DIAN Observational Study Publications

Below is a list of publications (by publication date) that are fundamental to DIAN. As the study progresses, publications based upon DIAN’s research will be posted here as well.

  1. Soosman SK, Joseph-Mathurin N, Braskie MN, Bordelon YM, Wharton D, CasadoM, Coppola G, McCallum H, Nuwer M, Coutin-Churchman P, Apostolova LG, Benzinger T, Ringman JM. Widespread white matter and conduction defects in PSEN1-related spastic paraparesis. Neurobiol Aging. 2016 Aug 8; 47:201-209. PMCID: PMC5075491.
  2. Lee S, Viqar F, Zimmerman ME, Narkhede A, Tosto G, Benzinger TL, Marcus DS, Fagan AM, Goate A, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, Martins RN, Saykin AJ, Masters CL, Ringman JM, Ryan NS, Förster S, Laske C, Schofield PR, Sperling RA, Salloway S, Correia S, Jack C Jr, Weiner M, Bateman RJ, Morris JC, Mayeux R, Brickman AM; Dominantly Inherited Alzheimer Network. White matter hyperintensities are a core feature of Alzheimer’s disease: Evidence from the dominantly inherited Alzheimer network. Ann Neurol. 2016 Jun;79(6):929-39. PMCID: PMC4884146.
  3. Su Y, Blazey TM, Owen CJ, Christensen JJ, Friedrichsen K, Joseph-Mathurin N, Wang Q, Hornbeck RC, Ances BM, Snyder AZ, Cash LA, Koeppe RA, Klunk WE, Galasko D, Brickman AM, McDade E, Ringman JM, Thompson PM, Saykin AJ, Ghetti B, Sperling RA, Johnson KA, Salloway SP, Schofield PR, Masters CL, Villemagne VL, Fox NC, Förster S, Chen K, Reiman EM, Xiong C, Marcus DS, Weiner MW, Morris JC, Bateman RJ, Benzinger TL; Dominantly Inherited Alzheimer Network. Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer’s Disease: Results from the DIAN Study Group. PLoS One. 2016 Mar 24; 11(3):e0152082. PMCID: PMC4807073.
  4. Ringman JM, Monsell S, Ng DW, Zhou Y, Nguyen A, Coppola G, Van Berlo V, Mendez MF, Tung S, Weintraub S, Mesulam MM, Bigio EH, Gitelman DR, Fisher-Hubbard AO, Albin RL, Vinters HV. Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database. J Neuropathol Exp Neurol.  2016 Mar;75(3):284-90. PMCID: PMC4934612.
  5. Reiman EM, Langbaum JB, Tariot PN, Lopera F, Bateman RJ, Morris JC, Sperling RA, Aisen PS, Roses AD, Welsh-Bohmer KA, Carrillo MC, Weninger S. CAP–advancing the evaluation of preclinical Alzheimer disease treatments. Nat Rev Neurol. 2016 Jan;12(1):56-61. PMCID: PMC4847536.
  6. Luo J, D’Angela G, Gao F, Ding J, Xiong C. Bivariate correlation coefficients in family-type clustered studies. Biom J. 2015 Nov;57(6):1084-109. PMCID: PMC4741284.
  7. Mielke MM, Machulda MM, Hagen CE, Edwards KK, Roberts RO, Pankratz VS, Knopman DS, Jack CR Jr, Petersen RC. Performance of the CogState computerized battery in the Mayo Clinic Study on Aging. Alzheimers Dement. 2015 Nov;11(11):1367-76. PMCID: PMC4595161.
  8. Wang F, Gordon BA, Ryman DC, Ma S, Xiong C, Hassenstab J, Goate A, Fagan AM, Cairns NJ, Marcus DS, McDade E, Ringman JM, Graff-Radford NR, Ghetti B, Farlow MR, Sperling R, Salloway S, Schofield PR, Masters CL, Martins RN, Rossor MN, Jucker M, Danek A, Forster S, Lane CAS, Morris JC, Benzinger TLS, Bateman RJ. Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease. Neurology. 2015 Sep 1;85(9):790-8. PMCID: PMC4553024.
