Search DIAN-TU Biospecimen Resource Requests
Yan Li
Gain Precision on the Measurement of Cognitive Impairment – Item Response Theory Scoring of the CDR
05/11/2021
Pending
DR_011
Evaluate the difficulty and discrimination level, and the longitudinal change of each item in CDR and their longitudinal change over time
Develop the best fitting item response theory (IRT) model for automatically scoring dementia severity (IRT score)
Compare the performance of the IRT score with that of the CDR sum of box in terms of powering a clinical trial and precision in tracking cognitive change over time, especially for cognitively normal participants
Valid the performance of the IRT score using other psychometric measures and biomarkers.
Suman Jayadev
Peripheral immune profiles in ADAD
04/20/2021
Pending
DR_016
Measure immune related microRNA, exosome, proteins in carriers and non-carriers
NA
Proposal for comparison between Dominantly Inherited Alzheimer Disease and sporadic early-onset Alzheimer’s disease
05/20/2020
Pending
DR_002
To compare clinical presentation, neuropsychological performance and cognitive decline rate between DIAD and sporadic EOAD
To examine in vivo the regional distribution of tau, amyloid-beta, brain glucose metabolism, and structural atrophy, as well as their relationships, in DIAD and sporadic EOAD
To compare CSF biomarkers levels and rates of change in DIAN and sporadic EOAD
NA
Imaging-Histology Comparisons of Tau Pathology in ADAD and LOAD
04/21/2020
Approved
DR_001
Perform a quantitative comparison of tau pathology in ADAD and LOAD using imaging and histology