Investigator:Elena Rodriguez-Vieitez
Title:Early hypermetabolism in Alzheimer?s disease? Investigating longitudinal multivariate associations between in vivo metabolism, pathophysiology, cognition and genotype
Date of Request:12/23/2016
ID:DIAN-D1703
Aim 1:Test the hypothesis of early hypermetabolism in autosomal dominant AD, and investigate longitudinal multivariate associations between in vivo metabolism, pathophysiology and cognition.
Aim 2:Test how cognitive reserve may modulate the longitudinal associations between in vivo biomarkers and cognition investigated in Aim 1.
Aim 3:Investigate the effect of genotype (familial gene type, mutation type, APOE) on the longitudinal associations investigated in Aims 1 and 2.