  9. Quiroz YT, Schultz AP, Chen K, Protas HD, Brickhouse M, Fleisher AS, Langbaum JB, Thiyyagura P, Fagan AM, Shah AR, Muniz M, Arboleda-Velasquez JF, Munoz C, Garcia G, Acosta-Baena N, Giraldo M, Tirado V, Ramírez DL, Tariot PN, Dickerson BC, Sperling RA, Lopera F, Reiman EM. Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study. JAMA Neurol. 2015 Aug;72(8):912-9. PMCID: PMC4625544.
  10. Cairns NJ, Perrin RJ, Franklin EE, Carter D, Vincent B, Xie M, Bateman RJ, Benzinger T, Friedrichsen K, Brooks WS, Halliday GM, McLean C, Ghetti B, Morris JC, Alzheimer Disease Neuroimaging Initiative; Dominantly Inherited Alzheimer Network. Neuropathologic assessment of participants in two multi-center longitudinal observational studies: the Alzheimer Disease Neuroimaging Initiative (ADNI) and the Dominantly Inherited Alzheimer Network (DIAN). Neuropathology. 2015 Aug;35(4):390-400. PMCID: PMC4521391.
  11. Grill JD, Bateman RJ, Buckles V, Oliver A, Morris JC, Masters CL, Klunk WE, Ringman JM, Dominantly Inherited Alzheimer’s Network. A survey of attitudes toward clinical trials and genetic disclosure in autosomal dominant Alzheimer’s disease. Alzheimers Res Ther. 2015 Jul 22;7(1):50. PMCID: PMC4511231.
  12. Franklin EE, Perrin RJ, Vincent B, Baxter M, Morris JC, Cairns NJ; Alzheimer’s Disease Neuroimaging Initiative. Brain collection, standardized neuropathologic assessment, and comorbidity in Alzheimer’s Disease Neuroimaging Initiative 2 participants. Alzheimers Dement. 2015 Jul; 11(7):815-822. PMCID: PMC4511380.
  13. Papp KV, Amariglio RE, Mormino EC, Hedden T, Dekhytar M, Johnson KA, Sperling RA, Rentz DM. Free and cued memory in relation to biomarker-defined abnormalities in clinically normal older adults and those at risk for Alzheimer’s disease. Neuropsychologia. 2015 Jul; 73:169-75. PMCID: PMC4479270.
  14. Bateman RJ, Morris JC. Factors Contributing to the Post-Lumbar Puncture Headache—Reply. JAMA Neurol. 2015 Jul;72(7):835. PMCID: PMC4943573.
  15. Ringman JM, Liang L-J, Zhou Y, Vangala S, Teng EH, Kremen S, Wharton D, Goate A, Marcus D, Farlow M, Ghetti B, McDade E, Masters CL, Mayeux RP, Rossor M, Salloway S, Schofield PR, Cummings JL, Buckles VB, Bateman R, Morris JC, and the Dominantly Inherited Alzheimer Network. Early behavioural changes in familial Alzheimer’s disease in the dominantly inherited Alzheimer network. Brain. 2015 Apr;138(Pt 4):1036-45. PMCID: PMC4963801.
  16. Monserrate AE, Ryman DC, Ma S, Xiong C, Noble JM, Ringman JM, Morris JC, Danek A, Müller-Sarnowski F, Clifford DB, McDade EM, Brooks WS, Darby DG, Masters CL, Weston PS, Farlow MR, Graff-Radford NR, Salloway SP, Fagan AM, Oliver A, Bateman RJ, for the Dominantly Inherited Alzheimer Network. Factors Associated with the Onset and Persistence of Post-Lumbar Puncture Headache. JAMA Neurol. 2015 Mar; 72(3):325-32. PMCID: PMC4364538.
  17. Su Y, Blazey TM, Snyder AZ, Raichle ME, Marcus DS, Ances BM, Bateman RJ, Cairns NJ, Aldea P, Cash L, Christensen JJ, Friedrichsen K, Hornbeck RC, Farrar AM, Owen CJ, Mayeux R, Brickman AM, Klunk W, Price JC, Thompson PM, Ghetti B, Saykin AJ, Sperling RA, Johnson KA, Schofield PR, Buckles V, Morris JC, Benzinger TL; Dominantly Inherited Alzheimer Network. Partial volume correction in quantitative amyloid imaging. Neuroimage. 2015 Feb 15; 107:55-64. PMCID: PMC4300252.
