Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 261 - 270 of 313

Investigator:Dale Bredesen


Title:Self-report and informant report personality change in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network

Date of Request:10/31/2014

ID:DIAN-D1411




Aim 1:Examine longitudinal change in different domains of personality in carriers and noncarriers of ADAD mutations.




Aim 2:Compare self-report and informant report personality ratings at different CDR levels.




Aim 3:Identify differences in baseline personality traits between entirely presymptomatic ADAD mutation carriers and non-carriers.




Aim 4Compare scores on IPIP sub-items that represent autistic traits between asymptomatic ADAD mutation carriers and non-carriers, separately for persons inheriting PSEN1, APP, and PSEN2 mutations.

Investigator:not applicable


Title:Clinical and cognitive comparison of LOAD and ADAD

Date of Request:11/17/2014

ID:DIAN-D1412




Aim 1:Determine whether change in cognition and clinical measures of the UDS is similar in LOAD and ADAD










Investigator:Eric M. Reiman


Title:evaluation of various biomarker longitudinal changes

Date of Request:11/18/2014

ID:DIAN-D1413




Aim 1:The possible use of ASL as a perfusion biomarker as possible replacement of FDG-PET




Aim 2:the possible use of perfusion PiB (early frames) as possible replacement of FDG-PET




Aim 3:comparison of ASL, perfusion PiB and FDG-PET




Aim 4the effects of atrophy and partial volume effects in evaluating the first 3 above

Investigator:N/A


Title:Comparison of graph characteristics in resting state fMRI in LOAD and DIAN participants

Date of Request:1/28/2015

ID:DIAN-D1501




Aim 1:Determine graph characteristics (wavelet-based coherence, binary graph diagnostics, weighted and cynamic graph diagnostics in LOAD and DIAN




Aim 2:Determine similarities and differences in these graph characteristics







Investigator:Roy Anderson


Title:Phase II and III trial simulators: Using mathematical, computational and statistical techniques to simulate trial design for new products in the treatment, vaccination and immunoprophylaxis of disease

Date of Request:3/5/2015

ID:DIAN-D1502




Aim 1:To develop mathematical models of the progression of Alzheimer's disease




Aim 2:To establish a database of Alzheimer's data, and to perform meta-analyses of this data




Aim 3:To create a clinical trial simulator of phase I and II trials of Alzheimer's interventions




Investigator:Simon Duchesne


Title:Neuromorphometric phenotypes in sporadic and dominantly inherited forms of Alzheimer's disease

Date of Request:3/16/2015

ID:DIAN-D1503




Aim 1:To compare the patterns of neuromorphometric changes throughout the predementia and dementia stages of dominantly inherited AD (diAD) and sporadic AD (sAD)










Investigator:n/a


Title:to be decided

Date of Request:3/27/2015

ID:DIAN-D1504




Aim 1:exploration of data using the structural equation modeling










Investigator:Walter A. Kukull, PhD; Scott Hofer, Andrea Piccinin, Jeffrey Kaye, and Diana Kuh


Title:Using DIAN to motivate statistical methods in aging and dementia research

Date of Request:6/11/2015

ID:DIAN-D1505




Aim 1:Use DIAN as an example dataset for the upcoming "Statistical Methods Conference on Aging & Dementia". The dataset will be used to stimulate discussion and novel ideas on the development of better statistical methods for study design and analysis in aging and dementia research.




Aim 2:As an particular example, DIAN will be investigated for building prediction models of conversion from normal/MCI to MCI/dementia







Investigator:Anne Poljak


Title:Amyloid-beta blood levels as an early marker of neurodegenerative disease

Date of Request:6/16/2015

ID:DIAN-D1506




Aim 1:Explore correlation of clinical covariates with Aβ levels




Aim 2:Compare corrected Aβ levels (all cohorts) across neurodegenerative diseases AD, PD, MCI, vascular dementia




Aim 3:Effects of soluble Aβ levels on brain volumetric parameters




Aim 4Effect of genetic factors on Aβ levels

Investigator:Suprateek Kundu


Title:Statistical approaches for early detection of Alzheimer's Disease

Date of Request:7/17/2015

ID:DIAN-D1507




Aim 1:Based on previous data on amyloids, predict if a future subject is likely to have Alzheimer's




Aim 2:Develop flexible statistical methodology for detecting the time of onset of Alzheimer's disease based on studying amyloid levels







Displaying 261 - 270 of 313