DIAN Observational Study Publications

    1. Farzaneh Rahmani, Matthew R. Brier, Brian A. Gordon, Nicole McKay, Shaney Flores, Sarah Keefe, Russ Hornbeck, Beau Ances, Nelly Joseph‐Mathurin, Chengjie Xiong, Guoqiao Wang, Cyrus A. Raji, Jorge J. Libre‐Guerra, Richard J. Perrin, Eric McDade, Alisha Daniels, Celeste Karch, Gregory S. Day, Adam M. Brickman, Michael Fulham, Clifford R. Jack, Jr, Christian la La Fougère, Gerald Reischl, Peter R. Schofield, Hwamee Oh, Johannes Levin, Jonathan Vöglein, David M. Cash, Igor Yakushev, Takeshi Ikeuchi, William E. Klunk, John C. Morris, Randall J. Bateman, Tammie L. S. Benzinger, For the Dominantly Inherited Alzheimer Network (DIAN). T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease. Hum Brain Mapp. 2023 Dec 15; 44(18): 6375–6387. Published online 2023 Oct 23. doi: 10.1002/hbm.26514 PMCID: PMC10681640
    2. Jiaxin Cindy Tu, Peter R. Millar, Jeremy F. Strain, Andrew Eck, Babatunde Adeyemo, Alisha Daniels, Celeste Karch, Edward D. Huey, Eric McDade, Gregory S. Day, Igor Yakushev, Jason Hassenstab, John Morris, Jorge J. Llibre-Guerra, Laura Ibanez, Mathias Jucker, Patricio Chrem Mendez, Randell J. Bateman, Richard J. Perrin, Tammie Benzinger, Clifford R. Jack, Jr, Richard Betzel, Beau M. Ances, Adam T. Eggebrecht, Brian A. Gordon, Muriah D. Wheelock, Dominantly Inherited Alzheimer Network. Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer disease Version 1. bioRxiv. Preprint. 2023 Nov 1. doi: 10.1101/2023.10.29.564633 PMCID: PMC10634945
    3. Jorge J Llibre-Guerra, Leonardo Iaccarino, Dean Coble, Lauren Edwards, Yan Li, Eric McDade, Amelia Strom, Brian Gordon, Nidhi Mundada, Suzanne E Schindler, Elena Tsoy, Yinjiao Ma, Ruijin Lu, Anne M Fagan, Tammie L S Benzinger, David Soleimani-Meigooni, Andrew J Aschenbrenner, Zachary Miller, Guoqiao Wang, Joel H Kramer, Jason Hassenstab, Howard J Rosen, John C Morris, Bruce L Miller, Chengjie Xiong, Richard J Perrin, Ricardo Allegri, Patricio Chrem, Ezequiel Surace, Sarah B Berman, Jasmeer Chhatwal, Colin L Masters, Martin R Farlow, Mathias Jucker, Johannes Levin, Nick C Fox, Gregory Day, Maria Luisa Gorno-Tempini, Adam L Boxer, Renaud La Joie, Gil D Rabinovici, Randall Bateman. Longitudinal clinical, cognitive and biomarker profiles in dominantly inherited versus sporadic early-onset Alzheimer’s disease. Brain Commun. 2023; 5(6): fcad280. Published online 2023 Oct 18. doi: 10.1093/braincomms/fcad280 PMCID: PMC10629466
    4. Johnson ECB, Bian S, Haque RU, Carter EK, Watson CM, Gordon BA, Ping L, Duong DM, Epstein MP, McDade E, Barthélemy NR, Karch CM, Xiong C, Cruchaga C, Perrin RJ, Wingo AP, Wingo TS, Chhatwal JP, Day GS, Noble JM, Berman SB, Martins R, Graff-Radford NR, Schofield PR, Ikeuchi T, Mori H, Levin J, Farlow M, Lah JJ, Haass C, Jucker M, Morris JC, Benzinger TLS, Roberts BR, Bateman RJ, Fagan AM, Seyfried NT, Levey AI; Dominantly Inherited Alzheimer Network. Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease. Nat Med. 2023 Aug;29(8):1979-1988. doi: 10.1038/s41591-023- 02476-4. Epub 2023 Aug 7. PMID: 37550416; PMCID: PMC10427428.
