DIAN Observational Study Publications

    1. O’Connor A, Rice H, Barnes J, Ryan NS, Liu KY, Allegri RF, Berman S, Ringman JM, Cruchaga C, Farlow MR, Hassenstab J, Lee JH, Perrin RJ, Xiong C, Gordon B, Levey AI, Goate A, Graff-Radford N, Levin J, Jucker M, Benzinger T, McDade E, Mori H, Noble JM, Schofield PR, Martins RN, Salloway S, Chhatwal J, Morris JC, Bateman R, Howard R, Reeves S, Fox NC. First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimer’s disease: the Dominantly Inherited Alzheimer’s Network Study. Journal of Neurology, Neurosurgery, and Psychiatry. 2023 May;94(5):403-405. PubMed PMID: 36522155; DOI: 10.1136/jnnp-2022-329843.
    2. Schindler SE, Li Y, Li M, Despotis A, Park E, Vittert L, Hamilton BH, Womack KB, Saef B, Holtzman DM, Morris JC, Bateman RJ, Gupta MR. Using Alzheimer’s disease blood tests to accelerate clinical trial enrollment. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2023 April;19(4):1175-1183. PubMed PMID: 35934777; PubMed Central PMCID: PMC9902574; DOI: 10.1002/alz.12754.
    3. Xu J, Farsad HL, Hou Y, Barclay K, Lopez BA, Yamada S, Saliu IO, Shi Y, Knight WC, Bateman RJ, Benzinger TLS, Yi JJ, Li Q, Wang T, Perlmutter JS, Morris JC, Zhao G. Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration. Nature aging. 2023 March;3(3):346-365. PubMed PMID: 36993867; PubMed Central PMCID: PMC10046522; DOI: 10.1038/s43587-023-00363-8.
    4. Horie K, Li Y, Barthélemy NR, Gordon B, Hassenstab J, Benzinger TLS, Fagan AM, Morris JC, Karch CM, Xiong C, Allegri R, Mendez PC, Ikeuchi T, Kasuga K, Noble J, Farlow M, Chhatwal J, Day G, Schofield PR, Masters CL, Levin J, Jucker M, Lee JH, Roh JH, Sato C, Sachdev P, Koyama A, Reyderman L, Bateman RJ, McDade E. Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer’s Disease. Annals of Neurology. 2023 February 26. PubMed PMID: 36843330; DOI: 10.1002/ana.26620.
    5. You SF, Brase L, Filipello F, Iyer AK, Del-Aguila J, He J, D’Oliveira Albanus R, Budde J, Norton J, Gentsch J, Dräger NM, Sattler SM, Kampmann M, Piccio L, Morris JC, Perrin RJ, McDade E, Paul SM, Cashikar AG, Benitez BA, Harari O, Karch CM. MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state. medRxiv : the preprint server for health sciences. 2023 February 8. PubMed PMID: 36798226; PubMed Central PMCID: PMC9934804; DOI: 10.1101/2023.02.06.23285545.
    6. Vöglein J, Franzmeier N, Morris JC, Dieterich M, McDade E, Simons M, Preische O, Hofmann A, Hassenstab J, Benzinger TL, Fagan A, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal JP, Salloway S, Xiong C, Karch CM, Cairns N, Perrin RJ, Day G, Martins R, Sanchez-Valle R, Mori H, Shimada H, Ikeuchi T, Suzuki K, Schofield PR, Masters CL, Goate A, Buckles V, Fox NC, Chrem P, Allegri R, Ringman JM, Yakushev I, Laske C, Jucker M, Höglinger G, Bateman RJ, Danek A, Levin J. Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2023 February; 19(2):632-645. PubMed PMID: 35609137; PubMed Central PMCID: PMC9684350; DOI: 10.1002/alz.12684.
    7. Xiong C, McCue LM, Buckles V, Grant E, Agboola F, Coble D, Bateman RJ, Fagan AM, Benzinger TLS, Hassenstab J, Schindler SE, McDade E, Moulder K, Gordon BA, Cruchaga C, Day GS, Ikeuchi T, Suzuki K, Allegri RF, Vöglein J, Levin J, Morris JC. Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer’s disease. Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2023 January 14. PubMed PMID: 36640138; DOI: 10.1002/alz.12912.
