DIAN Observational Study Publications

  1. Su Y, Flores S, Wang G, Hornbeck RC, Speidel B, Joseph-Mathurin N, Vlassenko AG, Gordon BA, Koeppe RA, Klunk WE, Jack CR Jr, Farlow MR, Salloway S, Snider BJ, Berman SB, Roberson ED, Brosch J, Jimenez-Velazques I, van Dyck CH, Galasko D, Yuan SH, Jayadev S, Honig LS, Gauthier S, Hsiung GR, Masellis M, Brooks WS, Fulham M, Clarnette R, Masters CL, Wallon D, Hannequin D, Dubois B, Pariente J, Sanchez-Valle R, Mummery C, Ringman JM, Bottlaender M, Klein G, Milosavljevic-Ristic S, McDade E, Xiong C, Morris JC, Bateman RJ, Benzinger TLS. Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies. Alzheimers Dement (Amst)2019 Dec;11:180-190doi: 10.1016/j.dadm.2018.12.008. eCollection 2019 Dec. PubMed PMID: 30847382; PubMed Central PMCID: PMC6389727.
  2. Wang G, Aschenbrenner AJ, Li Y, McDade E, Liu L, Benzinger TLS, Bateman RJ, Morris JC, Hassenstab JJ, Xiong C. Two-period linear mixed effects models to analyze clinical trials with run-in data when the primary outcome is continuous: Applications to Alzheimer’s disease. Alzheimers Dement (N Y)2019;5:450-457doi: 10.1016/j.trci.2019.07.007. eCollection 2019. PubMed PMID: 31517032; PubMed Central PMCID: PMC6732759.
  3. Buckley RF, Mormino EC, Chhatwal J, Schultz AP, Rabin JS, Rentz DM, Acar D, Properzi MJ, Dumurgier J, Jacobs H, Gomez-Isla T, Johnson KA, Sperling RA, Hanseeuw BJ. Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid. Neurobiol Aging2019 Jun;78:178-185doi: 10.1016/j.neurobiolaging.2019.02.019. Epub 2019 Mar 7. PubMed PMID: 30947113; PubMed Central PMCID: PMC6545139.
  4. Vöglein J, Paumier K, Jucker M, Preische O, McDade E, Hassenstab J, Benzinger TL, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal J, Salloway S, Xiong C, Karch CM, Cairns N, Mori H, Schofield PR, Masters CL, Goate A, Buckles V, Fox N, Rossor M, Chrem P, Allegri R, Ringman JM, Höglinger G, Steiner H, Dieterich M, Haass C, Laske C, Morris JC, Bateman RJ, Danek A, Levin J. Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer’s disease. Brain2019 May 1;142(5):1429-1440doi: 10.1093/brain/awz050. PubMed PMID: 30897203; PubMed Central PMCID: PMC6735903.
  5. Schindler SE, Li Y, Todd KW, Herries EM, Henson RL, Gray JD, Wang G, Graham DL, Shaw LM, Trojanowski JQ, Hassenstab JJ, Benzinger TLS, Cruchaga C, Jucker M, Levin J, Chhatwal JP, Noble JM, Ringman JM, Graff-Radford NR, Holtzman DM, Ladenson JH, Morris JC, Bateman RJ, Xiong C, Fagan AM. Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer’s disease. Alzheimers Dement2019 May;15(5):655-665doi: 10.1016/j.jalz.2018.12.019. Epub 2019 Mar 4. PubMed PMID: 30846386; PubMed Central PMCID: PMC6511459.
  6. Wang G, Coble D, McDade EM, Hassenstab J, Fagan AM, Benzinger TLS, Bateman RJ, Morris JC, Xiong C. Staging biomarkers in preclinical autosomal dominant Alzheimer’s disease by estimated years to symptom onset. Alzheimers Dement2019 Apr;15(4):506-514doi: 10.1016/j.jalz.2018.12.008. Epub 2019 Feb 15. PubMed PMID: 30773445; PubMed Central PMCID: PMC6461496.
  7. Gordon BA, Blazey TM, Christensen J, Dincer A, Flores S, Keefe S, Chen C, Su Y, McDade EM, Wang G, Li Y, Hassenstab J, Aschenbrenner A, Hornbeck R, Jack CR, Ances BM, Berman SB, Brosch JR, Galasko D, Gauthier S, Lah JJ, Masellis M, van Dyck CH, Mintun MA, Klein G, Ristic S, Cairns NJ, Marcus DS, Xiong C, Holtzman DM, Raichle ME, Morris JC, Bateman RJ, Benzinger TLS. Tau PET in autosomal dominant Alzheimer’s disease: relationship with cognition, dementia and other biomarkers. Brain2019 Apr 1;142(4):1063-1076doi: 10.1093/brain/awz019. PubMed PMID: 30753379; PubMed Central PMCID: PMC6439328.
