The Dominantly Inherited Alzheimer Network is a global research effort focused on dominantly inherited Alzheimer’s disease (DIAD). Our mission is to find solutions to treat or prevent DIAD and, potentially, all forms of Alzheimer’s.
These efforts, led by WashU Medicine in St. Louis, consist of a long-term observational study as well as basic science studies and clinical trials.
An overview of the DIAN Observational Study
DIAN Obs
Dominantly Inherited Alzheimer Network
Established in 2008, DIAN is an international research partnership involving institutions in the United States, Canada, Latin America, Australia, Europe, and Asia. This group operates the DIAN Observational (DIAN Obs) study, a long-term effort to observe changes that occur in individuals with dominantly inherited Alzheimer’s disease (DIAD). DIAN Obs is the key scientific and discovery study for ADAD and also provides natural history information for the DIAN Trials Unit (DIAN-TU), which is the therapeutic and target validation platform for treatment and prevention trials.
Our work is conducted in multiple countries around the world and involves researchers, clinicians, genetic counselors, individuals and families, all of whom connect through these efforts.
How did the DIAN-TU start?
DIAN-TU
Dominantly Inherited Alzheimer Network Trials Unit
Established in 2010, the DIAN-TU is the clinical research arm of DIAN. DIAN-TU is an international partnership dedicated to designing and managing interventional therapeutic trials for individuals with and at risk of DIAD.
The DIAN-TU’s primary goal is to implement effective, safe and efficient clinical trials that have the highest likelihood of success in advancing overall treatments as well as scientific understanding of inherited Alzheimer’s disease. In addition, research within the DIAN-TU is likely to advance broader understanding of all types Alzheimer’s disease with regards to causes, early detection/diagnosis, the effects of multiple classes of drugs and the impact of treating Alzheimer’s disease early.
Learn more
The DIAN Team
Meet the DIAN team.
Committees
Browse the DIAN Committees.
Contact Information
For questions or more information regarding DIAN EXR, DIAN Obs or DIAN-TU, please email our team at dianexr@wustl.edu.