DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 11 - 20 of 220

Investigator:Jeremy Strain

Title:Functional and Structural Correlates of Genetics in ADAD

Date of Request:06/15/2020

Aim 1:Does connectivity strength change based on APOE status or associate with the polygenetic risk score in an ADAD cohort.

Aim 2:Does structural connectivity change based on APOE status or associate with the polygenetic risk score in an ADAD cohort.

Aim 3:Does structural or functional connectivity temporally associate with proteomic data.


Title:Changes in personality in DIAN

Date of Request:05/08/2020

Aim 1:To evaluate the magnitude of within person personality change in DIAN.

Aim 2:To establish a causal link between personality change and AD biomarkers

Aim 3:Evaluate which specific “facets” of personality shown the most reliable change in preclinical ADAD.

Investigator:Patrick Luckett

Title:Effects of HIV and Aging on Resting-state Networks

Date of Request:05/06/2020

Aim 1:Combine data from numerous studies to investigate changes in resting state networks and volumetrics that occur over the lifespan in healthy controls and people living with HIV with machine learning.

Aim 2:Utilize data driven machine learning based feature selection methods to search for complex relationships among volumetrics, resting state, and genetic data.

Investigator:Ruth Peters

Title:Blood pressure and Alzheimer's pathology, the next step in understanding the relationship

Date of Request:05/04/2020

Aim 1:To examine the impact of blood pressure on cognitive function in the well characterised DIAN population

Aim 2:To evaluate the relationship between BP and Aß accumulation

Investigator:Xiaolei Shi

Title:The investigation of cerebral small vessel disease in The Dominantly Inherited Alzheimer Network

Date of Request:05/03/2020

Aim 1:To study the burden of cerebral small vessel disease in DIAN

Aim 2:To study the associations of cerebral small vessel disease neuroimaging markers with PSEN1, PSEN2, or APP gene mutations

Aim 3:To investigate the longitudinal changes of cerebral small vessel disease in DIAN

Investigator:Prof. dr. G.J. Biessels

Title:Critical white matter connections in AD: unraveling their sensitivity to AD pathology and functional relevance

Date of Request:04/06/2020

Aim 1:To examine if critical and non-critical white matter connections are differentially affected by AD in mutation carriers as compared to non-carriers, also considering burden of AD pathology and disease stage.

Aim 2:To explore if critical and non-critical white matter connections differentially affect cognition in AD mutation carriers, again also considering disease stage.

Investigator:Bret Bostwick

Title:Biomarker Modeling in Dominantly Inherited Alzheimer's Disease

Date of Request:03/17/2020

Aim 1:Compare longitudinal changes in CSF biomarkers, serum biomarkers and neuroimaging biomarkers.

Aim 2:Analyze longitudinal changes in CSF biomarkers, serum biomarkers and neuroimaging biomarkers.

Investigator:Nelly Joseph-Mathurin

Title:Genotype in dominantly inherited AD for clinical trial design

Date of Request:03/04/2020

Aim 1:Describe A/T/N trajectories per mutation type (APP, PS1, and PS2)

Aim 2:Define risk factors for ARIA per mutation type (APP, PS1, and PS2)

Aim 3:Develop and validate a prediction model for positive or adverse outcomes of anti-Aβ disease modifying treatment for DIAD individuals in clinical trials


Title:Cortical diffusion analysis in Dominantly Inherited Alzheimer’s disease (DIAD)

Date of Request:02/27/2020

Aim 1:Test a novel MRI analysis tool to investigate the cortical architecture

Aim 2:Identify neural cortical architecture signature in DIAD

Aim 3:Test the discrimination power of the novel cortical diffusivity measures in Alzhiemer's disease groups

Aim 4Test the prediction power of the novel cortical measures in Alzheimer’s disease groups

Investigator:Yakeel T. Quiroz

Title:Sex differences in Alzheimer’s disease pathology, neurodegeneration and cognition in autosomal dominant Alzheimer’s disease

Date of Request:02/18/2020

Aim 1:1. To extend our study on sex differences to other ADAD mutations and confirm our preliminary findings in a much larger sample of ADAD mutation carriers;

Aim 2:2. To inform power calculations for appropriate sample size, based on estimated effects, for an upcoming 2020 grant submission on sex differences in ADAD (i.e. career development award of postdoctoral fellow, Dr. Vila-Castelar).

Aim 3:3. To examine sex differences in ADAD mutation carriers at different clinical stages, from asymptomatic to symptomatic stages, with available biomarker and imaging data, and compare with age-matched noncarriers, which is not yet available in our group.