DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 231 - 240 of 319

Investigator:David Teplow, Ph.D.


Title:Peripheral gene expression in familial AD

Date of Request:11/26/2012

Status:IA

ID:-




Aim 1:To compare the expression of genes in peripheral leukocytes between non-demented FAD mutation carriers and at-risk non-carriers




Aim 2:No actual data is being requested.







Investigator:David Teplow, Ph.D.


Title:Generalization of Acquired Memory Pairings in Preclinical Familial Alzheimer's Disease

Date of Request:11/27/2012

Status:IA

ID:-




Aim 1:To establish if generalization of learned arbitrary pairings is impaired in preclinical familial Alzheimer's disease




Aim 2:This is a statement of intent to analyze local data.




Aim 3:This is not a request for data.




Investigator:John Ringman


Title:Pilot data for R01 Proposal, "Anti-amyloid vaccine in preclinical FAD mutation carriers in Mexico and the U.S."

Date of Request:11/30/2012

Status:A

ID:DIAN-D1212




Aim 1:To characterize longitudinal change in levels of tau and p-tau in the CSF in FAD mutation carriers.




Aim 2:To characterize longitudinal changes in amyloid signal on PIB scans in FAD mutation carriers.







Investigator:Anne Fagan


Title:Comparison of Biofluid Markers of Dominantly Inherited Alzheimer Disease (AD) with Sporadic Late Onset AD

Date of Request:12/6/2012

Status:IP

ID:DIAN-D1216




Aim 1:To compare biofluid markers of Dominantly Inherited Alzheimer Disease (AD) with sporadic Late Onset AD










Investigator:Tammie Benzinger


Title:Comparison of Neuroimaging Features of Dominantly Inherited Alzheimer Disease (AD) with Sporadic Late Onset AD

Date of Request:12/6/2012

Status:IP

ID:DIAN-D1215




Aim 1:To compare neuroimaging features of Dominantly Inherited Alzheimer Disease (AD) with sporadic Late Onset AD




Aim 2:To compare structural MRI features of Dominantly Inherited Alzheimer Disease (AD) with sporadic Late Onset AD




Aim 3:To compare FDG PET imaging features of Dominantly Inherited Alzheimer Disease (AD) with sporadic Late Onset AD




Aim 4To compare PIB amyloid imaging features of Dominantly Inherited Alzheimer Disease (AD) with sporadic Late Onset AD

Investigator:John C. Morris


Title:Comparison of Clinical and Cognitive Phenotypes of Dominantly Inherited Alzheimer Disease (AD) with Sporadic Late Onset AD

Date of Request:12/6/2012

Status:IP

ID:DIAN-D1214




Aim 1:To compare clinical and cognitive phenotypes of Dominantly Inherited Alzheimer Disease (DIAD) with sporadic Late Onset Alzheimer Disease (LOAD)










Investigator:Daniel Alexander


Title:Event-based models of disease progression

Date of Request:12/23/2012

Status:A

ID:DIAN-D1213




Aim 1:Validate the event-based model against previous results from DIAN data




Aim 2:Construct a multi-model event-based model of familial AD progression




Aim 3:Examine the effects of various factors (age, lifestyle, genetics, etc)




Investigator:Mathias Jucker


Title:Subjective memory complaints in prodromal familial Alzheimer’s disease and its association with amyloid burden in the brain

Date of Request:1/21/2013

Status:A

ID:DIAN-D1301




Aim 1:Find out whether presymptomatic FAD mutation carriers (CDR=0) with subjective memory complaints show a higher percentage and degree of pathological (positive) amyloid load in the brain (precuneus) measured by PIB-PET than those without subjective memory complaints.




Aim 2:Find out the time relation between subjective memory complaints and estimated years from symptom onset respectively development of clear deficits in cognitive tests (e.g., pathological logical memory test), MCI and dementia.




Aim 3:Find out the time relation between subjective memory complaints and development of pathological (positive) amyloid load in the brain (precuneus) measured by PIB-PET.




Investigator:Chengjie Xiong


Title:Correlation coefficients in Clustered data

Date of Request:2/19/2013

Status:A

ID:DIAN-D1302




Aim 1:We propose a statistical bivariate linear mixed model (BLMM) to evaluate correlation among AD markers at all levels systematically.




Aim 2:We will also evaluate the analysis in comparison to existing alternative methods.




Aim 3:We will provide easy-to-use correlation analysis tool for the DIAN study.




Investigator:Erik Roberson


Title:A Novel PS1 Mutation (PSEN1 N135Y)

Date of Request:3/13/2013

Status:A

ID:DIAN-D1303




Aim 1:Describe clinical and histopathological features of AD resulting from mutation (autopsy on patient's father)




Aim 2:Describe biomarker evaluation of the patient (PET, CSF)




Aim 3:Evaluate production of A-beta 1-42 production resulting from the mutation in vitro




Displaying 231 - 240 of 319