DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 201 - 210 of 294

Investigator:Prof. Ralph Martins


Title:Platelet APP Isoform Ratios in a subset of the Dominantly Inherited Alzheimer’s disease Network

Date of Request:10/12/2012

Status:A

ID:DIAN-D1208




Aim 1:Aim to observe whether platelet APP isoform ratios are lower in Mutation Carriers (mutation responsible for ADAD) compared to Non Carriers




Aim 2:Aim to observe whether platelet APP ratios correlate with neuropsychometric test scores and PiB-PET SUVR







Investigator:Paul Thompson


Title:Preclinical familial and late-onset Alzheimer’s disease brain changes

Date of Request:10/17/2012

Status:IA

ID:DIAN-D1209




Aim 1:Determine which sMRI, rs-fMRI, and DTI brain measures together best distinguish FAD mutation non-carriers from FAD mutation carriers within 10 years from their estimated age of disease onset.




Aim 2:Identify which sMRI, rs-fMRI, and DTI brain measures change faster over three years in FAD mutation carriers within 10 years from their estimated age of disease onset compared with age-matched FAD mutation non-carriers.




Aim 3:Discover whether Aim 1 effects are seen in higher AD risk ADNI adults (based on CSF Aβ42 levels and memory scores) versus lower risk ADNI adults (based on CSF Aβ42 levels), and whether the measures predict cognitive decline over 3 years.




Investigator:Paul Thompson


Title:Preclinical familial and late-onset Alzheimer’s disease brain changes

Date of Request:10/18/2012

Status:IA

ID:DIAN-D1209




Aim 1:Determine which sMRI, rs-fMRI, and DTI brain measures together best distinguish FAD mutation non-carriers from FAD mutation carriers within 10 years from their estimated age of disease onset.




Aim 2:Identify which sMRI, rs-fMRI, and DTI brain measures change faster over three years in FAD mutation carriers within 10 years from their estimated age of disease onset compared with age-matched FAD mutation non-carriers.




Aim 3:Discover whether Aim 1 effects are seen in higher AD risk ADNI adults (based on CSF Aβ42 levels and memory scores) versus lower risk ADNI adults (based on CSF Aβ42 levels), and whether the measures predict cognitive decline over 3 years.




Investigator:Chengjie Xiong


Title:Wavelet-based statistical analysis on brain functional connectivity

Date of Request:10/24/2012

Status:IA

ID:DIAN-D1210




Aim 1:Develop novel quantitative tools to comprehensively measure brain functional connectivity




Aim 2:Develop novel stat. methods to identify impairments of brain func. connectivity in elderly individuals







Investigator:Mayeux


Title:WHITE MATTER HYPERINTENSITIES AND CEREBRAL MICROBLEEDS IN DIAN

Date of Request:11/7/2012

Status:A

ID:DIAN-1211




Aim 1:1. To examine the natural history of WMH in the preclinical course of AD.




Aim 2:2. To examine the relationship between regionally distributed WMH and markers of AD pathology.







Investigator:David Teplow, Ph.D.


Title:Peripheral gene expression in familial AD

Date of Request:11/26/2012

Status:IA

ID:-




Aim 1:To compare the expression of genes in peripheral leukocytes between non-demented FAD mutation carriers and at-risk non-carriers




Aim 2:No actual data is being requested.







Investigator:David Teplow, Ph.D.


Title:Generalization of Acquired Memory Pairings in Preclinical Familial Alzheimer's Disease

Date of Request:11/27/2012

Status:IA

ID:-




Aim 1:To establish if generalization of learned arbitrary pairings is impaired in preclinical familial Alzheimer's disease




Aim 2:This is a statement of intent to analyze local data.




Aim 3:This is not a request for data.




Investigator:John Ringman


Title:Pilot data for R01 Proposal, "Anti-amyloid vaccine in preclinical FAD mutation carriers in Mexico and the U.S."

Date of Request:11/30/2012

Status:A

ID:DIAN-D1212




Aim 1:To characterize longitudinal change in levels of tau and p-tau in the CSF in FAD mutation carriers.




Aim 2:To characterize longitudinal changes in amyloid signal on PIB scans in FAD mutation carriers.







Investigator:Anne Fagan


Title:Comparison of Biofluid Markers of Dominantly Inherited Alzheimer Disease (AD) with Sporadic Late Onset AD

Date of Request:12/6/2012

Status:IP

ID:DIAN-D1216




Aim 1:To compare biofluid markers of Dominantly Inherited Alzheimer Disease (AD) with sporadic Late Onset AD










Investigator:Tammie Benzinger


Title:Comparison of Neuroimaging Features of Dominantly Inherited Alzheimer Disease (AD) with Sporadic Late Onset AD

Date of Request:12/6/2012

Status:IP

ID:DIAN-D1215




Aim 1:To compare neuroimaging features of Dominantly Inherited Alzheimer Disease (AD) with sporadic Late Onset AD




Aim 2:To compare structural MRI features of Dominantly Inherited Alzheimer Disease (AD) with sporadic Late Onset AD




Aim 3:To compare FDG PET imaging features of Dominantly Inherited Alzheimer Disease (AD) with sporadic Late Onset AD




Aim 4To compare PIB amyloid imaging features of Dominantly Inherited Alzheimer Disease (AD) with sporadic Late Onset AD

Displaying 201 - 210 of 294