DIAN-TU Funding and Study Team

The DIAN-TU acknowledges the many individuals who have contributed to the DIAN-TU Trials including funding partners, leadership team, core leaders, project arm leaders, study sites and institutional study partners.

DIAN-TU Support

Through public/private support and partnership, the DIAN-TU has launched trials to provide advancement of treatments, scientific understanding and improvements in the approach to Alzheimer’s disease drug developments.

  • Alzheimer’s Association
  • DIAN-TU Pharma Consortium: Biogen Idec, Eisai, Janssen, Lilly, Roche/Genentech (Former Members: Abbvie, Amgen, AstraZeneca, Elan, Forum, Mithridion, Novartis Pharm AG, Pfizer, Sanofi-Aventis, United NeuroScience)
  • National Institute on Aging of the National Institutes of Health: U01 AG042791, R01 AG046179, R01/R56 AG053267, R01 AG068319, U01 AG059798, R13 AG055232
  • Accelerating Medicines Partnership (AMP)
  • DIAN-TU Trial Industry Partners:
    • Eli Lilly and Company (Solanezumab)
    • F. Hoffmann-La Roche (Gantenerumab)
    • Janssen (Atabecestat)
  • Avid Radiopharmaceuticals a wholly owned subsidiary of Eli Lilly and Company
  • GHR Foundation
  • Anonymous Foundation
  • Cerveau Technologies
  • CogState
  • Signant Health (Formerly Bracket)

DIAN-TU Study Team

The DIAN-TU acknowledges the many individuals who have contributed to the DIAN-TU Trials including funding partners, leadership team, core leaders, project arm leaders, study sites and institutional study partners listed in the following pages.

DIAN-TU Leadership Team

  • Randall Bateman, MD, Director and Principal Investigator
  • Eric McDade, DO, Associate Director
  • David Clifford, MD, Associate Director and Medical Director
  • Jorge Llibre-Guerra, MD, MS, Assistant Director
  • Susan Mills, Senior Director of Clinical Operations
  • Mary Leigh Abbott, Associate Director of Clinical Operations
  • Stephanie Belyew, Assistant Director of Clinical Operations
  • Anna Santacruz, Administrative Director, Administration Core
  • Charlene Supnet, PhD, Associate Executive Director, Administration Core
  • Stephen Salloway, MD, Project Arm Leader, Gantenerumab
  • Martin Farlow, MD, Project Arm Leader, Solanezumab
  • Lon Schneider, MD, Project Arm Leader, BACE
  • Anne Fagan, PhD, Biomarker Core Leader
  • Chengjie Xiong, PhD, Biostatistics Core Leader
  • Guoqiao Wang, PhD, Biostatistics Co-Core Leader
  • Jason Hassenstab, PhD, Cognition Core Leader
  • Alan Renton, PhD, Genetics Co-Core Leader
  • Carlos Cruchaga, PhD, Genetics Co-Core Leader
  • Tammie Benzinger, MD, Imaging Core Leader
  • Rick Perrin, MD, Neuropathology Core Leader

DIAN-TU Core Leaders

  • Randall Bateman, MD, Administrative Core Leader, Washington University School of Medicine
  • Anne Fagan, PhD, Biomarker Core Leader, Washington University School of Medicine
  • Chengjie Xiong, PhD, Biostatistics Core Leader, Washington University School of Medicine
  • Guoqiao Wang, PhD, Biostatistics Co-Core Leader, Washington University School of Medicine
  • Jason Hassenstab, PhD, Cognition Core Leader, Washington University School of Medicine
  • Alan Renton, PhD, Genetics Core Leader, Mt. Sinai School of Medicine
  • Carlos Cruchaga, PhD, Genetics Core Leader, Washington University School of Medicine
  • Tammie Benzinger, MD, Imaging Core Leader, Washington University School of Medicine
  • Rick Perrin, MD, Neuropathology Core Leader, Washington University School of Medicine
  • Jorge Llibre-Guerra, MD, MSc, Post-Doctoral Associate
  • Cliff Jack, MD, MRI, Mayo Clinic
  • Robert Koeppe, MD, PET Imaging, University of Michigan
  • Nigel Cairns, MD (retired), Neuropathology Core Leader, Washington University School of Medicine
  • Peter Snyder, PhD, (former Cognition Core Leader), Brown University

