Finanziamento e gruppo di studio
Consorzio farmaceutico
DIAN Observational Study Publications
Su Y, Flores S, Wang G, Hornbeck RC, Speidel B, Joseph-Mathurin N, Vlassenko AG, Gordon BA, Koeppe RA, Klunk WE, Jack CR Jr, Farlow MR, Salloway S, Snider BJ, Berman SB, Roberson ED, Brosch J, Jimenez-Velazques I, van Dyck CH, Galasko D, Yuan SH, Jayadev S, Honig LS, Gauthier S, Hsiung GR, Masellis M, Brooks WS, Fulham M, Clarnette R, Masters CL, Wallon D, Hannequin D, Dubois B, Pariente J, Sanchez-Valle R, Mummery C, Ringman JM, Bottlaender M, Klein G, Milosavljevic-Ristic S, McDade E, Xiong C, Morris JC, Bateman RJ, Benzinger TLS. Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies. Alzheimers Dement (Amst) .
2019 Dec; 11 :180-190 .
doi: 10.1016/j.dadm.2018.12.008. eCollection 2019 Dec. PubMed PMID: 30847382 ; PubMed Central PMCID: PMC6389727 .
Buckley RF, Mormino EC, Chhatwal J, Schultz AP, Rabin JS, Rentz DM, Acar D, Properzi MJ, Dumurgier J, Jacobs H, Gomez-Isla T, Johnson KA, Sperling RA, Hanseeuw BJ. Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid. Neurobiol Aging .
2019 Jun; 78 :178-185 .
doi: 10.1016/j.neurobiolaging.2019.02.019. Epub 2019 Mar 7. PubMed PMID: 30947113 ; PubMed Central PMCID: PMC6545139 .
Vöglein J, Paumier K, Jucker M, Preische O, McDade E, Hassenstab J, Benzinger TL, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal J, Salloway S, Xiong C, Karch CM, Cairns N, Mori H, Schofield PR, Masters CL, Goate A, Buckles V, Fox N, Rossor M, Chrem P, Allegri R, Ringman JM, Höglinger G, Steiner H, Dieterich M, Haass C, Laske C, Morris JC, Bateman RJ, Danek A, Levin J. Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer’s disease. Brain .
2019 May 1; 142 (5) :1429-1440 .
doi: 10.1093/brain/awz050. PubMed PMID: 30897203 ; PubMed Central PMCID: PMC6735903 .
Schindler SE, Li Y, Todd KW, Herries EM, Henson RL, Gray JD, Wang G, Graham DL, Shaw LM, Trojanowski JQ, Hassenstab JJ, Benzinger TLS, Cruchaga C, Jucker M, Levin J, Chhatwal JP, Noble JM, Ringman JM, Graff-Radford NR, Holtzman DM, Ladenson JH, Morris JC, Bateman RJ, Xiong C, Fagan AM. Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer’s disease. Alzheimers Dement .
2019 May; 15 (5) :655-665 .
doi: 10.1016/j.jalz.2018.12.019. Epub 2019 Mar 4. PubMed PMID: 30846386 ; PubMed Central PMCID: PMC6511459 .
Gordon BA, Blazey TM, Christensen J, Dincer A, Flores S, Keefe S, Chen C, Su Y, McDade EM, Wang G, Li Y, Hassenstab J, Aschenbrenner A, Hornbeck R, Jack CR, Ances BM, Berman SB, Brosch JR, Galasko D, Gauthier S, Lah JJ, Masellis M, van Dyck CH, Mintun MA, Klein G, Ristic S, Cairns NJ, Marcus DS, Xiong C, Holtzman DM, Raichle ME, Morris JC, Bateman RJ, Benzinger TLS. Tau PET in autosomal dominant Alzheimer’s disease: relationship with cognition, dementia and other biomarkers. Brain .
2019 Apr 1; 142 (4) :1063-1076 .
doi: 10.1093/brain/awz019. PubMed PMID: 30753379 ; PubMed Central PMCID: PMC6439328 .
Vöglein J, Noachtar S, McDade E, Quaid KA, Salloway S, Ghetti B, Noble J, Berman S, Chhatwal J, Mori H, Fox N, Allegri R, Masters CL, Buckles V, Ringman JM, Rossor M, Schofield PR, Sperling R, Jucker M, Laske C, Paumier K, Morris JC, Bateman RJ, Levin J, Danek A. Seizures as an early symptom of autosomal dominant Alzheimer’s disease. Neurobiol Aging .
2019 Apr; 76 :18-23 .
doi: 10.1016/j.neurobiolaging.2018.11.022. Epub 2018 Dec 5. PubMed PMID: 30616208 ; PubMed Central PMCID: PMC6572755 .
Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, Düzel E, Rodríguez Gómez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Buerger K, Levin J, Duering M, Dichgans M, Suárez-Calvet M, Haass C, Gordon BA, Lim YY, Masters CL, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Milz E, Moreno-Grau S, Teipel S, Grothe MJ, Kilimann I, Rossor M, Fox N, Laske C, Chhatwal J, Falkai P, Perneczky R, Lee JH, Spottke A, Boecker H, Brosseron F, Fliessbach K, Heneka MT, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Salloway S, Danek A, Hassenstab J, Yakushev I, Schofield PR, Morris JC, Bateman RJ, Ewers M. The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease. Mol Psychiatry .
2019 Mar 21; .
doi: 10.1038/s41380-019-0404-6. [Epub ahead of print] PubMed PMID: 30899092 ; PubMed Central PMCID: PMC6754794 .
Wang Q, Wang Y, Liu J, Sutphen CL, Cruchaga C, Blazey T, Gordon BA, Su Y, Chen C, Shimony JS, Ances BM, Cairns NJ, Fagan AM, Morris JC, Benzinger TLS. Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer’s disease. Neuroimage Clin .
2019; 22 :101767 .
doi: 10.1016/j.nicl.2019.101767. Epub 2019 Mar 13. PubMed PMID: 30901713 ; PubMed Central PMCID: PMC6428957 .
Bussy A, Snider BJ, Coble D, Xiong C, Fagan AM, Cruchaga C, Benzinger TLS, Gordon BA, Hassenstab J, Bateman RJ, Morris JC. Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network. Neurobiol Aging .
2019 Mar; 75 :42-50 .
doi: 10.1016/j.neurobiolaging.2018.10.011. Epub 2018 Oct 13. PubMed PMID: 30530186 ; PubMed Central PMCID: PMC6385602 .
Preische O, Schultz SA, Apel A, Kuhle J, Kaeser SA, Barro C, Gräber S, Kuder-Buletta E, LaFougere C, Laske C, Vöglein J, Levin J, Masters CL, Martins R, Schofield PR, Rossor MN, Graff-Radford NR, Salloway S, Ghetti B, Ringman JM, Noble JM, Chhatwal J, Goate AM, Benzinger TLS, Morris JC, Bateman RJ, Wang G, Fagan AM, McDade EM, Gordon BA, Jucker M. Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease. Nat Med .