    5.  McKay NS, Gordon BA, Hornbeck RC, Dincer A, Flores S, Keefe SJ, Joseph-Mathurin N, Jack CR, Koeppe R, Millar PR, Ances BM, Chen CD, Daniels A, Hobbs DA, Jackson K, Koudelis D, Massoumzadeh P, McCullough A, Nickels ML, Rahmani F, Swisher L, Wang Q, Allegri RF, Berman SB, Brickman AM, Brooks WS, Cash DM, Chhatwal JP, Day GS, Farlow MR, la Fougère C, Fox NC, Fulham M, Ghetti B, Graff-Radford N, Ikeuchi T, Klunk W, Lee JH, Levin J, Martins R, Masters CL, McConathy J, Mori H, Noble JM, Reischl G, Rowe C, Salloway S, Sanchez-Valle R, Schofield PR, Shimada H, Shoji M, Su Y, Suzuki K, Vöglein J, Yakushev I, Cruchaga C, Hassenstab J, Karch C, McDade E, Perrin RJ, Xiong C, Morris JC, Bateman RJ, Benzinger TLS; Dominantly Inherited Alzheimer Network. Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN). Nat Neurosci. 2023 Aug;26(8):1449-1460. doi: 10.1038/s41593-023-01359- 8. Epub 2023 Jul 10. PMID: 37429916; PMCID: PMC10400428
    6. Phillips B, Western D, Wang L, Timsina J, Sun Y, Gorijala P, Yang C, Do A, Nykänen NP, Alvarez I, Aguilar M, Pastor P, Morris JC, Schindler SE, Fagan AM, Puerta R, García-González P, de Rojas I, Marquié M, Boada M, Ruiz A, Perlmutter JS; Dominantly Inherited Alzheimer Network (DIAN) Consortia; Ibanez L, Perrin RJ, Sung YJ, Cruchaga C. Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease. NPJ Parkinsons Dis. 2023 Jul 8;9(1):107. doi: 10.1038/s41531-023-00555-4. PMID: 37422510; PMCID: PMC10329646.
    7. Sung YJ, Yang C, Norton J, Johnson M, Fagan A, Bateman RJ, Perrin RJ, Morris JC, Farlow MR, Chhatwal JP, Schofield PR, Chui H, Wang F, Novotny B, Eteleeb A, Karch C, Schindler SE, Rhinn H, Johnson ECB, Oh HS, Rutledge JE, Dammer EB, Seyfried NT, Wyss-Coray T, Harari O, Cruchaga C. Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer’s disease. Sci Transl Med. 2023 Jul 5;15(703):eabq5923. doi: 10.1126/scitranslmed.abq5923. Epub 2023 Jul 5. PMID: 37406134.
    8. Cruchaga C, Western D, Timsina J, Wang L, Wang C, Yang C, Ali M, Beric A, Gorijala P, Kohlfeld P, Budde J, Levey A, Morris J, Perrin R, Ruiz A, Marquié M, Boada M, de Rojas I, Rutledge J, Oh H, Wilson E, Guen YL, Alvarez I, Aguilar M, Greicius M, Pastor P, Pulford D, Ibanez L, Wyss-Coray T, Sung YJ, Phillips B. Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and informs causal proteins for Alzheimer’s disease. Res Sq [Preprint]. 2023 Jun 9:rs.3.rs-2814616. doi: 10.21203/rs.3.rs- 2814616/v1. PMID: 37333337; PMCID: PMC10275048.
    9. Wang C, Western D, Yang C, Ali M, Wang L, Gorijala P, Timsina J, Ruiz A, Pastor P, Fernandez M, Panyard D, Engelman C, Deming Y, Boada M, Cano A, García- González P, Graff-Radford N, Mori H, Lee JH, Perrin R, Sung YJ, Dian DIAN, Adni ADNI, Cruchaga C. Unique genetic architecture of CSF and brain metabolites pinpoints the novel targets for the traits of human wellness. Res Sq [Preprint]. 2023 Jun 9:rs.3.rs-2923409. doi: 10.21203/rs.3.rs-2923409/v1. PMID: 37333177; PMCID: PMC10274943.
