DIAN Observational Study Publications

    1. McKay NS, Dincer A, Mehrotra V, Aschenbrenner AJ, Balota D, Hornbeck RC, Hassenstab J, Morris JC, Benzinger TLS, Gordon BA. Beta-amyloid moderates the relationship between cortical thickness and attentional control in middle- and older-aged adults. Neurobiology of aging. Neurobiol Aging. 2022 Apr;112:181-190. doi: 10.1016/j.neurobiolaging.2021.12.012. Epub 2022 Jan 10. PMID: 35227946.
    2. Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, Fagan AM, Schultz S, Gordon BA, Benzinger TLS, Hassenstab J, McDade E, Feederle R, Karch CM, Schlepckow K, Morris JC, Kleinberger G, Nellgard B, Vöglein J, Blennow K, Zetterberg H, Ewers M, Jucker M, Levin J, Bateman RJ, Haass C. Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer’s disease: a longitudinal observational study. The Lancet. Neurology. 2022 April;21(4):329-341. PubMed PMID: 35305339; PubMed Central PMCID: PMC8926925; DOI: 10.1016/S1474-4422(22)00027-8.
    3. Chen HH, Eteleeb A, Wang C, Fernandez MV, Budde JP, Bergmann K, Norton J, Wang F, Ebl C, Morris JC, Perrin RJ, Bateman RJ, McDade E, Xiong C, Goate A, Farlow M, Chhatwal J, Schofield PR, Chui H, Harari O, Cruchaga C, Ibanez L. Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer’s disease. Acta neuropathologica communications. 2022 March 4;10(1):29. PubMed PMID: 35246267; PubMed Central PMCID: PMC8895634; DOI: 10.1186/s40478-022-01328-5.
    4. Lim YY, Maruff P, Barthélemy NR, Goate A, Hassenstab J, Sato C, Fagan AM, Benzinger TLS, Xiong C, Cruchaga C, Levin J, Farlow MR, Graff-Radford NR, Laske C, Masters CL, Salloway S, Schofield PR, Morris JC, Bateman RJ, McDade E. Association of BDNF Val66Met With Tau Hyperphosphorylation and Cognition in Dominantly Inherited Alzheimer Disease. JAMA neurology. 2022 March 1;79(3):261-270. PubMed PMID: 35099506; PubMed Central PMCID: PMC8804973; DOI: 10.1001/jamaneurol.2021.5181.
    5. Raman F, Fang YD, Grandhi S, Murchison CF, Kennedy RE, Morris JC, Massoumzadeh P, Benzinger T, Roberson ED, McConathy J. Dynamic Amyloid PET: Relationships to 18FFlortaucipir Tau PET Measures. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2022 February;63(2):287-293. PubMed PMID: 34049986; PubMed Central PMCID: PMC8805772; DOI: 10.2967/jnumed.120.254490.
    6. Chhatwal JP, Schultz SA, McDade E, Schultz AP, Liu L, Hanseeuw BJ, Joseph-Mathurin N, Feldman R, Fitzpatrick CD, Sparks KP, Levin J, Berman SB, Renton AE, Esposito BT, Fernandez MV, Sung YJ, Lee JH, Klunk WE, Hofmann A, Noble JM, Graff-Radford N, Mori H, Salloway SM, Masters CL, Martins R, Karch CM, Xiong C, Cruchaga C, Perrin RJ, Gordon BA, Benzinger TLS, Fox NC, Schofield PR, Fagan AM, Goate AM, Morris JC, Bateman RJ, Johnson KA, Sperling RA. Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer’s disease: cross-sectional and longitudinal analyses of an observational study. The Lancet. Neurology. 2022 February;21(2):140-152. PubMed PMID: 35065037; PubMed Central PMCID: PMC8956209; DOI: 10.1016/S1474-4422(21)00375-6.
    7. Hubbard EE, Heil LR, Merrihew GE, Chhatwal JP, Farlow MR, McLean CA, Ghetti B, Newell KL, Frosch MP, Bateman RJ, Larson EB, Keene CD, Perrin RJ, Montine TJ, MacCoss MJ, Julian RR. Does Data-Independent Acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer’s Disease. Journal of proteome research. 2022 January 7;21(1):118-131. PubMed PMID: 34818016; PubMed Central PMCID: PMC8741752; DOI:10.1021/acs.jproteome.1c00558.