2019 Feb; 25 (2) :277-283 .
doi: 10.1038/s41591-018-0304-3. Epub 2019 Jan 21. PubMed PMID: 30664784 ; PubMed Central PMCID: PMC6367005 .
Lucey BP, McCullough A, Landsness EC, Toedebusch CD, McLeland JS, Zaza AM, Fagan AM, McCue L, Xiong C, Morris JC, Benzinger TLS, Holtzman DM. Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease. Sci Transl Med .
2019 Jan 9; 11 (474) .
doi: 10.1126/scitranslmed.aau6550. PubMed PMID: 30626715 ; PubMed Central PMCID: PMC6342564 .
Veitch DP, Weiner MW, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR Jr, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ. Understanding disease progression and improving Alzheimer’s disease clinical trials: Recent highlights from the Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Dement .
2019 Jan; 15 (1) :106-152 .
doi: 10.1016/j.jalz.2018.08.005. Epub 2018 Oct 13. Review. PubMed PMID: 30321505 .
Jiang S, Wen N, Li Z, Dube U, Del Aguila J, Budde J, Martinez R, Hsu S, Fernandez MV, Cairns NJ, Harari O, Cruchaga C, Karch CM. Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP. Transl Psychiatry .
2018 Dec 13; 8 (1) :265 .
doi: 10.1038/s41398-018-0319-z. PubMed PMID: 30546007 ; PubMed Central PMCID: PMC6293323 .
Wang G, Xiong C, McDade EM, Hassenstab J, Aschenbrenner AJ, Fagan AM, Benzinger TLS, Gordon BA, Morris JC, Li Y, Bateman RJ. Simultaneously evaluating the effect of baseline levels and longitudinal changes in disease biomarkers on cognition in dominantly inherited Alzheimer’s disease. Alzheimers Dement (N Y) .
2018; 4 :669-676 .
doi: 10.1016/j.trci.2018.10.009. eCollection 2018. PubMed PMID: 30569014 ; PubMed Central PMCID: PMC6288312 .
Suárez-Calvet M, Capell A, Araque Caballero MÁ, Morenas-Rodríguez E, Fellerer K, Franzmeier N, Kleinberger G, Eren E, Deming Y, Piccio L, Karch CM, Cruchaga C, Paumier K, Bateman RJ, Fagan AM, Morris JC, Levin J, Danek A, Jucker M, Masters CL, Rossor MN, Ringman JM, Shaw LM, Trojanowski JQ, Weiner M, Ewers M, Haass C. CSF progranulin increases in the course of Alzheimer’s disease and is associated with sTREM2, neurodegeneration and cognitive decline. EMBO Mol Med .
2018 Dec; 10 (12) .
doi: 10.15252/emmm.201809712. PubMed PMID: 30482868 ; PubMed Central PMCID: PMC6284390 .
Twohig D, Rodriguez-Vieitez E, Sando SB, Berge G, Lauridsen C, Møller I, Grøntvedt GR, Bråthen G, Patra K, Bu G, Benzinger TLS, Karch CM, Fagan A, Morris JC, Bateman RJ, Nordberg A, White LR, Nielsen HM. The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease. Acta Neuropathol Commun .
2018 Nov 26; 6 (1) :130 .
doi: 10.1186/s40478-018-0624-z. PubMed PMID: 30477568 ; PubMed Central PMCID: PMC6260771 .
Schindler SE, Gray JD, Gordon BA, Xiong C, Batrla-Utermann R, Quan M, Wahl S, Benzinger TLS, Holtzman DM, Morris JC, Fagan AM. Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging. Alzheimers Dement .
2018 Nov; 14 (11) :1460-1469 .
doi: 10.1016/j.jalz.2018.01.013. Epub 2018 Mar 2. PubMed PMID: 29501462 ; PubMed Central PMCID: PMC6119652 .
McDade E, Wang G, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Holtzman DM, Cairns NJ, Goate AM, Marcus DS, Morris JC, Paumier K, Xiong C, Allegri R, Berman SB, Klunk W, Noble J, Ringman J, Ghetti B, Farlow M, Sperling RA, Chhatwal J, Salloway S, Graff-Radford NR, Schofield PR, Masters C, Rossor MN, Fox NC, Levin J, Jucker M, Bateman RJ. Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. Neurology .
2018 Oct 2; 91 (14) :e1295-e1306 .
doi: 10.1212/WNL.0000000000006277. Epub 2018 Sep 14. PubMed PMID: 30217935 ; PubMed Central PMCID: PMC6177272 .
Araque Caballero MÁ, Suárez-Calvet M, Duering M, Franzmeier N, Benzinger T, Fagan AM, Bateman RJ, Jack CR, Levin J, Dichgans M, Jucker M, Karch C, Masters CL, Morris JC, Weiner M, Rossor M, Fox NC, Lee JH, Salloway S, Danek A, Goate A, Yakushev I, Hassenstab J, Schofield PR, Haass C, Ewers M. White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease. Brain .
2018 Oct 1; 141 (10) :3065-3080 .
doi: 10.1093/brain/awy229. PubMed PMID: 30239611 ; PubMed Central PMCID: PMC6158739 .
Joseph-Mathurin N, Su Y, Blazey TM, Jasielec M, Vlassenko A, Friedrichsen K, Gordon BA, Hornbeck RC, Cash L, Ances BM, Veale T, Cash DM, Brickman AM, Buckles V, Cairns NJ, Cruchaga C, Goate A, Jack CR Jr, Karch C, Klunk W, Koeppe RA, Marcus DS, Mayeux R, McDade E, Noble JM, Ringman J, Saykin AJ, Thompson PM, Xiong C, Morris JC, Bateman RJ, Benzinger TLS. Utility of perfusion PET measures to assess neuronal injury in Alzheimer’s disease. Alzheimers Dement (Amst) .
2018; 10 :669-677 .
doi: 10.1016/j.dadm.2018.08.012. eCollection 2018. PubMed PMID: 30417072 ; PubMed Central PMCID: PMC6215983 .
Lim YY, Hassenstab J, Goate A, Fagan AM, Benzinger TLS, Cruchaga C, McDade E, Chhatwal J, Levin J, Farlow MR, Graff-Radford NR, Laske C, Masters CL, Salloway S, Schofield P, Morris JC, Maruff P, Bateman RJ. Effect of BDNFVal66Met on disease markers in dominantly inherited Alzheimer’s disease. Ann Neurol .
2018 Sep; 84 (3) :424-435 .
doi: 10.1002/ana.25299. Epub 2018 Aug 25. PubMed PMID: 30014553 ; PubMed Central PMCID: PMC6153076 .
