DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 181 - 190 of 294

Investigator:Anthony Stevens


Title:Pharmacological chaperones effects on PS1 levels with the specific PS1 mutations

Date of Request:2/21/2011

Status:A

ID:DIAN-D1108




Aim 1:To investigate our pharmacological chaperones effects on PS1 levels with the specific PS1 mutations of patients currently enrolled in the DIAN studies, using our in-house cell based PS1 EOFAD models.




Aim 2:Knowledge of the mutations and pedigree size will help us prioritize which PS1 mutations to test in our models.







Investigator:Nick Fox


Title:Innate Immune System Dysfunction in Neurodegeneration

Date of Request:5/23/2011

Status:A

ID:DIAN-D1103




Aim 1:Registration and subtraction-based methods of volume change.




Aim 2:Use Voxel-based morphometry to look for patterns of difference between gene-positive and gene-negative individuals as well as differences between genetic sub-types.




Aim 3:Tensor-based morphometry. The power of non-linear registration to provide a realistic and very precise matching of serial data.




Investigator:Mark Raichle


Title:Resting Brain Metabolism in Familial Alzheimer's Disease

Date of Request:6/1/2011

Status:IA

ID:DIAN-D1109




Aim 1:Examine the relationship between oxygen and glucose in the brain.










Investigator:John Ringman


Title:Request for individual identifiable data for Case Report

Date of Request:8/3/2011

Status:A

ID:DIAN-D1102




Aim 1:Sole purpose is to write up a case report of a severely demented woman with a novel PSEN1 mutation.










Investigator:John Ringman


Title:Clinical and Imaging Characteristics of the I238M Mutation in Presenilin-1: Report of a New Mutation

Date of Request:8/22/2011

Status:A

ID:DIAN-D1106




Aim 1:The goal of this study is to describe, in depth, the clinical and imaging characteristics of this novel mutation.










Investigator:John Ringman


Title:Identification of cerebral microhemorrhages in persons carrying familial AD mutations

Date of Request:08/22/2011

Status:Pending

ID:DIAN-D1104




Aim 1:Ascertain the prevalence of CAA in FAD using the clinical radiological interpretation of the presence of microhemorrhages on susceptibility-weighted MRI images (SWI)




Aim 2:to relate the location of microhemorrhages to amyloid deposition as measured using PIB scans




Aim 3:explore the relationship of microhemorrhages to FAD mutation type, adjusted age, CDR sum of boxes score, gender, and APOE genotype.




Investigator:John Ringman


Title:Prevalence of REM Sleep Behavior Disorder and other DLB symptoms in Familial Alzheimers Disease

Date of Request:11/2/2011

Status:A

ID:z




Aim 1:ascertain how common symptoms of RBD are in early symptomatic and demented persons carrying FAD mutations




Aim 2:to assess whether symptoms of RBD are more common in FAD mutation carriers relative to their non-mutation carrying kin




Aim 3:to compare the prevalence of other symptoms of DLB (hallucinations, fluctuations, and Parkinsonism) between FAD mutation carriers (MCs) and non-carriers (NCs).




Investigator:Reisa Sperling


Title:Relationship of PiB-PET amyloid imaging and default network fc-MRI in DIAN subjects

Date of Request:11/15/2011

Status:A

ID:DIAN-D1101




Aim 1:To investigate whether level of cortical PiB retention is related to default network dysconnectivity across the spectrum of DIAN participants (ADAD mutation carriers, non-carriers, asymptomatic and symptomatic).




Aim 2:To determine whether ADAD mutation carriers demonstrate impaired connectivity compared to non-carriers, independent of PiB retention.




Aim 3:To elucidate the temporal relationship of the emergence of default network dysfunction in ADAD mutation carriers to their expected age of onset.




Investigator:Randall Bateman MD


Title:Development and validation of evidence-based criteria for estimating age of onset in the DIAN study

Date of Request:11/27/2011

Status:A

ID:DIAN-D1110




Aim 1:Development and validation of evidence-based estimates for expected age of onset within ADAD families




Aim 2:Pedigree analysis of DIAN families to directly assess heritability and examine the effects of additional prognostic variables in modifying familial age of onset







Investigator:Morris


Title:Imaging Committee Presentations at 2012 Human Amyloid Imaging Meeting

Date of Request:12/19/2011

Status:A

ID:-




Aim 1:The DIAN Imaging Committee is presenting 2 abstracts at the 2012 Human Amyloid Imaging Meeting, titiles are listed below.




Aim 2:[11C] PIB, FDG and MR findings of preclinical AD in the DIAN cohort




Aim 3:Reference tissue normalization in autosomal dominant AD: Comparison of cerebellar versus brainstem referencing for [11C]PIBin the DIAN cohort




Displaying 181 - 190 of 294