DIAN Trials Unit & Clinical Trials Leadership

Principal investigator and program director

Randall J. Bateman, MD
Knight Distinguished Professor of Neurology
Washington University in St. Louis School of Medicine

600 S. Euclid Ave., CB 8111
St. Louis, MO 63110
Email: batemanr@neuro.wustl.edu
Phone: 314-747-7066
Fax: 314-747-7060

Randall J. Bateman, M.D. is the Charles F. and Joanne Knight Distinguished Professor of Neurology at Washington University School of Medicine.

Dr. Bateman’s research focuses on the cause, and future diagnosis and treatments of Alzheimer’s disease. He is the Director of the Dominantly Inherited Alzheimer’s Network Trials Unit (DIAN-TU) which launched the first clinical trials in autosomal dominant Alzheimer’s disease (ADAD) aiming to prevent the onset of memory impairment and dementia. In 2010, he organized the Autosomal Dominant Alzheimer’s Disease Forum, a patient and family advocacy group for individuals affected by ADAD. He led efforts to form the first DIAN-TU Pharma Consortium, a collaboration of multiple pharmaceutical companies working together to support trial design and drug nominations for ADAD for the next several years. He was the recipient of an Alzheimer’s Association research grant for the DIAN-TU. Dr. Bateman also serves as the Director and Principal Investigator of the DIAN, an international collaboration of leading research centers dedicated to studying ADAD.

Dr. Bateman treats patients with dementia at the Memory Diagnostic Center of Washington University. He is also an investigator for the Charles F. and Joanne Knight Alzheimer’s Disease Research Center and for the Hope Center for Neurological Disorders.

Dr. Bateman’s research has been recognized with awards from the AlzForum Community, Alzheimer’s Association (Zenith Award), Scientific American, the Glenn Award for Aging Research, the MetLife Promising Investigator Award, the MetLife Medical Research Award, and the Chancellor’s Award for Innovation and Entrepreneurship.

Associate Director

Eric McDade, DO
Associate Professor of Neurology
Washington University School of Medicine
660 S. Euclid Ave., CB 8111
St. Louis, MO 63110
Email: ericmcdade@wustl.edu
Phone: 314-747-8423
Fax: 314-747-8427

Medical director

David Clifford, MD
Melba and Forest Seay Professor of Clinical Neuropharmacology in Neurology
Washington University School of Medicine
660 S. Euclid Ave., CB 8111
St. Louis, MO 63110
Email: clifforddb@wustl.edu
Phone: 314-747-8423
Fax: 314-747-8427

Project arm leaders

Martin Farlow, MD
Professor and Vice Chairman of Research, Department of Neurology
Associate Director, Indiana Alzheimer Disease Research Center
IU Alzheimer’s Disease and Related Disorders
355 W. 16th Street, GH-4342
Indianapolis, IN 46202
Email: mfarlow@iupui.edu
Phone: 317-963-7402
Fax: 317-963-7533

Stephen Salloway, MD, MS
Professor of Neurology, Psychiatry and Human Behavior
Director of Neurology and the Memory and Aging Program
Butler Hospital
345 Blackstone Boulevard
Providence, RI 02906
Email: ssalloway@butler.org
Phone: 401-455-6200

Lon Schneider, MD
Professor of Psychiatry, Neurology, and Gerontology
University of Southern California
1510 San Pablo Street, Suite 600
Los Angeles, CA 90033
Email: lschneid@usc.edu
Phone: 323-442-7600

Core leaders

Tammie Benzinger, MD, PhD
Imaging Core Leader
Associate Professor of Radiology
Washington University School of Medicine
660 S. Euclid Ave., CB 8131
St. Louis, MO 63110
Email: benzingert@wustl.edu
Phone: 314-362-5950
Fax: 314-362-4886

Dr. Benzinger is an expert in the use of imaging to look for biochemical and structural brain changes.

Carlos Cruchaga, PhD
Genetics Core Co-Leader
Associate Professor of Psychiatry
Washington University School of Medicine
660 South Euclid
Box 8134
St. Louis, MO 63110
Email: cruchagac@psychiatry.wustl.edu
Laboratory website
Phone: 314-747-1711
Dr. Cruchaga’s research interests are focused on the in the identification and characterization of coding variants implicated in Alzheimer’s disease (AD), Parkison’s Disease (PD), stroke recovery and other neurodegenerative diseases.

Anne Fagan, PhD
Biomarker Core Leader
Professor of Neurology
Washington University School of Medicine
660 S. Euclid Ave., CB 8111
St. Louis, MO 63110
Email: fagana@neuro.wustl.edu
Phone: 314-362-3452
Fax: 314-362-2244

Dr. Fagan’s research focuses on beta amyloid and other Alzheimer’s disease biomarkers in CSF.

Alison Goate, DPhil
Genetics Core Leader
Mount Sinai Professor of NeuroGenetics
Director, Ronald M. Loeb Center for Alzheimer’s Disease
Dept. of Neuroscience, B1065
Icahn School of Medicine at Mount Sinai
1425 Madison Ave.
New York, NY 10029
Email: alison.goate@mssm.edu
Phone: 212-659-9825

Dr. Goate reported the first causative mutation for autosomal dominant Alzheimer’s disease. Her projects involve high-throughout genotyping on several platforms. Dr. Goate has received both the MetLife and the Potamkin Awards in recognition of her research.

Jason Hassenstab, PhD
Leader, Cognition Core
Assistant Professor of Neurology and Psychology
Washington University School of Medicine
660 S. Euclid Ave., CB 8111
St. Louis, MO 63110
Email: hassenstabj@abraxas.wustl.edu
Phone: 314-747-4032
Fax: 314-747-7060

Dr. Hassenstab’s research follows the cognitive changes in the earliest stages of Alzheimer’s and their relationship to fluid biomarkers and neuroimaging indicators of Alzheimer’s disease. He is also studying the relationship between weight loss and improved metabolic functioning and how they may benefit neurocognitive function and possibly prevent Alzheimer’s disease.

Chengjie Xiong, PhD
Leader, Biostatistics Core
Professor of Biostatistics
Washington University School of Medicine
660 S. Euclid Ave., CB 8067
St. Louis, MO 63110
Email: chengjie@wubios.wustl.edu
Phone: 314-362-3635
Fax: 314-362-2693

Dr. Xiong has served as an associate editor of the Journal of Alzheimer’s Disease and the Associate Editor of Biostatistics for Alzheimer’s Disease and Associated Disorders. Dr. Xiong’s research interests include statistical design of experiments, linear and nonlinear mixed models, longitudinal data analysis, survival analysis and reliability, categorical data analysis, order restricted statistical inferences, and their applications in medicine, biology, education, and engineering.