Karch CM, Hernández D, Wang JC, Marsh J, Hewitt AW, Hsu S, Norton J, Levitch D, Donahue T, Sigurdson W, Ghetti B, Farlow M, Chhatwal J, Berman S, Cruchaga C, Morris JC, Bateman RJ, Pébay A, Goate AM. Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network. Alzheimers Res Ther .
2018 Jul 25; 10 (1) :69 .
doi: 10.1186/s13195-018-0400-0. PubMed PMID: 30045758 ; PubMed Central PMCID: PMC6060509 .
Hsu S, Gordon BA, Hornbeck R, Norton JB, Levitch D, Louden A, Ziegemeier E, Laforce R Jr, Chhatwal J, Day GS, McDade E, Morris JC, Fagan AM, Benzinger TLS, Goate AM, Cruchaga C, Bateman RJ, Karch CM. Discovery and validation of autosomal dominant Alzheimer’s disease mutations. Alzheimers Res Ther .
2018 Jul 18; 10 (1) :67 .
doi: 10.1186/s13195-018-0392-9. PubMed PMID: 30021643 ; PubMed Central PMCID: PMC6052673 .
Vlassenko AG, Gordon BA, Goyal MS, Su Y, Blazey TM, Durbin TJ, Couture LE, Christensen JJ, Jafri H, Morris JC, Raichle ME, Benzinger TL. Aerobic glycolysis and tau deposition in preclinical Alzheimer’s disease. Neurobiol Aging .
2018 Jul; 67 :95-98 .
doi: 10.1016/j.neurobiolaging.2018.03.014. Epub 2018 Mar 20. PubMed PMID: 29655050 ; PubMed Central PMCID: PMC5955846 .
Li Z, Del-Aguila JL, Dube U, Budde J, Martinez R, Black K, Xiao Q, Cairns NJ, Dougherty JD, Lee JM, Morris JC, Bateman RJ, Karch CM, Cruchaga C, Harari O. Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure. Genome Med .
2018 Jun 8; 10 (1) :43 .
doi: 10.1186/s13073-018-0551-4. PubMed PMID: 29880032 ; PubMed Central PMCID: PMC5992755 .
Lee S, Zimmerman ME, Narkhede A, Nasrabady SE, Tosto G, Meier IB, Benzinger TLS, Marcus DS, Fagan AM, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, Martins RN, Saykin AJ, Masters CL, Ringman JM, Fӧrster S, Schofield PR, Sperling RA, Johnson KA, Chhatwal JP, Salloway S, Correia S, Jack CR Jr, Weiner M, Bateman RJ, Morris JC, Mayeux R, Brickman AM. White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer’s disease. PLoS One .
2018; 13 (5) :e0195838 .
doi: 10.1371/journal.pone.0195838. eCollection 2018. PubMed PMID: 29742105 ; PubMed Central PMCID: PMC5942789 .
Chhatwal JP, Schultz AP, Johnson KA, Hedden T, Jaimes S, Benzinger TLS, Jack C Jr, Ances BM, Ringman JM, Marcus DS, Ghetti B, Farlow MR, Danek A, Levin J, Yakushev I, Laske C, Koeppe RA, Galasko DR, Xiong C, Masters CL, Schofield PR, Kinnunen KM, Salloway S, Martins RN, McDade E, Cairns NJ, Buckles VD, Morris JC, Bateman R, Sperling RA. Preferential degradation of cognitive networks differentiates Alzheimer’s disease from ageing. Brain .
2018 May 1; 141 (5) :1486-1500 .
doi: 10.1093/brain/awy053. PubMed PMID: 29522171 ; PubMed Central PMCID: PMC5917745 .
Villeneuve S, Vogel JW, Gonneaud J, Pichet Binette A, Rosa-Neto P, Gauthier S, Bateman RJ, Fagan AM, Morris JC, Benzinger TLS, Johnson SC, Breitner JCS, Poirier J. Proximity to Parental Symptom Onset and Amyloid-β Burden in Sporadic Alzheimer Disease. JAMA Neurol .
2018 May 1; 75 (5) :608-619 .
doi: 10.1001/jamaneurol.2017.5135. PubMed PMID: 29482212 ; PubMed Central PMCID: PMC5885216 .
Stout SH, Babulal GM, Ma C, Carr DB, Head DM, Grant EA, Williams MM, Holtzman DM, Fagan AM, Morris JC, Roe CM. Driving cessation over a 24-year period: Dementia severity and cerebrospinal fluid biomarkers. Alzheimers Dement .
2018 May; 14 (5) :610-616 .
doi: 10.1016/j.jalz.2017.11.011. Epub 2018 Jan 10. PubMed PMID: 29328928 ; PubMed Central PMCID: PMC5938126 .
Su Y, Flores S, Hornbeck RC, Speidel B, Vlassenko AG, Gordon BA, Koeppe RA, Klunk WE, Xiong C, Morris JC, Benzinger TLS. Utilizing the Centiloid scale in cross-sectional and longitudinal PiB PET studies. Neuroimage Clin .
2018; 19 :406-416 .
doi: 10.1016/j.nicl.2018.04.022. eCollection 2018. PubMed PMID: 30035025 ; PubMed Central PMCID: PMC6051499 .
Franzmeier N, Düzel E, Jessen F, Buerger K, Levin J, Duering M, Dichgans M, Haass C, Suárez-Calvet M, Fagan AM, Paumier K, Benzinger T, Masters CL, Morris JC, Perneczky R, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Teipel S, Kilimann I, Ramirez A, Rossor M, Jucker M, Chhatwal J, Spottke A, Boecker H, Brosseron F, Falkai P, Fliessbach K, Heneka MT, Laske C, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Kofler B, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Weiner M, Lee JH, Salloway S, Danek A, Goate A, Schofield PR, Bateman RJ, Ewers M. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease. Brain .
2018 Apr 1; 141 (4) :1186-1200 .
doi: 10.1093/brain/awy008. PubMed PMID: 29462334 ; PubMed Central PMCID: PMC5888938 .
Day GS, Gordon BA, Perrin RJ, Cairns NJ, Beaumont H, Schwetye K, Ferguson C, Sinha N, Bucelli R, Musiek ES, Ghoshal N, Ponisio MR, Vincent B, Mishra S, Jackson K, Morris JC, Benzinger TLS, Ances BM. In vivo [18 F]-AV-1451 tau-PET imaging in sporadic Creutzfeldt-Jakob disease. Neurology .
2018 Mar 6; 90 (10) :e896-e906 .
doi: 10.1212/WNL.0000000000005064. Epub 2018 Feb 7. PubMed PMID: 29438042 ; PubMed Central PMCID: PMC5863493 .