    8. Millar PR, Gordon BA, Luckett PH, Benzinger TLS, Cruchaga C, Fagan AM, Hassenstab JJ, Perrin RJ, Schindler SE, Allegri RF, Day GS, Farlow MR, Mori H, Nübling G, Bateman RJ, Morris JC, Ances BM. Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study. eLife. 2023 January 6; 12. PubMed PMID: 36607335; PubMed Central PMCID: PMC9988262; DOI: 10.7554/eLife.81869.
    9. Luckett PH, Chen C, Gordon BA, Wisch J, Berman SB, Chhatwal JP, Cruchaga C, Fagan AM, Farlow MR, Fox NC, Jucker M, Levin J, Masters CL, Mori H, Noble JM, Salloway S, Schofield PR, Brickman AM, Brooks WS, Cash DM, Fulham MJ, Ghetti B, Jack CR Jr, Vöglein J, Klunk WE, Koeppe R, Su Y, Weiner M, Wang Q, Marcus D, Koudelis D, Joseph-Mathurin N, Cash L, Hornbeck R, Xiong C, Perrin RJ, Karch CM, Hassenstab J, McDade E, Morris JC, Benzinger TLS, Bateman RJ, Ances BM. Biomarker clustering in autosomal dominant Alzheimer’s disease. Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2023 January; 19(1):274-284. PubMed PMID: 35362200; PubMed Central PMCID: PMC9525451; DOI: 10.1002/alz.12661.
    10. Liu L, Lauro BM, He A, Lee H, Bhattarai S, Wolfe MS, Bennett DA, Karch CM, Young-Pearse T, Selkoe DJ. Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer’s disease. Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2023 January; 19(1):79-96. PubMed PMID: 35278341; PubMed Central PMCID: PMC9464800; DOI: 10.1002/alz.12646.
    11. Boerwinkle AH, Gordon BA, Wisch J, Flores S, Henson RL, Butt OH, McKay N, Chen CD, Benzinger TLS, Fagan AM, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O’Bryant S, Lai F, Rosas HD, Lee JH, Silverman W, Brickman AM, Chhatwal JP, Cruchaga C, Perrin RJ, Xiong C, Hassenstab J, McDade E, Bateman RJ, Ances BM. Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer’s disease: a cross-sectional study. The Lancet. Neurology. 2023 January; 22(1):55-65. PubMed PMID: 36517172; PubMed Central PMCID: PMC9979840; DOI: 10.1016/S1474-4422(22)00408-2.
    12. Chatterjee P, Vermunt L, Gordon BA, Pedrini S, Boonkamp L, Armstrong NJ, Xiong C, Singh AK, Li Y, Sohrabi HR, Taddei K, Molloy M, Benzinger TLS, Morris JC, Karch C, Berman S, Chhatwal J, Cruchaga C, Graff-Radford NR, Day GS, Farlow M, Fox N, Goate A, Hassenstab J, Lee JH, Levin J, McDade E, Mori H, Perrin R, Sanchez-Valle R, Schofield PR, Levey A, Jucker M, Masters CL, Fagan AM, Bateman RJ, Martins RN, Teunissen C. Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer’s disease: Associations with Aβ-PET, neurodegeneration, and cognition. Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2022 December 28. PubMed PMID: 36576155; DOI: 10.1002/alz.12879.
    13. Luo J, Agboola F, Grant E, Morris JC, Masters CL, Albert MS, Johnson SC, McDade EM, Fagan AM, Benzinger TLS, Hassenstab J, Bateman RJ, Perrin RJ, Wang G, Li Y, Gordon B, Cruchaga C, Day GS, Levin J, Vöglein J, Ikeuchi T, Suzuki K, Allegri RF, Xiong C. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a journal of neurology. 2022 December 19; 145(12):4459-4473. PubMed PMID: 35925685; DOI: 10.1093/brain/awac238.
    14. Rother C, Uhlmann RE, Müller SA, Schelle J, Skodras A, Obermüller U, Häsler LM, Lambert M, Baumann F, Xu Y, Bergmann C, Salvadori G, Loos M, Brzak I, Shimshek D, Neumann U, Walker LC, Schultz SA, Chhatwal JP, Kaeser SA, Lichtenthaler SF, Staufenbiel M, Jucker M. Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae. Nature communications. 2022 November 28;13(1):7333. PubMed PMID: 36443293; PubMed Central PMCID: PMC9705543; DOI: 10.1038/s41467-022-34538-5.