  18. Klunk WE, Koeppe RA, Price JC, Benzinger TL, Devous MD Sr, Jagust WJ, Johnson KA, Mathis CA, Minhas D, Pontecorvo MJ, Rowe CC, Skovronsky DM, Mintun MA. The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET. Alzheimers Dement. 2015 Jan;11(1):1-15. e1-4. PMCID: PMC4300247.
  19. Chatterjee P, Gupta VB, Fagan AM, Jasielec MS, Xiong C, Sohrabi HR, Dhaliwal S, Taddei K, Bourgeat P, Brown BM, Benzinger T, Bateman RJ, Morris JC, Martins RN; Dominantly Inherited Alzheimer Network. Decreased platelet APP isoform ratios in autosomal dominant Alzheimer’s disease: baseline data from a DIAN cohort subset. Curr Alzheimer Res. 2015;12(2):157-64. PMCID: PMC4383703.
  20. Chatterjee P, Lim WL, Shui G, Gupta VB, James I, Fagan AM, Xiong C, Sohrabi HR, Taddei K, Brown BM, Benzinger T, Masters C, Snowden SG, Wenk MR, Bateman RJ, Morris JC, Martins RN. Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study. J Alzheimers Dis. 2015;50(3):887-94. PMCID: PMC4943576.
  21. Laske C, Sohrabi HR, Jasielec MS, Muller S, Koehler K, Graber S, Forster S, Drzezga A, Mueller-Sarnowski F, Danek A, Jucker M, Bateman R, Buckles V, Saykin AJ, Martins RN, Morris JC, and Dominantly Inherited Alzheimer Network (DIAN). Diagnostic value of subjective memory complaints assessed with a single item in Dominantly Inherited Alzheimer’s Disease: Results of the DIAN study. Biomed Res Int. 2015;2015:828120. doi: 10.1155/2015/828120. Epub 2015 Apr 2. PMCID: PMC4398930.
  22. Ringman JM, Goate A, Masters CL, Cairns NJ, Danek A, Graff-Radford N, Ghetti B, Morris JC; Dominantly Inherited Alzheimer Network. Genetic heterogeneity in Alzheimer disease and implications for treatment strategies. Curr Neurol Neurosci Rep. 2014 Nov;14(11):499. PMCID: PMC4162987.
  23. Brier MR, Thomas JB, Snyder AZ, Wang L, Fagan AM, Benzinger T, Morris JC, Ances BM. Unrecognized preclinical Alzheimer disease confounds rs-fcMRI studies of normal aging. Neurology. 2014 Sep 26; PMCID: PMC4223085.
  24. Thomas JB, Brier MR, Bateman RJ, Snyder AZ, Benzinger TLS, Xiong C, Raichle M, Holtzman DM, Sperling RA, Mayeux RP, Ghetti B, Ringman JM, Salloway S, McDade E, Rossor MN, Schofield PR, Masters CL, Martins RN, Danek A, Jucker M, Weiner MW, Graff-Radford NR, Thompson PM, Fox NC, Koeppe RA, Jack CR, Mathis CA, Klunk WE, Oliver A, Blazey TM, Moulder K, Buckles V, Hornbeck R, Chhatwal JP, Schultz AP, Goate AM, Fagan AM, Cairns NJ, Marcus DS, Morris JC, Ances BM, for the Dominantly Inherited Alzheimer Network. Functional connectivity in Autosomal dominant and late-onset Alzheimer disease. JAMA Neurology 2014; Sep 1; 71(9):1111-22. PMCID: PMC4240274.
  25. Ryman DC, Acosta-Baena N, Aisen PS, Bird T, Danek A, Fox NC, Goate A, Frommelt P, Ghetti B, Langbaum JB, Lopera F, Martins R, Masters CL, Mayeux RP, McDade E, Moreno S, Reiman EM, Ringman JM, Salloway S, Schofield PR, Sperling R, Tariot PN, Xiong C, Morris JC, Bateman RJ; Dominantly Inherited Alzheimer Network. Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology. 2014 Jul 15;83(3):253-60. PMCID: PMC4117367.
