Search DIAN Tissue Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-T1004), the full request has been submitted and is either approved, disapproved or in process.

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Investigator:

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Title:

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Date of Request:

07/01/2022

Aim 1:

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Investigator:

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Title:

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Date of Request:

06/26/2022

Aim 1:

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Investigator:

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Title:

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Date of Request:

06/26/2022

Aim 1:

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Investigator:

Sun Lin

Title:

The predictive biomarkers for cognitive impairment in non-dementia elderly

Date of Request:

06/25/2022

Aim 1:

The predictive biomarkers for cognitive impairment under different daily habits in non-dementia elderly

Aim 2:

The predictive biomarkers for cognitive impairment under different psychiatric symptoms in non-dementia elderly

Investigator:

Patrick Oeckl

Title:

Investigation of plasma Beta-Synuclein levels in asymptomatic and symptomatic autosomal dominant Alzheimer´s disease

Date of Request:

06/20/2022

Aim 1:

To investigate if blood levels of the synaptic marker Beta-Synuclein are already elevated in asymptomatic ADAD

Aim 2:

To estimate a time course of blood Beta-Synuclein changes in ADAD based on EYO and comparison with other blood/CSF biomarkers

Aim 3:

Relationship of blood Beta-Synuclein levels in ADAD with other fluid and imaging biomarkers, brain atrophy and cognitive impairment

Investigator:

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Title:

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Date of Request:

06/17/2022

Aim 1:

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Aim 2:

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Aim 3:

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Aim 4:

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Investigator:

Antonio Boza Serrano

Title:

Galectin-3 as a prognostic biomarker to monitor Autosomal dominant Alzheimer's Disease's progression

Date of Request:

04/27/2022

Aim 1:

We aim to evaluate if gal3 levels are elevated in ADAD and if they might track the progression of AD pathology.

Aim 2:

We want to compare the levels of gal3 with the levels of the classic biomarkers (amyloid-beta 42, total tau, p-tau (181, 217, etc), neurofilaments, precuneus SURV and PIB-Pet) as well as with global cognitive test (MMSE) and clinical measures (CDR total and SB) scores from the DIAN-obs

Investigator:

Giuseppina Tesco

Title:

Study of endolysosomal alterations (including exosomes) in brain cells cultures derived from fDA iPSC lines and isogenic controls

Date of Request:

01/25/2022

Aim 1:

Determine the effect of mutant APP on exosome dynamics in CNS cells in human AD models.

Investigator:

Jee Hoon Roh/Jae-Hong Lee

Title:

Epigenetic analyses to assess the resilience among DIAN mutation carriers

Date of Request:

12/15/2021

Aim 1:

To investigate the potential epigenetic causes of resilience among DIAN mutation carriers who are discordant in disease courses measured by biomarkers.

Investigator:

Cruchaga

Title:

Multi-Omics CSF and plasma signature of ADAD

Date of Request:

10/16/2021

Aim 1:

To identify ADAD-specific multi-omic (proteomics and metabolomic) signatures CSF and plasma

Aim 2:

To identify multi-omic (metabolomics and proteomics) plasma signatures and QTLs in ADAD