    8. Koenig LN, LaMontagne P, Glasser MF, Bateman R, Holtzman D, Yakushev I, Chhatwal J, Day GS, Jack C, Mummery C, Perrin RJ, Gordon BA, Morris JC, Shimony JS, Benzinger TLS. Regional age-related atrophy after screening for preclinical alzheimer disease. Neurobiology of aging. 2022 January;109:43-51. PubMed PMID: 34655980; PubMed Central PMCID: PMC9009406; DOI: 10.1016/j.neurobiolaging.2021.09.010.
    9. Buckles VD, Xiong C, Bateman RJ, Hassenstab J, Allegri R, Berman SB, Chhatwal JP, Danek A, Fagan AM, Ghetti B, Goate A, Graff-Radford N, Jucker M, Levin J, Marcus DS, Masters CL, McCue L, McDade E, Mori H, Moulder KL, Noble JM, Paumier K, Preische O, Ringman JM, Fox NC, Salloway S, Schofield PR, Martins R, Vöglein J, Morris JC. Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2021 December 2. PubMed PMID: 34854530; DOI: 10.1002/alz.12505.
    10. Therneau TM, Knopman DS, Lowe VJ, Botha H, Graff-Radford J, Jones DT, Vemuri P, Mielke MM, Schwarz CG, Senjem ML, Gunter JL, Petersen RC, Jack CR Jr. Relationships between β-amyloid and tau in an elderly population: An accelerated failure time model. NeuroImage. 2021 November 15;242:118440. PubMed PMID: 34333107; PubMed Central PMCID: PMC8499700; DOI: 10.1016/j.neuroimage.2021.118440.
    11. Lucey BP, Wisch J, Boerwinkle AH, Landsness EC, Toedebusch CD, McLeland JS, Butt OH, Hassenstab J, Morris JC, Ances BM, Holtzman DM. Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer’s disease. Brain : a journal of neurology. 2021 October 22;144(9):2852-2862. PubMed PMID: 34668959; PubMed Central PMCID: PMC8536939; DOI: 10.1093/brain/awab272.
    12. Chen CD, Joseph-Mathurin N, Sinha N, Zhou A, Li Y, Friedrichsen K, McCullough A, Franklin EE, Hornbeck R, Gordon B, Sharma V, Cruchaga C, Goate A, Karch C, McDade E, Xiong C, Bateman RJ, Ghetti B, Ringman JM, Chhatwal J, Masters CL, McLean C, Lashley T, Su Y, Koeppe R, Jack C, Klunk WE, Morris JC, Perrin RJ, Cairns NJ, Benzinger TLS. Comparing amyloid-β plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease. Acta neuropathologica. 2021 October;142(4):689-706. PubMed PMID: 34319442; PubMed Central PMCID: PMC8815340; DOI: 10.1007/s00401-021-02342-y.
    13. Gonneaud J, Baria AT, Pichet Binette A, Gordon BA, Chhatwal JP, Cruchaga C, Jucker M, Levin J, Salloway S, Farlow M, Gauthier S, Benzinger TLS, Morris JC, Bateman RJ, Breitner JCS, Poirier J, Vachon-Presseau E, Villeneuve S. Accelerated functional brain aging in preclinical familial Alzheimer’s disease. Nature communications. 2021 September 9;12(1):5346.
      PubMed PMID: 34504080; PubMed Central PMCID: PMC8429427; DOI: 10.1038/s41467-021- 25492-9.
    14. Zhou Y, Flores S, Mansor S, Hornbeck RC, Tu Z, Perlmutter JS, Ances B, Morris JC, Gropler RJ, Benzinger TLS. Spatially constrained kinetic modeling with dual reference tissues improves 18F-flortaucipir PET in studies of Alzheimer disease. European journal of nuclear medicine and molecular imaging. 2021 September;48(10):3172-3186. PubMed PMID: 33599811; PubMed Central PMCID: PMC8371062; DOI: 10.1007/s00259-020-05134-w.