Gordon BA, Blazey TM, Su Y, Hari-Raj A, Dincer A, Flores S, Christensen J, McDade E, Wang G, Xiong C, Cairns NJ, Hassenstab J, Marcus DS, Fagan AM, Jack CR Jr, Hornbeck RC, Paumier KL, Ances BM, Berman SB, Brickman AM, Cash DM, Chhatwal JP, Correia S, Förster S, Fox NC, Graff-Radford NR, la Fougère C, Levin J, Masters CL, Rossor MN, Salloway S, Saykin AJ, Schofield PR, Thompson PM, Weiner MM, Holtzman DM, Raichle ME, Morris JC, Bateman RJ, Benzinger TLS. Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer’s disease: a longitudinal study. Lancet Neurol .
2018 Mar; 17 (3) :241-250 .
doi: 10.1016/S1474-4422(18)30028-0. Epub 2018 Feb 1. PubMed PMID: 29397305 ; PubMed Central PMCID: PMC5816717 .
Cruchaga C, Del-Aguila JL, Saef B, Black K, Fernandez MV, Budde J, Ibanez L, Deming Y, Kapoor M, Tosto G, Mayeux RP, Holtzman DM, Fagan AM, Morris JC, Bateman RJ, Goate AM, Harari O. Polygenic risk score of sporadic late-onset Alzheimer’s disease reveals a shared architecture with the familial and early-onset forms. Alzheimers Dement .
2018 Feb; 14 (2) :205-214 .
doi: 10.1016/j.jalz.2017.08.013. Epub 2017 Sep 21. PubMed PMID: 28943286 ; PubMed Central PMCID: PMC5803427 .
Martins RN, Villemagne V, Sohrabi HR, Chatterjee P, Shah TM, Verdile G, Fraser P, Taddei K, Gupta VB, Rainey-Smith SR, Hone E, Pedrini S, Lim WL, Martins I, Frost S, Gupta S, O’Bryant S, Rembach A, Ames D, Ellis K, Fuller SJ, Brown B, Gardener SL, Fernando B, Bharadwaj P, Burnham S, Laws SM, Barron AM, Goozee K, Wahjoepramono EJ, Asih PR, Doecke JD, Salvado O, Bush AI, Rowe CC, Gandy SE, Masters CL. Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies. J Alzheimers Dis .
2018; 62 (3) :965-992 .
doi: 10.3233/JAD-171145. Review. PubMed PMID: 29562546 ; PubMed Central PMCID: PMC5870031 .
Kinnunen KM, Cash DM, Poole T, Frost C, Benzinger TLS, Ahsan RL, Leung KK, Cardoso MJ, Modat M, Malone IB, Morris JC, Bateman RJ, Marcus DS, Goate A, Salloway SP, Correia S, Sperling RA, Chhatwal JP, Mayeux RP, Brickman AM, Martins RN, Farlow MR, Ghetti B, Saykin AJ, Jack CR Jr, Schofield PR, McDade E, Weiner MW, Ringman JM, Thompson PM, Masters CL, Rowe CC, Rossor MN, Ourselin S, Fox NC. Presymptomatic atrophy in autosomal dominant Alzheimer’s disease: A serial magnetic resonance imaging study. Alzheimers Dement .
2018 Jan; 14 (1) :43-53 .
doi: 10.1016/j.jalz.2017.06.2268. Epub 2017 Jul 22. PubMed PMID: 28738187 ; PubMed Central PMCID: PMC5751893 .
Brown BM, Sohrabi HR, Taddei K, Gardener SL, Rainey-Smith SR, Peiffer JJ, Xiong C, Fagan AM, Benzinger T, Buckles V, Erickson KI, Clarnette R, Shah T, Masters CL, Weiner M, Cairns N, Rossor M, Graff-Radford NR, Salloway S, Vöglein J, Laske C, Noble J, Schofield PR, Bateman RJ, Morris JC, Martins RN. Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer’s disease. Alzheimers Dement .
2017 Nov; 13 (11) :1197-1206 .
doi: 10.1016/j.jalz.2017.03.008. Epub 2017 May 11. PubMed PMID: 28501451 ; PubMed Central PMCID: PMC5675772 .
Ringman JM, Casado M, Van Berlo V, Pa J, Joseph-Mathurin N, Fagan AM, Benzinger T, Bateman RJ, Morris JC. A novel PSEN1 (S230N) mutation causing early-onset Alzheimer’s Disease associated with prosopagnosia, hoarding, and Parkinsonism. Neurosci Lett .
2017 Sep 14; 657 :11-15 .
doi: 10.1016/j.neulet.2017.07.046. Epub 2017 Jul 29. PubMed PMID: 28764909 ; PubMed Central PMCID: PMC5731478 .
Goyal MS, Vlassenko AG, Blazey TM, Su Y, Couture LE, Durbin TJ, Bateman RJ, Benzinger TL, Morris JC, Raichle ME. Loss of Brain Aerobic Glycolysis in Normal Human Aging. Cell Metab .
2017 Aug 1; 26 (2) :353-360.e3 .
doi: 10.1016/j.cmet.2017.07.010. PubMed PMID: 28768174 ; PubMed Central PMCID: PMC5573225 .
Shimada H, Shoji M, Ikeuchi T, Suzuki K, Senda M, Ishii K, Matsuda H, Iwata A, Ihara R, Iwatsubo T, Mutoh K, Nakazawa E, Sekijima Y, Mori E, Ikeda M, Ikeda M, Kawakatsu S, Nakanishi A, Hashimoto M, Nunomura A, Matsubara E, Fukui M, Shirato T, Hirai K, Sakamoto M, Fujii H, Mori H. [DIAN/DIAN-J/DIAN-TU]. Brain Nerve .
2017 Jul; 69 (7) :701-709 .
doi: 10.11477/mf.1416200811. PubMed PMID: 28739983 .
Ng KP, Pascoal TA, Mathotaarachchi S, Chung CO, Benedet AL, Shin M, Kang MS, Li X, Ba M, Kandiah N, Rosa-Neto P, Gauthier S. Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease. Neurology .
2017 May 9; 88 (19) :1814-1821 .
doi: 10.1212/WNL.0000000000003916. Epub 2017 Apr 12. PubMed PMID: 28404803 ; PubMed Central PMCID: PMC5419982 .
Müller S, Preische O, Sohrabi HR, Gräber S, Jucker M, Dietzsch J, Ringman JM, Martins RN, McDade E, Schofield PR, Ghetti B, Rossor M, Graff-Radford NR, Levin J, Galasko D, Quaid KA, Salloway S, Xiong C, Benzinger T, Buckles V, Masters CL, Sperling R, Bateman RJ, Morris JC, Laske C. Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer’s disease. Sci Rep .
2017 Apr 27; 7 (1) :1225 .
doi: 10.1038/s41598-017-01327-w. PubMed PMID: 28450713 ; PubMed Central PMCID: PMC5430642 .