  8. Vöglein J, Noachtar S, McDade E, Quaid KA, Salloway S, Ghetti B, Noble J, Berman S, Chhatwal J, Mori H, Fox N, Allegri R, Masters CL, Buckles V, Ringman JM, Rossor M, Schofield PR, Sperling R, Jucker M, Laske C, Paumier K, Morris JC, Bateman RJ, Levin J, Danek A. Seizures as an early symptom of autosomal dominant Alzheimer’s disease. Neurobiol Aging2019 Apr;76:18-23doi: 10.1016/j.neurobiolaging.2018.11.022. Epub 2018 Dec 5. PubMed PMID: 30616208; PubMed Central PMCID: PMC6572755.
  9. Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, Düzel E, Rodríguez Gómez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Buerger K, Levin J, Duering M, Dichgans M, Suárez-Calvet M, Haass C, Gordon BA, Lim YY, Masters CL, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Milz E, Moreno-Grau S, Teipel S, Grothe MJ, Kilimann I, Rossor M, Fox N, Laske C, Chhatwal J, Falkai P, Perneczky R, Lee JH, Spottke A, Boecker H, Brosseron F, Fliessbach K, Heneka MT, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Salloway S, Danek A, Hassenstab J, Yakushev I, Schofield PR, Morris JC, Bateman RJ, Ewers M. The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease. Mol Psychiatry2019 Mar 21;doi: 10.1038/s41380-019-0404-6. [Epub ahead of print] PubMed PMID: 30899092; PubMed Central PMCID: PMC6754794.
  10. Wang Q, Wang Y, Liu J, Sutphen CL, Cruchaga C, Blazey T, Gordon BA, Su Y, Chen C, Shimony JS, Ances BM, Cairns NJ, Fagan AM, Morris JC, Benzinger TLS. Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer’s disease. Neuroimage Clin2019;22:101767doi: 10.1016/j.nicl.2019.101767. Epub 2019 Mar 13. PubMed PMID: 30901713; PubMed Central PMCID: PMC6428957.
  11. Bussy A, Snider BJ, Coble D, Xiong C, Fagan AM, Cruchaga C, Benzinger TLS, Gordon BA, Hassenstab J, Bateman RJ, Morris JC. Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network. Neurobiol Aging2019 Mar;75:42-50doi: 10.1016/j.neurobiolaging.2018.10.011. Epub 2018 Oct 13. PubMed PMID: 30530186; PubMed Central PMCID: PMC6385602.
  12. Preische O, Schultz SA, Apel A, Kuhle J, Kaeser SA, Barro C, Gräber S, Kuder-Buletta E, LaFougere C, Laske C, Vöglein J, Levin J, Masters CL, Martins R, Schofield PR, Rossor MN, Graff-Radford NR, Salloway S, Ghetti B, Ringman JM, Noble JM, Chhatwal J, Goate AM, Benzinger TLS, Morris JC, Bateman RJ, Wang G, Fagan AM, McDade EM, Gordon BA, Jucker M. Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease. Nat Med2019 Feb;25(2):277-283doi: 10.1038/s41591-018-0304-3. Epub 2019 Jan 21. PubMed PMID: 30664784; PubMed Central PMCID: PMC6367005.
  13. Properzi MJ, Buckley RF, Chhatwal JP, Donohue MC, Lois C, Mormino EC, Johnson KA, Sperling RA, Schultz AP. Nonlinear Distributional Mapping (NoDiM) for harmonization across amyloid-PET radiotracers. Neuroimage2019 Feb 1;186:446-454doi: 10.1016/j.neuroimage.2018.11.019. Epub 2018 Nov 17. PubMed PMID: 30458305; PubMed Central PMCID: PMC6338495.
  14. Lucey BP, McCullough A, Landsness EC, Toedebusch CD, McLeland JS, Zaza AM, Fagan AM, McCue L, Xiong C, Morris JC, Benzinger TLS, Holtzman DM. Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease. Sci Transl Med2019 Jan 9;11(474)doi: 10.1126/scitranslmed.aau6550. PubMed PMID: 30626715; PubMed Central PMCID: PMC6342564.
