Search DIAN Tissue Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-T1004), the full request has been submitted and is either approved, disapproved or in process.

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Investigator:

Mariah S. Hahn

Title:

Targeting Dysregulated Synapse and Proteostasis Mechanisms in Alzheimer's Disease

Date of Request:

06/03/2021

Aim 1:

Develop a 3D culture system compatible with long-term (>3 month) iNeuron culture, extension, synapse formation and elimination, and quantitative assessment of neural circuit activity using “healthy” networks.

Aim 2:

Compare AD_(PSEN1)-iNeuron cultures to iNeuron cultures derived from unaffected family member controls with respect to Aβ, tau phosphorylation, synapse maintenance and proteostasis.

Investigator:

Johannes Levin

Title:

Molecular detection of α-synuclein co-pathology in ADAD mutation carriers

Date of Request:

04/29/2021

Aim 1:

Use real time quaking induced conversion (RT-QuIC) for ante mortem detection of Synuclein pathology in ADAD mutation carriers

Aim 2:

Compare the data from RT-QuIC regarding in vivo detection of Synuclein pathology with data from post mortem examinations (manuscript in preparation).

Aim 3:

Within the time frame of 15 years EYO we will analyse the time-point of emergence of LB pathology as measured by RT-QuIC .

Aim 4:

We will analyse clinical and imaging data longitudinally comparing RT-QuIC positive and RT-QuIC negative participants.

Investigator:

Rawan Tarawneh

Title:

VE-cadherin in Alzheimer Disease

Date of Request:

04/04/2021

Aim 1:

Examine the diagnostic value of CSF and plasma levels of VE-cadherin as a marker of vascular injury in EOAD

Aim 2:

Investigate whether VE-cadherin correlates with CSF and imaging measures of amyloid, tau, brain atrophy, and glucose hypometabolism in EOAD in cross-sectional and longitudinal analyses

Aim 3:

Determine whether baseline VE-cadherin levels influences age of onset or rate of cognitive decline in asymptomatic and symptomatic mutation carriers

Investigator:

Oscar Harari

Title:

Metabolomic and lipidomics changes in ADAD

Date of Request:

08/13/2020

Aim 1:

Determine metabolite signatures of ADAD

Aim 2:

Identify locus-metabolite and lipids associations via Metabolite genome-wide association studies (M-GWAS).

Investigator:

Charlotte Teunissen

Title:

Measurement of glial fibrillary acidic protein (GFAP) levels in blood for evaluation of astrocyte reaction in Alzheimer disease.

Date of Request:

08/14/2020

Aim 1:

Determine trajectory of GFAP over the ADAD disease course in relation to amyloid

Investigator:

Teunissen

Title:

Add-on DIAN project 3 Novel mechanisms: pilot OLINK proteomics in left-over CSF aliquots

Date of Request:

08/14/2020

Aim 1:

Study which OLINK proteins (signature) are discriminative between ADAD and controls

Aim 2:

Compare with sporadi AD

Aim 3:

Compare with Mass Spec in ADAD

Investigator:

Ronald Hawley

Title:

TEST BIO SUBMISSION

Date of Request:

08/07/2020

Aim 1:

test the form

Aim 2:

test the form 2

Aim 3:

test the form 3

Aim 4:

test the form 4

Investigator:

Laura Ibanez

Title:

Plasma cell-free RNA as non-invasive biomarker for neurodegeneration

Date of Request:

08/05/2020

Aim 1:

Validate genomic models for disease pathology in Autosomal Dominant Alzheimer

Aim 2:

Develop a specific predictive model for ADAD

Investigator:

Randall Bateman

Title:

Identification and validation of novel AD biomarkers for clinical development of Eisai AD pipelines

Date of Request:

07/02/2020

Aim 1:

To profile of CSF MTBR-tau isoforms which can be captured by E2814 across all DIAD stages using CSF samples from DIAN-observation cohort.

Investigator:

1) Dr. Alison M. Goate, 2) Dr. Sarah M. Neuner

Title:

Defining the role of microglia in Alzheimer’s disease risk and resilience

Date of Request:

04/01/2020

Aim 1:

Aim 1: Investigate the effect of high-risk or protective amyloid precursor protein (APP) mutations on microglia cell function.