    15. Strain JF, Brier MR, Tanenbaum A, Gordon BA, McCarthy JE, Dincer A, Marcus DS, Chhatwal JP, Graff-Radford NR, Day GS, la Fougère C, Perrin RJ, Salloway S, Schofield PR, Yakushev I, Ikeuchi T, Vöglein J, Morris JC, Benzinger TLS, Bateman RJ, Ances BM, Snyder AZ. Covariance-based vs. correlation-based functional connectivity dissociates healthy aging from Alzheimer disease. NeuroImage. 2022 November 1; 261:119511. PubMed PMID: 35914670; PubMed Central PMCID: PMC9750733; DOI: 10.1016/j.neuroimage.2022.119511.
    16. Drieu A, Du S, Storck SE, Rustenhoven J, Papadopoulos Z, Dykstra T, Zhong F, Kim K, Blackburn S, Mamuladze T, Harari O, Karch CM, Bateman RJ, Perrin R, Farlow M, Chhatwal J, Hu S, Randolph GJ, Smirnov I, Kipnis J. Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid. Nature. 2022 November; 611(7936):585-593. PubMed PMID: 36352225; PubMed Central PMCID: PMC9899827; DOI: 10.1038/s41586-022-05397-3.
    17. Morris JC, Weiner M, Xiong C, Beckett L, Coble D, Saito N, Aisen PS, Allegri R, Benzinger TLS, Berman SB, Cairns NJ, Carrillo MC, Chui HC, Chhatwal JP, Cruchaga C, Fagan AM, Farlow M, Fox NC, Ghetti B, Goate AM, Gordon BA, Graff-Radford N, Day GS, Hassenstab J, Ikeuchi T, Jack CR, Jagust WJ, Jucker M, Levin J, Massoumzadeh P, Masters CL, Martins R, McDade E, Mori H, Noble JM, Petersen RC, Ringman JM, Salloway S, Saykin AJ, Schofield PR, Shaw LM, Toga AW, Trojanowski JQ, Vöglein J, Weninger S, Bateman RJ, Buckles VD. Autosomal dominant and sporadic late onset Alzheimer’s disease share a common in vivo pathophysiology. Brain: a journal of neurology. 2022 October 21;145(10):3594-3607. PubMed PMID: 35580594; PubMed Central PMCID: PMC9989348; DOI: 10.1093/brain/awac181.
    18. Novotny BC, Fernandez MV, Wang C, Budde JP, Bergmann K, Eteleeb AM, Bradley J, Webster C, Ebl C, Norton J, Gentsch J, Dube U, Wang F, Morris JC, Bateman RJ, Perrin RJ, McDade E, Xiong C, Chhatwal J, Goate A, Farlow M, Schofield P, Chui H, Karch CM, Cruchaga C, Benitez BA, Harari O. Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer’s disease brains. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2022 October 17. PubMed PMID: 36251323; PubMed Central PMCID: PMC10106526; DOI: 10.1002/alz.12800.
    19. Nicosia J, Aschenbrenner AJ, Balota DA, Sliwinski MJ, Tahan M, Adams S, Stout SS, Wilks H, Gordon BA, Benzinger TLS, Fagan AM, Xiong C, Bateman RJ, Morris JC, Hassenstab J. Unsupervised high-frequency smartphone-based cognitive assessments are reliable, valid, and feasible in older adults at risk for Alzheimer’s disease. Journal of the International Neuropsychological Society : JINS. 2022 September 5:1-13. PubMed PMID: 36062528; PubMed Central PMCID: PMC9985662; DOI: 10.1017/S135561772200042X.
    20. Shirzadi Z, Yau WW, Schultz SA, Schultz AP, Scott MR, Goubran M, Mojiri-Forooshani P, Joseph-Mathurin N, Kantarci K, Preboske G, Wermer MJH, Jack C, Benzinger T, Taddei K, Sohrabi HR, Sperling RA, Johnson KA, Bateman RJ, Martins RN, Greenberg SM, Chhatwal JP. Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy. Annals of neurology. 2022 September; 92(3):358-363. PubMed PMID: 35670654; PubMed Central PMCID: PMC9391284; DOI: 10.1002/ana.26429.
    21. Nicosia J, Wang B, Aschenbrenner AJ, Sliwinski MJ, Yabiku ST, Roque NA, Germine LT, Bateman RJ, Morris JC, Hassenstab J. To BYOD or not: Are device latencies important for bring-your-own-device (BYOD) smartphone cognitive testing?. Behavior research methods. 2022 August 11. PubMed PMID: 35953659; PubMed Central PMCID: PMC9918597; DOI: 10.3758/s13428-022-01925-1.
