DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 251 - 260 of 319

Investigator:Mathias Jucker


Title:Sample sizes for different EYO intervals with and without amyloid

Date of Request:11/1/2013

Status:IP

ID:DIAN-D1314




Aim 1:Determine sample sizes for different EYO intervals with and without amyloid










Investigator:Nick Fox


Title:Rates of longitudinal microstructural change in familial AD using diffusion weighted imaging

Date of Request:11/11/2013

Status:IP

ID:DIAN-D1315




Aim 1:Estimate rates of change in microstructure diffusion measurements (FA, MD, radial and axial diffusivity) in familial Alzheimer’s disease




Aim 2:Determine at what point in time do these changes diverge from non-carriers




Aim 3:Calculate sample sizes needed to detect a substantial treatment effect within a clinical trial similar to the population that will enter the DIAN clinical trials




Investigator:David Teplow


Title:Imaging and biomarker correlates of spastic paraparesis associated with PSEN1 mutations

Date of Request:11/21/2013

Status:IP

ID:DIAN-D1316




Aim 1:To compare white matter, among persons with PSEN1 mutations, between those with and without spastic paraparesis using DTI




Aim 2:To compare cerebral amyloidosis, among persons with PSEN1 mutations, between those with and without spastic paraparesis using PIB images







Investigator:Prof. Ralph Martins


Title:Plasma and cerebrospinal fluid phospholipid profiles in a DIAN cohort subset

Date of Request:11/22/2013

Status:A

ID:DIAN-D1317




Aim 1:To find phospholipid species which significantly differ in concentrations between mutation carriers and non carriers.




Aim 2:To correlate the phospholipid species obtained in aim 1, with the established gold standard biomarkers such as PiB-PET SUVR, cerebrospinal fluid concentrations of total-tau, phosphorylated-tau and Aβ42.




Aim 3:correlate the plasma phospholipid species obtained in aim 1, with FDG-PET SUVR, MRI data and plasma Abeta levels.




Investigator:Arthur Toga


Title:Alzheimer's Disease Biomarkers via a Multimodal statistical approach

Date of Request:12/11/2013

Status:IP

ID:DIAN-D1318




Aim 1:Determine imaging and clinical biomarkers for the risk of Alzheimer's Diease




Aim 2:Conceputalize a target sample size that could be used for clinical trials based on the power of targeted biomarkers







Investigator:Serena McCalla


Title:Patch-Based Analysis of Anatomical Brain Asymmetry

Date of Request:12/19/2013

Status:IA

ID:DIAN-D1319




Aim 1:Identify characteristic structural asymmetry patterns in diseased individuals versus healthy controls










Investigator:Ralph Martins


Title:Cerebral Amyloid Angiopathy due to APP mutation: Clinicopathological manifestations and brain imaging findings

Date of Request:1/7/2014

Status:IP

ID:DIAN-D1401




Aim 1:1. To investigate the clinicopathological features of cerebral amyloid angiopathy in an HCHWA-Dutch Type kindred




Aim 2:2. To investigate the CSF and Blood biomarkers related to Alzheimer’s disease in the APP Dutch Type mutation carriers and non-carriers




Aim 3:3. To compare the mutation carriers and non-carriers' on MRI, FDG and PiB PET imaging results




Aim 44. To compare the mutation carriers and non-carriers on clinical, cognitive and personality measures

Investigator:Ralph Martins


Title:Brain and cognitive reserve capacities in DIAN participants

Date of Request:1/8/2014

Status:IP

ID:DIAN-D1402




Aim 1:1. To examine whether DIAN participants differ in terms of their brain reserve (as indicated by brain volume, cortical thickness, white matter hyper intensities etc.) and cognitive reserve (as indicated by education years and Hollingshead Index of Social Position).




Aim 2:2. 2. To examine if cognitive and brain reserves indices are associated with delay in clinical manifestation of the AD.




Aim 3:3. 3. To Compare these groups on blood and CSF biomarkers and imaging results at baseline and follow ups




Aim 44. 4. To investigate whether higher baseline cognitive function delays the age at onset?

Investigator:Mathias Jucker


Title:Vital signs in the different stages of dominantly inherited Alzheimer`s disease

Date of Request:2/17/2014

Status:A

ID:DIAN-D1403




Aim 1:To compare vital signs between mutation carriers (MC) and non-mutation carriers (NMC) at different clinical stages as assessed with Clinical Dementia Rating (CDR) scale.




Aim 2:To compare vital signs between MC and NMC as a function of estimated years to onset (EYO).




Aim 3:To determine the association between vital signs and clinical parameters (age, gender, EYO, GDS), psychometric parameters (MMSE, CDR global, CDR sum of boxes, Logical Memory, delayed recall), biochemical biomarkers (CSF levels of Abeta 1-42 and tau) and neuro-imaging biomarkers (PiB-PET SUVR).




Investigator:Peter Nestor


Title:QSM analysis of susceptibility weighted imaging data

Date of Request:3/26/2014

Status:A

ID:DIAN-D1404




Aim 1:development of quantitative susceptibility mapping as a novel biomarker in preclinical AD




Aim 2:To examine whether early basal ganglia PIB ligand uptake is associated with altered iron levels







Displaying 251 - 260 of 319