Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

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Investigator:Jonathan Kipnis

Title:Parenchymal border macrophages regulate brain physiology via CSF flow dynamics

Date of Request:10/25/2021

Aim 1:Identify key mechanisms driving amyloid beta pathology in both mice and humans.

Investigator:Johannes Levin

Title:Correlates of synucleinopathy in DIAN mutation carriers

Date of Request:10/15/2021



Aim 1:The aim of the project is described in detail in data request DIAN-D1612 and amendment 1 and 2 to DIAN-D1612

Investigator:Beau Ances and Tammie Benzinger

Title:Imaging Tauopathy in the Dominantly Inherited Alzheimer Network

Date of Request:10/13/2021

Aim 1:To use an accelerated failure time model to see if plasma markers predict tau deposition.


Title:Relationship between CSF sTREM2 and Cognitive Decline in AD

Date of Request:09/30/2021

Aim 1:To characterize the relationship between soluble TREM2 (sTREM2) dynamics and the nature and magnitude of cognitive changes in autosomal dominant Alzheimer Disease (ADAD).

Investigator:Prof. Dr. Johannes Levin

Title:Frequency and longitudinal course of neuropsychiatric symptoms in autosomal dominant Alzheimer’s Disease

Date of Request:09/10/2021



Aim 1:Describing neuropsychiatric phenotypes in ADAD mutation carriers using a data driven approach by PCA

Aim 2:Examine the occurence of neuropsychiatric symptoms in the course of the disease

Aim 3:Test whether structural and metabolic brain changes are associated with particular neuropsychiatric symptoms


Title:Variation and study of dynamic effective connection in default model network of DIAN corhort

Date of Request:08/08/2021

Status:Pending Approval


Aim 1:The dynamic effective connection method was used to study the related brain directed networks in AD patients with autosomal imaging inheritance

Aim 2:Identify relevant effective brain networks, especially the variation of DMN brain network structure, judge their abnormalities within and between networks, and look for specific network image markers

Investigator:Arunima Kapoor

Title:Small Vessel Disease and Vascular Risk Factors in Dominantly Inherited Alzheimer’s Disease

Date of Request:08/03/2021

Status:Pending Approval


Aim 1:To examine small vessel disease features, vascular risk factors and angiogenesis in dominantly inherited Alzheimer’s disease

Investigator:Muriah Wheelock

Title:Network level analysis of progressive brain degeneration in autosomal dominant Alzheimer disease

Date of Request:07/23/2021



Aim 1:1. Characterize the spatio-temporal progression of structural and functional brain network degeneration in AD based on estimated year of symptom onset

Aim 2:2. Determine the relationship between neuronal injury markers based on blood (e.g., NfL), cerebrospinal fluid (e.g., AB42), and PET (e.g., tau) with MRI markers of brain network dysfunction and clinical symptoms of cognitive decline cross-sectionally and longitudinally.


Title:Relationship between regional baseline and longitudinal tau PET SUVR, and correlations with change in cognition in participants from the DIAN-TU study

Date of Request:07/19/2021



Aim 1:Characterize the spatial patterns of tau deposition at baseline and over time in the DIAD population

Aim 2:Estimate the rate of change in tau deposition in DIAD participants in each of the provided parcellated brain regions

Aim 3:Identify the (meta)ROI(s) at baseline that best correlate with change in tau PET SUVR and change in cognition, respectively, over time

Aim 4Characterize the relationship between change in tau PET SUVR and change in cognition (and other biomarkers)

Investigator:Eric Schaeffer

Title:Gene Therapy for ADAD patients harboring PS1 mutations

Date of Request:07/13/2021

Status:Pending Approval


Aim 1:Develop AAV9 vectors expressing hPSEN1 (completed)

Aim 2:Evaluate AAV-PSEN1 vectors in transfected HEK293 cells and PS1 mutant iPSC lines (ongoing)

Aim 3:Evaluate AAV-PSEN1 vectors in PS1 mutant knock-in mice for rescue of biochemical and neuropathological phenotypes (ongoing)

Aim 4Evaluate AAV-PSEN1 vectors in nonhuman primates for expression and biodistribution in brain