Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 191 - 200 of 294

Investigator:Andrei Vlassenko


Title:Regional beta-amyloid deposition in cognitively normal adults

Date of Request:2/7/2012

Status:IP

ID:DIAN-D1201




Aim 1:Examine regional differences in PIB BP in PIB-negative older compared to younger adults










Investigator:Christopher Leatherday


Title:An Investigation of Optimised Hippocampal Masking Techniques in Alzheimer's Disease Diagnosis.

Date of Request:3/7/2012

Status:IA

ID:DIAN-D1202




Aim 1:Verify the optimised pes hippocampal masking results obtained by Mosconi et al. in their 2005 paper: “Reduced hippocampal metabolism in MCI and AD: Automated FDG-PET image analysis”.




Aim 2:Compare the efficacy of a volumetric pes hippocampal mask to one that includes the whole hippocampus; in terms of their ability to distinguish between functional brain images of Alzheimer’s disease, mild cognitive impairment and healthy elderly subjects.







Investigator:David Teplow


Title:Behavioral and mood disturbances in prodromal familial Alzheimer’s disease

Date of Request:3/15/2012

Status:A

ID:DIAN-D1203




Aim 1:Compare the frequency of behavioral disturbances on the NPI-Q between asymptomatic FAD mutation carriers and non-carriers




Aim 2:Compare the severity of behavioral disturbances on the NPI-Q between asymptomatic FAD mutation carriers and non-carriers




Aim 3:Compare the level of self-rated depression (GDS) between asymptomatic FAD mutation carriers and non-carriers




Aim 4Compare the rate of self-rated depression and informant-rated depression in FAD mutation carriers

Investigator:Reisa Sperling, MD


Title:Relationship of CSF markers to Functional Connectivity in DIAN

Date of Request:8/7/2012

Status:A

ID:DIAN-D1101




Aim 1:(This is an amendment to add the CSF biomarkers to our approved PiB-fc-MRI project). To elucidate the temporal relationship of the emergence of default network dysfunction in ADAD mutation carriers to CSF markers of Abeta, phospho-tau and tau.










Investigator:Randall J. Bateman, M.D.


Title:DIAN Treatment Trials - Cognitive Test Battery

Date of Request:8/8/2012

Status:A

ID:DIAN-D1100




Aim 1:Analyze the DIAN cognitive data set to determine the most effective cognitive test measures to use in the DIAN Treatment Trials while allowing for historical run-in comparisons and some measure of continuity between the studies.




Aim 2:Compare the DIAN Data to existing, published data (e.g. RUSH, ABEL) to determine a cognitive composite test battery that overlaps well with those measures selected for use in other large, planned secondary prevention trials (i.e., A4 and API trials).







Investigator:Jeff Prescott


Title:Relationship between fibrillar amyloid deposition and functional connectivity in the DIAN population

Date of Request:9/11/2012

Status:IA

ID:DIAN-D1204




Aim 1:Analyze the cross-sectional relationship between fibrillar amyloid deposition and whole brain functional connectivity in homogeneous subsets of the DIAN population.




Aim 2:Analyze the relationship between baseline fibrillar amyloid deposition and future changes in whole brain functional connectivity in the DIAN population.







Investigator:Beau Ances


Title:Comparison of Early and Late Onset AD Using rs-fcMRI

Date of Request:9/17/2012

Status:A

ID:DIAN-D1205




Aim 1:To characterize the RSNs affected in early onset AD




Aim 2:To charterize the RSNs affected in late onset AD




Aim 3:To understand the temporal course of changes in RSNs in early onset AD




Aim 4To characterize the effects of mutations on RSNs

Investigator:Koeppe


Title:Standardizing Biomarker Reporting for Amyloid Plaque Estimation by PET

Date of Request:9/27/2012

Status:A

ID:DIAN-D1206




Aim 1:To provide a standard method for quantifying scaling of amyloid burden with PET




Aim 2:The quantification scale would be applicable to different radiotracers




Aim 3:The quantification scale would be applicable to different analysis methods




Aim 4Methods for conversion of SUVr or DVR results into the standard scale will be developed

Investigator:Ivo Dinov


Title:Neuroimaging-Genetics Study of Early-Onset Alzheimer's Disease

Date of Request:9/27/2012

Status:IA

ID:DIAN-D1207




Aim 1:Obtain shape and volume derived neuroimaigng biomarkers




Aim 2:Obtain Genetics/SNP Cleaned data and Identify significant predictors of MCI/AD




Aim 3:Integrate genetics and biomedical imaging correlated/post-hoc analysis




Investigator:Koeppe


Title:Centiloids Project

Date of Request:10/8/2012

Status:A

ID:DIAN-D1206




Aim 1:Standardize amyloid imaging outcome measures










Displaying 191 - 200 of 294