DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 11 - 20 of 317

Investigator:Jason Hassenstab


Title:Establishing the utility and sensitivity of high-frequency cognitive assessments in Dominantly Inherited Alzheimer Disease.

Date of Request:08/22/2024

Status:approved

ID:DIAN-D2424




Aim 1:To quantify the cognitive effects of ADAD mutations, APOE genotype and AD biomarkers using a high-frequency cognitive assessment (HFCA) paradigm, the Ambulatory Research in Cognition (ARC) smartphone application










Investigator:Hongtu Zhu


Title:Knowledge-enhanced Cognitive System for Alzheimer’s Disease

Date of Request:07/28/2024

Status:pending approval

ID:DIAN-D2423




Aim 1:Construct an AD-KG by utilizing multiple curated resources, literature, and individual data across different domains and studies for AD.




Aim 2:Construct OKG for harmonization, imputation, and knowledge representation of AD-related multi-omics data.




Aim 3:Construct NKG for presentation, imputation, and knowledge representation of neuroimaging data and NOKG for knowledge representation of neuroimaging omics association maps, including, building a functional-facilitated structural connectome (FFSC) atlas, training cognitive systems methods for imputation and synthesis, constructing NKG and NOKG, respectively, to augment and complement AD-KG in 1).




Aim 4Develop an AD-KG-enhanced cognitive system (AD-KG-CS) for clinically transformative research.

Investigator:Karen Aguilar-Mateu


Title:Association between white matter (WM) specific tracts integrity and cognition profile in asymptomatic and symptomatic individuals whit Autosomal Dominant Alzheimer's Disease.

Date of Request:07/27/2024

Status:approved

ID:DIAN-D2422




Aim 1:Identify patterns of cognitive profile in asymptomatic and symptomatic individuals with Autosomal Dominant Alzheimer's Disease.




Aim 2:Assess microstructural integrity of WM specific tracts in asymptomatic and symptomatic individuals with Autosomal Dominant Alzheimer's Disease.




Aim 3:Explore the relationship between cognitive profile and changes in WM specifict tracts on potential shared mechanisms and differences in asymptomatic and symptomatic individuals with Autosomal Dominant Alzheimer's Disease.




Investigator:Prof. Ralph Martins


Title:Dominantly inherited Alzheimer's disease and Dutch-type cerebral amyloid angiopathy: a comparison of fluid biomarkers, imaging, cognitive and neuropsychiatric measures

Date of Request:07/24/2024

Status:approved

ID:DIAN-D2421




Aim 1:To examine the difference between D-CAA and ADAD in CSF and blood biomarkers, including Amyloid beta (Aβ) 40, Aβ42, total tau, p-tau181, matrix metalloproteinase 9 (MMP-9), fibrinogen, vascular cell adhesion molecule-1 (VCAM-1), Neurofilament light chain (NfL), and Glial Fibrillary Acidic Protein M(GFAP), over time.




Aim 2:To identify changes over time in cognitive domains, such as executive functions and memory, and NPS like depression, anxiety, and apathy in (pre)clinical stages of ADAD and D-CAA




Aim 3:To examine the relationship between fluid and imaging (amyloid PET and MRI) biomarkers in ADAD and D-CAA, and their relationship with cognition and NPS in (pre)symptomatic ADAD and D-CAA.




Aim 4To investigate whether demographic and lifestyle factors (such as age, education, exercise and socioeconomic status) influence on cognitive decline and NPS in (pre)symptomatic ADAD and D-CAA over time and whether these changes affect functioning and caregiver burden.

Investigator:Michael Ewers


Title:Analysis of proteomic signatures of MFG-E8 and medin amyloid in patients with autosomal dominant Alzheimer’s disease (ADAD)

Date of Request:07/21/2024

Status:approved

ID:DIAN-D2420




Aim 1:To test the association between MFG-E8 levels and neuroimaging markers of CAA




Aim 2:To test modulating factors of biofluid MFG-E8 levels including APOE e4 genotype and vascular risk factors




Aim 3:To determine the proteomic network and levels of medin associated with alterations in MFG-E8




Investigator:Francisco J. Martinez-Murcia


Title:Age of Onset determination in Autosomal Dominantly Inherited Alzheimer‘s Disease

Date of Request:07/09/2024

Status:approved

ID:DIAN-D2419




Aim 1:To inform a neuroimaging data-driven representation of AD progression that could be used to estimate the AoO of ADAD affected subjects.




Aim 2:To develop a deep latent variable model specifically targeted at modelling the fusion of neuroimaging data from different modalities







Investigator:Ellen Beard


Title:Investigating Personality Profiles in the Prediction of Dementia Clinical Presentation

Date of Request:07/05/2024

Status:approved

ID:DIAN-D2418




Aim 1:To explore whether personality profiles prior to dementia diagnosis predict subsequent behavioural and psychological symptoms of dementia










Investigator:Jorge J Llibre Guerra


Title:"Elucidating Protective Mechanisms in a PSEN1 Mutation Carrier Exhibiting Delayed Onset of Alzheimer's Disease"

Date of Request:07/03/2024

Status:approved

ID:DIAN- D2417




Aim 1:Investigate genetic variants contributing to the delayed onset of Alzheimer’s symptoms in a PSEN1 mutation carrier.




Aim 2:Analyze cross-sectional imaging and biomarker data to characterize disease progression and resilience mechanisms.




Aim 3:Identify and validate environmental factors contributing to the unique resilience observed in the individual.




Aim 4Develop comprehensive profiles for the proteomic and metabolomic alterations distinguishing the subject from typical DIAD mutation carriers.

Investigator:Randall Bateman


Title:Addendum to “Comparing biomarkers between Down Syndrome, Autosomal Dominant, and Late onset Alzheimer Disease.”

Date of Request:06/26/2024

Status:approved

ID:DIAN-D2416




Aim 1:Question 1a: How does the severity of white matter hyperintensities compare between DS and ADAD?




Aim 2:How does the presence of microbleeds compare across DS and ADAD?




Aim 3:Is enlarged perivascular space a common finding across DS and ADAD?




Aim 4Are the presence and progression of WMH, microbleeds, and PVS due to inflammatory processes?

Investigator:Mathias Jucker / Johannes Levin


Title:Is Maternal or Paternal origin of ADAD mutations relevant for clinical or biomarker outcome?

Date of Request:06/14/2024

Status:approved

ID:DIAN-D2415




Aim 1:Our aim is to determine whether the onset of Alzheimer's disease (AD) is affected by the inheritance pattern (paternal versus maternal) of AD-causing mutations.