Publications | Dominantly Inherited Alzheimer Network (DIAN)

Latest from PubMed

Retraction notice to "Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation" [Stem Cell Res. 79 (2024) 103495]
March 20, 2026
No abstract
Longitudinal subcortical volume changes and their correlations with multiple PET and fluid biomarkers in dominantly inherited Alzheimer's disease
February 28, 2026
CONCLUSIONS: The present findings may provide a unique and well-characterized model for investigating the temporal ordering of Alzheimer's disease biomarkers.
15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN
February 19, 2026
The Dominantly Inherited Alzheimer Network Observational Study (DIAN Obs) is a longitudinal, global cohort study investigating brain aging and autosomal dominant Alzheimer's disease (ADAD), a rare monogenic form of Alzheimer's disease (AD). Established in 2008 with support from the National […]
Critical and non-critical connections not differently associated with either Alzheimer's disease or vascular pathologies
February 12, 2026
Following observations from a pilot study that, contrary to expectations, indicated that critical white matter (WM) connections were not more vulnerable to either SVD or AD pathologies than non-critical connections, we set out to systematically evaluate the relation between these […]
Brain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease
January 19, 2026
INTRODUCTION: It is unknown if neurodegeneration trajectories differ between Down syndrome (DS) and autosomal dominant Alzheimer's disease (ADAD), both of which are genetic forms of Alzheimer's disease (AD).