Search DIAN Tissue Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-T1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 21 - 30 of 53

Investigator:

Alison Goate

Title:

Defining the mechanisms of AD pathogenesis in human IPSC-derived neurons

Date of Request:

11/5/2012

Status:

A

ID:

DIAN-T1204

Aim 1:

To measure the influence of pathogenic FAD mutations on APP and tau metabolism in human neurons

Investigator:

John M. Ringman, M.D., M.S.

Title:

Metabolic profiling of biofluids in Alzheimer's Disease

Date of Request:

11/15/2012

Status:

A

ID:

DIAN-T1206

Aim 1:

Identify the compounds in the combined gas chromatography-mass spectrometry profiles that differentiate the samples collected from patients carrying and not carrying causative FAD mutations. Further analyses will compare presymptomatic and symptomatic persons carrying FAD mutations.

Aim 2:

Identify peaks in the combined liquid chromatography-mass spectrometry profiles that differentiate samples collected from causative FAD mutation carriers and non-carriers, and presymptomatic and symptomatic FAD mutation carriers and identify the responsible compounds.

Aim 3:

Establish and apply quantitative assays to the compounds identified in Aims 1 and 2.

Aim 4:

Integrate all the compounds that are identified in Aims 1 and 2 into a biochemical overview, and rationalize these data with the extant knowledge about Alzheimer's Disease pathology.

Investigator:

Richard J. Perrin

Title:

Quantitative label-free proteomics for CSF Biomarkers in Dominantly Inherited AD

Date of Request:

2/6/2013

Status:

A

ID:

DIAN-T1301

Aim 1:

To evaluate and map the temporal patterns of novel CSF biomarkers, measured in DIAN samples using quantitative label-free proteomics. Data will be aligned according to expected symptom onset; values from carriers (N=120) and non-carriers (N=80) will be compared (as in Bateman RJ, et al. NEJM 2012).

Aim 2:

To integrate proteomics data into the context of known AD-associated changes for this cohort (Bateman RJ, NEJM 2012), to compare novel and existing markers, and to compare this autosomal dominant dataset to a sporadic AD dataset already derived from proteomic analysis of a Knight ADRC cohort.

Investigator:

Karen H. Ashe

Title:

Specific CSF Abeta oligomers in unimpaired DIAN subjects

Date of Request:

3/26/2013

Status:

A

ID:

DIAN-T1302

Aim 1:

Compare CSF Abeta*56 and Abeta trimer levels in unimpaired carriers and non-carriers

Aim 2:

Correlate CSF Abeta oligomers with Abeta1-42, tau and p-tau181

Aim 3:

Relate CSF Abeta*56 and Abeta trimer levels to predicted age of onset

Investigator:

Ajay Verma MD Ph.D., VP, Development Sciences Biogen Idec

Title:

Proposal to evaluate the prognostic and diagnostic potential of selected AD biomarkers using plasma and CSF samples from DIAN registry

Date of Request:

4/11/2013

Status:

IP

ID:

DIAN-T1303

Aim 1:

Evaluate total pyroglutamate-Aβ(pE3-Aβ) in plasma and CSF and other selected amyloid Aβ isoforms in CSF as prognostic/diagnostic markers of AD in symptomatic and pre-symptomatic populations of mutation carriers and non-carriers in the DIAN registry

Aim 2:

Evaluate the CSF sTREM2 and VLP-1 markers as prognostic/diagnostic markers of AD in symptomatic and pre-symptomatic populations of mutation carriers and non-carriers in the DIAN registry

Aim 3:

Evaluate the selected modified by oxidative stress tyrosine moieties in CSF as markers linked to amyloidogenesis, inflammation, and neuronal injury

Aim 4:

Publish the findings from the above evaluations and share the results with Alzheimer’s disease research community

Investigator:

Randall Bateman

Title:

DIAN TU Biomarker Core Validation Testing

Date of Request:

6/5/2013

Status:

A

ID:

DIAN-T1304

Aim 1:

To develop and validate a method of measuring biomarker kit lot variability and new lot acceptance criteria

Aim 2:

To establish and verify our internal quality control (QC) process for assay plate and sample acceptance criteria

Aim 3:

To test DIAN TU drug interference on the ability of the AlzBio3 assay to detect CSF tau and ptau181

Aim 4:

To validate the DIAN TU internal CSF pools as suitable internal controls to be used for Incurred Sample Reanalysis (ISR) during the trial

Investigator:

Lucas Restrepo

Title:

Antibody Signature of Alzheimer's Disease

Date of Request:

2/5/2014

Status:

IP

ID:

DIAN-T1401

Aim 1:

To confirm whether AD has a specific and reproducible antibody signature that can be used as diagnostic test

Aim 2:

Confirm that patients with PSEN-1 mutations have an Alzheimer-type signature

Aim 3:

Determine whether PSEN-2 and APP mutation carrieres have an Alzheimer signature

Aim 4:

Determine whether Alzheimer signature is present before the onset of dementia in mutation carriers

Investigator:

Wyss-Coray

Title:

plasma proteomic markers associated with CSF biomarkers in AD

Date of Request:

3/17/2014

Status:

A

ID:

DIAN-T1402

Aim 1:

correlate CSF biomarkers with 700 plasma proteins using sliding threshold analysis

Aim 2:

validate discovery of CSF Abeta threshold obtained with samples from sporadic AD

Aim 3:

assess effects of APOE

Aim 4:

find thresholds for tau, ptau and correlate plasma proteins with cognitive function

Investigator:

Christian Haass

Title:

Soluble TREM2 in autosomal dominant Alzheimer’s disease

Date of Request:

4/17/2014

Status:

IP

ID:

DIAN-T1403

Aim 1:

Determine whether and how many years before the estimated time point of symptom onset (EYO), mutation carriers (MC) of autosomal dominant Alzheimer’s disease (ADAD) show altered cerebrospinal fluid (CSF) and plasma levels of soluble TREM2 (sTREM2) compared to non-mutation carriers (NC).

Aim 2:

Test whether differences in CSF and plasma levels of sTREM2 are associated with longitudinal changes in PIB-PET, FDG-PET, and structural MRI, rsfMRI, with other CSF biomarkers (Aß42, T-tau, p-tau), clinical symptoms (MMSE, CDR-SOB) and cognitive performance (memory and executive functions).

Investigator:

Brian Gordon

Title:

Insulin and glucose levels in autosomal dominant Alzheimer's Disease

Date of Request:

9/24/2014

ID:

DIAN-T1404

Aim 1:

To measure fasting blood insulin and glucose levels in non-carriers, asymptomatic carriers, and symptomatic carriers

Aim 2:

Relate alterations in insulin and glucose to biomarkers of AD pathology drawn from CSF, PET, and structural imaging