Jack CR Jr, Wiste HJ, Weigand SD, Therneau TM, Lowe VJ, Knopman DS, Gunter JL, Senjem ML, Jones DT, Kantarci K, Machulda MM, Mielke MM, Roberts RO, Vemuri P, Reyes DA, Petersen RC. Defining imaging biomarker cut points for brain aging and Alzheimer’s disease. Alzheimers Dement .
2017 Mar; 13 (3) :205-216 .
doi: 10.1016/j.jalz.2016.08.005. Epub 2016 Sep 30. PubMed PMID: 27697430 ; PubMed Central PMCID: PMC5344738 .
Natelson Love M, Clark DG, Cochran JN, Den Beste KA, Geldmacher DS, Benzinger TL, Gordon BA, Morris JC, Bateman RJ, Roberson ED. Clinical, imaging, pathological, and biochemical characterization of a novel presenilin 1 mutation (N135Y) causing Alzheimer’s disease. Neurobiol Aging .
2017 Jan; 49 :216.e7-216.e13 .
doi: 10.1016/j.neurobiolaging.2016.09.020. Epub 2016 Oct 3. PubMed PMID: 27793474 ; PubMed Central PMCID: PMC5154842 .
Bateman RJ, Benzinger TL, Berry S, Clifford DB, Duggan C, Fagan AM, Fanning K, Farlow MR, Hassenstab J, McDade EM, Mills S, Paumier K, Quintana M, Salloway SP, Santacruz A, Schneider LS, Wang G, Xiong C. The DIAN-TU Next Generation Alzheimer’s prevention trial: Adaptive design and disease progression model. Alzheimers Dement .
2017 Jan; 13 (1) :8-19 .
doi: 10.1016/j.jalz.2016.07.005. Epub 2016 Aug 29. PubMed PMID: 27583651 ; PubMed Central PMCID: PMC5218895 .
Gurney J, Olsen T, Flavin J, Ramaratnam M, Archie K, Ransford J, Herrick R, Wallace L, Cline J, Horton W, Marcus DS. The Washington University Central Neuroimaging Data Archive. Neuroimage .
2017 Jan; 144 (Pt B) :287-293 .
doi: 10.1016/j.neuroimage.2015.09.060. Epub 2015 Oct 9. PubMed PMID: 26439514 ; PubMed Central PMCID: PMC4967044 .
Tang M, Ryman DC, McDade E, Jasielec MS, Buckles VD, Cairns NJ, Fagan AM, Goate A, Marcus DS, Xiong C, Allegri RF, Chhatwal JP, Danek A, Farlow MR, Fox NC, Ghetti B, Graff-Radford NR, Laske C, Martins RN, Masters CL, Mayeux RP, Ringman JM, Rossor MN, Salloway SP, Schofield PR, Morris JC, Bateman RJ. Neurological manifestations of autosomal dominant familial Alzheimer’s disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS). Lancet Neurol .
2016 Dec; 15 (13) :1317-1325 .
doi: 10.1016/S1474-4422(16)30229-0. Epub 2016 Oct 21. Review. PubMed PMID: 27777020 ; PubMed Central PMCID: PMC5116769 .
Soosman SK, Joseph-Mathurin N, Braskie MN, Bordelon YM, Wharton D, Casado M, Coppola G, McCallum H, Nuwer M, Coutin-Churchman P, Apostolova LG, Benzinger T, Ringman JM. Widespread white matter and conduction defects in PSEN1-related spastic paraparesis. Neurobiol Aging .
2016 Nov; 47 :201-209 .
doi: 10.1016/j.neurobiolaging.2016.07.030. Epub 2016 Aug 8. PubMed PMID: 27614114 ; PubMed Central PMCID: PMC5075491 .
Lim YY, Hassenstab J, Cruchaga C, Goate A, Fagan AM, Benzinger TL, Maruff P, Snyder PJ, Masters CL, Allegri R, Chhatwal J, Farlow MR, Graff-Radford NR, Laske C, Levin J, McDade E, Ringman JM, Rossor M, Salloway S, Schofield PR, Holtzman DM, Morris JC, Bateman RJ. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer’s disease. Brain .
2016 Oct; 139 (Pt 10) :2766-2777 .
doi: 10.1093/brain/aww200. Epub 2016 Aug 12. PubMed PMID: 27521573 ; PubMed Central PMCID: PMC5815565 .
Su Y, Blazey TM, Owen CJ, Christensen JJ, Friedrichsen K, Joseph-Mathurin N, Wang Q, Hornbeck RC, Ances BM, Snyder AZ, Cash LA, Koeppe RA, Klunk WE, Galasko D, Brickman AM, McDade E, Ringman JM, Thompson PM, Saykin AJ, Ghetti B, Sperling RA, Johnson KA, Salloway SP, Schofield PR, Masters CL, Villemagne VL, Fox NC, Förster S, Chen K, Reiman EM, Xiong C, Marcus DS, Weiner MW, Morris JC, Bateman RJ, Benzinger TL. Correction: Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer’s Disease: Results from the DIAN Study Group. PLoS One .
2016; 11 (9) :e0163669 .
doi: 10.1371/journal.pone.0163669. eCollection 2016. PubMed PMID: 27649320 ; PubMed Central PMCID: PMC5029931 .
Muenchhoff J, Poljak A, Thalamuthu A, Gupta VB, Chatterjee P, Raftery M, Masters CL, Morris JC, Bateman RJ, Fagan AM, Martins RN, Sachdev PS. Changes in the plasma proteome at asymptomatic and symptomatic stages of autosomal dominant Alzheimer’s disease. Sci Rep .
2016 Jul 6; 6 :29078 .
doi: 10.1038/srep29078. PubMed PMID: 27381087 ; PubMed Central PMCID: PMC4933916 .
Lee S, Viqar F, Zimmerman ME, Narkhede A, Tosto G, Benzinger TL, Marcus DS, Fagan AM, Goate A, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, Martins RN, Saykin AJ, Masters CL, Ringman JM, Ryan NS, Förster S, Laske C, Schofield PR, Sperling RA, Salloway S, Correia S, Jack C Jr, Weiner M, Bateman RJ, Morris JC, Mayeux R, Brickman AM. White matter hyperintensities are a core feature of Alzheimer’s disease: Evidence from the dominantly inherited Alzheimer network. Ann Neurol .
2016 Jun; 79 (6) :929-39 .
doi: 10.1002/ana.24647. Epub 2016 Apr 27. PubMed PMID: 27016429 ; PubMed Central PMCID: PMC4884146 .
Su Y, Blazey TM, Owen CJ, Christensen JJ, Friedrichsen K, Joseph-Mathurin N, Wang Q, Hornbeck RC, Ances BM, Snyder AZ, Cash LA, Koeppe RA, Klunk WE, Galasko D, Brickman AM, McDade E, Ringman JM, Thompson PM, Saykin AJ, Ghetti B, Sperling RA, Johnson KA, Salloway SP, Schofield PR, Masters CL, Villemagne VL, Fox NC, Förster S, Chen K, Reiman EM, Xiong C, Marcus DS, Weiner MW, Morris JC, Bateman RJ, Benzinger TL. Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer’s Disease: Results from the DIAN Study Group. PLoS One .
