2022-2024
Dr. Haiyan Liu earned her MD. MSc. Degrees in China. She completed four years of physician training in China and rotated in Internal Medicine, Neurology, and Dermatology. She pursued her postdoctoral training at the University of Michigan, studying central nervous system sensitization, synaptic plasticity, and circuit-level interactions in chronic visceral pain. Dr. Liu conducted seven years of biomedical research in CCR at Washington University School of Medicine related to lysosome function and pathways in Cardiovascular disease, Type II Diabetes Mellitus and Alzheimer’s Disease. She then Joined Dr. Lucey and Dr. Bateman’s lab in the Department of Neurology, Washington University School of Medicine. Her work focused on Amyloid β and Tau measurement in human plasma and CSF, and the effect of Sleep-Deprivation on plasma Aβ and Tau dynamics.
Selected publications:
Yan P, Kim KW, Xiao Q, Ma X, Czerniewski LR, Liu H, Rawnsley DR, Yan Y, Randolph GJ, Epelman S, Lee JM, Diwan A. Peripheral monocyte-derived cells counter amyloid plaque pathogenesis in a mouse model of Alzheimer’s disease. J Clin Invest. 2022 Jun 1;132(11):e152565. doi: 10.1172/JCI152565. PMID: 35511433; PMCID: PMC9151689.
Barthélemy NR, Liu H, Lu W, Kotzbauer PT, Bateman RJ, Lucey BP. Sleep Deprivation Affects Tau Phosphorylation in Human Cerebrospinal Fluid. Ann Neurol. 2020 May;87(5):700-709. doi: 10.1002/ana.25702. Epub 2020 Feb 27. PMID: 32057125; PMCID: PMC7289061.
Murphy JT*, Liu H*, Ma X, Shaver A, Egan BM, Oh C, Boyko A, Mazer T, Ang S, Khopkar R, Javaheri A, Kumar S, Jiang X, Ory D, Mani K, Matkovich SJ, Kornfeld K, Diwan A. Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival. PLoS Biol. 2019 May 14;17(5):e3000245. doi: 10.1371/journal.pbio.3000245. PMID: 31086360; PMCID: PMC6516633.
Liu H, Javaheri A, Godar RJ, Murphy J, Ma X, Rohatgi N, Mahadevan J, Hyrc K, Saftig P, Marshall C, McDaniel ML, Remedi MS, Razani B, Urano F, Diwan A. Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway. Autophagy. 2017;13(11):1952-1968. doi: 10.1080/15548627.2017.1368596. Epub 2017 Nov 25. PMID: 28853981; PMCID: PMC5788488.
Xiao Q, Yan P, Ma X, Liu H, Perez R, Zhu A, Gonzales E, Tripoli DL, Czerniewski L, Ballabio A, Cirrito JR, Diwan A, Lee JM. Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis. J Neurosci. 2015 Sep 2;35(35):12137-51. doi: 10.1523/JNEUROSCI.0705-15.2015. PMID: 26338325; PMCID: PMC4556784.
Xiao Q, Yan P, Ma X, Liu H, Perez R, Zhu A, Gonzales E, Burchett JM, Schuler DR, Cirrito JR, Diwan A, Lee JM. Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis. J Neurosci. 2014 Jul 16;34(29):9607-20. doi: 10.1523/JNEUROSCI.3788-13.2014. PMID: 25031402; PMCID: PMC4099542.
Ma X, Liu H, Foyil SR, Godar RJ, Weinheimer CJ, Hill JA, Diwan A. Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury. Circulation. 2012 Jun 26;125(25):3170-81. doi: 10.1161/CIRCULATIONAHA.111.041814. Epub 2012 May 16. PMID: 22592897; PMCID: PMC3397471.
Li Y, Zhang X, Liu H, Cao Z, Chen S, Cao B, Liu J. Phosphorylated CaMKII post-synaptic binding to NR2B subunits in the anterior cingulate cortex mediates visceral pain in visceral hypersensitive rats. J Neurochem. 2012 May;121(4):662-71. doi: 10.1111/j.1471-4159.2012.07717.x. Epub 2012 Mar 27. Retraction in: J Neurochem. 2020 Jun;153(5):662-664. PMID: 22380661.