    15. Ewers M, Luan Y, Frontzkowski L, Neitzel J, Rubinski A, Dichgans M, Hassenstab J, Gordon BA, Chhatwal JP, Levin J, Schofield P, Benzinger TLS, Morris JC, Goate A, Karch CM, Fagan AM, McDade E, Allegri R, Berman S, Chui H, Cruchaga C, Farlow M, Graff-Radford N, Jucker M, Lee JH, Martins RN, Mori H, Perrin R, Xiong C, Rossor M, Fox NC, O’Connor A, Salloway S, Danek A, Buerger K, Bateman RJ, Habeck C, Stern Y, Franzmeier N. Segregation of functional networks is associated with cognitive resilience in Alzheimer’s disease. Brain: a journal of neurology. 2021 August 17;144(7):2176-2185. PubMed PMID: 33725114; PubMed Central PMCID: PMC8370409; DOI: 10.1093/brain/awab112.
    16. Fagan AM, Henson RL, Li Y, Boerwinkle AH, Xiong C, Bateman RJ, Goate A, Ances BM, Doran E, Christian BT, Lai F, Rosas HD, Schupf N, Krinsky-McHale S, Silverman W, Lee JH, Klunk WE, Handen BL, Allegri RF, Chhatwal JP, Day GS, Graff-Radford NR, Jucker M, Levin J, Martins RN, Masters CL, Mori H, Mummery CJ, Niimi Y, Ringman JM, Salloway S, Schofield PR, Shoji M, Lott IT. Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer’s disease: a cross-sectional study. The Lancet. Neurology. 2021 August;20(8):615-626. PubMed PMID: 34302786; PubMed Central PMCID: PMC8496347; DOI: 10.1016/S1474-4422(21)00139-3.
    17. McDade E, Llibre-Guerra JJ, Holtzman DM, Morris JC, Bateman RJ. The informed road map to prevention of Alzheimer Disease: A call to arms. Molecular neurodegeneration. 2021 July 21;16(1):49. PubMed PMID: 34289882; PubMed Central PMCID: PMC8293489; DOI: 10.1186/s13024-021-00467-y.
    18. Salloway S, Farlow M, McDade E, Clifford DB, Wang G, Llibre-Guerra JJ, Hitchcock JM, Mills SL, Santacruz AM, Aschenbrenner AJ, Hassenstab J, Benzinger TLS, Gordon BA, Fagan AM, Coalier KA, Cruchaga C, Goate AA, Perrin RJ, Xiong C, Li Y, Morris JC, Snider BJ, Mummery C, Surti GM, Hannequin D, Wallon D, Berman SB, Lah JJ, Jimenez-Velazquez IZ, Roberson ED, van Dyck CH, Honig LS, Sánchez-Valle R, Brooks WS, Gauthier S, Galasko DR, Masters CL, Brosch JR, Hsiung GR, Jayadev S, Formaglio M, Masellis M, Clarnette R, Pariente J, Dubois B, Pasquier F, Jack CR Jr, Koeppe R, Snyder PJ, Aisen PS, Thomas RG, Berry SM, Wendelberger BA, Andersen SW, Holdridge KC, Mintun MA, Yaari R, Sims JR, Baudler M, Delmar P, Doody RS, Fontoura P, Giacobino C, Kerchner GA, Bateman RJ. A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease. Nature medicine. 2021 July;27(7):1187-1196. PubMed PMID: 34155411; PubMed Central PMCID: PMC8988051; DOI: 10.1038/s41591-021-01369-8.
    19. Chen Y, Ying C, Binkley MM, Juttukonda MR, Flores S, Laforest R, Benzinger TLS, An H. Deep learning-based T1-enhanced selection of linear attenuation coefficients (DL-TESLA) for PET/MR attenuation correction in dementia neuroimaging. Magnetic resonance in medicine. 2021 July;86(1):499-513. PubMed PMID: 33559218; PubMed Central PMCID: PMC8091494; DOI: 10.1002/mrm.28689.