  15. Veitch DP, Weiner MW, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR Jr, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ. Understanding disease progression and improving Alzheimer’s disease clinical trials: Recent highlights from the Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Dement2019 Jan;15(1):106-152doi: 10.1016/j.jalz.2018.08.005. Epub 2018 Oct 13. Review. PubMed PMID: 30321505.
  16. Jiang S, Wen N, Li Z, Dube U, Del Aguila J, Budde J, Martinez R, Hsu S, Fernandez MV, Cairns NJ, Harari O, Cruchaga C, Karch CM. Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP. Transl Psychiatry2018 Dec 13;8(1):265doi: 10.1038/s41398-018-0319-z. PubMed PMID: 30546007; PubMed Central PMCID: PMC6293323.
  17. Wang G, Xiong C, McDade EM, Hassenstab J, Aschenbrenner AJ, Fagan AM, Benzinger TLS, Gordon BA, Morris JC, Li Y, Bateman RJ. Simultaneously evaluating the effect of baseline levels and longitudinal changes in disease biomarkers on cognition in dominantly inherited Alzheimer’s disease. Alzheimers Dement (N Y)2018;4:669-676doi: 10.1016/j.trci.2018.10.009. eCollection 2018. PubMed PMID: 30569014; PubMed Central PMCID: PMC6288312.
  18. Suárez-Calvet M, Capell A, Araque Caballero MÁ, Morenas-Rodríguez E, Fellerer K, Franzmeier N, Kleinberger G, Eren E, Deming Y, Piccio L, Karch CM, Cruchaga C, Paumier K, Bateman RJ, Fagan AM, Morris JC, Levin J, Danek A, Jucker M, Masters CL, Rossor MN, Ringman JM, Shaw LM, Trojanowski JQ, Weiner M, Ewers M, Haass C. CSF progranulin increases in the course of Alzheimer’s disease and is associated with sTREM2, neurodegeneration and cognitive decline. EMBO Mol Med2018 Dec;10(12)doi: 10.15252/emmm.201809712. PubMed PMID: 30482868; PubMed Central PMCID: PMC6284390.
  19. Twohig D, Rodriguez-Vieitez E, Sando SB, Berge G, Lauridsen C, Møller I, Grøntvedt GR, Bråthen G, Patra K, Bu G, Benzinger TLS, Karch CM, Fagan A, Morris JC, Bateman RJ, Nordberg A, White LR, Nielsen HM. The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease. Acta Neuropathol Commun2018 Nov 26;6(1):130doi: 10.1186/s40478-018-0624-z. PubMed PMID: 30477568; PubMed Central PMCID: PMC6260771.
  20. Schindler SE, Gray JD, Gordon BA, Xiong C, Batrla-Utermann R, Quan M, Wahl S, Benzinger TLS, Holtzman DM, Morris JC, Fagan AM. Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging. Alzheimers Dement2018 Nov;14(11):1460-1469doi: 10.1016/j.jalz.2018.01.013. Epub 2018 Mar 2. PubMed PMID: 29501462; PubMed Central PMCID: PMC6119652.
  21. McDade E, Wang G, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Holtzman DM, Cairns NJ, Goate AM, Marcus DS, Morris JC, Paumier K, Xiong C, Allegri R, Berman SB, Klunk W, Noble J, Ringman J, Ghetti B, Farlow M, Sperling RA, Chhatwal J, Salloway S, Graff-Radford NR, Schofield PR, Masters C, Rossor MN, Fox NC, Levin J, Jucker M, Bateman RJ. Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. Neurology2018 Oct 2;91(14):e1295-e1306doi: 10.1212/WNL.0000000000006277. Epub 2018 Sep 14. PubMed PMID: 30217935; PubMed Central PMCID: PMC6177272.
  22. Araque Caballero MÁ, Suárez-Calvet M, Duering M, Franzmeier N, Benzinger T, Fagan AM, Bateman RJ, Jack CR, Levin J, Dichgans M, Jucker M, Karch C, Masters CL, Morris JC, Weiner M, Rossor M, Fox NC, Lee JH, Salloway S, Danek A, Goate A, Yakushev I, Hassenstab J, Schofield PR, Haass C, Ewers M. White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease. Brain2018 Oct 1;141(10):3065-3080doi: 10.1093/brain/awy229. PubMed PMID: 30239611; PubMed Central PMCID: PMC6158739.