DIAN Expanded Registry (DIAN EXR)

  • Eric McDade – Director
  • Randall Bateman – Associate Director
  • Jorge Llibre-Guerra – Associate Director
  • Ellen Ziegemeier – Senior Clinical Research Coordinator
  • Jennifer Petranek – Clinical Coordinator I
  • Sarah Adams – Clinical Research Coordinator II
  • Susan Brandon – Clinical Research Coordinator II

DIAN-TU Faculty and Staff

  • Elizabeth Cook, Administrative Coordinator II, Administration Core
  • Ron Hawley, IT Audiovisual and Interactive web designer, Administration Core
  • Emily Klinke, Clinical Research Study Assistant I, Administration Core
  • Jacki Mallmann, Senior Grant Specialist, Administration Core
  • Karen McCann, Financial Accounting Assistant, Administration Core
  • Julie Murphy, Accounting/Purchasing Assistant, Administration Core
  • Jeanette Schillizzi, Research Administrator, Administration Core
  • Wendy Simpson, Financial Accounting Assistant, Administration Core
  • Shannon Sweeney, Finance Analyst, Administration Core
  • Bryce Baker, Technician, Biomarker Core
  • Elizabeth McKee, Clinical Research Specialist, Biomarker Core
  • Sushila Sathyan, Archivist, Biomarker Core
  • Jennifer Stauber, Research Specialist, Biomarker Core
  • Angela Fuqua, Clinical Trial Manager, Clinical Scale, Drug Supply and Vendor Management, Clinical Operations
  • Alyssa Galley, Senior Clinical Trial Manager, Clinical Operations
  • Inbal Meshulam, Clinical Trials Manager, Clinical Operations
  • Jeanine Portell, Clinical Trial Manager, MRI Sites, Clinical Operations
  • Annette Stiebel, Clinical Trial Manager, Regulatory, Clinical Operations
  • Arthur Gipson, Contract Specialist Clinical Data Manager, Clinical Operations
  • Tayona Mayhew, Data Management Specialist, Clinical Operations
  • Dana Burgdorf, Research Nurse Coordinator II, Clinical Operations
  • Erica Fowler, Clinical Research Coordinator I, Clinical Operations
  • Dottie Heller, Research Nurse Coordinator II, Clinical Operations
  • Miranda Jany, Clinical Research Coordinator I, Clinical Operations
  • Michelle Jorke, Clinical Research Coordinator II, Clinical Operations
  • Paulette MacDougall, Research Nurse Coordinator II, Clinical Operations
  • Eugene Rubin, QC, Clinical Operations
  • Andy Aschenbrenner, Assistant Professor, Cognition Core
  • Jennifer Smith, Clinical Research Specialist, Cognition Core
  • John Budde, Laboratory Manager, Genetics Core
  • Jonathan Heusel, Chief Medical Officer Genomics and Pathology, Genetics Core
  • Samantha McNulty, Instructor, Genetics Core
  • Joanne Norton, Research Nurse Coordinator, Genetics Core
  • Jon Christensen, Staff Scientist, Imaging Core
  • Aylin Dincer, Research Assistant, Imaging Core
  • Stephanie Doering, Imaging Analyst, Imaging Core
  • Tony Durbin, Senior Clinical Research Coordinator, Imaging Core
  • Shaney Flores, Research Assistant, Imaging Core
  • Karl Friedrichsen, Research Assistant, Imaging Core
  • Brian Gordon, Co-Investigator, Imaging Core
  • Russ Hornbeck, Project Manager, Imaging Core
  • Nelly Joseph-Mathurin, Post-doc, Imaging Core
  • Nicole McKay, Imaging Analyst, Imaging Core
  • Sarah Keefe, Research Assistant, Imaging Core
  • Lakisha Lloyd, Research Coordinator, Imaging Core
  • Laura Marple, Research Technician II, Imaging Core
  • Austin McCullough, Graduate Research Assistant, Imaging Core
  • Farzaneh Rahmani, Imaging Analyst, Imaging Core
  • Stephanie Schultz, Pre-Doctoral Trainee, Imaging Core
  • Sally Schwarz, Co-Investigator, Imaging Core
  • Yi Su, Co-Investigator, Imaging Core
  • Andrei Vlassenko, Co-Investigator, Imaging Core
  • Qing Wang, Post-doc, Imaging Core
  • Jinbin Xu, Co-Investigator, Imaging Core
  • Erin Franklin, Research Coordinator, Neuropathology Core

