Search DIAN-TU Biospecimen Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. TU1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 26 - 29 of 29

Investigator:

Yan Li

Title:

Gain Precision on the Measurement of Cognitive Impairment – Item Response Theory Scoring of the CDR

Date of Request:

05/11/2021

Status:

Pending

ID:

DR_011

Aim 1:

Evaluate the difficulty and discrimination level, and the longitudinal change of each item in CDR and their longitudinal change over time

Aim 2:

Develop the best fitting item response theory (IRT) model for automatically scoring dementia severity (IRT score)

Aim 3:

Compare the performance of the IRT score with that of the CDR sum of box in terms of powering a clinical trial and precision in tracking cognitive change over time, especially for cognitively normal participants

Aim 4:

Valid the performance of the IRT score using other psychometric measures and biomarkers.

Investigator:

Suman Jayadev

Title:

Peripheral immune profiles in ADAD

Date of Request:

04/20/2021

Status:

Pending

ID:

DR_016

Aim 1:

Measure immune related microRNA, exosome, proteins in carriers and non-carriers

Investigator:

NA

Title:

Proposal for comparison between Dominantly Inherited Alzheimer Disease and sporadic early-onset Alzheimer’s disease

Date of Request:

05/20/2020

Status:

Pending

ID:

DR_002

Aim 1:

To compare clinical presentation, neuropsychological performance and cognitive decline rate between DIAD and sporadic EOAD

Aim 2:

To examine in vivo the regional distribution of tau, amyloid-beta, brain glucose metabolism, and structural atrophy, as well as their relationships, in DIAD and sporadic EOAD

Aim 3:

To compare CSF biomarkers levels and rates of change in DIAN and sporadic EOAD

Investigator:

NA

Title:

Imaging-Histology Comparisons of Tau Pathology in ADAD and LOAD

Date of Request:

04/21/2020

Status:

Approved

ID:

DR_001

Aim 1:

Perform a quantitative comparison of tau pathology in ADAD and LOAD using imaging and histology