DIAN-TU Biospecimen Resource Request Page
In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. TU1004), the full request has been submitted and is either approved, disapproved or in process.
Displaying 1 - 9 of 9
Unraveling the complexity of mitochondrial pathology in familial Alzheimer's disease
Referred to Obs
Use high-content and high-throughput assay to quantify the MT dynamics phenotypes that develop in neurons derived from iPSCs of fAD subjects and age-matched and/or isogenic controls.
Define the functional impairment in these neurons (IMM-inner mitochondrial membrane potential).
Interrogate the function of the electron transport chain (ETC) in these neurons.
Measure the structural integrity of MT, the ETC, and MT-related processes in these neurons by quantitative Western blotting of proteins and/or tandem mass tag quantitative mass spectroscopy.
Relationship between regional baseline and longitudinal tau PET SUVR, and correlations with change in cognition in participants from the DIAN-TU study
Characterize the spatial patterns of tau deposition at baseline and over time in the DIAD population
Estimate the rate of change in tau deposition in DIAD participants in each of the provided parcellated brain regions
Identify the (meta)ROI(s) at baseline that best correlate with change in tau PET SUVR and change in cognition, respectively, over time
Characterize the relationship between change in tau PET SUVR and change in cognition (and other biomarkers)
Mariah S. Hahn
Targeting Dysregulated Synapse and Proteostasis Mechanisms in Alzheimer's Disease
Referred to Obs
Develop a 3D culture system compatible with long-term (>3 month) iNeuron culture, extension, synapse formation and elimination, and quantitative assessment of neural circuit activity using “healthy” networks.
Compare AD_(PSEN1)-iNeuron cultures to iNeuron cultures derived from unaffected family member controls with respect to Aβ, tau phosphorylation, synapse maintenance and proteostasis.
Gain Precision on the Measurement of Cognitive Impairment – Item Response Theory Scoring of the CDR
Evaluate the difficulty and discrimination level, and the longitudinal change of each item in CDR and their longitudinal change over time
Develop the best fitting item response theory (IRT) model for automatically scoring dementia severity (IRT score)
Compare the performance of the IRT score with that of the CDR sum of box in terms of powering a clinical trial and precision in tracking cognitive change over time, especially for cognitively normal participants
Valid the performance of the IRT score using other psychometric measures and biomarkers.
Peripheral immune profiles in ADAD
Measure immune related microRNA, exosome, proteins in carriers and non-carriers
Proposal for comparison between Dominantly Inherited Alzheimer Disease and sporadic early-onset Alzheimer’s disease
To compare clinical presentation, neuropsychological performance and cognitive decline rate between DIAD and sporadic EOAD
To examine in vivo the regional distribution of tau, amyloid-beta, brain glucose metabolism, and structural atrophy, as well as their relationships, in DIAD and sporadic EOAD
To compare CSF biomarkers levels and rates of change in DIAN and sporadic EOAD
Imaging-Histology Comparisons of Tau Pathology in ADAD and LOAD
Perform a quantitative comparison of tau pathology in ADAD and LOAD using imaging and histology