    22. Takada LT, Aláez-Verson C, Burgute BD, Nitrini R, Sosa AL, Castilhos RM, Chaves MF, Longoria EM, Carrillo-Sánchez K, Brucki SMD, Flores-Lagunes LL, Molina C, Olivares MJ, Ziegemeier E, Petranek J, Goate AM, Cruchaga C, Renton AE, Fernández MV, Day GS, McDade E, Bateman RJ, Karch CM, Llibre-Guerra JJ. Discovery and validation of dominantly inherited Alzheimer’s disease mutations in populations from Latin America. Alzheimer’s research & therapy. 2022 August 5;14(1):108. PubMed PMID: 35932032; PubMed Central PMCID: PMC9354296; DOI: 10.1186/s13195-022-01052-1.
    23. Millar PR, Luckett PH, Gordon BA, Benzinger TLS, Schindler SE, Fagan AM, Cruchaga C, Bateman RJ, Allegri R, Jucker M, Lee JH, Mori H, Salloway SP, Yakushev I, Morris JC, Ances BM. Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease. NeuroImage. 2022 August 1;256:119228. PubMed PMID: 35452806; PubMed Central PMCID: PMC9178744; DOI: 10.1016/j.neuroimage.2022.119228.
    24. Strain JF, Barthelemy N, Horie K, Gordon BA, Kilgore C, Aschenbrenner A, Cruchaga C, Xiong C, Joseph-Mathurin N, Hassenstab J, Fagan AM, Li Y, Karch CM, Perrin RJ, Berman SB, Chhatwal JP, Graff-Radford NR, Mori H, Levin J, Noble JM, Allegri R, Schofield PR, Marcus DS, Holtzman DM, Morris JC, Benzinger TLS, McDade EM, Bateman RJ, Ances BM. CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease. Neurobiology of disease. 2022 June 15;168:105714. PubMed PMID: 35358703; PubMed Central PMCID: PMC9701560; DOI: 10.1016/j.nbd.2022.105714.
    25. Meeker KL, Butt OH, Gordon BA, Fagan AM, Schindler SE, Morris JC, Benzinger TLS, Ances BM. Cerebrospinal fluid neurofilament light chain is a marker of aging and white matter damage. Neurobiology of disease. 2022 May;166:105662. PubMed PMID: 35167933; PubMed Central PMCID: PMC9112943; DOI: 10.1016/j.nbd.2022.105662.
    26. Nicosia J, Aschenbrenner AJ, Adams SL, Tahan M, Stout SH, Wilks H, Balls-Berry JE, Morris JC, Hassenstab J. Bridging the Technological Divide: Stigmas and Challenges With Technology in Digital Brain Health Studies of Older Adults. Frontiers in digital health. 2022;4:880055. PubMed PMID: 35574256; PubMed Central PMCID: PMC9098948; DOI: 10.3389/fdgth.2022.880055.
    27. Levitis E, Vogel JW, Funck T, Hachinski V, Gauthier S, Vöglein J, Levin J, Gordon BA, Benzinger T, Iturria-Medina Y, Evans AC. Differentiating amyloid beta spread in autosomal dominant and sporadic Alzheimer’s disease. Brain communications. 2022;4(3):fcac085. PubMed PMID: 35602652; PubMed Central PMCID: PMC9116976; DOI: 10.1093/braincomms/fcac085.
    28. Ali M, Sung YJ, Wang F, Fernández MV, Morris JC, Fagan AM, Blennow K, Zetterberg H, Heslegrave A, Johansson PM, Svensson J, Nellgård B, Lleó A, Alcolea D, Clarimon J, Rami L, Molinuevo JL, Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Haass C, Ewers M, Levin J, Farlow MR, Perrin RJ, Cruchaga C. Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk. PloS one. 2022;17(5):e0267298. PubMed PMID: 35617280; PubMed Central PMCID: PMC9135221; DOI: 10.1371/journal.pone.0267298.