  26. Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TL, Ghetti B, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Salloway S, Schofield PR, Sperling RA, Marcus D, Cairns NJ, Buckles VD, Ladenson JH, Morris JC, Holtzman DM; Dominantly Inherited Alzheimer Network. Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer’s disease. Sci Transl Med 2014 Mar 5; 6(226):226ra30. PMCID: PMC4038930.
  27. Storandt M, Balota DA, Aschenbrenner AJ, Morris JC. Clinical and psychological characteristics of the initial cohort of the Dominantly Inherited Alzheimer Network (DIAN). Neuropsychology. 2014 Jan; 28(1):19-29. PMCID: PMC3877741.
  28. Ting, SKS, Benzinger, TLS, Kepe, V, Fagan, A, Coppola, G, Porter, V, Hecimovic, S, Chakraverty, S, Alvarez-Retuerto, AI, Goate, A, Ringman, J. A novel PSEN1 Mutation (I238M) associated with early-onset Alzheimerʼs disease in an African-American woman. Journal of Alzheimers Disease, 2014; 40(2):271-275. PMCID: PMC3972314.
  29. Gordon BA, Blazey T, Benzinger TL. Regional variability in Alzheimer’s disease biomarkers. Future Neurol. 2014;9(2):131-134. PMCID: PMC4192718.
  30. Moulder KL, Snider BJ, Mills SL, Buckles VD, Santacruz AM, Bateman RJ, Morris JC. Dominantly Inherited Alzheimer Network: facilitating research and clinical trials. Alzheimers Res Ther. 2013 Oct 17; 5(5):48. PMCID: PMC3978584.
  31. Frost SM, Kanagasingam Y, Sohrabi HR, Taddei K, Bateman R, Morris J, Benzinger T, Goate A, Masters CL, Martins RN. Pupil response biomarkers distinguish amyloid precursor protein mutation carriers from non-carriers. Curr Alzheimer Res. 2013 Oct; 10:790-796. PMCID: PMC3879087.
  32. Mills SM, Mallmann J, Santacruz AM, Fuqua A, Carril M, Aisen PS, Althage MC, Belyew S, Benzinger TL, Brooks WS, Buckles VD, Cairns NJ, Clifford D, Danek A, Fagan AM, Farlow M, Fox N, Ghetti B, Goate AM, Heinrichs D, Hornbeck R, Jack C, Jucker M, Klunk WE, Marcus DS, Martins RN, Masters CM, Mayeux R, McDade E, Morris JC, Oliver A, Ringman JM, Rossor MN, Salloway S, Schofield PR, Snider J, Snyder P, Sperling RA, Stewart C, Thomas RG, Xiong C, Bateman RJ. Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial. Rev Neurol (Paris). 2013 Oct; 169(10):737-743. PMCID: PMC3880800.
  33. Hooper M, Grill JD, Rodriguez-Agudelo Y, Medina LD, Fox M, Alvarez-Retuerto AI, Wharton D, Brook J, Ringman JM. The impact of the availability of prevention studies on the desire to undergo predictive testing in persons at risk for autosomal dominant Alzheimer’s disease. Contemp Clin Trials. 2013 Sep; 36:256-262. PMCID: PMC3858206.
  34. Chhatwal JP, Schultz AP, Johnson K, Benzinger TL, Jack C Jr, Ances BM, Sullivan CA, Salloway SP, Ringman JM, Koeppe RA, Marcus DS, Thompson P, Saykin AJ, Correia S, Schofield PR, Rowe CC, Fox NC, Brickman AM, Mayeux R, McDade E, Bateman R, Fagan AM, Goate AM, Xiong C, Buckles VD, Morris JC, Sperling RA. Impaired default network functional connectivity in autosomal dominant Alzheimer disease. Neurology. 2013 Aug 20;81: 736-744. PMCID: PMC3776464.
  35. Cash DM, Ridgway GR, Liang Y, Ryan NS, Kinnunen KM, Yeatman T, Malone IB, Benzinger TL, Jack CR Jr, Thompson PM, Ghetti BF, Saykin AJ, Masters CL, Ringman JM, Salloway SP, Schofield PR, Sperling RA, Cairns NJ, Marcus DS, Xiong C, Bateman RJ, Morris JC, Rossor MN, Ourselin S, Fox NC; Dominantly Inherited Alzheimer Network (DIAN). The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study. Neurology. 2013; 81:1425-1433. PMCID: PMC3806583.