    20. Day GS, Yarbrough MY, Körtvelyessy P, Prüss H, Bucelli RC, Fritzler MJ, Mason W, Tang-Wai DF, Steriade C, Hébert J, Henson RL, Herries EM, Ladenson JH, Lopez Chiriboga AS, Graff-Radford NR, Morris JC, Fagan A. Prospective Quantification of CSF Biomarkers in Antibody-Mediated Encephalitis. Neurology. 2021 May 18;96(20):e2546-e2557. PubMed PMID: 33795390; PubMed Central PMCID: PMC8205475; DOI: 10.1212/WNL.0000000000011937.
    21. Pichet Binette A, Theaud G, Rheault F, Roy M, Collins DL, Levin J, Mori H, Lee JH, Farlow MR, Schofield P, Chhatwal JP, Masters CL, Benzinger T, Morris J, Bateman R, Breitner JC, Poirier J, Gonneaud J, Descoteaux M, Villeneuve S. Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer’s disease. eLife. 2021 May 13;10. PubMed PMID: 33983116; PubMed Central PMCID: PMC8169107; DOI:10.7554/eLife.62929.
    22. Martin WRW, Miles M, Zhong Q, Hartlein J, Racette BA, Norris SA, Ushe M, Maiti B, Criswell S, Davis AA, Kotzbauer PT, Cairns NJ, Perrin RJ, Perlmutter JS. Is Levodopa Response a Valid Indicator of Parkinson’s Disease?. Movement disorders : official journal of the Movement Disorder Society. 2021 April;36(4):948-954. PubMed PMID: 33253432; PubMed Central PMCID: PMC8046721; DOI: 10.1002/mds.28406.
    23. Liu J, Xiong C, Liu L, Wang G, Jingqin L, Gao F, Chen L, Li Y. Relative efficiency of equal versus unequal cluster sizes in cluster randomized trials with a small number of clusters. Journal of biopharmaceutical statistics. 2021 March;31(2):191-206. PubMed PMID: 32970522; PubMed Central PMCID: PMC8734433; DOI: 10.1080/10543406.2020.1814795.
    24. Pannee J, Shaw LM, Korecka M, Waligorska T, Teunissen CE, Stoops E, Vanderstichele HMJ, Mauroo K, Verberk IMW, Keshavan A, Pesini P, Sarasa L, Pascual-Lucas M, Fandos N, Allué JA, Portelius E, Andreasson U, Yoda R, Nakamura A, Kaneko N, Yang SY, Liu HC, Palme S, Bittner T, Mawuenyega KG, Ovod V, Bollinger J, Bateman RJ, Li Y, Dage JL, Stomrud E, Hansson O, Schott JM, Blennow K, Zetterberg H. The global Alzheimer’s Association round robin study on plasma amyloid β methods. Alzheimer’s & dementia (Amsterdam, Netherlands). 2021;13(1):e12242. PubMed PMID: 34692980; PubMed Central PMCID: PMC8515356; DOI: 10.1002/dad2.12242.
    25. Keret O, Staffaroni AM, Ringman JM, Cobigo Y, Goh SM, Wolf A, Allen IE, Salloway S, Chhatwal J, Brickman AM, Reyes-Dumeyer D, Bateman RJ, Benzinger TLS, Morris JC, Ances BM, Joseph-Mathurin N, Perrin RJ, Gordon BA, Levin J, Vöglein J, Jucker M, la Fougère C, Martins RN, Sohrabi HR, Taddei K, Villemagne VL, Schofield PR, Brooks WS, Fulham M, Masters CL, Ghetti B, Saykin AJ, Jack CR, Graff-Radford NR, Weiner M, Cash DM, Allegri RF, Chrem P, Yi S, Miller BL, Rabinovici GD, Rosen HJ; Dominantly Inherited Alzheimer Network. Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer’s disease. Alzheimer’s & dementia (Amsterdam, Netherlands). 2021;13(1):e12197. PubMed PMID: 34258377; PubMed Central PMCID: PMC8256623; DOI:10.1002/dad2.12197.