    29. Aschenbrenner AJ, Hassenstab J, Wang G, Li Y, Xiong C, McDade E, Clifford DB, Salloway S, Farlow M, Yaari R, Cheng EYJ, Holdridge KC, Mummery CJ, Masters CL, Hsiung GY, Surti G, Day GS, Weintraub S, Honig LS, Galvin JE, Ringman JM, Brooks WS, Fox NC, Snyder PJ, Suzuki K, Shimada H, Gräber S, Bateman RJ. Avoid or Embrace? Practice Effects in Alzheimer’s Disease Prevention Trials. Frontiers in aging neuroscience. 2022;14:883131. PubMed PMID: 35783127; PubMed Central PMCID: PMC9244171; DOI: 10.3389/fnagi.2022.883131.
    30. Wang G, Li Y, Xiong C, McDade E, Clifford DB, Mills SL, Santacruz AM, Aschenbrenner AJ, Hassenstab J, Benzinger TLS, Gordon BA, Fagan AM, Coalier KA, Libre-Guerra JJ, McCullough A, Joseph-Mathurin N, Chen CD, Mummery C, Wendelberger BA, Gauthier S, Masellis M, Holdridge KC, Yaari R, Chatterjee S, Sims J, Delmar P, Kerchner GA, Bittner T, Hofmann C, Bateman RJ. Evaluation of dose-dependent treatment effects after mid-trial dose escalation in biomarker, clinical, and cognitive outcomes for gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease. Alzheimer’s & dementia (Amsterdam, Netherlands). 2022;14(1):e12367. PubMed PMID: 36348972; PubMed Central PMCID: PMC9632865; DOI: 10.1002/dad2.12367.
    31. Timsina J, Gomez-Fonseca D, Wang L, Do A, Western D, Alvarez I, Aguilar M, Pastor P, Henson RL, Herries E, Xiong C, Schindler SE, Fagan AM, Bateman RJ, Farlow M, Morris JC, Perrin RJ, Moulder K, Hassenstab J, Vöglein J, Chhatwal J, Mori H, Sung YJ, Cruchaga C. Comparative Analysis of Alzheimer’s Disease Cerebrospinal Fluid Biomarkers Measurement by Multiplex SOMAscan Platform and Immunoassay-Based Approach. Journal of Alzheimer’s disease : JAD. 2022;89(1):193-207. PubMed PMID: 35871346; PubMed Central PMCID: PMC9562128; DOI: 10.3233/JAD-220399.
    32. Luo J, Gao F, Liu J, Wang G, Chen L, Fagan AM, Day GS, Vöglein J, Chhatwal JP, Xiong C. Statistical estimation and comparison of group-specific bivariate correlation coefficients in family-type clustered studies. Journal of Applied Statistics. 2022; 49(9):2246-2270. PubMed PMID: 35755087; PubMed Central PMCID: PMC9225315; DOI:10.1080/02664763.2021. 1899141.
    33. McKay NS, Dincer A, Mehrotra V, Aschenbrenner AJ, Balota D, Hornbeck RC, Hassenstab J, Morris JC, Benzinger TLS, Gordon BA. Beta-amyloid moderates the relationship between cortical thickness and attentional control in middle- and older-aged adults. Neurobiology of aging. Neurobiol Aging. 2022 Apr;112:181-190. doi: 10.1016/j.neurobiolaging.2021.12.012. Epub 2022 Jan 10. PMID: 35227946.
    34. Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, Fagan AM, Schultz S, Gordon BA, Benzinger TLS, Hassenstab J, McDade E, Feederle R, Karch CM, Schlepckow K, Morris JC, Kleinberger G, Nellgard B, Vöglein J, Blennow K, Zetterberg H, Ewers M, Jucker M, Levin J, Bateman RJ, Haass C. Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer’s disease: a longitudinal observational study. The Lancet. Neurology. 2022 April;21(4):329-341. PubMed PMID: 35305339; PubMed Central PMCID: PMC8926925; DOI: 10.1016/S1474-4422(22)00027-8.
    35. Chen HH, Eteleeb A, Wang C, Fernandez MV, Budde JP, Bergmann K, Norton J, Wang F, Ebl C, Morris JC, Perrin RJ, Bateman RJ, McDade E, Xiong C, Goate A, Farlow M, Chhatwal J, Schofield PR, Chui H, Harari O, Cruchaga C, Ibanez L. Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer’s disease. Acta neuropathologica communications. 2022 March 4;10(1):29. PubMed PMID: 35246267; PubMed Central PMCID: PMC8895634; DOI: 10.1186/s40478-022-01328-5.