  23. Joseph-Mathurin N, Su Y, Blazey TM, Jasielec M, Vlassenko A, Friedrichsen K, Gordon BA, Hornbeck RC, Cash L, Ances BM, Veale T, Cash DM, Brickman AM, Buckles V, Cairns NJ, Cruchaga C, Goate A, Jack CR Jr, Karch C, Klunk W, Koeppe RA, Marcus DS, Mayeux R, McDade E, Noble JM, Ringman J, Saykin AJ, Thompson PM, Xiong C, Morris JC, Bateman RJ, Benzinger TLS. Utility of perfusion PET measures to assess neuronal injury in Alzheimer’s disease. Alzheimers Dement (Amst)2018;10:669-677doi: 10.1016/j.dadm.2018.08.012. eCollection 2018. PubMed PMID: 30417072; PubMed Central PMCID: PMC6215983.
  24. Wang G, Berry S, Xiong C, Hassenstab J, Quintana M, McDade EM, Delmar P, Vestrucci M, Sethuraman G, Bateman RJ. A novel cognitive disease progression model for clinical trials in autosomal-dominant Alzheimer’s disease. Stat Med2018 Sep 20;37(21):3047-3055doi: 10.1002/sim.7811. Epub 2018 May 14. PubMed PMID: 29761523; PubMed Central PMCID: PMC6105413.
  25. Lim YY, Hassenstab J, Goate A, Fagan AM, Benzinger TLS, Cruchaga C, McDade E, Chhatwal J, Levin J, Farlow MR, Graff-Radford NR, Laske C, Masters CL, Salloway S, Schofield P, Morris JC, Maruff P, Bateman RJ. Effect of BDNFVal66Met on disease markers in dominantly inherited Alzheimer’s disease. Ann Neurol2018 Sep;84(3):424-435doi: 10.1002/ana.25299. Epub 2018 Aug 25. PubMed PMID: 30014553; PubMed Central PMCID: PMC6153076.
  26. Karch CM, Hernández D, Wang JC, Marsh J, Hewitt AW, Hsu S, Norton J, Levitch D, Donahue T, Sigurdson W, Ghetti B, Farlow M, Chhatwal J, Berman S, Cruchaga C, Morris JC, Bateman RJ, Pébay A, Goate AM. Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network. Alzheimers Res Ther2018 Jul 25;10(1):69doi: 10.1186/s13195-018-0400-0. PubMed PMID: 30045758; PubMed Central PMCID: PMC6060509.
  27. Hsu S, Gordon BA, Hornbeck R, Norton JB, Levitch D, Louden A, Ziegemeier E, Laforce R Jr, Chhatwal J, Day GS, McDade E, Morris JC, Fagan AM, Benzinger TLS, Goate AM, Cruchaga C, Bateman RJ, Karch CM. Discovery and validation of autosomal dominant Alzheimer’s disease mutations. Alzheimers Res Ther2018 Jul 18;10(1):67doi: 10.1186/s13195-018-0392-9. PubMed PMID: 30021643; PubMed Central PMCID: PMC6052673.
  28. Vlassenko AG, Gordon BA, Goyal MS, Su Y, Blazey TM, Durbin TJ, Couture LE, Christensen JJ, Jafri H, Morris JC, Raichle ME, Benzinger TL. Aerobic glycolysis and tau deposition in preclinical Alzheimer’s disease. Neurobiol Aging2018 Jul;67:95-98doi: 10.1016/j.neurobiolaging.2018.03.014. Epub 2018 Mar 20. PubMed PMID: 29655050; PubMed Central PMCID: PMC5955846.
  29. Li Z, Del-Aguila JL, Dube U, Budde J, Martinez R, Black K, Xiao Q, Cairns NJ, Dougherty JD, Lee JM, Morris JC, Bateman RJ, Karch CM, Cruchaga C, Harari O. Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure. Genome Med2018 Jun 8;10(1):43doi: 10.1186/s13073-018-0551-4. PubMed PMID: 29880032; PubMed Central PMCID: PMC5992755.
  30. Lee S, Zimmerman ME, Narkhede A, Nasrabady SE, Tosto G, Meier IB, Benzinger TLS, Marcus DS, Fagan AM, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, Martins RN, Saykin AJ, Masters CL, Ringman JM, Fӧrster S, Schofield PR, Sperling RA, Johnson KA, Chhatwal JP, Salloway S, Correia S, Jack CR Jr, Weiner M, Bateman RJ, Morris JC, Mayeux R, Brickman AM. White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer’s disease. PLoS One2018;13(5):e0195838doi: 10.1371/journal.pone.0195838. eCollection 2018. PubMed PMID: 29742105; PubMed Central PMCID: PMC5942789.
