DIAN Observational Study Publications

Below is a list of publications (by publication date) that are fundamental to DIAN. As the study progresses, publications based upon DIAN’s research will be posted here as well.

  1. Araque Caballero MÁ, Suárez-Calvet M, Duering M, Franzmeier N, Benzinger T, Fagan AM, Bateman RJ, Jack CR, Levin J, Dichgans M, Jucker M, Karch C, Masters CL, Morris JC, Weiner M, Rossor M, Fox NC, Lee JH, Salloway S, Danek A, Goate A, Yakushev I, Hassenstab J, Schofield PR, Haass C, Ewers M. White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease. Brain. 2018 Oct 1;141(10):3065-3080. doi: 10.1093/brain/awy229. PubMed PMID: 30239611; PubMed Central PMCID: PMC6158739.
  2. Wang G, Berry S, Xiong C, Hassenstab J, Quintana M, McDade EM, Delmar P, Vestrucci M, Sethuraman G, Bateman RJ; Dominantly Inherited Alzheimer Network Trials Unit.. A novel cognitive disease progression model for clinical trials in autosomal-dominant Alzheimer’s disease. Stat Med. 2018 Sep 20;37(21):3047-3055. doi: 10.1002/sim.7811. Epub 2018 May 14. PubMed PMID: 29761523; PubMed Central PMCID: PMC6105413.
  3. Lim YY, Hassenstab J, Goate A, Fagan AM, Benzinger TLS, Cruchaga C, McDade E, Chhatwal J, Levin J, Farlow MR, Graff-Radford NR, Laske C, Masters CL, Salloway S, Schofield P, Morris JC, Maruff P, Bateman RJ; Dominantly Inherited Alzheimer Network.. Effect of BDNFVal66Met on disease markers in dominantly inherited Alzheimer’s disease. Ann Neurol. 2018 Sep;84(3):424-435. doi: 10.1002/ana.25299. Epub 2018 Aug 25. PubMed PMID: 30014553; PubMed Central PMCID: PMC6153076.
  4. Karch CM, Hernández D, Wang JC, Marsh J, Hewitt AW, Hsu S, Norton J, Levitch D, Donahue T, Sigurdson W, Ghetti B, Farlow M, Chhatwal J, Berman S, Cruchaga C, Morris JC, Bateman RJ; Dominantly Inherited Alzheimer Network (DIAN)., Pébay A, Goate AM. Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network. Alzheimers Res Ther. 2018 Jul 25;10(1):69. doi: 10.1186/s13195-018-0400-0. PubMed PMID: 30045758; PubMed Central PMCID: PMC6060509.
  5. Hsu S, Gordon BA, Hornbeck R, Norton JB, Levitch D, Louden A, Ziegemeier E, Laforce R Jr, Chhatwal J, Day GS, McDade E, Morris JC, Fagan AM, Benzinger TLS, Goate AM, Cruchaga C, Bateman RJ; Dominantly Inherited Alzheimer Network (DIAN)., Karch CM. Discovery and validation of autosomal dominant Alzheimer’s disease mutations. Alzheimers Res Ther. 2018 Jul 18;10(1):67. doi: 10.1186/s13195-018-0392-9. PubMed PMID: 30021643; PubMed Central PMCID: PMC6052673.
  6. Vlassenko AG, Gordon BA, Goyal MS, Su Y, Blazey TM, Durbin TJ, Couture LE, Christensen JJ, Jafri H, Morris JC, Raichle ME, Benzinger TL. Aerobic glycolysis and tau deposition in preclinical Alzheimer’s disease. Neurobiol Aging. 2018 Jul;67:95-98. doi: 10.1016/j.neurobiolaging.2018.03.014. Epub 2018 Mar 20. PubMed PMID: 29655050; PubMed Central PMCID: PMC5955846.
  7. Li Z, Del-Aguila JL, Dube U, Budde J, Martinez R, Black K, Xiao Q, Cairns NJ; Dominantly Inherited Alzheimer Network (DIAN)., Dougherty JD, Lee JM, Morris JC, Bateman RJ, Karch CM, Cruchaga C, Harari O. Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure. Genome Med. 2018 Jun 8;10(1):43. doi: 10.1186/s13073-018-0551-4. PubMed PMID: 29880032; PubMed Central PMCID: PMC5992755.
