Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 231 - 240 of 318

Investigator:David Teplow, Ph.D.

Title:Generalization of Acquired Memory Pairings in Preclinical Familial Alzheimer's Disease

Date of Request:11/27/2012

Status:IA

ID:-

Aim 1:To establish if generalization of learned arbitrary pairings is impaired in preclinical familial Alzheimer's disease

Aim 2:This is a statement of intent to analyze local data.

Aim 3:This is not a request for data.

Investigator:John Ringman

Title:Pilot data for R01 Proposal, "Anti-amyloid vaccine in preclinical FAD mutation carriers in Mexico and the U.S."

Date of Request:11/30/2012

Status:A

ID:DIAN-D1212

Aim 1:To characterize longitudinal change in levels of tau and p-tau in the CSF in FAD mutation carriers.

Aim 2:To characterize longitudinal changes in amyloid signal on PIB scans in FAD mutation carriers.

Investigator:Anne Fagan

Title:Comparison of Biofluid Markers of Dominantly Inherited Alzheimer Disease (AD) with Sporadic Late Onset AD

Date of Request:12/6/2012

Status:IP

ID:DIAN-D1216

Aim 1:To compare biofluid markers of Dominantly Inherited Alzheimer Disease (AD) with sporadic Late Onset AD

Investigator:Tammie Benzinger

Title:Comparison of Neuroimaging Features of Dominantly Inherited Alzheimer Disease (AD) with Sporadic Late Onset AD

Date of Request:12/6/2012

Status:IP

ID:DIAN-D1215

Aim 1:To compare neuroimaging features of Dominantly Inherited Alzheimer Disease (AD) with sporadic Late Onset AD

Aim 2:To compare structural MRI features of Dominantly Inherited Alzheimer Disease (AD) with sporadic Late Onset AD

Aim 3:To compare FDG PET imaging features of Dominantly Inherited Alzheimer Disease (AD) with sporadic Late Onset AD

Aim 4To compare PIB amyloid imaging features of Dominantly Inherited Alzheimer Disease (AD) with sporadic Late Onset AD

Investigator:John C. Morris

Title:Comparison of Clinical and Cognitive Phenotypes of Dominantly Inherited Alzheimer Disease (AD) with Sporadic Late Onset AD

Date of Request:12/6/2012

Status:IP

ID:DIAN-D1214

Aim 1:To compare clinical and cognitive phenotypes of Dominantly Inherited Alzheimer Disease (DIAD) with sporadic Late Onset Alzheimer Disease (LOAD)

Investigator:Daniel Alexander

Title:Event-based models of disease progression

Date of Request:12/23/2012

Status:A

ID:DIAN-D1213

Aim 1:Validate the event-based model against previous results from DIAN data

Aim 2:Construct a multi-model event-based model of familial AD progression

Aim 3:Examine the effects of various factors (age, lifestyle, genetics, etc)

Investigator:Mathias Jucker

Title:Subjective memory complaints in prodromal familial Alzheimer’s disease and its association with amyloid burden in the brain

Date of Request:1/21/2013

Status:A

ID:DIAN-D1301

Aim 1:Find out whether presymptomatic FAD mutation carriers (CDR=0) with subjective memory complaints show a higher percentage and degree of pathological (positive) amyloid load in the brain (precuneus) measured by PIB-PET than those without subjective memory complaints.

Aim 2:Find out the time relation between subjective memory complaints and estimated years from symptom onset respectively development of clear deficits in cognitive tests (e.g., pathological logical memory test), MCI and dementia.

Aim 3:Find out the time relation between subjective memory complaints and development of pathological (positive) amyloid load in the brain (precuneus) measured by PIB-PET.

Investigator:Chengjie Xiong

Title:Correlation coefficients in Clustered data

Date of Request:2/19/2013

Status:A

ID:DIAN-D1302

Aim 1:We propose a statistical bivariate linear mixed model (BLMM) to evaluate correlation among AD markers at all levels systematically.

Aim 2:We will also evaluate the analysis in comparison to existing alternative methods.

Aim 3:We will provide easy-to-use correlation analysis tool for the DIAN study.

Investigator:Erik Roberson

Title:A Novel PS1 Mutation (PSEN1 N135Y)

Date of Request:3/13/2013

Status:A

ID:DIAN-D1303

Aim 1:Describe clinical and histopathological features of AD resulting from mutation (autopsy on patient's father)

Aim 2:Describe biomarker evaluation of the patient (PET, CSF)

Aim 3:Evaluate production of A-beta 1-42 production resulting from the mutation in vitro

Investigator:Beth Snitz

Title:Five factor personality dimensions and the Alzheimer pathology spectrum in Autosomal Dominant Alzheimer Disease

Date of Request:4/12/2013

Status:A

ID:DIAN-D1304

Aim 1:1) Determine whether Five-Factor personality dimensions are associated with biomarkers a-beta and tau (global PiB SUVR and CSF markers), cross-sectionally in mutation carriers, along a symptom spectrum from asymptomatic to mild AD.

Aim 2:2) Quantify the degree of longitudinal change in Five-Factor personality dimensions in mutation carriers, stratified by baseline clinical stage.

Aim 3:3) Investigate whether personality dimensions are associated with estimated time-to-symptom onset.

Aim 44) Explore the degree to which distress-related measures Neuroticism, depressive symptoms, and subjective cognitive symptoms are associated with each other and share outcome-associated variance (i.e., biomarkers and disease progression measures such as estimated time-to-onset).