2016; 11 (3) :e0152082 .
doi: 10.1371/journal.pone.0152082. eCollection 2016. PubMed PMID: 27010959 ; PubMed Central PMCID: PMC4807073 .
Ringman JM, Monsell S, Ng DW, Zhou Y, Nguyen A, Coppola G, Van Berlo V, Mendez MF, Tung S, Weintraub S, Mesulam MM, Bigio EH, Gitelman DR, Fisher-Hubbard AO, Albin RL, Vinters HV. Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database. J Neuropathol Exp Neurol .
2016 Mar; 75 (3) :284-90 .
doi: 10.1093/jnen/nlv028. Epub 2016 Feb 17. PubMed PMID: 26888304 ; PubMed Central PMCID: PMC4934612 .
Chatterjee P, Lim WL, Shui G, Gupta VB, James I, Fagan AM, Xiong C, Sohrabi HR, Taddei K, Brown BM, Benzinger T, Masters C, Snowden SG, Wenk MR, Bateman RJ, Morris JC, Martins RN. Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study. J Alzheimers Dis .
2016; 50 (3) :887-94 .
doi: 10.3233/JAD-150948. PubMed PMID: 26836186 ; PubMed Central PMCID: PMC4943576 .
Reiman EM, Langbaum JB, Tariot PN, Lopera F, Bateman RJ, Morris JC, Sperling RA, Aisen PS, Roses AD, Welsh-Bohmer KA, Carrillo MC, Weninger S. CAP–advancing the evaluation of preclinical Alzheimer disease treatments. Nat Rev Neurol .
2016 Jan; 12 (1) :56-61 .
doi: 10.1038/nrneurol.2015.177. Epub 2015 Sep 29. Review. PubMed PMID: 26416539 ; PubMed Central PMCID: PMC4847536 .
Wang F, Gordon BA, Ryman DC, Ma S, Xiong C, Hassenstab J, Goate A, Fagan AM, Cairns NJ, Marcus DS, McDade E, Ringman JM, Graff-Radford NR, Ghetti B, Farlow MR, Sperling R, Salloway S, Schofield PR, Masters CL, Martins RN, Rossor MN, Jucker M, Danek A, Förster S, Lane CA, Morris JC, Benzinger TL, Bateman RJ. Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease. Neurology .
2015 Sep 1; 85 (9) :790-8 .
doi: 10.1212/WNL.0000000000001903. Epub 2015 Aug 5. PubMed PMID: 26245925 ; PubMed Central PMCID: PMC4553024 .
Patterson BW, Elbert DL, Mawuenyega KG, Kasten T, Ovod V, Ma S, Xiong C, Chott R, Yarasheski K, Sigurdson W, Zhang L, Goate A, Benzinger T, Morris JC, Holtzman D, Bateman RJ. Age and amyloid effects on human central nervous system amyloid-beta kinetics. Ann Neurol .
2015 Sep; 78 (3) :439-53 .
doi: 10.1002/ana.24454. Epub 2015 Jul 20. PubMed PMID: 26040676 ; PubMed Central PMCID: PMC4546566 .
Yau WW, Tudorascu DL, McDade EM, Ikonomovic S, James JA, Minhas D, Mowrey W, Sheu LK, Snitz BE, Weissfeld L, Gianaros PJ, Aizenstein HJ, Price JC, Mathis CA, Lopez OL, Klunk WE. Longitudinal assessment of neuroimaging and clinical markers in autosomal dominant Alzheimer’s disease: a prospective cohort study. Lancet Neurol .
2015 Aug; 14 (8) :804-813 .
doi: 10.1016/S1474-4422(15)00135-0. Epub 2015 Jun 29. PubMed PMID: 26139022 ; PubMed Central PMCID: PMC4519011 .
Quiroz YT, Schultz AP, Chen K, Protas HD, Brickhouse M, Fleisher AS, Langbaum JB, Thiyyagura P, Fagan AM, Shah AR, Muniz M, Arboleda-Velasquez JF, Munoz C, Garcia G, Acosta-Baena N, Giraldo M, Tirado V, Ramírez DL, Tariot PN, Dickerson BC, Sperling RA, Lopera F, Reiman EM. Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study. JAMA Neurol .
2015 Aug; 72 (8) :912-9 .
doi: 10.1001/jamaneurol.2015.1099. PubMed PMID: 26121081 ; PubMed Central PMCID: PMC4625544 .
Cairns NJ, Perrin RJ, Franklin EE, Carter D, Vincent B, Xie M, Bateman RJ, Benzinger T, Friedrichsen K, Brooks WS, Halliday GM, McLean C, Ghetti B, Morris JC. Neuropathologic assessment of participants in two multi-center longitudinal observational studies: the Alzheimer Disease Neuroimaging Initiative (ADNI) and the Dominantly Inherited Alzheimer Network (DIAN). Neuropathology .
2015 Aug; 35 (4) :390-400 .
doi: 10.1111/neup.12205. Epub 2015 May 12. PubMed PMID: 25964057 ; PubMed Central PMCID: PMC4521391 .
Laske C, Sohrabi HR, Jasielec MS, Müller S, Koehler NK, Gräber S, Förster S, Drzezga A, Mueller-Sarnowski F, Danek A, Jucker M, Bateman RJ, Buckles V, Saykin AJ, Martins RN, Morris JC, Dominantly Inherited Alzheimer Network Dian. Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer’s Disease: Results of the DIAN Study. Biomed Res Int .
2015; 2015 :828120 .
doi: 10.1155/2015/828120. Epub 2015 Apr 2. PubMed PMID: 25922840 ; PubMed Central PMCID: PMC4398930 .
Ringman JM, Liang LJ, Zhou Y, Vangala S, Teng E, Kremen S, Wharton D, Goate A, Marcus DS, Farlow M, Ghetti B, McDade E, Masters CL, Mayeux RP, Rossor M, Salloway S, Schofield PR, Cummings JL, Buckles V, Bateman R, Morris JC. Early behavioural changes in familial Alzheimer’s disease in the Dominantly Inherited Alzheimer Network. Brain .
2015 Apr; 138 (Pt 4) :1036-45 .
doi: 10.1093/brain/awv004. Epub 2015 Feb 15. PubMed PMID: 25688083 ; PubMed Central PMCID: PMC4963801 .