    26. Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, Düzel E, Rodríguez Gómez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Buerger K, Levin J, Duering M, Dichgans M, Suárez-Calvet M, Haass C, Gordon BA, Lim YY, Masters CL, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Milz E, Moreno-Grau S, Teipel S, Grothe MJ, Kilimann I, Rossor M, Fox N, Laske C, Chhatwal J, Falkai P, Perneczky R, Lee JH, Spottke A, Boecker H, Brosseron F, Fliessbach K, Heneka MT, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Salloway S, Danek A, Hassenstab J, Yakushev I, Schofield PR, Morris JC, Bateman RJ, Ewers M. The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease. Mol Psychiatry. 2021 Feb;26(2):614-628. doi: 10.1038/s41380-019-0404-6. Epub 2019 Mar 21. PubMed PMID: 30899092; PubMed Central PMCID: PMC6754794.
    27. Chatterjee P, Fagan AM, Xiong C, McKay M, Bhatnagar A, Wu Y, Singh AK, Taddei K, Martins I, Gardener SL, Molloy MP, Multhaup G, Masters CL, Schofield PR, Benzinger TLS, Morris JC, Bateman RJ, Greenberg SM, Wermer MJH, van Buchem MA, Sohrabi HR, Martins RN. Presymptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy-Related Blood Metabolite Alterations. J Alzheimers Dis. 2021;79(2):895-903. doi: 10.3233/JAD-201267. PubMed PMID: 33361604.
    28. Luo J, Agboola F, Grant E, Masters CL, Albert MS, Johnson SC, McDade EM, Vöglein J, Fagan AM, Benzinger T, Massoumzadeh P, Hassenstab J, Bateman RJ, Morris JC, Perrin RJ, Chhatwal J, Jucker M, Ghetti B, Cruchaga C, Graff-Radford NR, Schofield PR, Mori H, Xiong C. Sequence of Alzheimer disease biomarker changes in cognitively normal adults: A cross-sectional study. Neurology. 2020 Dec 8;95(23):e3104-e3116. doi: 10.1212/WNL.0000000000010747. Epub 2020 Sep 1. PubMed PMID: 32873693; PubMed Central PMCID: PMC7734923.
    29. Finsterwalder S, Vlegels N, Gesierich B, Araque Caballero MÁ, Weaver NA, Franzmeier N, Georgakis MK, Konieczny MJ, Koek HL, Karch CM, Graff-Radford NR, Salloway S, Oh H, Allegri RF, Chhatwal JP, Jessen F, Düzel E, Dobisch L, Metzger C, Peters O, Incesoy EI, Priller J, Spruth EJ, Schneider A, Fließbach K, Buerger K, Janowitz D, Teipel SJ, Kilimann I, Laske C, Buchmann M, Heneka MT, Brosseron F, Spottke A, Roy N, Ertl-Wagner B, Scheffler K, Seo SW, Kim Y, Na DL, Kim HJ, Jang H, Ewers M, Levin J, Schmidt R, Pasternak O, Dichgans M, Biessels GJ, Duering M. Small vessel disease more than Alzheimer’s disease determines diffusion MRI alterations in memory clinic patients. Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2020 November;16(11):1504-1514. PubMed PMID: 32808747; PubMed Central PMCID: PMC8102202; DOI: 10.1002/alz.12150.
    30. Montal V, Vilaplana E, Pegueroles J, Bejanin A, Alcolea D, Carmona-Iragui M, Clarimón J, Levin J, Cruchaga C, Graff-Radford NR, Noble JM, Lee JH, Allegri R, Karch CM, Laske C, Schofield PR, Salloway S, Ances B, Benzinger T, McDale E, Bateman R, Blesa R, Sánchez-Valle R, Lleó A, Fortea J. Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer’s disease. Alzheimers Dement. 2020 Nov 16;. doi: 10.1002/alz.12224. [Epub ahead of print] PubMed PMID: 33196147.
