Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 71 - 80 of 150

Investigator:Erik Roberson

Title:A Novel PS1 Mutation (PSEN1 N135Y)

Date of Request:3/13/2013



Aim 1:Describe clinical and histopathological features of AD resulting from mutation (autopsy on patient's father)

Aim 2:Describe biomarker evaluation of the patient (PET, CSF)

Aim 3:Evaluate production of A-beta 1-42 production resulting from the mutation in vitro

Investigator:Beth Snitz

Title:Five factor personality dimensions and the Alzheimer pathology spectrum in Autosomal Dominant Alzheimer Disease

Date of Request:4/12/2013



Aim 1:1) Determine whether Five-Factor personality dimensions are associated with biomarkers a-beta and tau (global PiB SUVR and CSF markers), cross-sectionally in mutation carriers, along a symptom spectrum from asymptomatic to mild AD.

Aim 2:2) Quantify the degree of longitudinal change in Five-Factor personality dimensions in mutation carriers, stratified by baseline clinical stage.

Aim 3:3) Investigate whether personality dimensions are associated with estimated time-to-symptom onset.

Aim 44) Explore the degree to which distress-related measures Neuroticism, depressive symptoms, and subjective cognitive symptoms are associated with each other and share outcome-associated variance (i.e., biomarkers and disease progression measures such as estimated time-to-onset).

Investigator:Dr. Christian Gaser

Title:BrainAGE in dominantly inherited Alzheimer’s disease

Date of Request:4/16/2013



Aim 1:Exploring the brain aging pattern in subjects with DIAN and controls (cross-sectionally & longitudinally)

Aim 2:Disentangling the age-related atrophy pattern from the disease-specific atrophy pattern in the brain (structural MRI)

Aim 3:Estimating BrainAGE scores in subjects with DIAN and controls to predict conversion to AD

Aim 4Exploring factors / variables, which affect BrainAGE

Investigator:Yen Ying Lim

Title:Relationship between BDNF Val66Met, Aβ, cognitive function and hippocampal volume in patients who are at risk of developing autosomal dominant Alzheimer’s disease

Date of Request:4/30/2013



Aim 1:Examine the association between BDNF Val66Met, Aβ, disease classification (healthy and MCI), memory function and hippocampal volume cross-sectionally and prospectively

Aim 2:Examine whether physical activity modifies the relationship between BDNF Val66Met and Aβ-related decline in memory function and reductions in hippocampal volume

Aim 3:Examine whether changes in other areas of cognition are associated with BDNF Val66Met and Aβ

Aim 4Examine whether APOE genotype modifies the relationship between BDNF Val66Met and Aβ-related decline in memory function and reductions in hippocampal volume

Investigator:Randall Bateman

Title:Post-dural puncture headache: An analysis of the risks of experiencing headaches after a Lumbar Puncture procedure on the Dominantly Inherited Alzheimer Network (DIAN) participants

Date of Request:6/17/2013



Aim 1:Analyze the relationships between factors of CSF collection of LP procedures on and adverse events of DIAN participants.

Investigator:Randall Bateman

Title:Clinical and cognitive measures of the DIAN cohort

Date of Request:7/12/2013



Aim 1:Determine the longitudinal rate of clinical conversion from cognitively normal to dementia in a carefully studied population of DIAN participants including average age of onset and CDR and psychometric rate of progression.

Aim 2:Evaluate the cognitive and clinical change, including rate of change, by multifactorial analysis including age, estimated years to onset (parental age of onset), ApoE4, average familial onset, genetic risk factors and biomarkers.

Investigator:Anne Fagan

Title:Relationship between CSF cell counts and biomarkers

Date of Request:7/18/2013



Aim 1:To assess the relationship between CSF cell counts and biomarker levels

Investigator:Tammie Benzinger

Title:Analysis of cortical volume as a risk factor for post lumbar puncture headache

Date of Request:7/24/2013



Aim 1:To determine whether cortical volume is a risk factor for post lumbar puncture headache

Investigator:Jurgen Claassen

Title:Association between amyloid-beta, systemic (blood pressure) and brain vascular changes.

Date of Request:9/24/2013



Aim 1:To investigate associations between amyloid-β accumulation (carrier vs non-carrier) and baseline blood pressure changes

Aim 2:To investigate associations between amyloid-β accumulation (carrier vs non-carrier) and visit to visit blood pressure variability

Aim 3:To investigate associations between amyloid-β accumulation (carrier vs non-carrier) and cerebral blood flow (derived from PET)

Investigator:Jeffrey Petrella

Title:The Alzheimer's Connectome: Relationships between structural and functional changes in the DIAN population

Date of Request:10/9/2013



Aim 1:Determine whether changes in the structural connectome are associated with changes in the functional connectome across diagnostic groups in the DIAN population

Aim 2:Determine whether changes in the structural connectome are affected by increasing beta amyloid burden in the DIAN population.