  8. Lee S, Zimmerman ME, Narkhede A, Nasrabady SE, Tosto G, Meier IB, Benzinger TLS, Marcus DS, Fagan AM, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, Martins RN, Saykin AJ, Masters CL, Ringman JM, Fӧrster S, Schofield PR, Sperling RA, Johnson KA, Chhatwal JP, Salloway S, Correia S, Jack CR Jr, Weiner M, Bateman RJ, Morris JC, Mayeux R, Brickman AM; Dominantly Inherited Alzheimer Network.. White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer’s disease. PLoS One. 2018 May 9;13(5):e0195838. doi: 10.1371/journal.pone.0195838. eCollection 2018. PubMed PMID: 29742105; PubMed Central PMCID: PMC5942789.
  9. Villeneuve S, Vogel JW, Gonneaud J, Pichet Binette A, Rosa-Neto P, Gauthier S, Bateman RJ, Fagan AM, Morris JC, Benzinger TLS, Johnson SC, Breitner JCS, Poirier J; Presymptomatic Evaluation of Novel or Experimental Treatments for Alzheimer Disease (PREVENT-AD) Research Group.. Proximity to Parental Symptom Onset and Amyloid-β Burden in Sporadic Alzheimer Disease.JAMA Neurol. 2018 May 1;75(5):608-619. doi: 10.1001/jamaneurol.2017.5135. PubMed PMID: 29482212; PubMed Central PMCID: PMC5885216.
  10. Chhatwal JP, Schultz AP, Johnson KA, Hedden T, Jaimes S, Benzinger TLS, Jack C Jr, Ances BM, Ringman JM, Marcus DS, Ghetti B, Farlow MR, Danek A, Levin J, Yakushev I, Laske C, Koeppe RA, Galasko DR, Xiong C, Masters CL, Schofield PR, Kinnunen KM, Salloway S, Martins RN, McDade E, Cairns NJ, Buckles VD, Morris JC, Bateman R, Sperling RA; Dominantly Inherited Alzheimer Network.. Preferential degradation of cognitive networks differentiates Alzheimer’s disease from ageing. Brain. 2018 May 1;141(5):1486-1500. doi: 10.1093/brain/awy053. PubMed PMID: 29522171; PubMed Central PMCID: PMC5917745.
  11. Oxtoby NP, Young AL, Cash DM, Benzinger TLS, Fagan AM, Morris JC, Bateman RJ, Fox NC, Schott JM, Alexander DC. Data-driven models of dominantly-inherited Alzheimer’s disease progression. Brain. 2018 May 1;141(5):1529-1544. doi: 10.1093/brain/awy050. PubMed PMID: 29579160; PubMed Central PMCID: PMC5920320.
  12. Petok JR, Myers CE, Pa J, Hobel Z, Wharton DM, Medina LD, Casado M, Coppola G, Gluck MA, Ringman JM. Impairment of memory generalization in preclinical autosomal dominant Alzheimer’s disease mutation carriers. Neurobiol Aging. 2018 May;65:149-157. doi: 10.1016/j.neurobiolaging.2018.01.022. Epub 2018 Feb 8. PubMed PMID: 29494861; PubMed Central PMCID: PMC5871602.
  13. Su Y, Flores S, Hornbeck RC, Speidel B, Vlassenko AG, Gordon BA, Koeppe RA, Klunk WE, Xiong C, Morris JC, Benzinger TLS. Utilizing the Centiloid scale in cross-sectional and longitudinal PiB PET studies. Neuroimage Clin. 2018 Apr 25;19:406-416. doi: 10.1016/j.nicl.2018.04.022. eCollection 2018. PubMed PMID: 30035025; PubMed Central PMCID: PMC6051499.
  14. Franzmeier N, Düzel E, Jessen F, Buerger K, Levin J, Duering M, Dichgans M, Haass C, Suárez-Calvet M, Fagan AM, Paumier K, Benzinger T, Masters CL, Morris JC, Perneczky R, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Teipel S, Kilimann I, Ramirez A, Rossor M, Jucker M, Chhatwal J, Spottke A, Boecker H, Brosseron F, Falkai P, Fliessbach K, Heneka MT, Laske C, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Kofler B, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Weiner M, Lee JH, Salloway S, Danek A, Goate A, Schofield PR, Bateman RJ, Ewers M. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease. Brain. 2018 Apr 1;141(4):1186-1200. doi: 10.1093/brain/awy008. PubMed PMID: 29462334; PubMed Central PMCID: PMC5888938.
