Investigator:Mustapha Bouhrara
Title:Establishing Noninvasive Biomarkers of Axonal Degeneration in Autosomal Dominant Alzheimer's Disease using Multishell Diffusion MRI
Date of Request:08/27/2024
Status:pending approval
ID:DIAN-D2427
Aim 1:The purpose of this study is to investigate axonal degeneration in Autosomal Dominant Alzheimer's Disease (ADAD) using advanced multishell diffusion magnetic resonance imaging (MRI) analyses, including Constrained Neurite Orientation Dispersion and Density Imaging (C-NODDI), to better understand the timing, location, and mechanisms of axonal degeneration in ADAD, and to identify potential biomarkers for AD progression and therapeutic efficacy.
Aim 2:To investigate axonal degeneration in ADAD using multishell diffusion MRI analyses, including C-NODDI, NODDI, and SMI.
Aim 3:To map axonal degeneration alterations as a function of years from symptom onset and integrate them within the temporal biomarker model of ADAD.
Aim 4To examine the relationship between axonal degeneration alterations and CSF- or blood/plasma-based biomarkers of AD pathology in ADAD.