    36. Lim YY, Maruff P, Barthélemy NR, Goate A, Hassenstab J, Sato C, Fagan AM, Benzinger TLS, Xiong C, Cruchaga C, Levin J, Farlow MR, Graff-Radford NR, Laske C, Masters CL, Salloway S, Schofield PR, Morris JC, Bateman RJ, McDade E. Association of BDNF Val66Met With Tau Hyperphosphorylation and Cognition in Dominantly Inherited Alzheimer Disease. JAMA neurology. 2022 March 1;79(3):261-270. PubMed PMID: 35099506; PubMed Central PMCID: PMC8804973; DOI: 10.1001/jamaneurol.2021.5181.
    37. Raman F, Fang YD, Grandhi S, Murchison CF, Kennedy RE, Morris JC, Massoumzadeh P, Benzinger T, Roberson ED, McConathy J. Dynamic Amyloid PET: Relationships to 18FFlortaucipir Tau PET Measures. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2022 February;63(2):287-293. PubMed PMID: 34049986; PubMed Central PMCID: PMC8805772; DOI: 10.2967/jnumed.120.254490.
    38. Chhatwal JP, Schultz SA, McDade E, Schultz AP, Liu L, Hanseeuw BJ, Joseph-Mathurin N, Feldman R, Fitzpatrick CD, Sparks KP, Levin J, Berman SB, Renton AE, Esposito BT, Fernandez MV, Sung YJ, Lee JH, Klunk WE, Hofmann A, Noble JM, Graff-Radford N, Mori H, Salloway SM, Masters CL, Martins R, Karch CM, Xiong C, Cruchaga C, Perrin RJ, Gordon BA, Benzinger TLS, Fox NC, Schofield PR, Fagan AM, Goate AM, Morris JC, Bateman RJ, Johnson KA, Sperling RA. Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer’s disease: cross-sectional and longitudinal analyses of an observational study. The Lancet. Neurology. 2022 February;21(2):140-152. PubMed PMID: 35065037; PubMed Central PMCID: PMC8956209; DOI: 10.1016/S1474-4422(21)00375-6.
    39. Hubbard EE, Heil LR, Merrihew GE, Chhatwal JP, Farlow MR, McLean CA, Ghetti B, Newell KL, Frosch MP, Bateman RJ, Larson EB, Keene CD, Perrin RJ, Montine TJ, MacCoss MJ, Julian RR. Does Data-Independent Acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer’s Disease. Journal of proteome research. 2022 January 7;21(1):118-131. PubMed PMID: 34818016; PubMed Central PMCID: PMC8741752; DOI:10.1021/acs.jproteome.1c00558.
    40. Koenig LN, LaMontagne P, Glasser MF, Bateman R, Holtzman D, Yakushev I, Chhatwal J, Day GS, Jack C, Mummery C, Perrin RJ, Gordon BA, Morris JC, Shimony JS, Benzinger TLS. Regional age-related atrophy after screening for preclinical alzheimer disease. Neurobiology of aging. 2022 January;109:43-51. PubMed PMID: 34655980; PubMed Central PMCID: PMC9009406; DOI: 10.1016/j.neurobiolaging.2021.09.010.
    41. Buckles VD, Xiong C, Bateman RJ, Hassenstab J, Allegri R, Berman SB, Chhatwal JP, Danek A, Fagan AM, Ghetti B, Goate A, Graff-Radford N, Jucker M, Levin J, Marcus DS, Masters CL, McCue L, McDade E, Mori H, Moulder KL, Noble JM, Paumier K, Preische O, Ringman JM, Fox NC, Salloway S, Schofield PR, Martins R, Vöglein J, Morris JC. Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2021 December 2. PubMed PMID: 34854530; DOI: 10.1002/alz.12505.
    42. Therneau TM, Knopman DS, Lowe VJ, Botha H, Graff-Radford J, Jones DT, Vemuri P, Mielke MM, Schwarz CG, Senjem ML, Gunter JL, Petersen RC, Jack CR Jr. Relationships between β-amyloid and tau in an elderly population: An accelerated failure time model. NeuroImage. 2021 November 15;242:118440. PubMed PMID: 34333107; PubMed Central PMCID: PMC8499700; DOI: 10.1016/j.neuroimage.2021.118440.
    43. Lucey BP, Wisch J, Boerwinkle AH, Landsness EC, Toedebusch CD, McLeland JS, Butt OH, Hassenstab J, Morris JC, Ances BM, Holtzman DM. Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer’s disease. Brain : a journal of neurology. 2021 October 22;144(9):2852-2862. PubMed PMID: 34668959; PubMed Central PMCID: PMC8536939; DOI: 10.1093/brain/awab272.