  15. Xiong C, Luo J, Chen L, Gao F, Liu J, Wang G, Bateman R, Morris JC. Estimating diagnostic accuracy for clustered ordinal diagnostic groups in the three-class case-Application to the early diagnosis of Alzheimer disease. Stat Methods Med Res. 2018 Mar;27(3):701-714. doi: 10.1177/0962280217742539. Epub 2017 Nov 28. PubMed PMID: 29182052; PubMed Central PMCID: PMC5841923.
  16. Gordon BA, Blazey TM, Su Y, Hari-Raj A, Dincer A, Flores S, Christensen J, McDade E, Wang G, Xiong C, Cairns NJ, Hassenstab J, Marcus DS, Fagan AM, Jack CR Jr, Hornbeck RC, Paumier KL, Ances BM, Berman SB, Brickman AM, Cash DM, Chhatwal JP, Correia S, Förster S, Fox NC, Graff-Radford NR, la Fougère C, Levin J, Masters CL, Rossor MN, Salloway S, Saykin AJ, Schofield PR, Thompson PM, Weiner MM, Holtzman DM, Raichle ME, Morris JC, Bateman RJ, Benzinger TLS. Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer’s disease: a longitudinal study.Lancet Neurol. 2018 Mar;17(3):241-250. doi: 10.1016/S1474-4422(18)30028-0. Epub 2018 Feb 1. PubMed PMID: 29397305; PubMed Central PMCID: PMC5816717.
  17. Cruchaga C, Del-Aguila JL, Saef B, Black K, Fernandez MV, Budde J, Ibanez L, Deming Y, Kapoor M, Tosto G, Mayeux RP, Holtzman DM, Fagan AM, Morris JC, Bateman RJ, Goate AM; Dominantly Inherited Alzheimer Network (DIAN).; Disease Neuroimaging Initiative (ADNI).; NIA-LOAD family study., Harari O. Polygenic risk score of sporadic late-onset Alzheimer’s disease reveals a shared architecture with the familial and early-onset forms. Alzheimers Dement. 2018 Feb;14(2):205-214. doi: 10.1016/j.jalz.2017.08.013. Epub 2017 Sep 21. PubMed PMID: 28943286; PubMed Central PMCID: PMC5803427.
  18. Martins RN, Villemagne V, Sohrabi HR, Chatterjee P, Shah TM, Verdile G, Fraser P, Taddei K, Gupta VB, Rainey-Smith SR, Hone E, Pedrini S, Lim WL, Martins I, Frost S, Gupta S, O’Bryant S, Rembach A, Ames D, Ellis K, Fuller SJ, Brown B, Gardener SL, Fernando B, Bharadwaj P, Burnham S, Laws SM, Barron AM, Goozee K, Wahjoepramono EJ, Asih PR, Doecke JD, Salvado O, Bush AI, Rowe CC, Gandy SE, Masters CL. Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies. J Alzheimers Dis. 2018;62(3):965-992. doi: 10.3233/JAD-171145. PubMed PMID: 29562546; PubMed Central PMCID: PMC5870031.
  19. Kinnunen KM, Cash DM, Poole T, Frost C, Benzinger TLS, Ahsan RL, Leung KK, Cardoso MJ, Modat M, Malone IB, Morris JC, Bateman RJ, Marcus DS, Goate A, Salloway SP, Correia S, Sperling RA, Chhatwal JP, Mayeux RP, Brickman AM, Martins RN, Farlow MR, Ghetti B, Saykin AJ, Jack CR Jr, Schofield PR, McDade E, Weiner MW, Ringman JM, Thompson PM, Masters CL, Rowe CC, Rossor MN, Ourselin S, Fox NC; Dominantly Inherited Alzheimer Network (DIAN).. Presymptomatic atrophy in autosomal dominant Alzheimer’s disease: A serial magnetic resonance imaging study. Alzheimers Dement. 2018 Jan;14(1):43-53. doi: 10.1016/j.jalz.2017.06.2268. Epub 2017 Jul 22. PubMed PMID: 28738187; PubMed Central PMCID: PMC5751893.