Monserrate AE, Ryman DC, Ma S, Xiong C, Noble JM, Ringman JM, Morris JC, Danek A, Müller-Sarnowski F, Clifford DB, McDade EM, Brooks WS, Darby DG, Masters CL, Weston PS, Farlow MR, Graff-Radford NR, Salloway SP, Fagan AM, Oliver A, Bateman RJ. Factors associated with the onset and persistence of post-lumbar puncture headache. JAMA Neurol .
2015 Mar; 72 (3) :325-32 .
doi: 10.1001/jamaneurol.2014.3974. PubMed PMID: 25622095 ; PubMed Central PMCID: PMC4364538 .
Fleisher AS, Chen K, Quiroz YT, Jakimovich LJ, Gutierrez Gomez M, Langois CM, Langbaum JB, Roontiva A, Thiyyagura P, Lee W, Ayutyanont N, Lopez L, Moreno S, Muñoz C, Tirado V, Acosta-Baena N, Fagan AM, Giraldo M, Garcia G, Huentelman MJ, Tariot PN, Lopera F, Reiman EM. Associations between biomarkers and age in the presenilin 1 E280A autosomal dominant Alzheimer disease kindred: a cross-sectional study. JAMA Neurol .
2015 Mar; 72 (3) :316-24 .
doi: 10.1001/jamaneurol.2014.3314. PubMed PMID: 25580592 ; PubMed Central PMCID: PMC4355261 .
Su Y, Blazey TM, Snyder AZ, Raichle ME, Marcus DS, Ances BM, Bateman RJ, Cairns NJ, Aldea P, Cash L, Christensen JJ, Friedrichsen K, Hornbeck RC, Farrar AM, Owen CJ, Mayeux R, Brickman AM, Klunk W, Price JC, Thompson PM, Ghetti B, Saykin AJ, Sperling RA, Johnson KA, Schofield PR, Buckles V, Morris JC, Benzinger TLS. Partial volume correction in quantitative amyloid imaging. Neuroimage .
2015 Feb 15; 107 :55-64 .
doi: 10.1016/j.neuroimage.2014.11.058. Epub 2014 Dec 5. PubMed PMID: 25485714 ; PubMed Central PMCID: PMC4300252 .
Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol .
2015 Feb; 72 (2) :209-16 .
doi: 10.1001/jamaneurol.2014.2157. PubMed PMID: 25531812 ; PubMed Central PMCID: PMC4324097 .
Chatterjee P, Gupta VB, Fagan AM, Jasielec MS, Xiong C, Sohrabi HR, Dhaliwal S, Taddei K, Bourgeat P, Brown BM, Benzinger T, Bateman RJ, Morris JC, Martins RN. Decreased platelet APP isoform ratios in autosomal dominant Alzheimer’s disease: baseline data from a DIAN cohort subset. Curr Alzheimer Res .
2015; 12 (2) :157-64 .
PubMed PMID: 25654503 ; PubMed Central PMCID: PMC4383703 .
Klunk WE, Koeppe RA, Price JC, Benzinger TL, Devous MD Sr, Jagust WJ, Johnson KA, Mathis CA, Minhas D, Pontecorvo MJ, Rowe CC, Skovronsky DM, Mintun MA. The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET. Alzheimers Dement .
2015 Jan; 11 (1) :1-15.e1-4 .
doi: 10.1016/j.jalz.2014.07.003. Epub 2014 Oct 28. PubMed PMID: 25443857 ; PubMed Central PMCID: PMC4300247 .
Thomas JB, Brier MR, Bateman RJ, Snyder AZ, Benzinger TL, Xiong C, Raichle M, Holtzman DM, Sperling RA, Mayeux R, Ghetti B, Ringman JM, Salloway S, McDade E, Rossor MN, Ourselin S, Schofield PR, Masters CL, Martins RN, Weiner MW, Thompson PM, Fox NC, Koeppe RA, Jack CR Jr, Mathis CA, Oliver A, Blazey TM, Moulder K, Buckles V, Hornbeck R, Chhatwal J, Schultz AP, Goate AM, Fagan AM, Cairns NJ, Marcus DS, Morris JC, Ances BM. Functional connectivity in autosomal dominant and late-onset Alzheimer disease. JAMA Neurol .
2014 Sep; 71 (9) :1111-22 .
doi: 10.1001/jamaneurol.2014.1654. PubMed PMID: 25069482 ; PubMed Central PMCID: PMC4240274 .
Ryman DC, Acosta-Baena N, Aisen PS, Bird T, Danek A, Fox NC, Goate A, Frommelt P, Ghetti B, Langbaum JB, Lopera F, Martins R, Masters CL, Mayeux RP, McDade E, Moreno S, Reiman EM, Ringman JM, Salloway S, Schofield PR, Sperling R, Tariot PN, Xiong C, Morris JC, Bateman RJ. Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology .
2014 Jul 15; 83 (3) :253-60 .
doi: 10.1212/WNL.0000000000000596. Epub 2014 Jun 13. Review. PubMed PMID: 24928124 ; PubMed Central PMCID: PMC4117367 .
Yu P, Sun J, Wolz R, Stephenson D, Brewer J, Fox NC, Cole PE, Jack CR Jr, Hill DL, Schwarz AJ. Operationalizing hippocampal volume as an enrichment biomarker for amnestic mild cognitive impairment trials: effect of algorithm, test-retest variability, and cut point on trial cost, duration, and sample size. Neurobiol Aging .
2014 Apr; 35 (4) :808-18 .
doi: 10.1016/j.neurobiolaging.2013.09.039. Epub 2013 Oct 3. PubMed PMID: 24211008 ; PubMed Central PMCID: PMC4201941 .
Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TL, Ghetti B, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Salloway S, Schofield PR, Sperling RA, Marcus D, Cairns NJ, Buckles VD, Ladenson JH, Morris JC, Holtzman DM. Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer’s disease. Sci Transl Med .
2014 Mar 5; 6 (226) :226ra30 .
doi: 10.1126/scitranslmed.3007901. PubMed PMID: 24598588 ; PubMed Central PMCID: PMC4038930 .
Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S, Jeng AT, Cooper B, Skorupa T, Carrell D, Levitch D, Hsu S, Choi J, Ryten M, Sassi C, Bras J, Gibbs RJ, Hernandez DG, Lupton MK, Powell J, Forabosco P, Ridge PG, Corcoran CD, Tschanz JT, Norton MC, Munger RG, Schmutz C, Leary M, Demirci FY, Bamne MN, Wang X, Lopez OL, Ganguli M, Medway C, Turton J, Lord J, Braae A, Barber I, Brown K, Pastor P, Lorenzo-Betancor O, Brkanac Z, Scott E, Topol E, Morgan K, Rogaeva E, Singleton A, Hardy J, Kamboh MI, George-Hyslop PS, Cairns N, Morris JC, Kauwe JSK, Goate AM. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease. Nature .
2014 Jan 23; 505 (7484) :550-554 .
doi: 10.1038/nature12825. Epub 2013 Dec 11. PubMed PMID: 24336208 ; PubMed Central PMCID: PMC4050701 .