Eli Lilly and Company and Avid Radiopharmaceuticals

Eli Lilly and Company Team

  • John Sims, MD, Senior Medical Director
  • Karen Holdridge, MPH, Senior Clinical Research Scientist
  • Cheryl Brown, BS, Project Leader and Manager
  • Roy Yaari, MD, Senior Medical Advisor
  • Isabella Velona, Clinical Trial Project Manager
  • Scott Andersen, Biostatistician
  • Michele Mancini, GPS
  • Brian Willis, PK/PD Project Leader
  • Sonia Nijampatnam, Pharmaceutical Project Management
  • Kathryn Broderick, Global Regulatory Affairs
  • Julie Bush, Product Delivery
  • Shamrock Garrett, Sr. CTMA
  • Traci Peddie, Data Sciences & Solutions
  • Natalie Vantwoud, Data Management
  • Barbara Lightfoot-Owens, Medical Writer
  • John Brad-Holmes, Central Lab

Avid Radiopharmaceuticals Team

  • Michael Devous
  • Erica Elephant
  • Laura Harper
  • Marybeth Howlett
  • Mark Mintun
  • Michael Pontecorvo

Former Team Members

Phyllis Ferrell Barkman, Russ Barton, Lauren Brunke, Robert Dean, Deanilee Deckard. Ann Catherine Downing. Ganapathy Goppalrathnam. David Henley, Janice Hitchcock. Tracie Peddie. Melissa Pugh, Tami Jo Rayle, Shiloh Scott, James Senetar, Gopalan Sethuraman, Eric Siemers, Brian Steuenwald, Connie Tong, Jim Vandergriff

F. Hoffman-LaRoche, Ltd. Team

  • Greg Klein, PhD, Biomarker Experimental Medicine Leader
  • Smilijana Ristic, MD, Associate Group Medical Director
  • Rachelle Doody, MD, PhD, Global Head of Neurodegneration
  • Geoff Kerchner, MD, Global Development Leader
  • Monika Baudler, PhD, LifeCycle Leader
  • Paul Delmar, Principal Statistical Scientist
  • Carsten Hofmann, Clinical Pharmacologist
  • Michaela Jahn, Global Biometrics Team Leader
  • Alison Searle, Operations Program Leader
  • Marco Sonderegger, Technical Development Leader
  • Roz Sutton, EU Regulatory Partner
  • Janette Turner, US Regulatory Partner
  • Jaku Wojtowicz, Safety Science Director
  • Susan Yule, Global Regulatory Leader

Former Team Members

Elizabeth Ashford, Operations Program Leader; Bogdon Balas, Safety Science Leader; Estelle Vester-Blokland, LifeCycle Leader; Stephanie Capo-Chichi, EU Regulatory Partner; David Agnew, Global Study Manager; Ernest Dorflinger, Translational Medicine Leader; Efe Egharevba, Global Study Manager; Christelle Laroche, Technical Development Leader; Isabelle Bauer Dauphin, Technical Development Leader; Rob Lasser, Global Development Leader; Ferenc Martenyi, Global Development Leader; Glenn Morrison, Global Development Leader; Tania Nikolcheva, Biomarker Experimental Medicine Leader; Michael Rabbia, Statistical Scientist; Juha Savola, Project Leader; Janice Smith, Clinical Science Leader; Dietmar Volz, Statistical Scientist