  20. Yan L, Liu CY, Wong KP, Huang SC, Mack WJ, Jann K, Coppola G, Ringman JM, Wang DJJ. Regional association of pCASL-MRI with FDG-PET and PiB-PET in people at risk for autosomal dominant Alzheimer’s disease. Neuroimage Clin. 2017 Dec 6;17:751-760. doi: 10.1016/j.nicl.2017.12.003. eCollection 2018. PubMed PMID: 29527482; PubMed Central PMCID: PMC5842754.
  21. Brown BM, Sohrabi HR, Taddei K, Gardener SL, Rainey-Smith SR, Peiffer JJ, Xiong C, Fagan AM, Benzinger T, Buckles V, Erickson KI, Clarnette R, Shah T, Masters CL, Weiner M, Cairns N, Rossor M, Graff-Radford NR, Salloway S, Vöglein J, Laske C, Noble J, Schofield PR, Bateman RJ, Morris JC, Martins RN; Dominantly Inherited Alzheimer Network.. Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer’s disease. Alzheimers Dement. 2017 Nov;13(11):1197-1206. doi: 10.1016/j.jalz.2017.03.008. Epub 2017 May 11. PubMed PMID: 28501451; PubMed Central PMCID: PMC5675772.
  22. Ringman JM, Casado M, Van Berlo V, Pa J, Joseph-Mathurin N, Fagan AM, Benzinger T, Bateman RJ, Morris JC. A novel PSEN1 (S230N) mutation causing early-onset Alzheimer’s Disease associated with prosopagnosia, hoarding, and Parkinsonism. Neurosci Lett. 2017 Sep 14;657:11-15. doi: 10.1016/j.neulet.2017.07.046. Epub 2017 Jul 29. PubMed PMID: 28764909; PubMed Central PMCID: PMC5731478.
  23. Gao F, Philip Miller J, Xiong C, Luo J, Beiser JA, Chen L, Gordon MO. Estimating correlation between multivariate longitudinal data in the presence of heterogeneity. BMC Med Res Methodol. 2017 Aug 17;17(1):124. doi: 10.1186/s12874-017-0398-1. PubMed PMID: 28818061; PubMed Central PMCID: PMC5561646.
  24. Goyal MS, Vlassenko AG, Blazey TM, Su Y, Couture LE, Durbin TJ, Bateman RJ, Benzinger TL, Morris JC, Raichle ME. Loss of Brain Aerobic Glycolysis in Normal Human Aging. Cell Metab. 2017 Aug 1;26(2):353-360.e3. doi: 10.1016/j.cmet.2017.07.010. PubMed PMID: 28768174; PubMed Central PMCID: PMC5573225.
  25. Shimada H, Shoji M, Ikeuchi T, Suzuki K, Senda M, Ishii K, Matsuda H, Iwata A, Ihara R, Iwatsubo T, Mutoh K, Nakazawa E, Sekijima Y, Mori E, Ikeda M, Ikeda M, Kawakatsu S, Nakanishi A, Hashimoto M, Nunomura A, Matsubara E, Fukui M, Shirato T, Hirai K, Sakamoto M, Fujii H, Mori H. [DIAN/DIAN-J/DIAN-TU]. Brain Nerve. 2017 Jul;69(7):701-709. doi: 10.11477/mf.1416200811. Japanese. PubMed PMID: 28739983.
  26. Weng H, Bateman R, Morris JC, Xiong C. Validity and power of minimization algorithm in longitudinal analysis of clinical trials.Biostat Epidemiol. 2017;1(1):59-77. doi: 10.1080/24709360.2017.1331822. Epub 2017 Jun 13. PubMed PMID: 29250611; PubMed Central PMCID: PMC5730087.
  27. Xiong C, Luo J, Morris JC, Bateman R. Linear Combinations of Multiple Outcome Measures to Improve the Power of Efficacy Analysis —Application to Clinical Trials on Early Stage Alzheimer Disease. Biostat Epidemiol. 2017;1(1):36-58. doi: 10.1080/24709360.2017.1331821. Epub 2017 Jun 2. PubMed PMID: 29546251; PubMed Central PMCID: PMC5849424.
