DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 221 - 230 of 319

Investigator:Jeff Prescott


Title:Relationship between fibrillar amyloid deposition and functional connectivity in the DIAN population

Date of Request:9/11/2012

Status:IA

ID:DIAN-D1204




Aim 1:Analyze the cross-sectional relationship between fibrillar amyloid deposition and whole brain functional connectivity in homogeneous subsets of the DIAN population.




Aim 2:Analyze the relationship between baseline fibrillar amyloid deposition and future changes in whole brain functional connectivity in the DIAN population.







Investigator:Beau Ances


Title:Comparison of Early and Late Onset AD Using rs-fcMRI

Date of Request:9/17/2012

Status:A

ID:DIAN-D1205




Aim 1:To characterize the RSNs affected in early onset AD




Aim 2:To charterize the RSNs affected in late onset AD




Aim 3:To understand the temporal course of changes in RSNs in early onset AD




Aim 4To characterize the effects of mutations on RSNs

Investigator:Koeppe


Title:Standardizing Biomarker Reporting for Amyloid Plaque Estimation by PET

Date of Request:9/27/2012

Status:A

ID:DIAN-D1206




Aim 1:To provide a standard method for quantifying scaling of amyloid burden with PET




Aim 2:The quantification scale would be applicable to different radiotracers




Aim 3:The quantification scale would be applicable to different analysis methods




Aim 4Methods for conversion of SUVr or DVR results into the standard scale will be developed

Investigator:Ivo Dinov


Title:Neuroimaging-Genetics Study of Early-Onset Alzheimer's Disease

Date of Request:9/27/2012

Status:IA

ID:DIAN-D1207




Aim 1:Obtain shape and volume derived neuroimaigng biomarkers




Aim 2:Obtain Genetics/SNP Cleaned data and Identify significant predictors of MCI/AD




Aim 3:Integrate genetics and biomedical imaging correlated/post-hoc analysis




Investigator:Koeppe


Title:Centiloids Project

Date of Request:10/8/2012

Status:A

ID:DIAN-D1206




Aim 1:Standardize amyloid imaging outcome measures










Investigator:Prof. Ralph Martins


Title:Platelet APP Isoform Ratios in a subset of the Dominantly Inherited Alzheimer’s disease Network

Date of Request:10/12/2012

Status:A

ID:DIAN-D1208




Aim 1:Aim to observe whether platelet APP isoform ratios are lower in Mutation Carriers (mutation responsible for ADAD) compared to Non Carriers




Aim 2:Aim to observe whether platelet APP ratios correlate with neuropsychometric test scores and PiB-PET SUVR







Investigator:Paul Thompson


Title:Preclinical familial and late-onset Alzheimer’s disease brain changes

Date of Request:10/17/2012

Status:IA

ID:DIAN-D1209




Aim 1:Determine which sMRI, rs-fMRI, and DTI brain measures together best distinguish FAD mutation non-carriers from FAD mutation carriers within 10 years from their estimated age of disease onset.




Aim 2:Identify which sMRI, rs-fMRI, and DTI brain measures change faster over three years in FAD mutation carriers within 10 years from their estimated age of disease onset compared with age-matched FAD mutation non-carriers.




Aim 3:Discover whether Aim 1 effects are seen in higher AD risk ADNI adults (based on CSF Aβ42 levels and memory scores) versus lower risk ADNI adults (based on CSF Aβ42 levels), and whether the measures predict cognitive decline over 3 years.




Investigator:Paul Thompson


Title:Preclinical familial and late-onset Alzheimer’s disease brain changes

Date of Request:10/18/2012

Status:IA

ID:DIAN-D1209




Aim 1:Determine which sMRI, rs-fMRI, and DTI brain measures together best distinguish FAD mutation non-carriers from FAD mutation carriers within 10 years from their estimated age of disease onset.




Aim 2:Identify which sMRI, rs-fMRI, and DTI brain measures change faster over three years in FAD mutation carriers within 10 years from their estimated age of disease onset compared with age-matched FAD mutation non-carriers.




Aim 3:Discover whether Aim 1 effects are seen in higher AD risk ADNI adults (based on CSF Aβ42 levels and memory scores) versus lower risk ADNI adults (based on CSF Aβ42 levels), and whether the measures predict cognitive decline over 3 years.




Investigator:Chengjie Xiong


Title:Wavelet-based statistical analysis on brain functional connectivity

Date of Request:10/24/2012

Status:IA

ID:DIAN-D1210




Aim 1:Develop novel quantitative tools to comprehensively measure brain functional connectivity




Aim 2:Develop novel stat. methods to identify impairments of brain func. connectivity in elderly individuals







Investigator:Mayeux


Title:WHITE MATTER HYPERINTENSITIES AND CEREBRAL MICROBLEEDS IN DIAN

Date of Request:11/7/2012

Status:A

ID:DIAN-1211




Aim 1:1. To examine the natural history of WMH in the preclinical course of AD.




Aim 2:2. To examine the relationship between regionally distributed WMH and markers of AD pathology.







Displaying 221 - 230 of 319