    31. Chen CD, Holden TR, Gordon BA, Franklin EE, Li Y, Coble DW, Luo H, Bateman RJ, Ances BM, Perrin RJ, Benzinger TLS, Cairns NJ, Morris JC. Ante- and postmortem tau in autosomal dominant and late-onset Alzheimer’s disease. Ann Clin Transl Neurol. 2020 Nov 5;. doi: 10.1002/acn3.51237. [Epub ahead of print] PubMed PMID: 33150749; PubMed Central PMCID: PMC7732239.
    32. Gonneaud J, Bedetti C, Pichet Binette A, Benzinger TLS, Morris JC, Bateman RJ, Poirier J, Breitner JCS, Villeneuve S. Association of education with Aβ burden in preclinical familial and sporadic Alzheimer disease. Neurology. 2020 Sep 15;95(11):e1554-e1564. doi: 10.1212/WNL.0000000000010314. Epub 2020 Aug 5. PubMed PMID: 32759192; PubMed Central PMCID: PMC7713743.
    33. Vermunt L, Dicks E, Wang G, Dincer A, Flores S, Keefe SJ, Berman SB, Cash DM, Chhatwal JP, Cruchaga C, Fox NC, Ghetti B, Graff-Radford NR, Hassenstab J, Karch CM, Laske C, Levin J, Masters CL, McDade E, Mori H, Morris JC, Noble JM, Perrin RJ, Schofield PR, Xiong C, Scheltens P, Visser PJ, Bateman RJ, Benzinger TLS, Tijms BM, Gordon BA. Single-subject grey matter network trajectories over the disease course of autosomal dominant Alzheimer’s disease. Brain Commun. 2020;2(2):fcaa102. doi: 10.1093/braincomms/fcaa102. eCollection 2020. PubMed PMID: 32954344; PubMed Central PMCID: PMC7475695.
    34. Hsu S, Pimenova AA, Hayes K, Villa JA, Rosene MJ, Jere M, Goate AM, Karch CM. Systematic validation of variants of unknown significance in APP, PSEN1 and PSEN2. Neurobiol Dis. 2020 Jun;139:104817. doi: 10.1016/j.nbd.2020.104817. Epub 2020 Feb 19. PubMed PMID: 32087291; PubMed Central PMCID: PMC7236786.
    35. Castillo-Barnes D, Su L, Ramírez J, Salas-Gonzalez D, Martinez-Murcia FJ, Illan IA, Segovia F, Ortiz A, Cruchaga C, Farlow MR, Xiong C, Graff-Radford NR, Schofield PR, Masters CL, Salloway S, Jucker M, Mori H, Levin J, Gorriz JM. Autosomal Dominantly Inherited Alzheimer Disease: Analysis of genetic subgroups by Machine Learning. Inf Fusion. 2020 Jun;58:153-167. doi: 10.1016/j.inffus.2020.01.001. Epub 2020 Jan 7. PubMed PMID: 32284705; PubMed Central PMCID: PMC7153760.
    36. Gordon BA. Neurofilaments in disease: what do we know?. Curr Opin Neurobiol. 2020 Apr;61:105-115. doi: 10.1016/j.conb.2020.02.001. Epub 2020 Mar 6. Review. PubMed PMID: 32151970; PubMed Central PMCID: PMC7198337.
    37. Barthélemy NR, Li Y, Joseph-Mathurin N, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Perrin RJ, Goate AM, Morris JC, Karch CM, Xiong C, Allegri R, Mendez PC, Berman SB, Ikeuchi T, Mori H, Shimada H, Shoji M, Suzuki K, Noble J, Farlow M, Chhatwal J, Graff-Radford NR, Salloway S, Schofield PR, Masters CL, Martins RN, O’Connor A, Fox NC, Levin J, Jucker M, Gabelle A, Lehmann S, Sato C, Bateman RJ, McDade E. A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease. Nat Med. 2020 Mar;26(3):398-407. doi: 10.1038/s41591-020-0781-z. Epub 2020 Mar 11. PubMed PMID: 32161412; PubMed Central PMCID: PMC7309367.
