Search DIAN Tissue Requests
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07/01/2022
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06/26/2022
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06/26/2022
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Sun Lin
The predictive biomarkers for cognitive impairment in non-dementia elderly
06/25/2022
The predictive biomarkers for cognitive impairment under different daily habits in non-dementia elderly
The predictive biomarkers for cognitive impairment under different psychiatric symptoms in non-dementia elderly
Patrick Oeckl
Investigation of plasma Beta-Synuclein levels in asymptomatic and symptomatic autosomal dominant Alzheimer´s disease
06/20/2022
To investigate if blood levels of the synaptic marker Beta-Synuclein are already elevated in asymptomatic ADAD
To estimate a time course of blood Beta-Synuclein changes in ADAD based on EYO and comparison with other blood/CSF biomarkers
Relationship of blood Beta-Synuclein levels in ADAD with other fluid and imaging biomarkers, brain atrophy and cognitive impairment
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06/17/2022
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Antonio Boza Serrano
Galectin-3 as a prognostic biomarker to monitor Autosomal dominant Alzheimer's Disease's progression
04/27/2022
We aim to evaluate if gal3 levels are elevated in ADAD and if they might track the progression of AD pathology.
We want to compare the levels of gal3 with the levels of the classic biomarkers (amyloid-beta 42, total tau, p-tau (181, 217, etc), neurofilaments, precuneus SURV and PIB-Pet) as well as with global cognitive test (MMSE) and clinical measures (CDR total and SB) scores from the DIAN-obs
Giuseppina Tesco
Study of endolysosomal alterations (including exosomes) in brain cells cultures derived from fDA iPSC lines and isogenic controls
01/25/2022
Determine the effect of mutant APP on exosome dynamics in CNS cells in human AD models.
Jee Hoon Roh/Jae-Hong Lee
Epigenetic analyses to assess the resilience among DIAN mutation carriers
12/15/2021
To investigate the potential epigenetic causes of resilience among DIAN mutation carriers who are discordant in disease courses measured by biomarkers.
Cruchaga
Multi-Omics CSF and plasma signature of ADAD
10/16/2021
To identify ADAD-specific multi-omic (proteomics and metabolomic) signatures CSF and plasma
To identify multi-omic (metabolomics and proteomics) plasma signatures and QTLs in ADAD