    10. Schultz SA, Shirzadi Z, Schultz AP, Liu L, Fitzpatrick CD, McDade E, Barthelemy NR, Renton A, Esposito B, Joseph-Mathurin N, Cruchaga C, Chen CD, Goate A, Allegri RF, Benzinger TLS, Berman S, Chui HC, Fagan AM, Farlow MR, Fox NC, Gordon BA, Day GS, Graff-Radford NR, Hassenstab JJ, Hanseeuw BJ, Hofmann A, Jack CR Jr, Jucker M, Karch CM, Koeppe RA, Lee JH, Levey AI, Levin J, Martins RN, Mori H, Morris JC, Noble J, Perrin RJ, Rosa-Neto P, Salloway SP, Sanchez-Valle R, Schofield PR, Xiong C, Johnson KA, Bateman RJ, Sperling RA, Chhatwal JP; Dominantly Inherited Alzheimer Network Investigators. Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal- dominant Alzheimer’s disease. Aging Cell. 2023 Aug;22(8):e13871. doi: 10.1111/acel.13871. Epub 2023 Jun 8. PMID: 37291760; PMCID: PMC10410059.
    11. O’Connor A, Cash DM, Poole T, Markiewicz PJ, Fraser MR, Malone IB, Jiao J, Weston PSJ, Flores S, Hornbeck R, McDade E, Schöll M, Gordon BA, Bateman RJ, Benzinger TLS, Fox NC. Tau accumulation in autosomal dominant Alzheimer’s disease: a longitudinal [18F]flortaucipir study. Alzheimers Res Ther. 2023 May 25;15(1):99. doi: 10.1186/s13195-023-01234-5. PMID: 37231491; PMCID: PMC10210376.
    12. Timsina J, Ali M, Do A, Wang L, Sung YJ, Cruchaga C. Harmonization of CSF and imaging biomarkers for Alzheimer’s disease biomarkers: need and practical applications for genetics studies and preclinical classification. bioRxiv [Preprint]. 2023 May 24:2023.05.24.542118. doi: 10.1101/2023.05.24.542118. PMID: 37292823; PMCID: PMC10245826.
    13. Luo J, Ma Y, Agboola FJ, Grant E, Morris JC, McDade E, Fagan AM, Benzinger TLS, Hassenstab J, Bateman RJ, Perrin RJ, Gordon BA, Goyal M, Strain JF, Yakushev I, Day GS, Xiong C; for Dominantly Inherited Alzheimer Network (DIAN). Longitudinal Relationships of White Matter Hyperintensities and Alzheimer Disease Biomarkers Across the Adult Life Span. Neurology. 2023 Jul 11;101(2):e164-e177. doi: 10.1212/WNL.0000000000207378. Epub 2023 May 18. PMID: 37202169; PMCID: PMC10351551.
    14. O’Connor A, Rice H, Barnes J, Ryan NS, Liu KY, Allegri RF, Berman S, Ringman JM, Cruchaga C, Farlow MR, Hassenstab J, Lee JH, Perrin RJ, Xiong C, Gordon B, Levey AI, Goate A, Graff-Radford N, Levin J, Jucker M, Benzinger T, McDade E, Mori H, Noble JM, Schofield PR, Martins RN, Salloway S, Chhatwal J, Morris JC, Bateman R, Howard R, Reeves S, Fox NC. First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimer’s disease: the Dominantly Inherited Alzheimer’s Network Study. Journal of Neurology, Neurosurgery, and Psychiatry. 2023 May;94(5):403-405. PubMed PMID: 36522155; DOI: 10.1136/jnnp-2022-329843.