    38. Franzmeier N, Koutsouleris N, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Duering M, Dichgans M, Levin J, Gordon BA, Lim YY, Masters CL, Rossor M, Fox NC, O’Connor A, Chhatwal J, Salloway S, Danek A, Hassenstab J, Schofield PR, Morris JC, Bateman RJ, Ewers M. Predicting sporadic Alzheimer’s disease progression via inherited Alzheimer’s disease-informed machine-learning. Alzheimers Dement. 2020 Mar;16(3):501-511. doi: 10.1002/alz.12032. Epub 2020 Feb 11. PubMed PMID: 32043733; PubMed Central PMCID: PMC7222030.
    39. Pichet Binette A, Vachon-Presseau É, Morris J, Bateman R, Benzinger T, Collins DL, Poirier J, Breitner JCS, Villeneuve S. Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer’s Disease. Biol Psychiatry. 2020 Feb 6;. doi: 10.1016/j.biopsych.2020.01.023. [Epub ahead of print] PubMed PMID: 32228870; PubMed Central PMCID: PMC7415608.
    40. Day GS, Rappai T, Sathyan S, Morris JC. Deciphering the factors that influence participation in studies requiring serial lumbar punctures. Alzheimers Dement (Amst). 2020;12(1):e12003. doi: 10.1002/dad2.12003. eCollection 2020. PubMed PMID: 32211499; PubMed Central PMCID: PMC7085282.
    41. Aschenbrenner AJ, James BD, McDade E, Wang G, Lim YY, Benzinger TLS, Cruchaga C, Goate A, Xiong C, Perrin R, Buckles V, Allegri R, Berman SB, Chhatwal JP, Fagan A, Farlow M, O’Connor A, Ghetti B, Graff-Radford N, Goldman J, Gräber S, Karch CM, Lee JH, Levin J, Martins RN, Masters C, Mori H, Noble J, Salloway S, Schofield P, Morris JC, Bateman RJ, Hassenstab J. Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN). Alzheimers Dement. 2020 Jan;16(1):219-228. doi: 10.1002/alz.12010. PubMed PMID: 31914221; PubMed Central PMCID: PMC7206736.
    42. Ng KP, Richard-Devantoy S, Bertrand JA, Jiang L, Pascoal TA, Mathotaarachchi S, Therriault J, Yatawara C, Kandiah N, Greenwood CMT, Rosa-Neto P, Gauthier S. Suicidal ideation is common in autosomal dominant Alzheimer’s disease at-risk persons. Int J Geriatr Psychiatry. 2020 Jan;35(1):60-68. doi: 10.1002/gps.5215. Epub 2019 Oct 22. PubMed PMID: 31642105; PubMed Central PMCID: PMC7232741.
    43. Lessov-Schlaggar CN, Del Rosario OL, Morris JC, Ances BM, Schlaggar BL, Constantino JN. Adaptation of the Clinical Dementia Rating Scale for adults with Down syndrome. J Neurodev Disord. 2019 Dec 16;11(1):39. doi: 10.1186/s11689-019-9300-2. PubMed PMID: 31842726; PubMed Central PMCID: PMC6912998.
    44. Llibre-Guerra JJ, Li Y, Schindler SE, Gordon BA, Fagan AM, Morris JC, Benzinger TLS, Hassenstab J, Wang G, Allegri R, Berman SB, Chhatwal J, Farlow MR, Holtzman DM, Jucker M, Levin J, Noble JM, Salloway S, Schofield P, Karch C, Fox NC, Xiong C, Bateman RJ, McDade E. Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease. JAMA Netw Open. 2019 Dec 2;2(12):e1917126. doi: 10.1001/jamanetworkopen.2019.17126. PubMed PMID: 31825500; PubMed Central PMCID: PMC6991202.
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    71. Veitch DP, Weiner MW, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR Jr, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ. Understanding disease progression and improving Alzheimer’s disease clinical trials: Recent highlights from the Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Dement. 2019 Jan;15(1):106-152. doi: 10.1016/j.jalz.2018.08.005. Epub 2018 Oct 13. Review. PubMed PMID: 30321505.