  28. Day GS, Gordon BA, Jackson K, Christensen JJ, Rosana Ponisio M, Su Y, Ances BM, Benzinger TLS, Morris JC. Tau-PET Binding Distinguishes Patients With Early-stage Posterior Cortical Atrophy From Amnestic Alzheimer Disease Dementia. Alzheimer Dis Assoc Disord. 2017 Apr-Jun;31(2):87-93. doi: 10.1097/WAD.0000000000000196. PubMed PMID: 28394771; PubMed Central PMCID: PMC5443698.
  29. Ng KP, Pascoal TA, Mathotaarachchi S, Chung CO, Benedet AL, Shin M, Kang MS, Li X, Ba M, Kandiah N, Rosa-Neto P, Gauthier S; Alzheimer’s Disease Neuroimaging Initiative.. Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease. Neurology. 2017 May 9;88(19):1814-1821. doi: 10.1212/WNL.0000000000003916. Epub 2017 Apr 12. PubMed PMID: 28404803; PubMed Central PMCID: PMC5419982.
  30. Müller S, Preische O, Sohrabi HR, Gräber S, Jucker M, Dietzsch J, Ringman JM, Martins RN, McDade E, Schofield PR, Ghetti B, Rossor M, Graff-Radford NR, Levin J, Galasko D, Quaid KA, Salloway S, Xiong C, Benzinger T, Buckles V, Masters CL, Sperling R, Bateman RJ, Morris JC, Laske C. Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer’s disease.Sci Rep. 2017 Apr 27;7(1):1225. doi: 10.1038/s41598-017-01327-w. PubMed PMID: 28450713; PubMed Central PMCID: PMC5430642.
  31. Su Y, Vlassenko AG, Couture LE, Benzinger TL, Snyder AZ, Derdeyn CP, Raichle ME. Quantitative hemodynamic PET imaging using image-derived arterial input function and a PET/MR hybrid scanner. J Cereb Blood Flow Metab. 2017 Apr;37(4):1435-1446. doi: 10.1177/0271678X16656200. Epub 2016 Jan 1. PubMed PMID: 27401805; PubMed Central PMCID: PMC5453463.
  32. Jack CR Jr, Wiste HJ, Weigand SD, Therneau TM, Lowe VJ, Knopman DS, Gunter JL, Senjem ML, Jones DT, Kantarci K, Machulda MM, Mielke MM, Roberts RO, Vemuri P, Reyes DA, Petersen RC. Defining imaging biomarker cut points for brain aging and Alzheimer’s disease. Alzheimers Dement. 2017 Mar;13(3):205-216. doi: 10.1016/j.jalz.2016.08.005. Epub 2016 Sep 30. PubMed PMID: 27697430; PubMed Central PMCID: PMC5344738.
  33. Gurney J, Olsen T, Flavin J, Ramaratnam M, Archie K, Ransford J, Herrick R, Wallace L, Cline J, Horton W, Marcus DS. The Washington University Central Neuroimaging Data Archive. Neuroimage. 2017 Jan;144(Pt B):287-293. doi: 10.1016/j.neuroimage.2015.09.060. Epub 2015 Oct 9. PubMed PMID: 26439514; PubMed Central PMCID: PMC4967044.
  34. Bateman RJ, Benzinger TL, Berry S, Clifford DB, Duggan C, Fagan AM, Fanning K, Farlow MR, Hassenstab J, McDade EM, Mills S, Paumier K, Quintana M, Salloway SP, Santacruz A, Schneider LS, Wang G, Xiong C; DIAN-TU Pharma Consortium for the Dominantly Inherited Alzheimer Network.. The DIAN-TU Next Generation Alzheimer’s prevention trial: Adaptive design and disease progression model. Alzheimers Dement. 2017 Jan;13(1):8-19. doi: 10.1016/j.jalz.2016.07.005. Epub 2016 Aug 29. PubMed PMID: 27583651; PubMed Central PMCID: PMC5218895.