    15. Ali M, Archer DB, Gorijala P, Western D, Timsina J, Fernández MV, Wang TC, Satizabal CL, Yang Q, Beiser AS, Wang R, Chen G, Gordon B, Benzinger TLS, Xiong C, Morris JC, Bateman RJ, Karch CM, McDade E, Goate A, Seshadri S, Mayeux RP, Sperling RA, Buckley RF, Johnson KA, Won HH, Jung SH, Kim HR, Seo SW, Kim HJ, Mormino E, Laws SM, Fan KH, Kamboh MI, Vemuri P, Ramanan VK, Yang HS, Wenzel A, Rajula HSR, Mishra A, Dufouil C, Debette S, Lopez OL, DeKosky ST, Tao F, Nagle MW; Knight Alzheimer Disease Research Center (Knight ADRC); Dominantly Inherited Alzheimer Network (DIAN); Alzheimer’s Disease Neuroimaging Initiative (ADNI); ADNI-DOD, A4 Study Team; Australian Imaging Biomarkers, Lifestyle (AIBL) Study; Hohman TJ, Sung YJ, Dumitrescu L, Cruchaga C. Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease. Acta Neuropathol Commun. 2023 Apr 26;11(1):68. doi: 10.1186/s40478-023- 01563-4. PMID: 37101235; PMCID: PMC10134547.
    16. Brase L, You SF, D’Oliveira Albanus R, Del-Aguila JL, Dai Y, Novotny BC, Soriano-Tarraga C, Dykstra T, Fernandez MV, Budde JP, Bergmann K, Morris JC, Bateman RJ, Perrin RJ, McDade E, Xiong C, Goate AM, Farlow M; Dominantly Inherited Alzheimer Network (DIAN); Sutherland GT, Kipnis J, Karch CM, Benitez BA, Harari O. Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers. Nat Commun. 2023 Apr 21;14(1):2314. doi: 10.1038/s41467-023-37437-5. PMID: 37085492; PMCID: PMC10121712
    17. Aschenbrenner, AJ, Hassenstab, J, Morris, JC, Cruchaga, C, Jackson, JJ. Relationship between hourly cognitive variability and risk of Alzheimer disease revealed with mixed effects location scale models. Neuropsychology. 2023 Apr 20: 10.1037/neu0000905. doi: 10.1037/neu0000905.PMID: 37079810; PMCID: PMC10587364
    18. Schindler SE, Li Y, Li M, Despotis A, Park E, Vittert L, Hamilton BH, Womack KB, Saef B, Holtzman DM, Morris JC, Bateman RJ, Gupta MR. Using Alzheimer’s disease blood tests to accelerate clinical trial enrollment. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2023 April;19(4):1175-1183. PubMed PMID: 35934777; PubMed Central PMCID: PMC9902574; DOI: 10.1002/alz.12754.
    19. Chen CD, McCullough A, Gordon B, Joseph-Mathurin N, Flores S, McKay NS, Hobbs DA, Hornbeck R, Fagan AM, Cruchaga C, Goate AM, Perrin RJ, Wang G, Li Y, Shi X, Xiong C, Pontecorvo MJ, Klein G, Su Y, Klunk WE, Jack C, Koeppe R, et al. Longitudinal head-to-head comparison of (11)C-PiB and (18)F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly inherited Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 2023 Apr 5. doi: 10.1007/s00259-023-06209-0. [Epub ahead of print] PubMed [citation] PMID: 37017737; PMCID: PMC10330155
    20. Cochran JN, Acosta-Uribe J, Esposito BT, Madrigal L, Aguillón D, Giraldo MM, Taylor JW, Bradley J, Fulton- Howard B, Andrews SJ, Acosta-Baena N, Alzate D, Garcia GP, Piedrahita F, Lopez HE, Anderson AG, Rodriguez-Nunez I, Roberts K, Dominantly Inherited Alzheimer Network, Absher D, Myers RM, Beecham GW, Reitz C, Rizzardi LF, Fernandez MV, Goate AM, Cruchaga C, Renton AE, Lopera F, Kosik KS. Genetic associations with age at dementia onset in the PSEN1 E280A Colombian kindred. Alzheimers Dement. 2023 Mar 23. doi: 10.1002/alz.13021. Epub ahead of print. PMID: 36951251; PMCID: PMC10514237
    21. Vermunt L, Sutphen C, Dicks E, de Leeuw DM, Allegri R, Berman SB, Cash DM, Chhatwal JP, Cruchaga C, Day G, Ewers M, Farlow M, Fox NC, Ghetti B, Graff-Radford N, Hassenstab J, Jucker M, Karch CM, Kuhle J, Laske C, Levin J, Masters CL, McDade E, Mori H, Morris JC, Perrin RJ, Preische O, Schofield PR, Suárez- Calvet M, Xiong C, Scheltens P, Teunissen CE, Visser PJ, Bateman RJ, Benzinger TLS, Fagan AM, Gordon BA, Tijms BM. Axonal damage and astrocytosis are biological correlates of grey matter network integrity loss: a cohort study in autosomal dominant Alzheimer disease. medRxiv [Preprint]. 2023 Mar 22:2023.03.21.23287468. doi: 10.1101/2023.03.21.23287468. PMID: 37016671; PMCID: PMC10071836.