Janssen Team

  • Caitlin Beatty, MBA, Quality Monitoring and Compliance Manager
  • Jennifer Bogert, MS, Associate Director
  • Miranda Damen Carol Davis, Director, Clinical Program Leader
  • Marisa Ehinger, Director, Clinical Supplies
  • Suzanne Foy, BPharm, Senior Director, Global Regulatory Leader
  • Monique Franc, PhD, MSc, Scientific Director, Global Regulatory Affairs
  • Betty Guinter, BS, Global Data Management Specialist
  • Katrin Haeverans, BS, Clinical Scientist and External Affairs Director
  • Megan Katz, MBA, Senior Planner
  • Hartmuth Kolb, PhD, Neuroscience Biomarkers and Global Imaging
  • Cathy Marseca Reena Mistry, BscPharm, Global Trial Leader
  • Sophie Morin, MSc, Head Global Audit, Quality & Compliance
  • Maria Schpatschynskyj, Associate Director Pv Alliance Contracting
  • Hong Sun, MD, PhD, Sr. Director, Compound Development Team Leader & Clinical Leader
  • Monika Sulidis, Global Clinical Trial Assistant

Former team members

Gary Romano, MD, Head of Development, Alzheimer’s Disease; Luc Tritsmans, MD, Senior Director, Compound Development Team Leader, Late Development, Neuroscience TA

DIAN-TU DSMB Members

  • Gary Cutter, PhD, DSMB Chairperson, University of Alabama at Birmingham
  • Steve Greenberg, MD, PhD, Massachusetts General Hospital, Boston
  • Scott Kim, MD, PhD, National Institutes of Health, Bethesda
  • David Knopman, MD, Mayo Clinic, Rochester
  • Willis Maddrey, MD (retired), UT Southwestern, Dallas
  • Kristine Yaffe, MD, University of California, San Francisco
  • Karl Kieburtz, MD, PhD, (DSMB Chairperson, retired) University of Rochester, NY
  • Allan Levey, MD, PhD (retired), Emory University, Atlanta

DIAN-TU Therapy Evaluation Committee

  • Randall Bateman, MD, Chair, Washington University School of Medicine, St. Louis
  • Eric McDade, DO, Co-Chair, Washington University School of Medicine, St. Louis
  • Paul Aisen, MD, Alzheimer’s Therapeutic Research Institute, USC
  • Jasmeer Chhatwal, MD, PhD, MMSc, Massachusetts General Hospital, Harvard Medical School
  • David Clifford, MD, Washington University School of Medicine, St. Louis
  • David Cribbs, MD, UC Irvine, CA
  • Nick Fox, MD, FRCP, FMedSci, Dementia Research Centre
  • Serge Gauthier, Serge Gauthier, CM, MD, FRCPC, Director, AD & Related Disorders Unit McGill Centre for Studies in Aging
  • David Holtzman, MD, Washington University School of Medicine
  • Matthias Jucker, PhD, Hertie Institute for Clinical Brain Research, DZNE, Germany
  • Jeff Kelly, MD, Scripps University, California Virginia Lee, PhD, University of Pennsylvania, Perelman School of Medicine
  • Simon Mead, FRCP, PhD, Institute of Prion Diseases, London
  • Cath Mummery, PhD, FRCP, Dementia Research Centre, London
  • Erik Musiek, MD, PhD, Washington University School of Medicine
  • Erik Roberson, MD, PhD, University of Alabama
  • Mathias Staufenbiel, PhD, Hertie Institute for Clinical Brain Research, DZNE, Tubingen, Germany
  • Robert Vassar, PhD, Northwestern University, IL

Former TEC Members

Bart DeStrooper, PhD; William Klunk, MD, PhD; Cynthia Lemere, MD, John C. Morris, MD