  31. Oxtoby NP, Young AL, Cash DM, Benzinger TLS, Fagan AM, Morris JC, Bateman RJ, Fox NC, Schott JM, Alexander DC. Data-driven models of dominantly-inherited Alzheimer’s disease progression. Brain2018 May 1;141(5):1529-1544doi: 10.1093/brain/awy050. PubMed PMID: 29579160; PubMed Central PMCID: PMC5920320.
  32. Chhatwal JP, Schultz AP, Johnson KA, Hedden T, Jaimes S, Benzinger TLS, Jack C Jr, Ances BM, Ringman JM, Marcus DS, Ghetti B, Farlow MR, Danek A, Levin J, Yakushev I, Laske C, Koeppe RA, Galasko DR, Xiong C, Masters CL, Schofield PR, Kinnunen KM, Salloway S, Martins RN, McDade E, Cairns NJ, Buckles VD, Morris JC, Bateman R, Sperling RA. Preferential degradation of cognitive networks differentiates Alzheimer’s disease from ageing. Brain2018 May 1;141(5):1486-1500doi: 10.1093/brain/awy053. PubMed PMID: 29522171; PubMed Central PMCID: PMC5917745.
  33. Petok JR, Myers CE, Pa J, Hobel Z, Wharton DM, Medina LD, Casado M, Coppola G, Gluck MA, Ringman JM. Impairment of memory generalization in preclinical autosomal dominant Alzheimer’s disease mutation carriers. Neurobiol Aging2018 May;65:149-157doi: 10.1016/j.neurobiolaging.2018.01.022. Epub 2018 Feb 8. PubMed PMID: 29494861; PubMed Central PMCID: PMC5871602.
  34. Villeneuve S, Vogel JW, Gonneaud J, Pichet Binette A, Rosa-Neto P, Gauthier S, Bateman RJ, Fagan AM, Morris JC, Benzinger TLS, Johnson SC, Breitner JCS, Poirier J. Proximity to Parental Symptom Onset and Amyloid-β Burden in Sporadic Alzheimer Disease. JAMA Neurol2018 May 1;75(5):608-619doi: 10.1001/jamaneurol.2017.5135. PubMed PMID: 29482212; PubMed Central PMCID: PMC5885216.
  35. Stout SH, Babulal GM, Ma C, Carr DB, Head DM, Grant EA, Williams MM, Holtzman DM, Fagan AM, Morris JC, Roe CM. Driving cessation over a 24-year period: Dementia severity and cerebrospinal fluid biomarkers. Alzheimers Dement2018 May;14(5):610-616doi: 10.1016/j.jalz.2017.11.011. Epub 2018 Jan 10. PubMed PMID: 29328928; PubMed Central PMCID: PMC5938126.
  36. Su Y, Flores S, Hornbeck RC, Speidel B, Vlassenko AG, Gordon BA, Koeppe RA, Klunk WE, Xiong C, Morris JC, Benzinger TLS. Utilizing the Centiloid scale in cross-sectional and longitudinal PiB PET studies. Neuroimage Clin2018;19:406-416doi: 10.1016/j.nicl.2018.04.022. eCollection 2018. PubMed PMID: 30035025; PubMed Central PMCID: PMC6051499.
  37. Franzmeier N, Düzel E, Jessen F, Buerger K, Levin J, Duering M, Dichgans M, Haass C, Suárez-Calvet M, Fagan AM, Paumier K, Benzinger T, Masters CL, Morris JC, Perneczky R, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Teipel S, Kilimann I, Ramirez A, Rossor M, Jucker M, Chhatwal J, Spottke A, Boecker H, Brosseron F, Falkai P, Fliessbach K, Heneka MT, Laske C, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Kofler B, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Weiner M, Lee JH, Salloway S, Danek A, Goate A, Schofield PR, Bateman RJ, Ewers M. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease. Brain2018 Apr 1;141(4):1186-1200doi: 10.1093/brain/awy008. PubMed PMID: 29462334; PubMed Central PMCID: PMC5888938.
