Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 21 - 30 of 222


Title:Cortical diffusion analysis in Dominantly Inherited Alzheimer’s disease (DIAD)

Date of Request:02/27/2020

Aim 1:Test a novel MRI analysis tool to investigate the cortical architecture

Aim 2:Identify neural cortical architecture signature in DIAD

Aim 3:Test the discrimination power of the novel cortical diffusivity measures in Alzhiemer's disease groups

Aim 4Test the prediction power of the novel cortical measures in Alzheimer’s disease groups

Investigator:Yakeel T. Quiroz

Title:Sex differences in Alzheimer’s disease pathology, neurodegeneration and cognition in autosomal dominant Alzheimer’s disease

Date of Request:02/18/2020

Aim 1:1. To extend our study on sex differences to other ADAD mutations and confirm our preliminary findings in a much larger sample of ADAD mutation carriers;

Aim 2:2. To inform power calculations for appropriate sample size, based on estimated effects, for an upcoming 2020 grant submission on sex differences in ADAD (i.e. career development award of postdoctoral fellow, Dr. Vila-Castelar).

Aim 3:3. To examine sex differences in ADAD mutation carriers at different clinical stages, from asymptomatic to symptomatic stages, with available biomarker and imaging data, and compare with age-matched noncarriers, which is not yet available in our group.

Investigator:Ruchika S Prakash

Title:Brain-based model of Alzheimer’s disease pathology

Date of Request:02/05/2020

Aim 1:To externally validate a brain based model of Alzheimer’s disease pathology

Investigator:Prof. Dr. Martin Hofmann-Apitius

Title:The Virtual Brain Cloud

Date of Request:01/20/2020

Aim 1:Providing an overview on all accessible AD/dementia clinical cohort datasets. Systematically compare them by looking at the actual data, not only metadata. Assess the state of data sharing in the dementia field.

Aim 2:Multi-study comparative modeling of longitudinal patient trajectories.

Aim 3:Include longitudinal models into The Virtual Brain platform to allow for individual patient brain simulations.

Investigator:Jae Seung Kim

Title:The effect of resilience related life experiences on individual age-at-symptom onset in Dominantly Inherited Alzheimer’s Disease

Date of Request:12/31/2019

Aim 1:To investigate the effect of resilience related life experiences, such as leisure time physical activity, lifetime cognitive engagement and social gathering, on individual variation in age-at-symptom onset from the age of parental onset in Dominantly Inherited Alzheimer’s Disease.

Aim 2:among the modifiable lifestyle factors including leisure time physical activity, lifetime cognitive engagement and social gathering, we determine which of these behavioral factors may be associated with the brain’s ability to cope with the pathological burden of AD.

Aim 3:we present how lifestyle factors affect the individual variation in age-at-symptom onset through cognitive and brain resilience, despite the presence of adverse heritable and acquired factors.

Investigator:Xenia Kobeleva

Title:Modelling brain dynamics in dominantly inherited Alzheimer’s disease

Date of Request:12/16/2019

Aim 1:1. Modelling the effect of amyloid-beta and tau on neural dynamics in two models (dynamic mean-field model and Hopf model)

Aim 2:2. Modelling the effect of tau and amyloid beta in a model of effective connectivity

Investigator:DUC KHANH TO

Title:Estimating ROC surface and selecting an optimal pair of thresholds for CSF markers

Date of Request:12/13/2019

Aim 1:Estimate the ROC surfaces for visualizing the accuracy of CSF biomarkers in the clustered data setting

Aim 2:Obtain the optimal pairs of thresholds that can be used in practice for screening purposes.

Investigator:Colin Masters

Title:Alzheimer’s Dementia Onset and Progression in International Cohorts

Date of Request:12/11/2019

Aim 1:To determine cutpoints for preclinical, prodromal and clinical AD in relation to age, cognition, Aβ, tau and neurodegeneration markers

Aim 2:To determine rates of progression in preclinical, prodromal and clinical AD in relation to age, sex, cognition, Aβ, tau and neurodegeneration markers

Aim 3:To determine moderators of disease in preclinical, prodromal and clinical AD

Investigator:Jason Hassenstab

Title:Optimizing Cognitive Assessment in DIAN with Smartphone-Based Burst Testing

Date of Request:11/22/2019

Aim 1:Determine if ARC burst assessments will better characterize the nature and magnitude of cognitive decline in DIAD mutation carriers than traditional in-clinic cognitive assessments

Aim 2:Compare cross-sectional and longitudinal associations between ARC assessments and neuroimaging and fluid biomarkers in DIAD

Aim 3:Examine the role of environment, mood, fatigue, and sleep patterns on cognition in DIAD

Investigator:Jane Osbourn

Title:Protective autoantibodies in Alzheimer's disease

Date of Request:11/01/2019

Aim 1:To evaulate the DIAN database for individuals with unexpected protection form a genetic predisposition to Alzheimer's