DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 211 - 220 of 294

Investigator:John C. Morris


Title:Comparison of Clinical and Cognitive Phenotypes of Dominantly Inherited Alzheimer Disease (AD) with Sporadic Late Onset AD

Date of Request:12/6/2012

Status:IP

ID:DIAN-D1214




Aim 1:To compare clinical and cognitive phenotypes of Dominantly Inherited Alzheimer Disease (DIAD) with sporadic Late Onset Alzheimer Disease (LOAD)










Investigator:Daniel Alexander


Title:Event-based models of disease progression

Date of Request:12/23/2012

Status:A

ID:DIAN-D1213




Aim 1:Validate the event-based model against previous results from DIAN data




Aim 2:Construct a multi-model event-based model of familial AD progression




Aim 3:Examine the effects of various factors (age, lifestyle, genetics, etc)




Investigator:Mathias Jucker


Title:Subjective memory complaints in prodromal familial Alzheimer’s disease and its association with amyloid burden in the brain

Date of Request:1/21/2013

Status:A

ID:DIAN-D1301




Aim 1:Find out whether presymptomatic FAD mutation carriers (CDR=0) with subjective memory complaints show a higher percentage and degree of pathological (positive) amyloid load in the brain (precuneus) measured by PIB-PET than those without subjective memory complaints.




Aim 2:Find out the time relation between subjective memory complaints and estimated years from symptom onset respectively development of clear deficits in cognitive tests (e.g., pathological logical memory test), MCI and dementia.




Aim 3:Find out the time relation between subjective memory complaints and development of pathological (positive) amyloid load in the brain (precuneus) measured by PIB-PET.




Investigator:Chengjie Xiong


Title:Correlation coefficients in Clustered data

Date of Request:2/19/2013

Status:A

ID:DIAN-D1302




Aim 1:We propose a statistical bivariate linear mixed model (BLMM) to evaluate correlation among AD markers at all levels systematically.




Aim 2:We will also evaluate the analysis in comparison to existing alternative methods.




Aim 3:We will provide easy-to-use correlation analysis tool for the DIAN study.




Investigator:Erik Roberson


Title:A Novel PS1 Mutation (PSEN1 N135Y)

Date of Request:3/13/2013

Status:A

ID:DIAN-D1303




Aim 1:Describe clinical and histopathological features of AD resulting from mutation (autopsy on patient's father)




Aim 2:Describe biomarker evaluation of the patient (PET, CSF)




Aim 3:Evaluate production of A-beta 1-42 production resulting from the mutation in vitro




Investigator:Beth Snitz


Title:Five factor personality dimensions and the Alzheimer pathology spectrum in Autosomal Dominant Alzheimer Disease

Date of Request:4/12/2013

Status:A

ID:DIAN-D1304




Aim 1:1) Determine whether Five-Factor personality dimensions are associated with biomarkers a-beta and tau (global PiB SUVR and CSF markers), cross-sectionally in mutation carriers, along a symptom spectrum from asymptomatic to mild AD.




Aim 2:2) Quantify the degree of longitudinal change in Five-Factor personality dimensions in mutation carriers, stratified by baseline clinical stage.




Aim 3:3) Investigate whether personality dimensions are associated with estimated time-to-symptom onset.




Aim 44) Explore the degree to which distress-related measures Neuroticism, depressive symptoms, and subjective cognitive symptoms are associated with each other and share outcome-associated variance (i.e., biomarkers and disease progression measures such as estimated time-to-onset).

Investigator:Dr. Christian Gaser


Title:BrainAGE in dominantly inherited Alzheimer’s disease

Date of Request:4/16/2013

Status:IP

ID:DIAN-D1305




Aim 1:Exploring the brain aging pattern in subjects with DIAN and controls (cross-sectionally & longitudinally)




Aim 2:Disentangling the age-related atrophy pattern from the disease-specific atrophy pattern in the brain (structural MRI)




Aim 3:Estimating BrainAGE scores in subjects with DIAN and controls to predict conversion to AD




Aim 4Exploring factors / variables, which affect BrainAGE

Investigator:Yen Ying Lim


Title:Relationship between BDNF Val66Met, Aβ, cognitive function and hippocampal volume in patients who are at risk of developing autosomal dominant Alzheimer’s disease

Date of Request:4/30/2013

Status:A

ID:DIAN-D1306




Aim 1:Examine the association between BDNF Val66Met, Aβ, disease classification (healthy and MCI), memory function and hippocampal volume cross-sectionally and prospectively




Aim 2:Examine whether physical activity modifies the relationship between BDNF Val66Met and Aβ-related decline in memory function and reductions in hippocampal volume




Aim 3:Examine whether changes in other areas of cognition are associated with BDNF Val66Met and Aβ




Aim 4Examine whether APOE genotype modifies the relationship between BDNF Val66Met and Aβ-related decline in memory function and reductions in hippocampal volume

Investigator:Randall Bateman


Title:Post-dural puncture headache: An analysis of the risks of experiencing headaches after a Lumbar Puncture procedure on the Dominantly Inherited Alzheimer Network (DIAN) participants

Date of Request:6/17/2013

Status:A

ID:DIAN-D1307




Aim 1:Analyze the relationships between factors of CSF collection of LP procedures on and adverse events of DIAN participants.










Investigator:Randall Bateman


Title:Clinical and cognitive measures of the DIAN cohort

Date of Request:7/12/2013

Status:A

ID:DIAN-D1308




Aim 1:Determine the longitudinal rate of clinical conversion from cognitively normal to dementia in a carefully studied population of DIAN participants including average age of onset and CDR and psychometric rate of progression.




Aim 2:Evaluate the cognitive and clinical change, including rate of change, by multifactorial analysis including age, estimated years to onset (parental age of onset), ApoE4, average familial onset, genetic risk factors and biomarkers.







Displaying 211 - 220 of 294