    22. Xu J, Farsad HL, Hou Y, Barclay K, Lopez BA, Yamada S, Saliu IO, Shi Y, Knight WC, Bateman RJ, Benzinger TLS, Yi JJ, Li Q, Wang T, Perlmutter JS, Morris JC, Zhao G. Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration. Nature aging. 2023 March;3(3):346-365. PubMed PMID: 36993867; PubMed Central PMCID: PMC10046522; DOI: 10.1038/s43587-023-00363-8.
    23. Horie K, Li Y, Barthélemy NR, Gordon B, Hassenstab J, Benzinger TLS, Fagan AM, Morris JC, Karch CM, Xiong C, Allegri R, Mendez PC, Ikeuchi T, Kasuga K, Noble J, Farlow M, Chhatwal J, Day G, Schofield PR, Masters CL, Levin J, Jucker M, Lee JH, Roh JH, Sato C, Sachdev P, Koyama A, Reyderman L, Bateman RJ, McDade E. Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer’s Disease. Annals of Neurology. 2023 February 26. PubMed PMID: 36843330; DOI: 10.1002/ana.26620.
    24. You SF, Brase L, Filipello F, Iyer AK, Del-Aguila J, He J, D’Oliveira Albanus R, Budde J, Norton J, Gentsch J, Dräger NM, Sattler SM, Kampmann M, Piccio L, Morris JC, Perrin RJ, McDade E, Paul SM, Cashikar AG, Benitez BA, Harari O, Karch CM. MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state. medRxiv : the preprint server for health sciences. 2023 February 8. PubMed PMID: 36798226; PubMed Central PMCID: PMC9934804; DOI: 10.1101/2023.02.06.23285545.
    25. Vöglein J, Franzmeier N, Morris JC, Dieterich M, McDade E, Simons M, Preische O, Hofmann A, Hassenstab J, Benzinger TL, Fagan A, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal JP, Salloway S, Xiong C, Karch CM, Cairns N, Perrin RJ, Day G, Martins R, Sanchez-Valle R, Mori H, Shimada H, Ikeuchi T, Suzuki K, Schofield PR, Masters CL, Goate A, Buckles V, Fox NC, Chrem P, Allegri R, Ringman JM, Yakushev I, Laske C, Jucker M, Höglinger G, Bateman RJ, Danek A, Levin J. Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2023 February; 19(2):632-645. PubMed PMID: 35609137; PubMed Central PMCID: PMC9684350; DOI: 10.1002/alz.12684..
    26. Xiong C, McCue LM, Buckles V, Grant E, Agboola F, Coble D, Bateman RJ, Fagan AM, Benzinger TLS, Hassenstab J, Schindler SE, McDade E, Moulder K, Gordon BA, Cruchaga C, Day GS, Ikeuchi T, Suzuki K, Allegri RF, Vöglein J, Levin J, Morris JC. Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer’s disease. Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2023 January 14. PubMed PMID: 36640138; DOI: 10.1002/alz.12912.
