Investigator:Hongtu Zhu
Title:Knowledge-enhanced Cognitive System for Alzheimer’s Disease
Date of Request:07/28/2024
Status:pending approval
ID:DIAN-D2423
Aim 1:Construct an AD-KG by utilizing multiple curated resources, literature, and individual data across different domains and studies for AD.
Aim 2:Construct OKG for harmonization, imputation, and knowledge representation of AD-related multi-omics data.
Aim 3:Construct NKG for presentation, imputation, and knowledge representation of neuroimaging data and NOKG for knowledge representation of neuroimaging omics association maps, including, building a functional-facilitated structural connectome (FFSC) atlas, training cognitive systems methods for imputation and synthesis, constructing NKG and NOKG, respectively, to augment and complement AD-KG in 1).
Aim 4Develop an AD-KG-enhanced cognitive system (AD-KG-CS) for clinically transformative research.