Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 51 - 60 of 294

Investigator:Jonathan Wagg


Title:: Leverage DIAN data to derive and validate EYO estimation models applicable to Downs Syndrome (DS) populations

Date of Request:04/07/2022

ID:DIAN-D2209




Aim 1:Review and analyze DIAN longitudinal clinical endpoint and biomarker measure changes over time that are: (i) of potential utility for development of EYO estimation models; (ii) comparable to measures available in longitudinal DS cohort datasets such as the ABC-DS cohort.




Aim 2:Use measures identified in (1.) to derive alternative model structures for EYO estimation in the DIAN population.




Aim 3:Compare the predictive performance of candidate model structures in the DIAN population.




Aim 4Assess the best performing model structures in a DS population.

Investigator:Brian Gordon


Title:Comparing biomarkers between Down Syndrome, Autosomal Dominant, and Late onset Alzheimer Disease

Date of Request:03/25/2022

Status:approved

ID:DIAN-D2208




Aim 1:How do measures of tau pathology measured using PET compare among DS, ADAD, and LOAD?




Aim 2:Does the spread of tau pathology over time differ between cohorts?




Aim 3:Are white matter lesions a common finding in all three forms of AD?




Aim 4How do biofluid profiles compare between DS, ADAD, and LOAD?

Investigator:kun zhao


Title:Alzheimer's disease

Date of Request:03/18/2022

ID:DIAN-D2207




Aim 1:e want to provide a reference point for each individual during aging to provide a reference at each time of the lifespan.




Aim 2:we also provide a frame for the intersection of multi neurodegenerative disease and mental disorder.







Investigator:Randy Buckner


Title:Exploration of multimodal MRI Biomarkers in preclinical stage of Alzheimer's Disease

Date of Request:03/16/2022

ID:DIAN-D2206




Aim 1:The goal of this study is to combine multimodal structural imaging biomarkers to optimistically distinguish Alzheimer’s disease and normal aging in the early and mild stages of Alzheimer’s disease.










Investigator:Professor John Gallacher


Title:The biopsychosocial determinants of cognitive change and Alzheimer's disease

Date of Request:02/14/2022

ID:DIAN-D2205




Aim 1:The overall aim of the project will be to assess the biopsychosocial determinants of Alzheimer’s disease across modifiable and non-modifiable factors




Aim 2:To profile cognitive change by biopsychosocial construct determinants




Aim 3:To profile cognitive change and AD by biopsychosocial construct determinants and genetic stratification




Aim 4To create a biopsychosocial risk profiling tool for brain health

Investigator:John Ringman


Title:Biomarker Characterization of the A431E mutation in PSEN1

Date of Request:02/11/2022

Status:approved

ID:DIAN-D2204




Aim 1:To assess plasma and CSF biomarkers associated with the A431E mutation in PSEN1.




Aim 2:To assess volumetric changes, white matter hyperintensities, and microhemorrhages on MRI seen in association with the A4341E mutation in PSEN1.




Aim 3:To assess cerebral amyloid deposition measured using PiB PET associated with the A4341E mutation in PSEN1.




Aim 4To assess cerebral tau deposition measured using flortaucipir PET associated with the A4341E mutation in PSEN1.

Investigator:Jasmeer Chhatwal


Title:Evaluating ADAD Mutation-specific Biomarker and Cognitive Trajectories (Renewal of 1606A)

Date of Request:02/09/2022

ID:DIAN-D2203




Aim 1:Determine if simple categorizations of ADAD mutations can explain variability in biomarker and cognitive trajectories




Aim 2:Determine if biochemical characterizations of individual PSEN1 mutations can elucidate cognitive and biomarker trajectories in DIAN




Aim 3:Determine if there are mutation-specific effects that predict the development of CAA in mutation carriers




Investigator:Jan Torleif Pedersen, PhD MSc


Title:Investigation of pS396-tau in samples from DIAN-TU biobank

Date of Request:02/01/2022

ID:DIAN-D2202




Aim 1:Investigation of pS396-tau in samples from DIAN-TU biobank




Aim 2:To investigate pT217-tau levels in CSF samples from DIAN-TU




Aim 3:To establish potential correlation between pS396-tau, pT217-Tau and clinical progression parameters




Aim 4To investigate tau species in post-mortem brain material targeted by Lu AF87908

Investigator:Christopher Weise


Title:Hypothalamic volume in familial Alzheimer’s disease (FAD) and its associations with body weight and other FAD biomarkers

Date of Request:01/06/2022

ID:DIAN-D2201




Aim 1:• To compare hypothalamic volume in symptomatic and asymptomatic FAD with healthy controls




Aim 2:• To investigate potential associations of hypothalamic volume with cross sectional body weight (BMI) and longitudinal body weight changes in participants with FAD




Aim 3:• To explore the relationship of hypothalamic volume with additional biomarkers (Aß-burden, glucose metabolism and CSF based biomarkers), clinical/cognitive parameters and EYO




Investigator:Jee Hoon Roh/Jae-Hong Lee


Title:Epigenetic analyses to assess the resilience among DIAN mutation carriers

Date of Request:12/15/2021




Aim 1:To investigate the potential epigenetic causes of resilience among DIAN mutation carriers who are discordant in disease courses measured by biomarkers.










Displaying 51 - 60 of 294