DIAN Clinical Trials Committee (CTC) Members

  • Randall Bateman, Washington University in St. Louis School of Medicine
  • John Morris, Washington University in St. Louis School of Medicine
  • Chengjie Xiong, Washington University in St. Louis School of Medicine
  • Denise Heinrichs, DIAN Family Representative
  • John Ringman University of California, Los Angeles
  • Laurie Ryan, Division of Science, National Institute on Aging
  • Neil Buckholtz, National Institute on Aging
  • Reisa Sperling, Director, Center for Alzheimer Research and Treatment
  • Stephen Salloway, Butler Hospital
  • Paul Aisen, University of California, San Diego
  • Anna Santacruz, Washington University in St. Louis School of Medicine
  • Gabrielle Strobel, Alzheimer Research Forum
  • Bill Klunk, University of Pittsburgh
  • William Thies, Alzheimer’s Association
  • Anne Fagan, Washington University in St. Louis School of Medicine
  • Mark Mintun, Washington University in St. Louis School of Medicine
  • Natalie Ryan, University College London
  • Virginia Buckles, Washington University in St. Louis School of Medicine
  • David Hawver, Food and Drug Administration
  • Martin Farlow, Indiana University
  • Maritza Ciliberto, DIAN Family Representative
  • Ralph Martins, Edith Cowan University
  • Jennifer Williamson, Columbia University

Study Sites

  • Australia: Neuroscience Research Australia – W Brooks, MJ Fulham, J Bechara, D Foxe; Australian Alzheimer’s Research Foundation – R Clarnette, N Reynders, P Mather; University of Melbourne – C Masters, C Rowe, B Clinch, D Baxendale
  • Canada: McGill University – S Gauthier, P Rosa-Neto, C Mayhew, L Robb; University of British Columbia – R Hsiung, D Worsley, M Assaly, E Nicklin; Sunnybrook Research Institute – M Masellis, K Sharp, S Hetherington
  • Colombia: Grupo de Neurociencias, Universidad de Antioquia – F Lopera, Y León Varela
  • France: Hopital Charles Nicolle – D Wallon, D Hannequin, A Morin, A Zarea, E Gerardin, P Bohn, M Chastan, P Vera, M Colnot, N Donnadieu, M Quillard-Muraine, C Bergot, S Jourdain; Groupe Hospitalier Pitie-Salpetriere – B Dubois, M Habert, N Younsi; Hopital Pierre Wertheimer – M Formaglio, D Lebars, N El Kfif, A Jullien; Hopital Purpan – J Pariente, P Payoux, C Thalamas, A Driff, E Pomies, P Gauteul; Hôpital Roger Salengro – F Pasquier, A Rollin-Sillaire, F Semah, L Breuilh, M Laforce; Orsay Imaging – M Bottlaender
  • Spain: Hospital Clinic i Provincial de Barcelona – R Sanchez-Valle, M Balasa, A Lladó, B Bosch, N Bargalló, I Banzo, A Perisinotti
  • United Kingdom: University College London Hospital – C Mummery, I Kayani, J Douglas, M Grilo
  • United States: Washington University School of Medicine – BJ Snider, T Benzinger, W Sigurdson, B Blaes, P Kelly; Emory University – J Lah, C Meltzer, G Schwartz, P Vaughn, L Piendel; University of Pittsburgh – S Berman, J Mountz, S. Thompson, S Ikonomovic, S Goldberg, E Weamer, J Ruskiewiecz, S Hegedus, L Tarr, T Potter, G Valetti; University of Alabama at Birmingham – E Roberson, D Geldmacher, M Love, A Watkins, L Ashley; Indiana University – J Brosch, A Kohn, N McClaskey, J Buck, J Fletcher; Butler Hospital – G Surti, R Noto, C Bodge, W Menard; University of Puerto Rico – I Jimenez Velazquez, J Diaz, K Aleman; Yale University – C van Dyck, M Chen, E Cooper, A Mecca, S Good; University of California San Diego – D Galasko, C Hoh, D Szpak, S Peacock, L Martinez; University of Washington – S Jayadev, D Lewis, S McDermott; Advocate Lutheran – D Gitelman, M Holldorf

