identification of common pathways across Alzheimer Disease phenotypes.

Date of Request:10/06/2019

Aim 1:Transcriptomic profiling of AD brains

Aim 2:eQTL profiling of AD brains

Title:Alzheimer's dementia onset and progression in international cohorts

Date of Request:09/23/2019

Aim 1:Using unsupervised machine learning techniques (latent Gaussian processes, auto encoders, disentanglement) in order to identify ‘pure’ (and potentially highly non-linear) Alzheimer factors using DIAN cohort.

Aim 2:Study the utility of the resulting latent structure for progression prediction of the late-onset patients.

Title:Role of toxoplasmosis in AD

Date of Request:09/09/2019

Aim 1:Evaluate differences in amyloid PET based on Toxoplasma serological status

Aim 2:Evaluate differences in cognative function based on Toxoplasma serological status

Title:The effect of exercise participation on Aβ accumulation, CSF biomarkers and brain atrophy and age at onset

Date of Request:08/27/2019

Aim 1:1. Compare the rates of brain Aβ accumulation between exercising and sedentary asymptomatic mutation carriers.

Aim 2:2. Compare longitudinal changes in CSF levels of Aβ and tau between exercising and sedentary asymptomatic mutation carriers.

Aim 3:3. Compare rates of hippocampal and prefrontal cortex atrophy between exercising and sedentary asymptomatic mutation carriers.

Aim 44. Examine the relationship between baseline exercise levels and age at onset in symptomatic mutation carriers.

Title:Head to head comparison of CSF assay platforms for identifying amyloid positivity

Date of Request:08/20/2019

Aim 1:To compare the analytic performance of the two automated assay platforms (Elecsys and Lumipulse) for measurement of CSF AB40, AB42, total tau and ptau181 in a common sub-cohort of DIAN samples

Aim 2:To define the best-performing CSF biomarker cut-point(s) for amyloid PET positivity for each of the assay platforms

Title:Drug-disease-trial model for Alzheimer's prevention drug development

Date of Request:07/22/2019

Aim 1:Develop a drug-disease trial model to optimize clinical trial design in Alzheimer's prevention

Aim 2:Submit the model for regulatory endorsement at FDA and EMA

Aim 3:Develop a graphical user interface for the model

Aim 4Make model publicly available

Title:Modelling Alzheimer’s disease with human neurons generated by direct conversion (reprogramming) of patient fibroblasts

Date of Request:07/14/2019

Aim 1:Developing cellular models of AD through direct neuronal reprogramming

Aim 2:Application of direct neuronal reprogramming in patient fibroblasts