Ting SK, Benzinger T, Kepe V, Fagan A, Coppola G, Porter V, Hecimovic S, Chakraverty S, Alvarez-Retuerto AI, Goate A, Ringman JM. A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer’s disease in an African-American woman. J Alzheimers Dis .
2014; 40 (2) :271-5 .
doi: 10.3233/JAD-131844. PubMed PMID: 24413619 ; PubMed Central PMCID: PMC3972314 .
Royle NA, Booth T, Valdés Hernández MC, Penke L, Murray C, Gow AJ, Maniega SM, Starr J, Bastin ME, Deary IJ, Wardlaw JM. Estimated maximal and current brain volume predict cognitive ability in old age. Neurobiol Aging .
2013 Dec; 34 (12) :2726-33 .
doi: 10.1016/j.neurobiolaging.2013.05.015. Epub 2013 Jul 11. PubMed PMID: 23850342 ; PubMed Central PMCID: PMC3988920 .
Benzinger TL, Blazey T, Jack CR Jr, Koeppe RA, Su Y, Xiong C, Raichle ME, Snyder AZ, Ances BM, Bateman RJ, Cairns NJ, Fagan AM, Goate A, Marcus DS, Aisen PS, Christensen JJ, Ercole L, Hornbeck RC, Farrar AM, Aldea P, Jasielec MS, Owen CJ, Xie X, Mayeux R, Brickman A, McDade E, Klunk W, Mathis CA, Ringman J, Thompson PM, Ghetti B, Saykin AJ, Sperling RA, Johnson KA, Salloway S, Correia S, Schofield PR, Masters CL, Rowe C, Villemagne VL, Martins R, Ourselin S, Rossor MN, Fox NC, Cash DM, Weiner MW, Holtzman DM, Buckles VD, Moulder K, Morris JC. Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease. Proc Natl Acad Sci U S A .
2013 Nov 19; 110 (47) :E4502-9 .
doi: 10.1073/pnas.1317918110. Epub 2013 Nov 5. PubMed PMID: 24194552 ; PubMed Central PMCID: PMC3839740 .
Cash DM, Ridgway GR, Liang Y, Ryan NS, Kinnunen KM, Yeatman T, Malone IB, Benzinger TL, Jack CR Jr, Thompson PM, Ghetti BF, Saykin AJ, Masters CL, Ringman JM, Salloway SP, Schofield PR, Sperling RA, Cairns NJ, Marcus DS, Xiong C, Bateman RJ, Morris JC, Rossor MN, Ourselin S, Fox NC. The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study. Neurology .
2013 Oct 15; 81 (16) :1425-33 .
doi: 10.1212/WNL.0b013e3182a841c6. Epub 2013 Sep 18. PubMed PMID: 24049139 ; PubMed Central PMCID: PMC3806583 .
Shimada H. [The DIAN study]. Brain Nerve .
2013 Oct; 65 (10) :1179-84 .
Review. PubMed PMID: 24101429 .
Mills SM, Mallmann J, Santacruz AM, Fuqua A, Carril M, Aisen PS, Althage MC, Belyew S, Benzinger TL, Brooks WS, Buckles VD, Cairns NJ, Clifford D, Danek A, Fagan AM, Farlow M, Fox N, Ghetti B, Goate AM, Heinrichs D, Hornbeck R, Jack C, Jucker M, Klunk WE, Marcus DS, Martins RN, Masters CM, Mayeux R, McDade E, Morris JC, Oliver A, Ringman JM, Rossor MN, Salloway S, Schofield PR, Snider J, Snyder P, Sperling RA, Stewart C, Thomas RG, Xiong C, Bateman RJ. Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial. Rev Neurol (Paris) .
2013 Oct; 169 (10) :737-43 .
doi: 10.1016/j.neurol.2013.07.017. Epub 2013 Sep 6. Review. PubMed PMID: 24016464 ; PubMed Central PMCID: PMC3880800 .
Wang L, Brier MR, Snyder AZ, Thomas JB, Fagan AM, Xiong C, Benzinger TL, Holtzman DM, Morris JC, Ances BM. Cerebrospinal fluid Aβ42, phosphorylated Tau181, and resting-state functional connectivity. JAMA Neurol .
2013 Oct; 70 (10) :1242-8 .
doi: 10.1001/jamaneurol.2013.3253. PubMed PMID: 23959173 ; PubMed Central PMCID: PMC3836828 .
Chhatwal JP, Schultz AP, Johnson K, Benzinger TL, Jack C Jr, Ances BM, Sullivan CA, Salloway SP, Ringman JM, Koeppe RA, Marcus DS, Thompson P, Saykin AJ, Correia S, Schofield PR, Rowe CC, Fox NC, Brickman AM, Mayeux R, McDade E, Bateman R, Fagan AM, Goate AM, Xiong C, Buckles VD, Morris JC, Sperling RA. Impaired default network functional connectivity in autosomal dominant Alzheimer disease. Neurology .
2013 Aug 20; 81 (8) :736-44 .
doi: 10.1212/WNL.0b013e3182a1aafe. Epub 2013 Jul 24. PubMed PMID: 23884042 ; PubMed Central PMCID: PMC3776464 .
Morris JC, Aisen PS, Bateman RJ, Benzinger TL, Cairns NJ, Fagan AM, Ghetti B, Goate AM, Holtzman DM, Klunk WE, McDade E, Marcus DS, Martins RN, Masters CL, Mayeux R, Oliver A, Quaid K, Ringman JM, Rossor MN, Salloway S, Schofield PR, Selsor NJ, Sperling RA, Weiner MW, Xiong C, Moulder KL, Buckles VD. Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network. Clin Investig (Lond) .
2012 Oct 1; 2 (10) :975-984 .
doi: 10.4155/cli.12.93. PubMed PMID: 23139856 ; PubMed Central PMCID: PMC3489185 .
Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, Aisen PS, Ghetti B, Klunk WE, McDade E, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Schofield PR, Sperling RA, Salloway S, Morris JC. Clinical and biomarker changes in dominantly inherited Alzheimer’s disease. N Engl J Med .
2012 Aug 30; 367 (9) :795-804 .
doi: 10.1056/NEJMoa1202753. Epub 2012 Jul 11. PubMed PMID: 22784036 ; PubMed Central PMCID: PMC3474597 .
Ryan NS, Bastos-Leite AJ, Rohrer JD, Werring DJ, Fox NC, Rossor MN, Schott JM. Cerebral microbleeds in familial Alzheimer’s disease. Brain .
2012 Jan; 135 (Pt 1) :e201; author reply e202 .
doi: 10.1093/brain/awr126. Epub 2011 Jun 17. PubMed PMID: 21685457 ; PubMed Central PMCID: PMC3859452 .