    27. Millar PR, Gordon BA, Luckett PH, Benzinger TLS, Cruchaga C, Fagan AM, Hassenstab JJ, Perrin RJ, Schindler SE, Allegri RF, Day GS, Farlow MR, Mori H, Nübling G, Bateman RJ, Morris JC, Ances BM. Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study. eLife. 2023 January 6; 12. PubMed PMID: 36607335; PubMed Central PMCID: PMC9988262; DOI: 10.7554/eLife.81869.
    28. Luckett PH, Chen C, Gordon BA, Wisch J, Berman SB, Chhatwal JP, Cruchaga C, Fagan AM, Farlow MR, Fox NC, Jucker M, Levin J, Masters CL, Mori H, Noble JM, Salloway S, Schofield PR, Brickman AM, Brooks WS, Cash DM, Fulham MJ, Ghetti B, Jack CR Jr, Vöglein J, Klunk WE, Koeppe R, Su Y, Weiner M, Wang Q, Marcus D, Koudelis D, Joseph-Mathurin N, Cash L, Hornbeck R, Xiong C, Perrin RJ, Karch CM, Hassenstab J, McDade E, Morris JC, Benzinger TLS, Bateman RJ, Ances BM. Biomarker clustering in autosomal dominant Alzheimer’s disease. Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2023 January; 19(1):274-284. PubMed PMID: 35362200; PubMed Central PMCID: PMC9525451; DOI: 10.1002/alz.12661.
    29. Liu L, Lauro BM, He A, Lee H, Bhattarai S, Wolfe MS, Bennett DA, Karch CM, Young-Pearse T, Selkoe DJ. Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer’s disease. Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2023 January; 19(1):79-96. PubMed PMID: 35278341; PubMed Central PMCID: PMC9464800; DOI: 10.1002/alz.12646.
    30. Boerwinkle AH, Gordon BA, Wisch J, Flores S, Henson RL, Butt OH, McKay N, Chen CD, Benzinger TLS, Fagan AM, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O’Bryant S, Lai F, Rosas HD, Lee JH, Silverman W, Brickman AM, Chhatwal JP, Cruchaga C, Perrin RJ, Xiong C, Hassenstab J, McDade E, Bateman RJ, Ances BM. Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer’s disease: a cross-sectional study. The Lancet. Neurology. 2023 January; 22(1):55-65. PubMed PMID: 36517172; PubMed Central PMCID: PMC9979840; DOI: 10.1016/S1474-4422(22)00408-2.
    31. Wheelock MD, Strain JF, Mansfield P, Tu JC, Tanenbaum A, Preische O, Chhatwal JP, Cash DM, Cruchaga C, Fagan AM, Fox NC, Graff-Radford NR, Hassenstab J, Jack CR, Karch CM, Levin J, McDade EM, Perrin RJ, Schofield PR, Xiong C, Morris JC, Bateman RJ, Jucker M, Benzinger TLS, Ances BM, Eggebrecht AT, Gordon BA; Dominantly Inherited Alzheimer Network. Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer’s disease. Brain. 2023 Jan 10:awac498. doi: 10.1093/brain/awac498. Online ahead of print. PMID: 36625756; PMCID: PMC10316768.
    32. Chatterjee P, Vermunt L, Gordon BA, Pedrini S, Boonkamp L, Armstrong NJ, Xiong C, Singh AK, Li Y, Sohrabi HR, Taddei K, Molloy M, Benzinger TLS, Morris JC, Karch C, Berman S, Chhatwal J, Cruchaga C, Graff-Radford NR, Day GS, Farlow M, Fox N, Goate A, Hassenstab J, Lee JH, Levin J, McDade E, Mori H, Perrin R, Sanchez-Valle R, Schofield PR, Levey A, Jucker M, Masters CL, Fagan AM, Bateman RJ, Martins RN, Teunissen C. Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer’s disease: Associations with Aβ-PET, neurodegeneration, and cognition. Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2022 December 28. PubMed PMID: 36576155; DOI: 10.1002/alz.12879.
