Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

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Investigator:Jasmeer Chhatwal


Title:Evaluating Mutation Type and Genotype Specific Amyloid Trajectories in DIAN

Date of Request:2/9/2016

ID:DIAN-D1606




Aim 1:Determine if mutation genotype significantly interacts with EYO in predicting amyloid burden measured by PET and CSF.










Investigator:Carlos Cruchaga


Title:Genetic Studies Using CSF biomarker levels

Date of Request:2/19/2016

ID:DIAN-D1607




Aim 1:to identify novel genetic modifiers factors using use the CSF biomarker levels (tau, ptau, AB, YKL40, VILIP1, GRN and TREM2) as endophenotype for genetic studies




Aim 2:to determine whether we can incorporate genetic information to increase the sensitivity and specify of the CSF biomarkers







Investigator:PD Dr. Johannes Levin


Title:Frequency of movement disorders in ADAD mutation carriers

Date of Request:2/24/2016

ID:DIAN-D1608




Aim 1:The specific aim for the proposed work with the DIAN data set is to find out whether there is a difference in frequency of movement disorders in ADAD mutation carriers compared to non-carriers.




Aim 2:Additionally we aim for the examination of the kind of movement disorders respectively their particular frequency and the time of occurrence in the course of the disease.




Aim 3:Furthermore we are planning to follow an enhanced approach by querying the NACC data base for a comparison of frequency of movement disorders between patients with sporadic Alzheimer�s disease, ADAD mutation carriers and non-carriers.




Aim 4A further possibility is to additionally include patients with frontotemporal lobar degeneration for comparison of frequency of movement disorders.

Investigator:John C. Morris, MD


Title:Prevelence and growth of microbleeds in autosomal dominant Alzheimer's disease: link with amyloidosis and white matter disease

Date of Request:3/8/2016

ID:DIAN-D1609




Aim 1:Evaluate correspondance between microbleeds oberved in vivo and vascular abnormalities (as CAA) observed at autopsie




Aim 2:Evaluate impact of the mutation type on microbleeds and CAA observed on imaging and at autopsie







Investigator:Jonathan V�glein


Title:Effect of cigarette smoking on the age of onset in ADAD

Date of Request:3/29/2016

ID:DIAN-D1610




Aim 1:The specific aim for the proposed work with the DIAN data set is to find out whether there is an influence of cigarette smoking on the age of onset in individuals with ADAD.










Investigator:Beau Ances


Title:Structure Function of Amyloid Progression

Date of Request:4/15/2016

ID:DIAN-D1611




Aim 1:Can function alone predict Amyloid Progression across time.




Aim 2:Can structure alone predict Amyloid Progression across time.




Aim 3:Can structure and function predict Amyloid Progression across time.




Investigator:Beau Ances


Title:Structure Function of Amyloid Progression

Date of Request:5/17/2016

ID:-




Aim 1:Can function alone predict Amyloid Progression across time.




Aim 2:Can structure alone predict Amyloid Progression across time.




Aim 3:Can structure and function predict Amyloid Progression across time.




Investigator:John C Morris


Title:Correlates of synucleinopathy in DIAN mutation carriers

Date of Request:6/1/2016

ID:DIAN-D1612




Aim 1:Determine in autopsied DIAN participants and their autopsied family members wherther synculeinopathy is associated with particular mutations




Aim 2:In the same sample as for Aim 1, determine whether autopsied DIAN participants with synculeinopathy had clinical (behavioral, cognitive, neurological) features of Lewy body disease




Aim 3:Examine clinical (behavioral, cognitive, neurological) features of Lewy body disease in DIAN mutation carriers (asymptomatic and symptomatic)




Investigator:E Coulson


Title:Basal forebrain degeneration in familial AD

Date of Request:6/13/2016

ID:DIAN-D1613




Aim 1:Determine whether basal forebrain (BF) degeneration occurs in familial AD




Aim 2:Determine the relationship between BF degeneration and cognitive decline




Aim 3:Determine the relationship between BF degeneration and hippocampal/cortical degneration




Aim 4Determine the relationship between BF degeneration and A load

Investigator:Katrina Paumier


Title:Antidepressant-mediated disease-modifying effects in ADAD

Date of Request:7/5/2016

ID:DIAN-D1614




Aim 1:Determine whether antidepressant treatment reduces brain amyloid deposition (PET)




Aim 2:Determine if antidepressants alter CSF biomarkers (A-beta, tau, ptau, etc.)




Aim 3:Determine if the onset of symptoms is delayed in antidepressant treated individuals.




Aim 4Assess whether the rate of disease progression is slowed with antidepressant treatment (DPM)

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