  36. Liu CY, Krishnan AP, Yan L, Smith RX, Kilroy E, Alger JR, Ringman JM, Wang DJ. Complexity and synchronicity of resting state blood oxygenation level-dependent (BOLD) functional MRI in normal aging and cognitive decline. J Magn Reson Imaging 2013; 38(1):36-45. PMCID: PMC3610850.
  37. Morris JC, Aisen PS, Bateman RJ, Benzinger T, Cairns NJ, Fagan AM, Ghetti B, Goate AM, Holtzman DM, Klunk WE, McDade E, Marcus DS, Martins RN, Masters CL, Mayeux R, Oliver A, Quaid K, Ringman JM, Rossor MN, Salloway S, Schofield PR, Selsor NJ, Sperling RA, Weiner MW, Xiong C, Moulder KL, Buckles VD. Developing an international network for Alzheimer’s research: the Dominantly Inherited Alzheimer Network.  Clin Investig (Lond). 2012 Oct 1;2(10):975-984. PMCID: PMC3489185.
  38. Luo J, Xiong C. DiagTest3Grp: An R Package for Analyzing Diagnostic Tests with Three Ordinal Groups. J Stat Softw. 2012 Oct; 51(3):1-24. PMCID: PMC3595562.
  39. Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, Aisen PS, Ghetti B, Klunk WE, McDade E, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Schofield PR, Sperling RA, Salloway S, Morris JC. Dominantly Inherited Alzheimer Network. Clinical and biomarker changes in dominantly inherited Alzheimer’s disease. N Engl J Med. 2012 Aug 30; 367 (9):795-804. Epub 2012 Jul 11. PMCID: PMC3474597.
  40. Ryan NS, Bastos-Leite AJ, Rohrer JD, Werring DJ, Fox NC, Rossor MN, Schott JM. Cerebral microbleeds in familial Alzheimer’s disease. Brain. 2012 Jan; 135(Pt 1): e201; author reply e202. PMCID: PMC3859452.
  41. Ryan NS, Rossor MN. Defining and describing the pre-dementia stages of familial Alzheimer’s disease. Alzheimers Res Ther. 2011 Sep 27; 3(5):29. PMCID: PMC3218806.
  42. Holtzman DM, Morris JC, Goate AM. Alzheimer’s disease: the challenge of the second century. Sci Transl Med. 2011 Apr 6;3(77):77sr1. PMCID: PMC3130546.
  43. Medina LD, Rodriguez-Agudelo Y, Geschwind DH, Gilbert PE, Liang LJ, Cummings JL, Ringman JM. Propositional density and apolipoprotein E genotype among persons at risk for familial Alzheimer’s disease. Dement Geriatr Cogn Disord. 2011; 32(3):188-192. PMCID: PMC3542946.
  44. Bateman, R.J., Aisen, P.S., De Strooper, B., Fox, N.C., Lemere, C.A., Ringman, J.M., Salloway, S., Sperling, R.A., Windisch, M., Xiong, C. Autosomal-dominant Alzheimer’s disease: A review and proposal for the prevention of Alzheimer’s disease. Alzheimer’s Research and Therapy. 2011 Jan 6; 3:1-13. PMCID: PMC3109410.
  45. Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA, Windisch M, Xiong C.  Autosomal-dominant Alzheimer’s disease: a review and proposal for the prevention of Alzheimer’s disease. Alzheimers Res Ther. 2011 Jan 6;3 (1):1. PMCID: PMC3109410.
  46. Ryan NS, Rossor MN. Correlating familial Alzheimer’s disease gene mutations with clinical phenotype. Biomark Med. 2010 Feb;4(1):99-112. PMCID: PMC3937872.
  47. Ringman JM, Grill J, Rodriguez-Agudelo Y, Chavez M, Xiong C. Commentary on “a roadmap for the prevention of dementia II: Leon Thal Symposium 2008.” Prevention trials in persons at risk for dominantly inherited Alzheimer’s disease: opportunities and challenges. Alzheimers Dement. 2009 Mar; 5(2):166-171. PMCID: PMC2746429.