    44. Chen CD, Joseph-Mathurin N, Sinha N, Zhou A, Li Y, Friedrichsen K, McCullough A, Franklin EE, Hornbeck R, Gordon B, Sharma V, Cruchaga C, Goate A, Karch C, McDade E, Xiong C, Bateman RJ, Ghetti B, Ringman JM, Chhatwal J, Masters CL, McLean C, Lashley T, Su Y, Koeppe R, Jack C, Klunk WE, Morris JC, Perrin RJ, Cairns NJ, Benzinger TLS. Comparing amyloid-β plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease. Acta neuropathologica. 2021 October;142(4):689-706. PubMed PMID: 34319442; PubMed Central PMCID: PMC8815340; DOI: 10.1007/s00401-021-02342-y.
    45. Wilks H, Aschenbrenner AJ, Gordon BA, Balota DA, Fagan AM, Musiek E, Balls-Berry J, Benzinger TLS, Cruchaga C, Morris JC, Hassenstab J. Sharper in the morning: Cognitive time of day effects revealed with high-frequency smartphone testing. Journal of clinical and experimental neuropsychology. 2021 October; 43(8):825-837. PubMed PMID: 35037593; PubMed Central PMCID: PMC9116128; DOI: 10.1080/13803395.2021.2009447.
    46. Gonneaud J, Baria AT, Pichet Binette A, Gordon BA, Chhatwal JP, Cruchaga C, Jucker M, Levin J, Salloway S, Farlow M, Gauthier S, Benzinger TLS, Morris JC, Bateman RJ, Breitner JCS, Poirier J, Vachon-Presseau E, Villeneuve S. Accelerated functional brain aging in preclinical familial Alzheimer’s disease. Nature communications. 2021 September 9;12(1):5346.
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    105. Veitch DP, Weiner MW, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR Jr, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ. Understanding disease progression and improving Alzheimer’s disease clinical trials: Recent highlights from the Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Dement. 2019 Jan;15(1):106-152. doi: 10.1016/j.jalz.2018.08.005. Epub 2018 Oct 13. Review. PubMed PMID: 30321505.
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    111. Schindler SE, Gray JD, Gordon BA, Xiong C, Batrla-Utermann R, Quan M, Wahl S, Benzinger TLS, Holtzman DM, Morris JC, Fagan AM. Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging. Alzheimers Dement. 2018 Nov;14(11):1460-1469. doi: 10.1016/j.jalz.2018.01.013. Epub 2018 Mar 2. PubMed PMID: 29501462; PubMed Central PMCID: PMC6119652.
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    127. Oxtoby NP, Young AL, Cash DM, Benzinger TLS, Fagan AM, Morris JC, Bateman RJ, Fox NC, Schott JM, Alexander DC. Data-driven models of dominantly-inherited Alzheimer’s disease progression. Brain. 2018 May 1;141(5):1529-1544. doi: 10.1093/brain/awy050. PubMed PMID: 29579160; PubMed Central PMCID: PMC5920320.
    128. Chhatwal JP, Schultz AP, Johnson KA, Hedden T, Jaimes S, Benzinger TLS, Jack C Jr, Ances BM, Ringman JM, Marcus DS, Ghetti B, Farlow MR, Danek A, Levin J, Yakushev I, Laske C, Koeppe RA, Galasko DR, Xiong C, Masters CL, Schofield PR, Kinnunen KM, Salloway S, Martins RN, McDade E, Cairns NJ, Buckles VD, Morris JC, Bateman R, Sperling RA. Preferential degradation of cognitive networks differentiates Alzheimer’s disease from ageing. Brain. 2018 May 1;141(5):1486-1500. doi: 10.1093/brain/awy053. PubMed PMID: 29522171; PubMed Central PMCID: PMC5917745.
    129. Villeneuve S, Vogel JW, Gonneaud J, Pichet Binette A, Rosa-Neto P, Gauthier S, Bateman RJ, Fagan AM, Morris JC, Benzinger TLS, Johnson SC, Breitner JCS, Poirier J. Proximity to Parental Symptom Onset and Amyloid-β Burden in Sporadic Alzheimer Disease. JAMA Neurol. 2018 May 1;75(5):608-619. doi: 10.1001/jamaneurol.2017.5135. PubMed PMID: 29482212; PubMed Central PMCID: PMC5885216.
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