Investigator:John C Morris
Title:Correlates of synucleinopathy in DIAN mutation carriers
Date of Request:6/1/2016
ID:DIAN-D1612
Aim 1:Determine in autopsied DIAN participants and their autopsied family members wherther synculeinopathy is associated with particular mutations
Aim 2:In the same sample as for Aim 1, determine whether autopsied DIAN participants with synculeinopathy had clinical (behavioral, cognitive, neurological) features of Lewy body disease
Aim 3:Examine clinical (behavioral, cognitive, neurological) features of Lewy body disease in DIAN mutation carriers (asymptomatic and symptomatic)