DIAN Target Validation Symposium Agenda
The first DIAN Target Validation Symposium took place on May 25-26, 2023 in Washington, DC, USA. Recorded presentations are available via hotlinks below but are password protected. Please send request for passwords to zangela@wustl.edu.
Welcome/Opening Remarks: May 25
Dr. Randall Bateman, MD- Washington University School of Medicine, St. Louis, Mo
Presentations
Primers on Target Validation: How we validate and factors that influence robustness- 8:45am
Moderator: Dr. Todd Golde, MD, PhD
Presenters:
Dr. Eric Karran, PhD– Vice President, Distinguished Research Fellow, Neuroscience and Ophthalmology Discovery Research at AbbVie
Presentation: Clinical Translation of Preclinical Targets by Dr. Geoffrey A. Kerchner, MD, PhD– Vice President and Global Head of Early Development in Neuroscience and Rare Disease at F. Hoffman- La Roche, Ltd
Panelist: Dr. Jaren Landen, PhD; Dr. Eric Karran, PhD, Dr. Geoffrey Kerchner, MD, PhD
Known Amyloid Target Validation- 10:30am
Moderator: Dr. Tammie Benzinger, MD, PhD
Presenters:
Dr. Lucia Chavez-Gutierrez, PhD– VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium
Dr. Jasmeer Chhatwal, MD, PhD– Harvard Medical School, Boston, MA
Panelist: Randall J. Bateman, MD; Dr. Colin Masters, MD; Dr. Lucia Chavez-Gutierrez, PhD; Dr. Jasmeer Chhawtal, MD, PhD
Known Tau Target Validation- 1:00pm
Moderator: Dr. Eric McDade, DO
Presenters:
Presentation: Tau Species in DIAN by Dr. Nicolas Barthelemy, PhD– Washington University School of Medicine, St. Louis, MO
Presentation: Biomarkers for Tau Target Validation by Dr. Oskar Hansson, PhD– Lund University, Lund, Sweden
Panelist: Dr. Judith Steen, PhD; Dr. Jeff Dage, PhD; Dr. Nicolas Barthelemy, PhD; Dr. Oskar Hansson, PhD
Potential Omics Target Validation-2:45pm
Moderator: Dr. Allan Levey, MD, PhD
Presenters:
Presentation: Proteomics in LOAD & ADAD by Dr. Erik Johnson, MD, PhD– Emory University, Atlanta, Georgia
Presentation: MS4A4A Modifiers AD Risk by Regulating Microglia States by Dr. Celeste Karch, PhD– Washington University School of Medicine, St. Louis, Mo
Panelists: Dr. Li-Huei Tsai, PhD; Dr. Laura Ibanez, PhD; Dr. Erik Johnson, MD, PhD; Dr. Celeste Karch, PhD
Closing Remarks: May 25
Dr. Randall Bateman, MD- Washington University School of Medicine, St. Louis, MO
Opening Remarks: May 26
Dr. Randall Bateman, MD- Washington University School of Medicine, St. Louis, Mo
Presentations
Biomarkers for non-Amyloid/non Tau Target Validation- 8:45am
Moderator: Dr. Johannes Levin, MD
Presenters:
Presentation: Outcome Measures in AD Trials-Astrocytes by Dr. Charlotte Teunissen, PhD – Amsterdam University Medical Centers, Amsterdam, Netherlands
Presentation: Biomarkers for non-Amyloid/non-Tau Target Validation: soluble TREM2 by Dr. Marc Suárez-Calvet, MD, PhD– BarcelonaBeta Brain Research Center (BBRC), Barcelona, Spain
Panelists: Dr. Naresha Saligrama, PhD; Dr. Pedro Rosa-Neto, MD, PhD; Dr. Charlotte Teunissen, PhD; Dr. Marc Suarez- Calvet, MD, PhD
Clinical/Cognitive Validation of Targets- 10:30am
Moderator: Dr. Jorge Llibre-Guerra, MD, MS
Presenters:
Presentation: Development & Validation of Clinically Meaningful Target in AD Trials by Dr. Lynn Kramer, MD, FAAN– Chief Clinical Officer, Alzheimer’s Disease & Brain Health at Eisai
Presentation: Validating Clinical Outcomes-Prevention & Minimal Symptomatic Stage by Dr. Paul Maruff, PhD– Chief Innovation Officer at Cogstate, Ltd and Professor at the Alzheimer’s Disease Research Group, Florey Institute for Neuroscience at the University of Melbourne, Australia
Panelists: Dr. Jason Hassenstab, PhD; Dr. Eric McDade, DO; Dr. Kathy Welsh-Bohmer, PhD; Dr. Lynn Kramer, MD; Dr. Paul Maruff, PhD
Protective/Escapee-1:00pm
Moderator: Dr. Alison Goate, DPhil
Presenter:
Presentation: Untangling the Role of Rare Genetic Variants in Protecting Against Alzheimer’s Disease: From Biomarker to Novel Therapeutic Targets by Dr. Yakeel T. Quiroz, PhD– Harvard Medical School, Boston, MA
Panelists: Dr. Jorge Llibre-Guerra, MD, MS; Dr. Alison Goate, DPhil; Dr. Yakeel Quiroz, PhD
Disease Modification- 1:45pm
Moderator: Dr. Randall J. Bateman, MD
Presenters:
Presentation: DIAN Target Validation Symposium: Dominantly Inherited AD compared to sporadic AD for Disease Modification by Dr. Randall Bateman, MD– Washington University School of Medicine, St, Louis Mo
Presentation: How to Clinically Demonstrate Disease Modification & Target Validation by Dr. Alireza Atri, MD, PhD– Director at Banner Sun Health Research Institute, Sun City , AZ
Panelist: Dr. Allan Levey, MD, PhD; Dr. Michael Irizzary, MD, MPH; Dr. Randall Bateman, MD; Dr. Alireza Atri, MD, PhD
TU Pharma Consortium – 3:15pm
Dr. Randall Bateman, MD- Washington University School of Medicine, St. Louis, MO
Closing Remarks– May 26
Dr. Randall Bateman, MD- Washington University School of Medicine, St. Louis, MO