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    75. Twohig D, Rodriguez-Vieitez E, Sando SB, Berge G, Lauridsen C, Møller I, Grøntvedt GR, Bråthen G, Patra K, Bu G, Benzinger TLS, Karch CM, Fagan A, Morris JC, Bateman RJ, Nordberg A, White LR, Nielsen HM. The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease. Acta Neuropathol Commun. 2018 Nov 26;6(1):130. doi: 10.1186/s40478-018-0624-z. PubMed PMID: 30477568; PubMed Central PMCID: PMC6260771.
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    77. Schindler SE, Gray JD, Gordon BA, Xiong C, Batrla-Utermann R, Quan M, Wahl S, Benzinger TLS, Holtzman DM, Morris JC, Fagan AM. Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging. Alzheimers Dement. 2018 Nov;14(11):1460-1469. doi: 10.1016/j.jalz.2018.01.013. Epub 2018 Mar 2. PubMed PMID: 29501462; PubMed Central PMCID: PMC6119652.
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    80. Araque Caballero MÁ, Suárez-Calvet M, Duering M, Franzmeier N, Benzinger T, Fagan AM, Bateman RJ, Jack CR, Levin J, Dichgans M, Jucker M, Karch C, Masters CL, Morris JC, Weiner M, Rossor M, Fox NC, Lee JH, Salloway S, Danek A, Goate A, Yakushev I, Hassenstab J, Schofield PR, Haass C, Ewers M. White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease. Brain. 2018 Oct 1;141(10):3065-3080. doi: 10.1093/brain/awy229. PubMed PMID: 30239611; PubMed Central PMCID: PMC6158739.
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    83. Wang G, Berry S, Xiong C, Hassenstab J, Quintana M, McDade EM, Delmar P, Vestrucci M, Sethuraman G, Bateman RJ. A novel cognitive disease progression model for clinical trials in autosomal-dominant Alzheimer’s disease. Stat Med. 2018 Sep 20;37(21):3047-3055. doi: 10.1002/sim.7811. Epub 2018 May 14. PubMed PMID: 29761523; PubMed Central PMCID: PMC6105413.
    84. Lim YY, Hassenstab J, Goate A, Fagan AM, Benzinger TLS, Cruchaga C, McDade E, Chhatwal J, Levin J, Farlow MR, Graff-Radford NR, Laske C, Masters CL, Salloway S, Schofield P, Morris JC, Maruff P, Bateman RJ. Effect of BDNFVal66Met on disease markers in dominantly inherited Alzheimer’s disease. Ann Neurol. 2018 Sep;84(3):424-435. doi: 10.1002/ana.25299. Epub 2018 Aug 25. PubMed PMID: 30014553; PubMed Central PMCID: PMC6153076.
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    86. Karch CM, Hernández D, Wang JC, Marsh J, Hewitt AW, Hsu S, Norton J, Levitch D, Donahue T, Sigurdson W, Ghetti B, Farlow M, Chhatwal J, Berman S, Cruchaga C, Morris JC, Bateman RJ, Pébay A, Goate AM. Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network. Alzheimers Res Ther. 2018 Jul 25;10(1):69. doi: 10.1186/s13195-018-0400-0. PubMed PMID: 30045758; PubMed Central PMCID: PMC6060509.
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    88. Gabel M, Gooblar J, Roe CM, Selsor NJ, Morris JC. Political Ideology, Confidence in Science, and Participation in Alzheimer Disease Research Studies. Alzheimer Dis Assoc Disord. 2018 Jul-Sep;32(3):179-184. doi: 10.1097/WAD.0000000000000244. PubMed PMID: 29351092; PubMed Central PMCID: PMC6051930.
    89. Vlassenko AG, Gordon BA, Goyal MS, Su Y, Blazey TM, Durbin TJ, Couture LE, Christensen JJ, Jafri H, Morris JC, Raichle ME, Benzinger TL. Aerobic glycolysis and tau deposition in preclinical Alzheimer’s disease. Neurobiol Aging. 2018 Jul;67:95-98. doi: 10.1016/j.neurobiolaging.2018.03.014. Epub 2018 Mar 20. PubMed PMID: 29655050; PubMed Central PMCID: PMC5955846.
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