  35. Natelson Love M, Clark DG, Cochran JN, Den Beste KA, Geldmacher DS, Benzinger TL, Gordon BA, Morris JC, Bateman RJ, Roberson ED. Clinical, imaging, pathological, and biochemical characterization of a novel presenilin 1 mutation (N135Y) causing Alzheimer’s disease. Neurobiol Aging. 2017 Jan;49:216.e7-216.e13. doi: 10.1016/j.neurobiolaging.2016.09.020. Epub 2016 Oct 3. PubMed PMID: 27793474; PubMed Central PMCID: PMC5154842.
  36. Suárez-Calvet M, Araque Caballero MÁ, Kleinberger G, Bateman RJ, Fagan AM, Morris JC, Levin J, Danek A, Ewers M, Haass C; Dominantly Inherited Alzheimer Network.. Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury. Sci Transl Med. 2016 Dec 14;8(369):369ra178. PubMed PMID: 27974666; PubMed Central PMCID: PMC5385711.
  37. Tang M, Ryman DC, McDade E, Jasielec MS, Buckles VD, Cairns NJ, Fagan AM, Goate A, Marcus DS, Xiong C, Allegri RF, Chhatwal JP, Danek A, Farlow MR, Fox NC, Ghetti B, Graff-Radford NR, Laske C, Martins RN, Masters CL, Mayeux RP, Ringman JM, Rossor MN, Salloway SP, Schofield PR, Morris JC, Bateman RJ; Dominantly Inherited Alzheimer Network (DIAN). Neurological manifestations of autosomal dominant familial Alzheimer’s disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS). Lancet Neurol. 2016 Dec;15(13):1317-1325. doi: 10.1016/S1474-4422(16)30229-0. Epub 2016 Oct 21. Review. PubMed PMID: 27777020; PubMed Central PMCID: PMC5116769.
  38. Chen L, Sun J, Xiong C. A multiple imputation approach to the analysis of clustered interval-censored failure time data with the additive hazards model. Comput Stat Data Anal. 2016 Nov;103:242-249. Epub 2016 May 28. PubMed PMID: 27773956; PubMed Central PMCID: PMC5072417.
  39. Soosman SK, Joseph-Mathurin N, Braskie MN, Bordelon YM, Wharton D, CasadoM, Coppola G, McCallum H, Nuwer M, Coutin-Churchman P, Apostolova LG, Benzinger T, Ringman JM. Widespread white matter and conduction defects in PSEN1-related spastic paraparesis. Neurobiol Aging. 2016 Aug 8; 47:201-209. PMCID: PMC5075491.
  40. Lee S, Viqar F, Zimmerman ME, Narkhede A, Tosto G, Benzinger TL, Marcus DS, Fagan AM, Goate A, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, Martins RN, Saykin AJ, Masters CL, Ringman JM, Ryan NS, Förster S, Laske C, Schofield PR, Sperling RA, Salloway S, Correia S, Jack C Jr, Weiner M, Bateman RJ, Morris JC, Mayeux R, Brickman AM; Dominantly Inherited Alzheimer Network. White matter hyperintensities are a core feature of Alzheimer’s disease: Evidence from the dominantly inherited Alzheimer network. Ann Neurol. 2016 Jun;79(6):929-39. PMCID: PMC4884146.
  41. Su Y, Blazey TM, Owen CJ, Christensen JJ, Friedrichsen K, Joseph-Mathurin N, Wang Q, Hornbeck RC, Ances BM, Snyder AZ, Cash LA, Koeppe RA, Klunk WE, Galasko D, Brickman AM, McDade E, Ringman JM, Thompson PM, Saykin AJ, Ghetti B, Sperling RA, Johnson KA, Salloway SP, Schofield PR, Masters CL, Villemagne VL, Fox NC, Förster S, Chen K, Reiman EM, Xiong C, Marcus DS, Weiner MW, Morris JC, Bateman RJ, Benzinger TL; Dominantly Inherited Alzheimer Network. Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer’s Disease: Results from the DIAN Study Group. PLoS One. 2016 Mar 24; 11(3):e0152082. PMCID: PMC4807073.
  42. Ringman JM, Monsell S, Ng DW, Zhou Y, Nguyen A, Coppola G, Van Berlo V, Mendez MF, Tung S, Weintraub S, Mesulam MM, Bigio EH, Gitelman DR, Fisher-Hubbard AO, Albin RL, Vinters HV. Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database. J Neuropathol Exp Neurol.  2016 Mar;75(3):284-90. PMCID: PMC4934612.