DIAN-TU Collaborators and Advisors

  • John Morris, MD, Senior Advisor, Washington University School of Medicine, St. Louis, MO
  • David Holtzman, MD, Senior Advisor, Washington University School of Medicine, St. Louis, MO
  • Alisha Daniels, MD, MHA, Executive Director, DIAN, Washington University School of Medicine, St. Louis, MO
  • Janice Hitchcock, PhD, Hitchcock Regulatory Consulting Inc.
  • Thomas Bird, MD, University of Washington, Seattle
  • Dennis Dickson, MD, Mayo Clinic, Jacksonville, FL
  • M. Marsel Mesulam, MD, Cognitive Neurology and Alzheimer’s Disease Center, Northwestern University, Chicago, IL
  • Cornelia Kamp, MBA, University of Rochester, New York
  • Ron Thomas, PhD, ADCS, University of California, San Diego
  • Paul Aisen, MD, ADCS, University of Southern California, Los Angeles

DIAN Observational Study Site Investigators

  • James Noble, MD, Columbia University, New York
  • Martin Farlow, MD, Indiana University, Indianapolis, IN
  • Jasmeer Chhatwal, MD, PhD, Brigham and Women’s Hospital-Massachusetts GH, Charlestown, MA
  • Stephen Salloway, MD, Butler Hospital, Warren Alpert School of Medicine, Brown University
  • Sarah Berman, MD, PhD, University of Pittsburgh, PA
  • Gregg Day, MD, Mayo Clinic Jacksonville, FL
  • Hiroyuki Shimada, MD, PhD, Osaka City University, Japan
  • Takeshi Ikeuchi, MD, PhD, Brain Research Institute, Nigata, Japan
  • Kazushi Suzuki, MD, PhD, The University of Tokyo, Japan
  • Peter Schofield, PhD, DSc, Neuroscience Research Australia, Sydney
  • Ralph Martins, BSc, PhD, Edith Cowan University, Nedlands, Western Australia
  • Nick Fox, MD, FRCP, FMedSci, Dementia Research Centre, University College London, United Kingdom
  • Johannes Levin, MD, PhD, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
  • Mathias Jucker, PhD, German Center for Neurodegenerative Diseases (DZNE), Tubingen, Germany
  • Raquel Sanchez Valle, MD, Hospital Clinic i Provincial de Barcelona, Spain
  • Patricio Chrem, MD, Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Buenos Aires, Argentina

DIAN EXR Referring Clinicians, Researchers and Partner Sites

  • Neelum T. Aggarwal, MD, Rush University Medical Center, Chicago IL
  • Tom Ala, Center for Alzheimer’s Disease and Related Disorders, Southern Illinois University School of Medicine
  • Thomas Bird, University of Washington, Seattle
  • Sandra E. Black, Sunnybrook Health Sciences Centre, University of Toronto, Canada
  • William J. Burke, MD, Banner Alzheimer’s Institute
  • Cynthia M. Carlsson, MD, MS, University of Wisconsin School of Medicine and Public Health
  • Andrew Frank M.D. B.Sc.H. F.R.C.P.(C), Bruyere Continuing Care, Ottawa, Ontario, Canada
  • James E. Galvin, MD, MPH, Charles E. Schmidt College of Medicine, Florida Atlantic University
  • Alvin C Holm, MD, Bethesda Hospital, St. Paul, MN
  • John S.K. Kauwe, Brigham Young University
  • David Knopman MD, Mayo Clinic, Rochester MN
  • Sarah Kremen, MD, University of California, Los Angeles
  • Alan J. Lerner, University Hospitals Cleveland Medical Center
  • Barry S. Oken, MD, PhD, Oregon Health & Science University
  • Hamid R. Okhravi, Eastern Virginia Medical School
  • Ronald C. Petersen, Mayo Clinic, Rochester, MN
  • Aimee L. Pierce, MD, University of California Irvine
  • Marsha J. Polk, MEd, University of Texas Health Science Center at San Antonio
  • John M. Ringman, MD, MS, University Southern California
  • Peter St. George Hyslop, MD, FRS, FRSC, FRCPC, University of Toronto
  • Sanjeev N. Vaishnavi, MD, PhD, University of Pennsylvania
  • Sandra Weintraub, PhD, Northwestern University Feinberg School of Medicine, IL