Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 21 - 30 of 265


Title:Develop an Item Response Theory Based Score for the Clinical Dementia Rating (CDR®)

Date of Request:04/10/2022


Aim 1:Develop an item response theory (IRT) based score for the CDR based on the item level data collected for the CDR in DIAN Obs

Aim 2:Demonstrate the superiority of the IRT based score compared to the CDR sum of box in terms of detecting cognitive change and association with other cognitive/clinical, imaging and fluid biomarkers

Investigator:Jonathan Wagg

Title:: Leverage DIAN data to derive and validate EYO estimation models applicable to Downs Syndrome (DS) populations

Date of Request:04/07/2022


Aim 1:Review and analyze DIAN longitudinal clinical endpoint and biomarker measure changes over time that are: (i) of potential utility for development of EYO estimation models; (ii) comparable to measures available in longitudinal DS cohort datasets such as the ABC-DS cohort.

Aim 2:Use measures identified in (1.) to derive alternative model structures for EYO estimation in the DIAN population.

Aim 3:Compare the predictive performance of candidate model structures in the DIAN population.

Aim 4Assess the best performing model structures in a DS population.

Investigator:Brian Gordon

Title:Comparing biomarkers between Down Syndrome, Autosomal Dominant, and Late onset Alzheimer Disease

Date of Request:03/25/2022



Aim 1:How do measures of tau pathology measured using PET compare among DS, ADAD, and LOAD?

Aim 2:Does the spread of tau pathology over time differ between cohorts?

Aim 3:Are white matter lesions a common finding in all three forms of AD?

Aim 4How do biofluid profiles compare between DS, ADAD, and LOAD?

Investigator:kun zhao

Title:Alzheimer's disease

Date of Request:03/18/2022


Aim 1:e want to provide a reference point for each individual during aging to provide a reference at each time of the lifespan.

Aim 2:we also provide a frame for the intersection of multi neurodegenerative disease and mental disorder.

Investigator:Randy Buckner

Title:Exploration of multimodal MRI Biomarkers in preclinical stage of Alzheimer's Disease

Date of Request:03/16/2022


Aim 1:The goal of this study is to combine multimodal structural imaging biomarkers to optimistically distinguish Alzheimer’s disease and normal aging in the early and mild stages of Alzheimer’s disease.

Investigator:Professor John Gallacher

Title:The biopsychosocial determinants of cognitive change and Alzheimer's disease

Date of Request:02/14/2022


Aim 1:The overall aim of the project will be to assess the biopsychosocial determinants of Alzheimer’s disease across modifiable and non-modifiable factors

Aim 2:To profile cognitive change by biopsychosocial construct determinants

Aim 3:To profile cognitive change and AD by biopsychosocial construct determinants and genetic stratification

Aim 4To create a biopsychosocial risk profiling tool for brain health

Investigator:John Ringman

Title:Biomarker Characterization of the A431E mutation in PSEN1

Date of Request:02/11/2022



Aim 1:To assess plasma and CSF biomarkers associated with the A431E mutation in PSEN1.

Aim 2:To assess volumetric changes, white matter hyperintensities, and microhemorrhages on MRI seen in association with the A4341E mutation in PSEN1.

Aim 3:To assess cerebral amyloid deposition measured using PiB PET associated with the A4341E mutation in PSEN1.

Aim 4To assess cerebral tau deposition measured using flortaucipir PET associated with the A4341E mutation in PSEN1.

Investigator:Jasmeer Chhatwal

Title:Evaluating ADAD Mutation-specific Biomarker and Cognitive Trajectories (Renewal of 1606A)

Date of Request:02/09/2022


Aim 1:Determine if simple categorizations of ADAD mutations can explain variability in biomarker and cognitive trajectories

Aim 2:Determine if biochemical characterizations of individual PSEN1 mutations can elucidate cognitive and biomarker trajectories in DIAN

Aim 3:Determine if there are mutation-specific effects that predict the development of CAA in mutation carriers

Investigator:Jan Torleif Pedersen, PhD MSc

Title:Investigation of pS396-tau in samples from DIAN-TU biobank

Date of Request:02/01/2022


Aim 1:Investigation of pS396-tau in samples from DIAN-TU biobank

Aim 2:To investigate pT217-tau levels in CSF samples from DIAN-TU

Aim 3:To establish potential correlation between pS396-tau, pT217-Tau and clinical progression parameters

Aim 4To investigate tau species in post-mortem brain material targeted by Lu AF87908

Investigator:Christopher Weise

Title:Hypothalamic volume in familial Alzheimer’s disease (FAD) and its associations with body weight and other FAD biomarkers

Date of Request:01/06/2022


Aim 1:• To compare hypothalamic volume in symptomatic and asymptomatic FAD with healthy controls

Aim 2:• To investigate potential associations of hypothalamic volume with cross sectional body weight (BMI) and longitudinal body weight changes in participants with FAD

Aim 3:• To explore the relationship of hypothalamic volume with additional biomarkers (Aß-burden, glucose metabolism and CSF based biomarkers), clinical/cognitive parameters and EYO