Search DIAN Data Resource Requests

Title:Traumatic brain injury, emotional adversity and the long-term effects on adult outcomes and dementia

Date of Request:03/28/2019

Status:Pending

ID:DIAN-D1907

Aim 1:Assess the relationship between retrospective self-report ACEs, TBIs and multiple adult biomedical, psychosocial, cognitive, and dementia outcomes in adults age 40-70 years. The consequences of traumatic brain injuries (TBI) on long-term cognitive outcomes is poorly understood however, there is support for evidence which suggests those who have experienced a TBI in younger adulthood experience diminished cognitive reserve which may accelerate cognitive deficits, premature cognitive decline and dementia risk (Wood, 2017). Furthermore, individuals who have experienced traumatic emotional experiences in younger years, also known as adverse childhood experiences (ACEs), a broad construct encompassing overall extreme difficulties and adverse experiences during childhood such as sexual, physical and emotional abuse, deprivation, and family dysfunction (e.g., McLaughlin, 2016) are at risk of adult depression (Liu, 2017), lower adult life satisfaction (Hughes et al., 2016) and dementia (Radford et al., 2017).

Aim 2:Investigate the longitudinal association between ACEs, TBIs and, cognitive decline and dementia outcomes across multiple time points in adults aged 40 to 70 years, testing the hypothesis that there may be an accumulative neurobiological load response associated with ACEs and TBIs. We propose a cross-platform cross-cohort investigation interrogating population cohorts to investigate self-report retrospective TBIs and ACEs as determinants of adult outcomes including cognition and dementia.

Title:CSF and blood protein biomarkers and APOE genotype status of early-onset Alzheimer’s disease variants: A systematic review and meta-analysis

Date of Request:03/20/2019

Status:Pending

ID:DIAN-D1906

Aim 1:We have performed a meta-analysis and systematic review to compare core biomarkers (CSF Aβ42 and tau) across early-onset AD (EOAD) subtypes i.e. autosomal dominant Alzheimer’s disease (ADAD) and early onset sporadic Alzheimer’s disease (EOsAD). Furthermore, we are exploring several other potential markers of neurodegeneration in EOAD, including NFL, IgG and IL-6 which are emerging in the literature. A recent published article from DIAN group “Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease” Nature Medicine volume 25, pages 277–283 (2019)”. This article includes data for measurement of NFL in serum and CSF, provided data in graphical format. We need data in mean and standard deviation format to perform meta-analysis on NFL serum and CSF.

Title:Sex-specific differences in cognitive decline in AD

Date of Request:03/05/2019

Status:Pending

ID:DIAN-D1905

Aim 1:Study differences in trajectory of cognitive decline in males and females from DIAN dataset

Aim 2:Study differences in age of onset in AD between males and females

Title:Dedifferentiation and neuronal lineage repression orchestrated through remodeling of the chromatin landscape define PSEN1 mutation-induced Alzheimer’s Disease

Date of Request:02/27/2019

Status:Pending

ID:DIAN-D1904

Aim 1:Compare gene signature profiles and changes in chromatin topology observed in iPSC-derived EOFAD neurons to those reported in EOFAD subject post-mortem brain tissue

Title:Association of morphology and network connectivity of degenerative disease

Date of Request:02/21/2019

Status:Pending

ID:DIAN-D1903

Aim 1:Morphological change mechanism of Alzheimer’s continuum

Aim 2:Structural connectivity change mechanism of Alzheimer’s continuum

Aim 3:Brain function connectivity variation of Alzheimer’s continuum

Aim 4Association of morphology and network connectivity in AD development

Title:MicroRNA regulation of central nervous system and systemic inflammation in AD

Date of Request:05/25/2017

ID:DIAN-D1716

Aim 1:Determine if FAD and SAD brain develop distinct patterns of myeloid cell heterogeneity.

Title:Individualized prediction of symptom onset in familial AD using structural MRI

Date of Request:02/11/2019

Status:Approved

ID:DIAN-1803A

Aim 1:create individualized atrophy maps in patients with fAD

Aim 2:investigate the utility of these maps for predicting the likelihood of developing symptoms of dementia on longitudinal follow-up

Title:Dominantly Inherited Alzheimer's Disease Protective Factor Study

Date of Request:01/29/2019

Status:Approved

ID:DIAN-D1902

Aim 1:The overall objective is to identify factors that protect mutation-carriers from AD symptoms.

Aim 2:1. Obtaining the clinical, cognitive, biomarker and genetic results from the DIAN research study .

Aim 3:2. Administering a number of questionnaires assessing health and lifestyle factors to include the following: Current Health Status, Medical Conditions, Physical Functioning, Exposure History Form, Occupational and Environmental Exposure History.

Title:Advanced analytics on DIAN imaging data

Date of Request:01/28/2019

Status:Pending

ID:DIAN-D1901

Aim 1:Use advanced analytics to predict mutation carrier status of DIAN patients by vMRI data only

Aim 2:Use advanced analytics to predict mutation carrier status of DIAN patients by amyloid PET data only

Title:Relationship between literacy, socio-economic status, Alzheimer pathology and cognitive decline in autosomal dominant Alzheimer’s disease.

Date of Request:12/27/2018

Status:Approved

ID:DIAN-D1822

Aim 1:Aim 1: To examine the extent to which environmental risk factors like level of education and SES influence age of onset in ADAD. Hypothesis 1a: Age at symptom onset will be earlier in those with a lower level of education or lower SES.

Aim 2:Aim 2: To determine the influence of educational level (EL) and SES on cognitive decline, disease progression and mortality rate. Hypothesis 2a: Educational Level and SES has a significant effect on cognitive decline and mortality rate after diagnosis, so cognitive decline rate and mortality rate will be faster in those with less than 9 years of education and lower SES.