  38. Day GS, Gordon BA, Perrin RJ, Cairns NJ, Beaumont H, Schwetye K, Ferguson C, Sinha N, Bucelli R, Musiek ES, Ghoshal N, Ponisio MR, Vincent B, Mishra S, Jackson K, Morris JC, Benzinger TLS, Ances BM. In vivo [18F]-AV-1451 tau-PET imaging in sporadic Creutzfeldt-Jakob disease. Neurology2018 Mar 6;90(10):e896-e906doi: 10.1212/WNL.0000000000005064. Epub 2018 Feb 7. PubMed PMID: 29438042; PubMed Central PMCID: PMC5863493.
  39. Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nat Neurosci2018 Mar;21(3):424-431doi: 10.1038/s41593-018-0070-z. Epub 2018 Feb 5. PubMed PMID: 29403032; PubMed Central PMCID: PMC5857215.
  40. Gordon BA, Blazey TM, Su Y, Hari-Raj A, Dincer A, Flores S, Christensen J, McDade E, Wang G, Xiong C, Cairns NJ, Hassenstab J, Marcus DS, Fagan AM, Jack CR Jr, Hornbeck RC, Paumier KL, Ances BM, Berman SB, Brickman AM, Cash DM, Chhatwal JP, Correia S, Förster S, Fox NC, Graff-Radford NR, la Fougère C, Levin J, Masters CL, Rossor MN, Salloway S, Saykin AJ, Schofield PR, Thompson PM, Weiner MM, Holtzman DM, Raichle ME, Morris JC, Bateman RJ, Benzinger TLS. Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer’s disease: a longitudinal study. Lancet Neurol2018 Mar;17(3):241-250doi: 10.1016/S1474-4422(18)30028-0. Epub 2018 Feb 1. PubMed PMID: 29397305; PubMed Central PMCID: PMC5816717.
  41. Xiong C, Luo J, Chen L, Gao F, Liu J, Wang G, Bateman R, Morris JC. Estimating diagnostic accuracy for clustered ordinal diagnostic groups in the three-class case-Application to the early diagnosis of Alzheimer disease. Stat Methods Med Res2018 Mar;27(3):701-714doi: 10.1177/0962280217742539. Epub 2017 Nov 28. PubMed PMID: 29182052; PubMed Central PMCID: PMC5841923.
  42. Cruchaga C, Del-Aguila JL, Saef B, Black K, Fernandez MV, Budde J, Ibanez L, Deming Y, Kapoor M, Tosto G, Mayeux RP, Holtzman DM, Fagan AM, Morris JC, Bateman RJ, Goate AM, Harari O. Polygenic risk score of sporadic late-onset Alzheimer’s disease reveals a shared architecture with the familial and early-onset forms. Alzheimers Dement2018 Feb;14(2):205-214doi: 10.1016/j.jalz.2017.08.013. Epub 2017 Sep 21. PubMed PMID: 28943286; PubMed Central PMCID: PMC5803427.
  43. Luo J, Weng H, Morris JC, Xiong C. Minimizing the Sample Sizes of Clinical Trials on Preclinical and Early Symptomatic Stage of Alzheimer Disease. J Prev Alzheimers Dis2018;5(2):110-119doi: 10.14283/jpad.2018.16. PubMed PMID: 29616704; PubMed Central PMCID: PMC6429951.
  44. Martins RN, Villemagne V, Sohrabi HR, Chatterjee P, Shah TM, Verdile G, Fraser P, Taddei K, Gupta VB, Rainey-Smith SR, Hone E, Pedrini S, Lim WL, Martins I, Frost S, Gupta S, O’Bryant S, Rembach A, Ames D, Ellis K, Fuller SJ, Brown B, Gardener SL, Fernando B, Bharadwaj P, Burnham S, Laws SM, Barron AM, Goozee K, Wahjoepramono EJ, Asih PR, Doecke JD, Salvado O, Bush AI, Rowe CC, Gandy SE, Masters CL. Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies. J Alzheimers Dis2018;62(3):965-992doi: 10.3233/JAD-171145. Review. PubMed PMID: 29562546; PubMed Central PMCID: PMC5870031.
  45. Yan L, Liu CY, Wong KP, Huang SC, Mack WJ, Jann K, Coppola G, Ringman JM, Wang DJJ. Regional association of pCASL-MRI with FDG-PET and PiB-PET in people at risk for autosomal dominant Alzheimer’s disease. Neuroimage Clin2018;17:751-760doi: 10.1016/j.nicl.2017.12.003. eCollection 2018. PubMed PMID: 29527482; PubMed Central PMCID: PMC5842754.
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