Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

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Investigator:Joshua Grill

Title:Understanding attitudes toward clinical trials among persons at risk for autosomal dominant Alzheimer's disease

Date of Request:6/3/2014

Status:IP

ID:DIAN-D1405

Aim 1:To characterize the differences in DIAN participants who do and do not want to know their genetic status

Aim 2:To examine the proportion of at-risk individuals who would change their mind whether to undergo genetic testing in the setting of a clinical trial and to characterize differences in these participants, compared to those continue to refuse genetic testing

Aim 3:To assess the effects of the possibility of receiving placebo and varying drug/placebo ratios on persons’ desire to undergo genetic testing and participate in a clinical trial

Aim 4To assess the effects of the possibility of an open-label extension on persons’ desire to undergo genetic testing and participate in a clinical trial

Investigator:Randall Bateman

Title:Phenotypic Variability in Autosomal Dominant Alzheimer's Disease

Date of Request:6/30/2014

Status:IP

ID:DIAN-D1406

Aim 1:Establish correlations between specific ADAD mutation types and clinical presentation, taking into account the familial genetic background.

Aim 2:Aim 2. Identify groups of mutations which have similarities in both clinical phenotype and biomarker and imaging profiles.

Investigator:Anders Martin Fjell

Title:Patterns and mechanisms of brain atrophy in healthy aging and dementia

Date of Request:8/13/2014

Status:IP

ID:DIAN-D1407

Aim 1:To test the relationship between structural brain measures, amyloid levels and cognitive function

Investigator:Dr Kirsi Kinnunen

Title:Fronto-thalamic effective connectivity in familial Alzheimer?s disease

Date of Request:9/18/2014

ID:DIAN-D1409

Aim 1:To investigate effective connectivity of three anatomically defined fronto-thalamic circuits in the DIAN baseline data. Specifically, we propose to use stochastic dynamic causal modelling (sDCM) of regional time-courses extracted from resting-state functional MRI (rs-fMRI).

Aim 2:To determine whether abnormalities of effective connectivity within these neural circuits can be detected during presymptomatic or early-stage familial Alzheimers disease (FAD), and to evaluate the utility of different metrics as potential imaging biomarkers.

Aim 3:To explore the (cross-sectional) relationships between the imaging metrics and measures of cognitive function and behaviour.

Investigator:Paul Thompson, Ph.D.

Title:Growth factors, neuroinflammation, exercise, and brain integrity

Date of Request:9/18/2014

ID:DIAN-D1408

Aim 1:Determine how inflammation gene risk variants influence inflammation marker TNFα, and how genes and TNFα together relate to brain volume.

Aim 2:Show how growth factors and homocysteine relate ROI (hippocampus, cingulate gyrus, prefrontal cortex) volumes.

Aim 3:Determine (1) how our ROI volumes relate to measures of exercise (2) how growth factors and TNFα modulate any relationship between exercise and these ROIs.

Aim 4Evaluate how baseline serum measures and candidate risk genes together predict changes in ROI volume and cognition over 2 years.

Investigator:Clifford R. Jack, Jr., M.D.

Title:TBM-SyN in DIAN

Date of Request:10/2/2014

ID:DIAN-D1410

Aim 1:Measure atrophy rates in DIAN subjects with a new algorithm called TBM-SyN

Aim 2:Test hypothesis that sample size estimates will be superior with TBM-SyN than with longitudinal freesurfer

Investigator:Dale Bredesen

Title:Self-report and informant report personality change in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network

Date of Request:10/31/2014

ID:DIAN-D1411

Aim 1:Examine longitudinal change in different domains of personality in carriers and noncarriers of ADAD mutations.

Aim 2:Compare self-report and informant report personality ratings at different CDR levels.

Aim 3:Identify differences in baseline personality traits between entirely presymptomatic ADAD mutation carriers and non-carriers.

Aim 4Compare scores on IPIP sub-items that represent autistic traits between asymptomatic ADAD mutation carriers and non-carriers, separately for persons inheriting PSEN1, APP, and PSEN2 mutations.

Investigator:not applicable

Title:Clinical and cognitive comparison of LOAD and ADAD

Date of Request:11/17/2014

ID:DIAN-D1412

Aim 1:Determine whether change in cognition and clinical measures of the UDS is similar in LOAD and ADAD

Investigator:Eric M. Reiman

Title:evaluation of various biomarker longitudinal changes

Date of Request:11/18/2014

ID:DIAN-D1413

Aim 1:The possible use of ASL as a perfusion biomarker as possible replacement of FDG-PET

Aim 2:the possible use of perfusion PiB (early frames) as possible replacement of FDG-PET

Aim 3:comparison of ASL, perfusion PiB and FDG-PET

Aim 4the effects of atrophy and partial volume effects in evaluating the first 3 above

Investigator:N/A

Title:Comparison of graph characteristics in resting state fMRI in LOAD and DIAN participants

Date of Request:1/28/2015

ID:DIAN-D1501

Aim 1:Determine graph characteristics (wavelet-based coherence, binary graph diagnostics, weighted and cynamic graph diagnostics in LOAD and DIAN

Aim 2:Determine similarities and differences in these graph characteristics