  43. Reiman EM, Langbaum JB, Tariot PN, Lopera F, Bateman RJ, Morris JC, Sperling RA, Aisen PS, Roses AD, Welsh-Bohmer KA, Carrillo MC, Weninger S. CAP–advancing the evaluation of preclinical Alzheimer disease treatments. Nat Rev Neurol. 2016 Jan;12(1):56-61. PMCID: PMC4847536.
  44. Luo J, D’Angela G, Gao F, Ding J, Xiong C. Bivariate correlation coefficients in family-type clustered studies. Biom J. 2015 Nov;57(6):1084-109. PMCID: PMC4741284.
  45. Mielke MM, Machulda MM, Hagen CE, Edwards KK, Roberts RO, Pankratz VS, Knopman DS, Jack CR Jr, Petersen RC. Performance of the CogState computerized battery in the Mayo Clinic Study on Aging. Alzheimers Dement. 2015 Nov;11(11):1367-76. PMCID: PMC4595161.
  46. Wang F, Gordon BA, Ryman DC, Ma S, Xiong C, Hassenstab J, Goate A, Fagan AM, Cairns NJ, Marcus DS, McDade E, Ringman JM, Graff-Radford NR, Ghetti B, Farlow MR, Sperling R, Salloway S, Schofield PR, Masters CL, Martins RN, Rossor MN, Jucker M, Danek A, Forster S, Lane CAS, Morris JC, Benzinger TLS, Bateman RJ. Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease. Neurology. 2015 Sep 1;85(9):790-8. PMCID: PMC4553024.
  47. Quiroz YT, Schultz AP, Chen K, Protas HD, Brickhouse M, Fleisher AS, Langbaum JB, Thiyyagura P, Fagan AM, Shah AR, Muniz M, Arboleda-Velasquez JF, Munoz C, Garcia G, Acosta-Baena N, Giraldo M, Tirado V, Ramírez DL, Tariot PN, Dickerson BC, Sperling RA, Lopera F, Reiman EM. Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study. JAMA Neurol. 2015 Aug;72(8):912-9. PMCID: PMC4625544.
  48. Cairns NJ, Perrin RJ, Franklin EE, Carter D, Vincent B, Xie M, Bateman RJ, Benzinger T, Friedrichsen K, Brooks WS, Halliday GM, McLean C, Ghetti B, Morris JC, Alzheimer Disease Neuroimaging Initiative; Dominantly Inherited Alzheimer Network. Neuropathologic assessment of participants in two multi-center longitudinal observational studies: the Alzheimer Disease Neuroimaging Initiative (ADNI) and the Dominantly Inherited Alzheimer Network (DIAN). Neuropathology. 2015 Aug;35(4):390-400. PMCID: PMC4521391.
  49. Grill JD, Bateman RJ, Buckles V, Oliver A, Morris JC, Masters CL, Klunk WE, Ringman JM, Dominantly Inherited Alzheimer’s Network. A survey of attitudes toward clinical trials and genetic disclosure in autosomal dominant Alzheimer’s disease. Alzheimers Res Ther. 2015 Jul 22;7(1):50. PMCID: PMC4511231.
  50. Franklin EE, Perrin RJ, Vincent B, Baxter M, Morris JC, Cairns NJ; Alzheimer’s Disease Neuroimaging Initiative. Brain collection, standardized neuropathologic assessment, and comorbidity in Alzheimer’s Disease Neuroimaging Initiative 2 participants. Alzheimers Dement. 2015 Jul; 11(7):815-822. PMCID: PMC4511380.
  51. Papp KV, Amariglio RE, Mormino EC, Hedden T, Dekhytar M, Johnson KA, Sperling RA, Rentz DM. Free and cued memory in relation to biomarker-defined abnormalities in clinically normal older adults and those at risk for Alzheimer’s disease. Neuropsychologia. 2015 Jul; 73:169-75. PMCID: PMC4479270.
  52. Bateman RJ, Morris JC. Factors Contributing to the Post-Lumbar Puncture Headache—Reply. JAMA Neurol. 2015 Jul;72(7):835. PMCID: PMC4943573.
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