    33. Luo J, Agboola F, Grant E, Morris JC, Masters CL, Albert MS, Johnson SC, McDade EM, Fagan AM, Benzinger TLS, Hassenstab J, Bateman RJ, Perrin RJ, Wang G, Li Y, Gordon B, Cruchaga C, Day GS, Levin J, Vöglein J, Ikeuchi T, Suzuki K, Allegri RF, Xiong C. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a journal of neurology. 2022 December 19; 145(12):4459-4473. PubMed PMID: 35925685; DOI: 10.1093/brain/awac238.
    34. Rother C, Uhlmann RE, Müller SA, Schelle J, Skodras A, Obermüller U, Häsler LM, Lambert M, Baumann F, Xu Y, Bergmann C, Salvadori G, Loos M, Brzak I, Shimshek D, Neumann U, Walker LC, Schultz SA, Chhatwal JP, Kaeser SA, Lichtenthaler SF, Staufenbiel M, Jucker M. Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae. Nature communications. 2022 November 28;13(1):7333. PubMed PMID: 36443293; PubMed Central PMCID: PMC9705543; DOI: 10.1038/s41467-022-34538-5.
    35. Strain JF, Brier MR, Tanenbaum A, Gordon BA, McCarthy JE, Dincer A, Marcus DS, Chhatwal JP, Graff-Radford NR, Day GS, la Fougère C, Perrin RJ, Salloway S, Schofield PR, Yakushev I, Ikeuchi T, Vöglein J, Morris JC, Benzinger TLS, Bateman RJ, Ances BM, Snyder AZ. Covariance-based vs. correlation-based functional connectivity dissociates healthy aging from Alzheimer disease. NeuroImage. 2022 November 1; 261:119511. PubMed PMID: 35914670; PubMed Central PMCID: PMC9750733; DOI: 10.1016/j.neuroimage.2022.119511.
    36. Drieu A, Du S, Storck SE, Rustenhoven J, Papadopoulos Z, Dykstra T, Zhong F, Kim K, Blackburn S, Mamuladze T, Harari O, Karch CM, Bateman RJ, Perrin R, Farlow M, Chhatwal J, Hu S, Randolph GJ, Smirnov I, Kipnis J. Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid. Nature. 2022 November; 611(7936):585-593. PubMed PMID: 36352225; PubMed Central PMCID: PMC9899827; DOI: 10.1038/s41586-022-05397-3.
    37. Morris JC, Weiner M, Xiong C, Beckett L, Coble D, Saito N, Aisen PS, Allegri R, Benzinger TLS, Berman SB, Cairns NJ, Carrillo MC, Chui HC, Chhatwal JP, Cruchaga C, Fagan AM, Farlow M, Fox NC, Ghetti B, Goate AM, Gordon BA, Graff-Radford N, Day GS, Hassenstab J, Ikeuchi T, Jack CR, Jagust WJ, Jucker M, Levin J, Massoumzadeh P, Masters CL, Martins R, McDade E, Mori H, Noble JM, Petersen RC, Ringman JM, Salloway S, Saykin AJ, Schofield PR, Shaw LM, Toga AW, Trojanowski JQ, Vöglein J, Weninger S, Bateman RJ, Buckles VD. Autosomal dominant and sporadic late onset Alzheimer’s disease share a common in vivo pathophysiology. Brain: a journal of neurology. 2022 October 21;145(10):3594-3607. PubMed PMID: 35580594; PubMed Central PMCID: PMC9989348; DOI: 10.1093/brain/awac181.
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    122. Lucey BP, McCullough A, Landsness EC, Toedebusch CD, McLeland JS, Zaza AM, Fagan AM, McCue L, Xiong C, Morris JC, Benzinger TLS, Holtzman DM. Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease. Sci Transl Med2019 Jan 9;11(474)doi: 10.1126/scitranslmed.aau6550. PubMed PMID: 30626715; PubMed Central PMCID: PMC6342564.
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    125. Veitch DP, Weiner MW, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR Jr, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ. Understanding disease progression and improving Alzheimer’s disease clinical trials: Recent highlights from the Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Dement2019 Jan;15(1):106-152doi: 10.1016/j.jalz.2018.08.005. Epub 2018 Oct 13. Review. PubMed PMID: 30321505.
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