DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 31 - 40 of 316

Investigator:Joon-Kyung Seong


Title:A pretrained foundation model for learning representation of regional tau accumulation pattern

Date of Request:02/15/2024

Status:pending approval

ID:DIAN-D2403




Aim 1:The aim of this study is to develop a model trained on large-scale datasets to recognize patterns in brain images.




Aim 2:The versatility of this model allows for fine-tuning with smaller datasets, making it suitable for implementation in medical institutions with limited data.







Investigator:Yujia Zhou


Title:Researching Alzheimer's disease

Date of Request:02/02/2024

Status:pending approval

ID:DIAN-D2402




Aim 1:Image-based diagnosis




Aim 2:Biomarker-based diagnosis







Investigator:Prashant Upadhyay


Title:Deep Learning based ensembled method for Alzheimer's Disease Classification

Date of Request:01/15/2024




Aim 1:My Grandmother suffered from the same disease. Since then I am working on this Disease. That's why I have chosen this as my research topic in my PhD. I have experience working with similar datasets and am committed to upholding ethical data practices and ensuring data security.










Investigator:0


Title:PET/MRI-based Alzheimer's Disease Research Using Deep Learning

Date of Request:12/26/2023

Status:pending approval

ID:DIAN-D2327




Aim 1:Longitudinal imaging markers describing changes in AD over time




Aim 2:Explore the relationship with AB deposition, related genes and cognition to obtain the most relevant imaging and biological indicators




Aim 3:Multiple features were extracted and machine learning and deep learning were used to explore their biological markers




Investigator:Qunxi Dong


Title:Classification based on hippocampal multivariate morphometry statistics

Date of Request:11/19/2023

Status:pending approval

ID:DIAN-D2326




Aim 1:High-dimensional morphological features of the hippocampus were extracted to analyze group differences among different populations




Aim 2:The dimension of high-dimensional morphological features is reduced for subsequent classification







Investigator:Qunxi Dong


Title:Classification based on hippocampal multivariate morphometry statistics

Date of Request:11/19/2023




Aim 1:Extracting the high-dimensional morphological features of the hippocampus and cerebral ventricle of ADAD




Aim 2:Analyzing high-dimensional features to identify inter-group morphological differences in the hippocampus.




Aim 3:Using high-dimensional features for classification.




Investigator:Philippe Ravassard


Title:Organoid-based lncRNA discovery platform for Alzheimer's Disease.

Date of Request:11/14/2023

Status:approved

ID:DIAN-D2325




Aim 1:Generate assembloid cultures (assembled organoids) from familial and sporadic Alzheimer's Disease induced pluripotent stem cell (iPSC) lines, as well as their Crispr-Cas9 generated isogenic controls.




Aim 2:Extract cell-type specific long non-coding RNA (lncRNA) repertoires by using a combination of lineage purification, deep RNA sequencing and ATAC sequencing.




Aim 3:Annotate novel lncRNA and identify transcripts that are dysregulated in patient vs control cells.




Aim 4Use bulk and single-cell transcriptomes from the DIAN cohorts to validate newly identified lncRNA that may be associated with the disease.

Investigator:Prof Daniel Alexander


Title:Computational Modelling and Inference of Neurodegenerative Disease Propagation (CU-MONDAI)

Date of Request:09/29/2023

Status:approved

ID:DIAN-D2324




Aim 1:To provide new insights into how pathology spread is linked to the brain’s connectivity architecture in autosomal dominant Alzheimer’s disease and validate new computational models of pathology propagation in neurodegenerative diseases.










Investigator:Nelly Joseph-Mathurin


Title:Examining the Predictive Value of Synaptic Dysfunction and Neuronal Injury Measures on Imaging Markers of Disease Presentation and Progression in Alzheimer's Disease

Date of Request:09/26/2023

Status:approved

ID:DIAN-D2323




Aim 1:Evaluate association between rates of longitudinal change in CSF levels of Ng, SNAP-25, VILIP-1 and imaging brain changes and cognition in a DIAD cohort.




Aim 2:Evaluate association between rates of longitudinal change in CSF levels of Ng, SNAP-25, VILIP-1 and imaging brain changes and cognition in aged adults LOAD cohort.







Investigator:Seonjoo Lee


Title:Evaluating neural correlates of apathy in Alzheimer’s disease

Date of Request:09/18/2023

Status:pending approval

ID:DIAN-D2322




Aim 1:Aim1. We will seek to determine if apathy is embedded in a larger network of NPS and functional and cognitive impairment using clustering analysis. In the subset of data with neuropathology information, we will identify the association between apathy clusters and neuropathology.




Aim 2:Aim2. We will examine brain morphometry, structural connectivity, metabolism, amyloid PET in reward-sensitive areas, and effort valuation processing areas in apathy and/or its networks.




Aim 3:Aim3. We will evaluate the association between the intrinsic time scale (fMRI) and apathy and apathy networks in the course of disease.




Displaying 31 - 40 of 316