DIAN Target Validation Symposium | Dominantly Inherited Alzheimer Network (DIAN)

Our Symposium forum will occur every three years. Our next symposium is scheduled for 2026, please check back for more information.

2023 symposium recap

The DIAN Observational Study hosted the inaugural DIAN Target Validation Symposium in Washington, D.C. on May 24-26, 2023 following the Alzheimer’s Association Research Roundtable. The Symposium was a scientific gathering for academia, research, medical, and industry professionals that allowed physician investigators, researchers, and drug developers to review the scientific discoveries that inform about targets and target validation based on data from dominantly inherited AD (DIAD). The meeting helped to facilitate sharing of the most recent findings, discuss ideas, and network on potential future drug development for DIAD and sporadic AD.

2023 Speakers

This unique meeting brought together the world’s leading researchers, physician investigators, and industry leaders.

**Eric Karran, PhD**
Topic: Primers on Target Validation

**Geoffrey Kerchner, MD, PhD**
Topic: Primers on Target Validation

**Lucia Chavez-Gutierrez, PhD**
Topic: Known Amyloid Target Validations

**Jasmeer Chhatwal, MD, PhD**
Topic: Known Amyloid Target Validators

**Nicolas Barthélemy, PhD**
Topic: Known Tau Target Validation

**Oskar Hansson, MD, PhD**
Topic: Known Tau Target Validations

**Erik Johnson, MD, PhD**
Topic: Potential Omics Target Validation

**Celeste Karch, PhD**
Topic: Potential Omics Target Validation

**Charlotte Teunissen, PhD**
Topic: Biomarkers for non-Amyloid/non-Tau Target Validations

**Marc Suárez-Calvet, MD, PhD**
Topic: Biomarkers for non-Amyloid/non-Tau Target Validations

**Lynn D. Kramer, MD, FAAN**
Topic: Clinical/Cognitive Validation of Targets

**Paul Maruff, PhD**
Topic: Clinical and Cognitive Validations of Targets

**Yakeel Quiroz, PhD**
Topic: Protective/ Escapee

**Randall Bateman, MD**
Topic: Disease Modification

**Ali Atri, MD, PhD**
Topic: Disease Modification

2023 Agenda

May 25, 2023: Symposium Agenda

Welcome/Open Remarks: May 25

Dr. Randall Bateman, MD- Washington University School of Medicine, St. Louis, MO

Presentations

Primers on Target Validation: How we validate and factors that influence robustness- 8:45am

Moderator: Dr. Todd Golde, MD, PhD
Presenters:
Dr. Eric Karran, PhD- Vice President AbbVie Neuroscience
Dr. Geoffrey A. Kerchner, MD, PhD– Vice President and Global Head of Early Development in Neuroscience and Rare Disease at F. Hoffman- La Roche, Ltd
Panelist: Dr. Jaren Landen, PhD; Dr. Eric Karran, PhD, Dr. Geoffrey Kerchner, MD, PhD

Known Amyloid Target Validation- 10:30am

Moderator: Dr. Tammie Benzinger, MD, PhD

Presenters:

Dr. Lucia Chavez-Gutierrez, PhD– VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium
Dr. Jasmeer Chhawtal, MD, PhD– Harvard Medical School, Boston, MA
Panelist: Randall J. Bateman, MD; Dr. Colin Masters, MD; Dr. Lucia Chavez-Gutierrez, PhD; Dr. Jasmeer Chhawtal, MD, PhD

Known Tau Target Validation- 1:00pm

Moderator: Dr. Eric McDade, DO

Presenters:

Dr. Nicolas Barthelemy, PhD– Washington University School of Medicine, St. Louis, MO
Dr. Oskar Hansson, PhD– Lund University, Lund, Sweden
Panelist: Dr. Judith Steen, PhD; Dr. Jeff Dage, PhD; Dr. Nicolas Barthelemy, PhD; Dr. Oskar Hansson, PhD

Potential Omics Target Validation-2:45pm

Moderator: Dr. Allan Levey, MD, PhD

Presenters:

Dr. Erik Johnson, MD, PhD– Emory University, Atlanta, Georgia
Dr. Celeste Karch, PhD– Washington University School of Medicine, St. Louis, Mo
Panelists: Dr. Li-Huei Tsai, PhD; Dr. Laura Ibanez, PhD; Dr. Erik Johnson, MD, PhD; Dr. Celeste Karch, PhD

May 26, 2023: Symposium Agenda

Opening Remarks: May 26

Dr. Randall Bateman, MD- Washington University of Medicine, St. Louis, Mo

Presentations

Biomarkers for non-Amyloid/non Tau Target Validation- 8:45am

Moderator: Dr. Johannes Levin, MD

Presenters:

Dr. Charlotte Teunissen, PhD – Amsterdam University Medical Centers, Amsterdam, Netherlands
Dr. Marc Suárez-Calvet, MD, PhD– BarcelonaBeta Brain Research Center (BBRC), Barcelona, Spain
Panelists: Dr. Naresha Saligrama, PhD; Dr. Pedro Rosa-Neto, MD, PhD; Dr. Charlotte Teunissen, PhD; Dr. Marc Suarez- Calvet, MD, PhD

Clinical/Cognitive Validation of Targets- 10:30am

Moderator: Dr. Jorge Llibre-Guerra, MD, MS

Presenters:

Dr. Lynn Kramer, MD, FAAN– Chief Clinical Officer, Alzheimer’s Disease & Brain Health at Eisai
Dr. Paul Maruff, PhD– Chief Innovation Officer at Cogstate, Ltd and Professor at the Alzheimer’s Disease Research Group, Florey Institute for Neuroscience at the University of Melbourne, Australia
Panelists: Dr. Jason Hassenstab, PhD; Dr. Eric McDade, DO; Dr. Kathy Welsh-Bohmer, PhD; Dr. Lynn Kramer, MD; Dr. Paul Maruff, PhD

Protective/Escapee-1:00pm

Moderator: Dr. Alison Goate, DPhil

Presenter:

Dr. Yakeel T. Quiroz, PhD– Harvard Medical School, Boston, MA
Panelists: Dr. Jorge Llibre-Guerra, MD, MS; Dr. Alison Goate, DPhil; Dr. Yakeel Quiroz, PhD

Disease Modification- 1:45pm

Moderator: Dr. Randall J. Bateman, MD

Presenters:

Dr. Randall Bateman, MD– Washington University School of Medicine, St, Louis Mo
Dr. Alireza Atri, MD, PhD– Director at Banner Sun Health Research Institute, Sun City , AZ
Panelist: Dr. Allan Levey, MD, PhD; Dr. Michael Irizzary, MD, MPH; Dr. Randall Bateman, MD; Dr. Alireza Atri, MD, PhD

Questions?

Email the administration at
Neuro-DIANCoordinatingCenter@email.wustl.edu

Please note: Our symposiums are an internal event and is not open to the public.