Latest from PubMed
- CONCLUSION: iPSC-derived neurons demonstrated that familial EOAD mutations share common regulatory changes within endotypes with varying severity, leading to reversion to a less-differentiated neuron state. Extending the usage of these neurons to non-familial EOAD may not serve as ideal to […]
- CONCLUSION: FC-BAG was elevated in symptomatic ADAD, consistent with recent demonstrations in sporadic AD. However, we did not detect a predicted biphasic response to presymptomatic ADAD pathology. This inconsistency may be driven by differences between AD forms or by low […]
- CONCLUSION: Safety data from the DIAN-TU-001 OLE study indicate that tripling the dose of gantenerumab is well tolerated in DIAD populations, with the incidence and severity of adverse events remaining comparable to the DB period^(1,2) and without new/unexpected safety findings. […]
- CONCLUSION: Sample size estimates needed to detect a 25% reduction in pathology levels in prevention studies are in the range of 30-40 participants per arm.
- CONCLUSION: DBSI-HR measurements indicate increased WM neuroinflammation in the posterior thalamic radiation, tapetum, and sagittal stratum prior to symptom onset in ADAD. We have recently identified these three WM tracts as having the earliest change in DBSI-HR in sporadic AD. […]
